![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_3bd5dcd12d2ef57fd5cbefabf7849aa3.svg) | Gefitinib | IC50 | 845.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_2fe889f799cec7506279c157504449d3.svg) | WZ4002 | IC50 | 3.82 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_e2f99194617c96946324b426e112d809.svg) | Erlotinib | IC50 | 68.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_e2f99194617c96946324b426e112d809.svg) | Erlotinib | Ki | 95.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_5738ec28038a4926c8269d2115296097.svg) | Osimertinib | IC50 | 17.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_5738ec28038a4926c8269d2115296097.svg) | Osimertinib | Ki | 2.2 [1], 3.2 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_4938c13890e3f4591a69ccf63f3cb40e.svg) | Rociletinib | IC50 | 46.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_4938c13890e3f4591a69ccf63f3cb40e.svg) | Rociletinib | Ki | 1.65 [1], 1.75 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_96c0cd234b23fa7ffb03b03aeac09007.svg) | Afatinib | IC50 | 0.97 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_b00468f0510480824ea80b0bd6be8280.svg) | CID 78209992 | IC50 | 2.4 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_843c581680fbe07f0105a5c17ad3b9a9.svg) | Unii-5IE92SK9EB | IC50 | 7.0 [1], 13.0 [2], 21.0 [3], 90.0 [4], 140.0 [5] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_843c581680fbe07f0105a5c17ad3b9a9.svg) | Unii-5IE92SK9EB | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_742783a8c608ce00555d240a8897775a.svg) | N-(1H-Indazol-3-yl)-7,7-dimethyl-2-(1H-pyrazol-4-yl)-5H-furo[3,4-d]pyrimidin-4-amine | IC50 | 600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_742783a8c608ce00555d240a8897775a.svg) | N-(1H-Indazol-3-yl)-7,7-dimethyl-2-(1H-pyrazol-4-yl)-5H-furo[3,4-d]pyrimidin-4-amine | Ki | 0.2 [1], 0.5 [2], 1.6 [3], 2.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_c78d01397d1fe40f3a407e2d01509b3a.svg) | N-(7-Chloro-1H-indazol-3-yl)-2-[5-(difluoromethyl)-1H-pyrazol-4-yl]-7,7-dimethyl-5H-furo[3,4-d]pyrimidin-4-amine | IC50 | 370.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_c78d01397d1fe40f3a407e2d01509b3a.svg) | N-(7-Chloro-1H-indazol-3-yl)-2-[5-(difluoromethyl)-1H-pyrazol-4-yl]-7,7-dimethyl-5H-furo[3,4-d]pyrimidin-4-amine | Ki | 1.7 [1], 2.5 [2], 3.4 [3], 9.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_95e14fd60d9426b71665e3497a5c20dd.svg) | N-(1H-Indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5H-furo[3,4-d]pyrimidin-4-amine | IC50 | 3000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_95e14fd60d9426b71665e3497a5c20dd.svg) | N-(1H-Indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5H-furo[3,4-d]pyrimidin-4-amine | Ki | 0.5 [1], 21.3 [2], 34.3 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_d647b4216cc23ce18ecae6d5591434bc.svg) | Naquotinib | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_e911dd0c7211c476b2d44cc09654e736.svg) | CID 71496460 | IC50 | 2.0 [1], 2000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ece97f8d6e94cb5a87a9cb94a0ab04b0.svg) | N-[(3R,4R)-4-Fluoro-1-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide | IC50 | 2.0 [1], 7.0 [2], 9.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_d62343d9c06376fed17e27c3cc07ddf8.svg) | N-[4-Methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide | IC50 | 26.0 [1], 45.0 [2], 26000.0 [3], 45000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_2669792861d1011f78a41485888f7d7c.svg) | N-[5-[(5-Chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide | IC50 | 19.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_2c30a5f7265be9d58a6961ef0724922e.svg) | N-[5-[[4-(1H-Indol-3-yl)pyrimidin-2-yl]amino]-4-methoxy-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide | IC50 | 15.0 [1], 17.0 [2], 63.0 [3], 68.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_416ff4b392ea4e8e63ec0f54a0996901.svg) | (E)-N-[3-[(5-Chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxyphenyl]-4-(dimethylamino)but-2-enamide | IC50 | 91.0 [1], 96.0 [2], 388.0 [3], 400.