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Ephrin type-B receptor 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
8-Butyl-1-methyl-7-phenyl-1H-imidazo(2,1-f)purine-2,4(3H,8H)-dioneIC50538.0 [1], 1500.0 [2], 1900.0 [3], 8300.0 [4]
CID 44478401IC501.6 [1], 5.0 [2], 130.0 [3]
N'-(5-Chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC5025.0 [1], 90.0 [2], 187.0 [3], 190.0 [4]
SorafenibIC500.2 [1], 4.46 [2], 4.62 [3], 1900.0 [4]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5040.0 [1]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineKi63.8 [1]
N4-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-N2-(3,5-dimorpholinophenyl)pyrimidine-2,4-diamineIC502.0 [1], 4.0 [2], 14.0 [3], 17.0 [4]
6-(2-Methoxyphenyl)-4-methyl-7-phenylpurino[7,8-a]imidazole-1,3-dioneIC503300.0 [1], 4350.0 [2]
8-(4-Hydroxybutyl)-1-methyl-7-phenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dioneIC501600.0 [1], 5680.0 [2], 6800.0 [3], 7000.0 [4]
3-({4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamideIC5040.0 [1], 172.0 [2]
8-Butyl-1-Methyl-7-(2-Methylphenyl)-1h-Imidazo[2,1-F]purine-2,4(3h,8h)-DioneIC5050.0 [1], 56.0 [2], 82.0 [3]
1-Amino-5-(5-Hydroxy-2-Methylphenyl)-7,8,9,10-Tetrahydropyrimido[4,5-C]isoquinolin-6(5h)-OneIC50160.0 [1], 300.0 [2], 930.0 [3]
6-Butyl-7-(4-fluoro-2-methylphenyl)-4-methylpurino[7,8-a]imidazole-1,3-dioneIC5068.0 [1], 91.0 [2], 139.0 [3]
6-Butyl-7-[5-(1H-indazol-4-yl)-2-methylphenyl]-4-methylpurino[7,8-a]imidazole-1,3-dioneIC5014.0 [1], 133.0 [2], 150.0 [3]
StaurosporineIC50126.4 [1], 233.0 [2]
Nvp-aew541IC5010000.0 [1]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC505100.0 [1], 16000.0 [2]
4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC5015.9 [1]
3-(4-Amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)benzenesulfonamideIC5019.0 [1], 21.0 [2]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5049.0 [1], 64.0 [2]
7-(2-Chlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5058.0 [1]
cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenolIC505.0 [1]
7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineIC502700.0 [1]
4-[[7-(2-Chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC5030.8 [1]
5-Methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amineIC50391.0 [1]
N'-(5-Chloro-1,3-Benzodioxol-4-Yl)-N-(3-Morpholin-4-Ylphenyl)pyrimidine-2,4-DiamineIC50580.0 [1]
[4-Methyl-3-[methyl-[2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanolIC503.0 [1], 11.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamineIC501.3 [1], 9.0 [2]
3-(3-Chloro-4-fluorophenyl)-7-(pyridin-3-yl)thieno[3,2-c]pyridin-4-amineIC5029.0 [1], 51.0 [2]
3-(3-Chloro-4-fluorophenyl)-7-(3-(methylsulfonyl)phenyl)thieno[3,2-c]pyridin-4-amineIC5018.0 [1], 59.0 [2]
1-[2-Methoxy-5-(trifluoromethyl)phenyl]-3-[3-[8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]ureaIC5037.0 [1], 50.0 [2]
1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[3-[8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]ureaIC5049.0 [1], 400.0 [2]
N-[3-[[4-(1H-Indazol-4-ylamino)pyrimidin-2-yl]amino]phenyl]methanesulfonamideIC5084.0 [1], 8420.0 [2]
N^4^-1H-Indazol-4-YL-N^2^-[3-(methylsulfonyl)phenyl]pyrimidine-2,4-diamineIC5061.0 [1], 2530.0 [2]
4-[[7-(2,6-Dimethylphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC5073.7 [1]
4-N-(1H-Indazol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC5036.0 [1], 51.0 [2]
1-Amino-5-(3-methoxyphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-oneIC505200.0 [1], 9400.0 [2]
3-({4-[(5-Chloro-1,3-benzodioxol-4-YL)amino]pyrimidin-2-YL}amino)benzamideIC50220.0 [1], 900.0 [2]
(3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanolIC504.0 [1], 12.0 [2]
