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Epidermal growth factor receptor and ErbB2 (HER1 and HER2) Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amineIC5012.0 [1], 110.0 [2]
4-[4-[(1-Benzylindazol-5-yl)amino]quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amineIC5012.0 [1], 89.0 [2]
4-[4-(3-Chloro-4-phenylmethoxyanilino)quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amineIC5011.0 [1], 290.0 [2]
4-[4-(3-Chloro-4-fluoroanilino)quinazolin-6-yl]-N-(2-methylsulfonylethyl)-1,3-thiazol-2-amineIC5054.0 [1], 2450.0 [2]
N-(2-Methylsulfonylethyl)-4-[4-(4-phenylmethoxyanilino)quinazolin-6-yl]-1,3-thiazol-2-amineIC5028.0 [1], 1320.0 [2]
N-(2-Methylsulfonylethyl)-4-[4-[4-[[3-(trifluoromethyl)phenyl]methoxy]anilino]quinazolin-6-yl]-1,3-thiazol-2-amineIC50320.0 [1], 7400.0 [2]
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amineIC5070.0 [1]
Tyrphostin AG 825IC50350.0 [1]
4-(3-Bromoanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC50190.0 [1]
4-(3,4-Dimethoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC5050490.0 [1]
4-(3-Chloro-4-fluoroanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC50540.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 20IC5013850.0 [1]
6,7-Dialkoxyquinoline deriv. 53IC5034220.0 [1]
2-Cyano-3-(4-hydroxy-3-methoxy-5-((phenylthio)methyl)phenyl)-2-propenamideIC50130.0 [1]
4-[4-(4-Fluorophenyl)-2-(1-methylpiperidin-4-yl)-1,3-thiazol-5-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC50280.0 [1]
3-[3-(2-Chloro-benzylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamideIC50250.0 [1]
(3-Chloro-4-fluoro-phenyl)-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amineIC50602000.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 55IC50350.0 [1]
(E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamideIC502000.0 [1]
2-[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acidIC508000.0 [1]
2-Cyano-3-[4-hydroxy-3-methoxy-5-(pyridin-2-ylsulfanylmethyl)-phenyl]-acrylamideIC50700.0 [1]
2-Cyano-3-[4-hydroxy-3-[[(2-carboxyphenyl)thio]methyl]-5-methoxyphenyl]propenamideIC50450.0 [1]
2-[3-Methyl-4-hydroxy-5-methoxybenzylidene]propanedinitrileIC50112000.0 [1]
2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl)-benzylidene]-malononitrileIC5017400.0 [1]
3-[3-(5-Chloro-benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamideIC5015000.0 [1]
2-Cyano-3-[4-hydroxy-3-[(benzylthio)methyl]-5-methoxyphenyl]propenamideIC50200.0 [1]
3-(3-Benzylsulfanylmethyl-4,5-dihydroxy-phenyl)-2-cyano-acrylamideIC501020.0 [1]
3-[3-(2-Acetylamino-phenylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamideIC503300.0 [1]
2-(4-Hydroxy-3-methoxy-5-phenylsulfanylmethyl-benzylidene)-malononitrileIC502500.0 [1]
3-[3-(1H-Benzoimidazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamideIC506100.0 [1]
3-[3-(Benzooxazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamideIC501500.0 [1]
2-Cyano-3-(4-hydroxy-3-methoxy-5-p-tolylsulfanylmethyl-phenyl)-acrylamideIC501650.0 [1]
4-(3-Bromoanilino)-6,7-diethoxyquinoline-3-carbonitrileIC50420.0 [1]
4-(3-Chloro-4-fluoroanilino)-6,7-diethoxyquinoline-3-carbonitrileIC50980.0 [1]
4-(3-Chloroanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC50180.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 10IC501450.0 [1]
4-(3-Fluoroanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC50740.0 [1]
4-(3-Cyanoanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC5014180.0 [1]
4-[(4-Fluorophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrileIC5047940.0 [1]
4-(3-Acetylanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC507380.0 [1]
4-(3-Aminoanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC50820.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 18IC50870.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 21IC506360.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 22IC502730.0 [1]
3-[(3-Cyano-6,7-dimethoxyquinolin-4-yl)amino]benzamideIC507690.0 [1]
4-(3-Bromo-4-methylanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC501790.0 [1]
4-(3-Chloro-4-hydroxyanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC509040.0 [1]
4-(3,5-Dichloro-4-hydroxyanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC503150.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 27IC5017020.0 [1]
4-(3-Chloro-4-methylanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC501480.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 31IC50230.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 32IC50360.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 33IC5062320.0 [1]