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ea575fd7d861e6b3b5798b7527b2a77d.svg) | 1-[(3As,6aR)-2-[6-[4-(4-methylpiperazin-1-yl)anilino]-9-propan-2-ylpurin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]prop-2-en-1-one | IC50 | 8.0 [1], 14.0 [2], 18.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_0bd6610c993b3d2e72df5bedd9191dda.svg) | N-[(3R,4R)-1-[6-[(1-Ethyl-3-methoxypyrazol-4-yl)amino]-9-methylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide | IC50 | 1.0 [1], 2.0 [2], 6.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_d5efabaa41fdd5a03af9566e4fe6e14c.svg) | N-[(3R,4R)-4-Fluoro-1-[6-[[3-methoxy-1-(1-methylpyrrolidin-3-yl)pyrazol-4-yl]amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide | IC50 | 2.0 [1], 3.0 [2], 5.0 [3], 6.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_fb0ec7700d37359b352ffc9d4c88b743.svg) | N-[3-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]oxyphenyl]prop-2-enamide | IC50 | 30.0 [1], 500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_fb0ec7700d37359b352ffc9d4c88b743.svg) | N-[3-[4-(4-Methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]oxyphenyl]prop-2-enamide | Ki | 0.64 [1], 70.2 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_d684fbc92f8d210d41a758873fa7e8b9.svg) | N-[3-[4-(1H-Indazol-3-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]oxyphenyl]prop-2-enamide | IC50 | 70.0 [1], 500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_d684fbc92f8d210d41a758873fa7e8b9.svg) | N-[3-[4-(1H-Indazol-3-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]oxyphenyl]prop-2-enamide | Ki | 0.32 [1], 833.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_f280634d704aee4b2fbe150947eb0805.svg) | N-[3-[7-[2-Methoxy-4-(4-methyl-1,4-diazepan-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 2.11 [1], 2.75 [2], 5.17 [3], 11.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_259908e7e9b247a8583daf1ceaf13fc5.svg) | N-[3-[7-[4-[4-(Dimethylamino)piperidin-1-yl]-2-methoxyanilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 2.41 [1], 2.83 [2], 5.2 [3], 9.52 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_dc542483ced957bccffe0f33edd8b5c2.svg) | N-[3-(7-Anilino-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl)phenyl]prop-2-enamide | IC50 | 10.9 [1], 12.1 [2], 28.3 [3], 45.7 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_a1673d2de9e67c44126eb3218aad955f.svg) | N-[3-[3-Methyl-7-(methylamino)-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 837.1 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ad21c73c70e6cbaf35bf58af0ae2fcf2.svg) | N-[3-[3-Methyl-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 0.53 [1], 0.56 [2], 1.19 [3], 1.66 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_1fe66a54585ab3f2cabe3937d0f8d7f2.svg) | N-[3-[7-[3-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 0.63 [1], 1.67 [2], 2.04 [3], 2.31 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_38f938471566aabcf75081f88688a5d4.svg) | N-[3-[7-[2-Ethoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 2.68 [1], 3.02 [2], 7.1 [3], 12.7 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_15f8baa9bd17853d0d3bed599a8e1865.svg) | N-[3-[3-Methyl-7-[4-(4-methylpiperazin-1-yl)-2-propan-2-yloxyanilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 13.5 [1], 13.7 [2], 36.3 [3], 39.9 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_4d1fcadc2b7dea2e4ea71ab49386eafa.svg) | N-[3-[3-Methyl-7-[2-methyl-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 1.21 [1], 1.31 [2], 4.18 [3], 9.37 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_07106871a3706cdb6331273e00cb65ef.svg) | N-[3-[7-[2-Fluoro-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_f2ebeea8b17131b3b109a1df6f205d3a.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-propan-2-yl-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 0.45 [1], 0.46 [2], 4.42 [3], 6.02 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_dd59aae7ab59aa79d4b8b2cf236fa148.svg) | N-[3-[3-Cyclopropyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 0.66 [1], 0.73 [2], 6.02 [3], 10.5 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_c196d7da8cca697e2feef53794dd2be7.