N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-YL)amino]pyrimidin-2-YL]amino]phenyl]methanesulfonamideIC50741.0 [1], 794.0 [2]
(3-((2-(3-Methoxy-5-morpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanolIC505.0 [1], 32.0 [2]
[3-[[2-[3-(2-Methoxyethoxy)-5-morpholin-4-ylanilino]pyrimidin-4-yl]-methylamino]-4-methylphenyl]methanolIC508.0 [1], 35.0 [2]
[4-Methyl-3-[[2-(3-methylsulfonyl-5-morpholin-4-ylanilino)pyrimidin-4-yl]-propan-2-ylamino]phenyl]methanolIC502.0 [1], 7.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(3-methoxyphenyl)-4-N-methylpyrimidine-2,4-diamineIC502.0 [1], 10.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-methyl-4-N-phenylpyrimidine-2,4-diamineIC5017.0 [1], 84.0 [2]
4-N-(3-Chlorophenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamineIC506.0 [1], 12.0 [2]
(3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanolIC5010.0 [1], 114.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-methyl-4-N-(3-methylphenyl)pyrimidine-2,4-diamineIC508.0 [1], 28.0 [2]
4-N-(2,5-Dimethylphenyl)-2-N-(3,5-dimorpholin-4-ylphenyl)-4-N-methylpyrimidine-2,4-diamineIC5019.0 [1], 38.0 [2]
(2-Chloro-5-((2-(3,5-dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)phenyl)methanolIC502.0 [1], 13.0 [2]
(3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-5-methoxyphenyl)methanolIC502.0 [1], 7.0 [2]
1-(3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)ethanolIC5035.0 [1], 180.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(5-methoxy-2-methylphenyl)-4-N-methylpyrimidine-2,4-diamineIC5010.0 [1], 21.0 [2]
[4-Methyl-3-[methyl-[2-[3-morpholin-4-yl-5-(oxan-4-yloxy)anilino]pyrimidin-4-yl]amino]phenyl]methanolIC508.0 [1], 23.0 [2]
[3-[[4-[5-(Hydroxymethyl)-N,2-dimethylanilino]pyrimidin-2-yl]amino]-5-morpholin-4-ylphenyl]-morpholin-4-ylmethanoneIC5017.0 [1], 459.0 [2]
(3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(2-methoxyethyl)amino)-4-methylphenyl)methanolIC5012.0 [1]
[4-Methyl-3-[methyl-[2-[3-morpholin-4-yl-5-(1,4-oxazepan-4-yl)anilino]pyrimidin-4-yl]amino]phenyl]methanolIC509.0 [1], 28.0 [2]
[4-Methyl-3-[methyl-[2-[3-(4-methylpiperazin-1-yl)-5-morpholin-4-ylanilino]pyrimidin-4-yl]amino]phenyl]methanolIC504.0 [1], 32.0 [2]
[4-Methyl-3-[methyl-[2-(3-morpholin-4-yl-5-pyrrolidin-1-ylanilino)pyrimidin-4-yl]amino]phenyl]methanolIC5016.0 [1], 27.0 [2]
[4-Methyl-3-[methyl-[2-(3-morpholin-4-yl-5-piperidin-1-ylanilino)pyrimidin-4-yl]amino]phenyl]methanolIC5010.0 [1], 11.0 [2]
[4-Methyl-3-[methyl-[2-[3-morpholin-4-yl-5-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]phenyl]methanolIC506.0 [1], 25.0 [2]
(3-((2-(2,6-Dimorpholinopyridin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanolIC508.0 [1], 14.0 [2]
(3-((2-(2,6-Dimorpholinopyrimidin-4-ylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanolIC5015.0 [1], 106.0 [2]
2-N-(2,6-Dimorpholin-4-ylpyridin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamineIC500.9 [1], 5.0 [2]
2-N-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamineIC502.6 [1], 24.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(4-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamineIC5013.0 [1], 41.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(6-methoxypyridin-2-yl)-4-N-methylpyrimidine-2,4-diamineIC506.0 [1], 28.0 [2]
2-N-(4,6-Dimorpholin-4-ylpyrimidin-2-yl)-4-N-(1H-indazol-4-yl)-4-N-methylpyrimidine-2,4-diamineIC50432.0 [1], 12000.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(5-methoxypyridin-3-yl)-4-N-methylpyrimidine-2,4-diamineIC502.0 [1], 30.0 [2]
2-(3-(4-Amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)phenyl)acetamideIC5020.0 [1], 44.0 [2]