4-(4-Bromoanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC506650.0 [1]
4-(2-Bromoanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC504180.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 37IC50840.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 38IC50620.0 [1]
4-(3-Azidoanilino)-6,7-dimethoxyquinoline-3-carbonitrileIC502210.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 40IC5069400.0 [1]
4-(3-Bromophenylamino)-6-ethoxy-7-methoxyquinoline-3-carbonitrileIC5021190.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 49IC5033020.0 [1]
4-(3-Bromoanilino)-6,7-dimethoxyquinoline-3-carbaldehydeIC503370.0 [1]
6,7-Dialkoxyquinoline deriv. 54IC5015170.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 56IC506750.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 57IC501100.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 58IC506790.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 59IC505150.0 [1]
6,7-Dimethoxyisoquinoline-4-carbonitrile deriv. 62IC5088290.0 [1]
6-Alkoxy-4-anilinoquinazoline 8fIC50540.0 [1]
2-(3,4-Dihydroxy-5-methylbenzylidene)malononitrileIC5059000.0 [1]
4-[1-[2-(Cyclopentylamino)pyrimidin-4-yl]-2-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-1-methylpiperidin-4-olIC5010000.0 [1]
2-Methyl-5-(6-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenolIC50644000.0 [1]
2-Methyl-5-(7-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenolIC50101000.0 [1]
N-(3-Chloro-4-fluorophenyl)-7-methylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC502500000.0 [1]
N-(3-Chloro-4-fluorophenyl)-6-methylpyrrolo[2,1-f][1,2,4]triazin-4-amineIC50509000.0 [1]
N-(3-Chloro-4-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amineIC50345000.0 [1]
3-(3-Benzylsulfanylmethyl-4-hydroxy-5-methoxy-phenyl)-2-(3,4-dihydroxy-benzoyl)-acrylonitrileIC506200.0 [1]
3-[3-(Benzothiazol-2-ylsulfanylmethyl)-4,5-dihydroxy-phenyl]-2-cyano-acrylamideIC508100.0 [1]
4-[[5-[(E)-3-Amino-2-cyano-3-oxoprop-1-enyl]-2-hydroxy-3-methoxyphenyl]methylsulfanyl]butanoic acidIC5016000.0 [1]
2-Cyano-3-[4-hydroxy-3-(4-hydroxy-phenylsulfanylmethyl)-5-methoxy-phenyl]-acrylamideIC501600.0 [1]
3-[3-(4-Chloro-benzylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamideIC503000.0 [1]
2-Cyano-3-[4-hydroxy-3-methoxy-5-(naphthalen-2-ylsulfanylmethyl)-phenyl]-acrylamideIC504600.0 [1]
[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-acetic acidIC5091000.0 [1]
4-[5-[2-(Cyclohexylamino)pyridin-4-yl]-4-(4-fluorophenyl)-1,3-oxazol-2-yl]piperidin-4-olIC501100.0 [1]
6,7-Dimethoxy-4-(3-methylsulfanylanilino)quinoline-3-carbonitrile;hydrochlorideIC50760.0 [1]
4-[3-(Dimethylamino)anilino]-6,7-dimethoxyquinoline-3-carbonitrile;hydrochlorideIC50850.0 [1]
1-(3-Bromoanilino)-6,7-dimethoxyisoquinoline-4-carbonitrile;hydrochlorideIC5070840.0 [1]
4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinoline-3-carbonitrile;hydrochlorideIC5091200.0 [1]
4-[4-Fluoro-3-(trifluoromethyl)anilino]-6,7-dimethoxyquinoline-3-carbonitrile;hydrochlorideIC50160.0 [1]
4-Anilino-6,7-dialkoxyquinoline deriv. 5IC5081300.0 [1]
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 50IC50104700.0 [1]
6,7-Dialkoxyquinoline deriv. 51IC50102200.0 [1]
N-Cyclopentyl-4-[2-(4-fluorophenyl)-5-(4-methylpiperazin-1-yl)imidazo[4,5-b]pyridin-1-yl]pyrimidin-2-amineIC5010000.0 [1]
2-Methyl-5-(5-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-phenolIC50270000.0 [1]
5-O-(4-Fluorophenyl) 1-O-[4-[(E)-2-nitroethenyl]phenyl] pentanedioateIC5010000.0 [1]
Pentanedioic acid 4-((E)-2-nitro-vinyl)-phenyl ester phenyl esterIC50420.0 [1]
[4-[(E)-2-Nitroethenyl]phenyl] 5-anilino-5-oxopentanoateIC5010000.0 [1]
1-O-Benzyl 5-O-[4-[(E)-2-nitroethenyl]phenyl] pentanedioateIC5010000.0 [1]
Pentanedioic acid 4-methoxy-phenyl ester 4-((E)-2-nitro-vinyl)-phenyl esterIC501000.0 [1]
Pentanedioic acid furan-2-ylmethyl ester 4-((E)-2-nitro-vinyl)-phenyl esterIC50290.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Epidermal growth factor receptor and ErbB2 (HER1 and HER2) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/epidermal-growth-factor-receptor-and-erbb2-her1-and-her2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Epidermal growth factor receptor and ErbB2 (HER1 and HER2) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/epidermal-growth-factor-receptor-and-erbb2-her1-and-her2-inhibitors-ic50-ki.
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