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-phenyl-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 0.46 [1], 0.51 [2], 0.93 [3], 0.98 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_8cc4728e6b48148b2e18d65d326c10a8.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-naphthalen-2-yl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 1.16 [1], 1.34 [2], 1.59 [3], 2.44 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_f05f30410eef875d8476eee592d44689.svg) | N-[3-[3-Benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 0.38 [1], 0.67 [2], 0.72 [3], 0.93 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_be0fb66cca193a21675c0b9245df429c.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-(4-phenylphenyl)-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 1.67 [1], 3.43 [2], 4.64 [3], 5.24 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_f48e98f39fa9a2470156252450f1d056.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-(4-phenoxyphenyl)-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 1.66 [1], 2.03 [2], 2.31 [3], 3.57 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_876c53816750505ea2171aa2157471c2.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-(4-phenylmethoxyphenyl)-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 2.42 [1], 2.43 [2], 2.56 [3], 6.31 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_b6ca520c75245260f50fbd5ef5b27c89.svg) | 1-(3-Aminophenyl)-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-4H-pyrimido[4,5-d]pyrimidin-2-one | IC50 | 478.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_9f83585a615f367625c20cb251fb8f59.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]propanamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_c631592e2e877d5d785794aeeb9e4957.svg) | N-[3-[7-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 1.08 [1], 1.21 [2], 3.14 [3], 6.56 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_4c6ca1184d762dad6a81134cf585d37a.svg) | N-[3-[7-[4-(Dimethylamino)-2-methoxyanilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 4.95 [1], 6.22 [2], 11.5 [3], 24.9 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_892a91d47255f80919fdd7987bde1d2c.svg) | N-[3-[7-(2-Methoxy-4-piperidin-1-ylanilino)-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 10.42 [1], 15.4 [2], 36.43 [3], 95.71 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_09635c13b0959fadd25861fc0cafda89.svg) | N-[3-[7-(2-Methoxy-4-morpholin-4-ylanilino)-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide | IC50 | 10.33 [1], 12.74 [2], 28.85 [3], 60.31 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_900c7860c14568997e05fe525eb02993.svg) | 7-[3-Methyl-4-(4-methylpiperazin-1-yl)anilino]-3-phenyl-1-[(3S)-1-prop-2-enoylpyrrolidin-3-yl]-4H-pyrimido[4,5-d]pyrimidin-2-one | IC50 | 3.0 [1], 9.2 [2], 10.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_0f23829d3103d8f37a84d80e191b3fd2.svg) | N-[4-Methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_0f23829d3103d8f37a84d80e191b3fd2.svg) | N-[4-Methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(4-methylpiperazin-1-yl)phenyl]prop-2-enamide | Ki | 1.46 [1], 1.58 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_bccadbb4062a6f6216d236a7562621df.svg) | N-(7-Chloro-1H-indazol-3-yl)-7,7-dimethyl-2-(1H-pyrazol-4-yl)-5H-furo[3,4-d]pyrimidin-4-amine | Ki | 0.4 [1], 1.3 [2], 2.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_05090f201096f21774324dd40d6817c4.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-6-methyl-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 15.11 [1], 22.34 [2], 52.63 [3], 110.1 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_b692c463285e1eccec1a77a4bfc08099.svg) | N-[3-[12-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,8-dioxo-3,9,11,13-tetrazatricyclo[8.4.0.03,7]tetradeca-1(14),10,12-trien-9-yl]phenyl]prop-2-enamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_83d4b4392cc2fa2f8ed9b88fd91d3929.svg) | N-[3-[6-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-2,10-dioxo-1,5,7,9-tetrazatricyclo[9.4.0.03,8]pentadeca-3,5,7-trien-9-yl]phenyl]prop-2-enamide | IC50 | 2.74 [1], 4.3 [2], 40.73 [3], 114.99 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_34d01672c7c7964c393d801dcd261ab8.