6-(2-Methoxyphenyl)-4-methyl-7-(2-methylphenyl)purino[7,8-a]imidazole-1,3-dioneIC5047.0 [1], 180.0 [2]
7-(3-Hydroxyphenyl)-6-(2-methoxyphenyl)-4-methylpurino[7,8-a]imidazole-1,3-dioneIC50213.0 [1], 368.0 [2]
2-N-[3,5-Bis(methylsulfonyl)phenyl]-4-N-(5-chloro-1,3-benzodioxol-4-yl)pyrimidine-2,4-diamineIC50114.0 [1], 209.0 [2]
N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-methylsulfonylphenyl]methanesulfonamideIC5012.0 [1], 2054.0 [2]
3-(4-(5-Chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-(methylsulfonyl)benzamideIC5023.0 [1], 22200.0 [2]
4-N-(5-Chloro-1,3-benzodioxol-4-yl)-2-N-(3-methylsulfonyl-5-morpholin-4-ylphenyl)pyrimidine-2,4-diamineIC502.0 [1], 32.0 [2]
3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)benzenesulfonamideIC501.0 [1], 14117.0 [2]
N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-morpholin-4-ylphenyl]methanesulfonamideIC502.0 [1], 170.0 [2]
N-[3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)phenyl]methanesulfonamideIC5015.0 [1], 7175.0 [2]
3-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]-5-(methanesulfonamido)benzamideIC50370.0 [1], 30000.0 [2]
3-(4-(5-Chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)-5-morpholinobenzamideIC5013.0 [1], 887.0 [2]
5-(4-(5-Chlorobenzo[d][1,3]dioxol-4-ylamino)pyrimidin-2-ylamino)isophthalamideIC5077.0 [1], 30000.0 [2]
1-(5-Bromo-2-methoxyphenyl)-3-[3-[8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]ureaIC5026.0 [1], 50.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indazol-7-yl)pyrimidine-2,4-diamineIC5089.0 [1], 3500.0 [2]
(3-(4-((1H-Indazol-4-yl)(methyl)amino)pyrimidin-2-ylamino)phenyl)methanolIC5021.0 [1], 232.0 [2]
2-((5-Chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methylsulfonyl)phenylamino)pyrimidin-4-yl)amino)ethanolIC50121.0 [1], 187.0 [2]
4-N-(2H-Benzotriazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamineIC50115.0 [1], 8600.0 [2]
3-[[4-[1H-Indazol-4-yl(methyl)amino]pyrimidin-2-yl]amino]-N,N-dimethylbenzamideIC5029.0 [1], 453.0 [2]
4-N-(1,3-Benzoxazol-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC50219.0 [1], 1350.0 [2]
4-N-(6-Chloro-1-benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC50300.0 [1], 897.0 [2]
(3-(4-(1H-Indazol-4-ylamino)pyrimidin-2-ylamino)phenyl)methanolIC50204.0 [1], 4400.0 [2]
4-N-(1,3-Benzoxazol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC50549.0 [1], 1760.0 [2]
4-N-(3-Chloro-2H-indazol-4-yl)-2-N-(3,5-dimorpholin-4-ylphenyl)pyrimidine-2,4-diamineIC5055.0 [1], 227.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indol-4-yl)pyrimidine-2,4-diamineIC50117.0 [1], 856.0 [2]
4-N-(1-Benzofuran-7-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC50205.0 [1], 460.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(1H-indazol-4-yl)pyrimidine-2,4-diamineIC5011.0 [1], 302.0 [2]
2-N-(3,5-Dimorpholin-4-ylphenyl)-4-N-(3-methyl-2H-indazol-4-yl)pyrimidine-2,4-diamineIC5067.0 [1], 513.0 [2]
3-[[4-(1H-Indazol-4-ylamino)pyrimidin-2-yl]amino]-N,N-dimethylbenzamideIC50246.0 [1], 10400.0 [2]
4-N-(1,3-Benzodioxol-4-yl)-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC5034.0 [1], 186.0 [2]
4-N-(5-Chloro-1,3-benzodioxol-4-yl)-4-N-methyl-2-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC5036.0 [1], 42.0 [2]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ephrin type-B receptor 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/ephrin-type-b-receptor-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Ephrin type-B receptor 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ephrin-type-b-receptor-4-inhibitors-ic50-ki.
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