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-6,7-dimethyl-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 6.02 [1], 41.59 [2], 50.85 [3], 122.45 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_1d7f0bc3506956060fd3322c6e04b96f.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-6-methyl-5,8-dioxo-7-propan-2-yl-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 24.11 [1], 24.83 [2], 44.05 [3], 56.49 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_e8e5728cf1f9e97c04e0d9f262dfff29.svg) | N-[3-[7-Butan-2-yl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6-methyl-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 7.25 [1], 13.25 [2], 86.76 [3], 87.45 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_0c185b1732131cf867383ecb1d41ba2d.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-6-methyl-5,8-dioxo-7-phenyl-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 77.09 [1], 173.73 [2], 778.15 [3], 1000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_652af9a7d02afbe8cbe0086c426966bd.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-5,8-dioxo-6-phenyl-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 6.86 [1], 30.74 [2], 193.97 [3], 221.2 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_9dde0b20662d2fdc7a875b665fd35983.svg) | N-[3-[7-Benzyl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6-methyl-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 5.3 [1], 8.33 [2], 8.95 [3], 16.46 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_b8fafd9ea3c9b04c3544b7ff2bd0b7ac.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-7-[(4-methoxyphenyl)methyl]-6-methyl-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 50.02 [1], 53.94 [2], 88.34 [3], 97.12 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_885a2ff43e0f37d93b295dc03846a265.svg) | N-[3-[7-[(4-Chlorophenyl)methyl]-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6-methyl-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 34.67 [1], 59.36 [2], 62.19 [3], 87.23 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_6ea88e3591dcb208d0c7ed695fe6c689.svg) | N-[3-[7-[(4-Fluorophenyl)methyl]-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-6-methyl-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 7.57 [1], 14.08 [2], 17.91 [3], 24.53 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ffd34b45013407517a877611bd2e8caa.svg) | N-[3-[6-Benzyl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5,8-dioxo-7H-pyrimido[4,5-e][1,4]diazepin-9-yl]phenyl]prop-2-enamide | IC50 | 8.4 [1], 9.12 [2], 32.83 [3], 84.25 [4] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 0.6 [1], 1.1 [2], 10.6 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_997fe095318226e799cbe61db5e4d8fd.svg) | 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline | IC50 | 1.0 [1], 1.1 [2], 28.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_da657d36ed91f5e7a4dfe12c5a05cabd.svg) | Nazartinib | IC50 | 9.0 [1], 11.0 [2], 25.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_01eaa129829cbfe04f38d9c7a41b4b7e.svg) | N-[(3R,4R)-1-[6-[(1,3-Dimethylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide | IC50 | 2127.0 [1], 6138.0 [2], 6651.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_9869d4afb98ef2c3ccd6540bb969cfa4.svg) | CID 46864270 | IC50 | 231.0 [1], 3000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_55e138809d3d887495336e7416b52ac1.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | IC50 | 0.8 [1], 4.0 [2], 12.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_325e47bbd33a1e64c8ed39bc2ce4cf31.svg) | N-[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl]-1-propan-2-ylimidazo[4,5-c]pyridin-6-amine | Ki | 40.0 [1], 211.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_b3b279e822291bc0a37d757ef146e2c8.svg) | N-[(3S)-1-[9-(2-Hydroxyethyl)-6-[4-(4-methylpiperazin-1-yl)anilino]purin-2-yl]pyrrolidin-3-yl]prop-2-enamide | IC50 | 7.0 [1], 31.0 [2], 387.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_65315251a7bd4732eddefe6fa6450532.svg) | (1R)-1-[6-[[2-[(3R,4S)-3-Fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]amino]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-2-yl]ethanol | IC50 | 27.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_65315251a7bd4732eddefe6fa6450532.svg) | (1R)-1-[6-[[2-[(3R,4S)-3-Fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl]amino]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-2-yl]ethanol | Ki | 1.1 [1], 7.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_c78f2e2340ddf078eb0d508494ada155.svg) | N-[3-[[5-Chloro-2-[(2E)-2-[1-(4-fluorophenyl)ethylidene]hydrazinyl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide | IC50 | 1290.0 [1], 1680.0 [2], 2530.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_c9c6e17d26c56a2f42362c2989022d1b.svg) | (E)-N-[3-[[2-[(2E)-2-[(1-Benzylindol-3-yl)methylidene]hydrazinyl]-5-chloropyrimidin-4-yl]amino]phenyl]-4-(dimethylamino)but-2-enamide | IC50 | 760.0 [1], 790.0 [2], 880.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ab79e67c13ffcb196d0e5b38a2c42227.svg) | (E)-N-[3-[[5-Chloro-2-[(2E)-2-[1-(2,4-difluorophenyl)ethylidene]hydrazinyl]pyrimidin-4-yl]amino]phenyl]-4-(dimethylamino)but-2-enamide | IC50 | 720.0 [1], 820.0 [2], 1250.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_d6f03a6960800559bcace03e1ea1696a.svg) | (E)-N-[3-[[5-Chloro-2-[(2E)-2-[(2-fluorophenyl)methylidene]hydrazinyl]pyrimidin-4-yl]amino]phenyl]-4-(dimethylamino)but-2-enamide | IC50 | 790.0 [1], 1560.0 [2], 3270.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_7a774b19efd4ea6babf6c2093bbfeb26.svg) | (E)-N-[3-[[5-Chloro-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazinyl]pyrimidin-4-yl]amino]phenyl]-4-(dimethylamino)but-2-enamide | IC50 | 680.0 [1], 1490.0 [2], 2230.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_81a0371625c87b1a0e678d995272d3f4.svg) | (E)-N-[3-[[5-Chloro-2-[(2E)-2-[(2,4-difluorophenyl)methylidene]hydrazinyl]pyrimidin-4-yl]amino]phenyl]-4-(dimethylamino)but-2-enamide | IC50 | 2510.0 [1], 2520.0 [2], 5110.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_55e842e2cd49c37e6873bd5dcee6738e.svg) | N-[3-[[5-Chloro-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazinyl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide | IC50 | 570.0 [1], 860.0 [2], 1120.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_fe24d400fe15b1e167ee66e44220001c.svg) | N-[3-[[5-Chloro-2-[(2E)-2-[(2-fluorophenyl)methylidene]hydrazinyl]pyrimidin-4-yl]amino]phenyl]prop-2-enamide | IC50 | 1510.0 [1], 1910.0 [2], 4740.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_9233475e42dbf562df6dfa67c4499dc1.svg) | 1-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]-3-(2-piperidin-1-ylethyl)urea | IC50 | 500.0 [1], 2030.0 [2], 2380.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_c87b88adfe0fb8e46a355a960c353ecf.svg) | 1-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]-3-(2-piperidin-1-ylethyl)thiourea | IC50 | 500.0 [1], 1760.0 [2], 2310.0 [3] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_6fea68e6f317eff5116cc3480e1e9d13.svg) | N-[3-[2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-7-oxopyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | IC50 | 0.5 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ad946fa32618a037eb1c316583993f21.svg) | 9-[[8-Fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-4-methyl-[1,4]oxazino[3,2-c]quinolin-3-one | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ee6f1a0cc6c324a3ee6995083e89094f.svg) | (3R,4S)-3-Fluoro-1-[4-[[2-[(1R)-1-hydroxyethyl]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-6-yl]amino]pyrimidin-2-yl]piperidin-4-ol | IC50 | 81.0 [1] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_ee6f1a0cc6c324a3ee6995083e89094f.svg) | (3R,4S)-3-Fluoro-1-[4-[[2-[(1R)-1-hydroxyethyl]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-6-yl]amino]pyrimidin-2-yl]piperidin-4-ol | Ki | 2.5 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_4242da2ee2a3321b0efd00f1d63fdcf7.svg) | Neratinib | IC50 | 3.0 [1], 66.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_e5e549ece7aea0a406367a90c52ffced.svg) | Dacomitinib | IC50 | 0.63 [1], 42.0 [2] |
![](https://images.aatbio.com/dataset/ic50/epidermal-growth-factor-receptor_291fdc26c251ab1eb139e1406ed05831.svg) | Canertinib | IC50 | 3.0 [1] |