![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_6cf1f414542c58ca1124fcce0b334418.svg) | Endothelin | IC50 | 0.05 [1], 0.2 [2], 0.38 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_6cf1f414542c58ca1124fcce0b334418.svg) | Endothelin | Ki | 0.14 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_575acb7546adcaf4c25ef5e411968354.svg) | Bosentan | IC50 | 40.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_575acb7546adcaf4c25ef5e411968354.svg) | Bosentan | Ki | 6.5 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_f8da4c939e9dfa613f89fa67af28a282.svg) | 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide | IC50 | 5.8 [1], 50.12 [2], 150.0 [3], 570.0 [4] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_f8da4c939e9dfa613f89fa67af28a282.svg) | 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide | Ki | 48.0 [1], 55.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_b4fc4550d5fd79e950249a18184391cc.svg) | 3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one | IC50 | 0.3 [1], 0.37 [2], 1.1 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_b4fc4550d5fd79e950249a18184391cc.svg) | 3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one | Ki | 0.17 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_568398354ee28fedcb9bb28f9ee726f3.svg) | (1,1'-Biphenyl)-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)- | Ki | 1.4 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_2ebd348a954c820062561554c154e76e.svg) | Atrasentan | IC50 | 0.03 [1], 0.08 [2], 0.31 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_2ebd348a954c820062561554c154e76e.svg) | Atrasentan | Ki | 0.03 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_39d33a1ae4080358753cdbccd24f5f69.svg) | Sitaxentan | IC50 | 1.4 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_39d33a1ae4080358753cdbccd24f5f69.svg) | Sitaxentan | Ki | 0.43 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_8caaf26cfbf2a8f0ff8e60cab756856b.svg) | Bms-248360 | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_8caaf26cfbf2a8f0ff8e60cab756856b.svg) | Bms-248360 | Ki | 1.9 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c7bb82b6cf04c96e7efaf71b330484e9.svg) | Sulfisoxazole | IC50 | 780.0 [1], 850.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c7bb82b6cf04c96e7efaf71b330484e9.svg) | Sulfisoxazole | Ki | 13465.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_e1721e8bf84a067f7d014f1ad73c8025.svg) | A-216546 Free base | IC50 | 0.49 [1], 24900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_e1721e8bf84a067f7d014f1ad73c8025.svg) | A-216546 Free base | Ki | 0.46 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_e69e320d759488f08a64e57078448583.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-Acetamido-3,3-diphenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 15.0 [1], 40.0 [2], 58.0 [3], 70.0 [4] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_150832d032a38f4bd62288688232e10d.svg) | 3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(2,4,6-trimethylphenyl)thiophene-2-carboxamide | IC50 | 0.15 [1], 0.17 [2], 0.63 [3], 630.0 [4] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_41d670a776f6fa41b373f4a782b75efc.svg) | (3S)-3-[[(2S)-2-[[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 8900.0 [1], 9500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_1dc9a0a164ff0b269f8eb0aad66c5bd2.svg) | 3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-(4-chloro-phenyl)-5-hydroxy-5H-furan-2-one | IC50 | 430.0 [1], 2200.0 [2], 3800.0 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_6ec6adb97b0b13d8004d412b34f2d0cd.svg) | 5-Benzyloxy-3-isopropoxy-benzo[b]thiophene-2-carboxylic acid | IC50 | 6000.0 [1], 8800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c54686e7ba1b8f8a75fa8e6b4047c4d0.svg) | Irbesartan | Ki | 0.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_25b8ee7272dc3c2a08c2a64615329d50.svg) | Cyclo(D-trp-D-asp-pro-D-val-leu) | IC50 | 20.5 [1], 24.8 [2], 37.0 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_f7a59374a35f2341db802dd190f7516f.svg) | Unii-0I32bcl40Z | Ki | 0.2 [1], 0.43 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_7a779baef2adde284f6e94c9e26c07ac.svg) | (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-2-(3-fluoro-4-methoxyphenyl)-1-[2-[pentylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid | IC50 | 0.08 [1], 0.48 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c16577c029c997cf71da5ed43ec7a159.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_1fdd0035896984ce765f9b03e1938feb.svg) | 3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(4-methylphenyl)thiophene-2-carboxamide | IC50 | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_f12869d01e2ce655fef00c6612ef5271.svg) | N-(1,3-Benzodioxol-5-yl)-3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide | IC50 | 19.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_46e4758f47a45e880926d4ea0d059415.svg) | 5-Hydroxy-4-(4-methoxy-benzyl)-5-(4-methoxy-phenyl)-3-phenyl-5H-furan-2-one | IC50 | 2000.0 [1], 2200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_bd0dfd21dfdfe687577abda33cd54ae4.svg) | 3-(1,3-Benzodioxol-5-yl)-4-benzyl-5-(3,4-dichlorophenyl)-5-hydroxyfuran-2-one | IC50 | 400.0 [1], 560.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_a4de583e151f3cee3a67543444bd8a77.svg) | 5-Hydroxy-4-(4-methoxy-benzyl)-5-(4-methoxy-phenyl)-3-p-tolyl-5H-furan-2-one | IC50 | 570.0 [1], 750.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_47e4d6056f8d65ae23916ad145166a6c.svg) | 3-(1,3-Benzodioxol-5-yl)-4-benzyl-5-hydroxy-5-(4-methoxy-3-methylphenyl)furan-2-one | IC50 | 12.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_f0f7ee0c4b808e785c383baf18abb8cb.svg) | 5-Hydroxy-4-(4-methoxy-benzyl)-3,5-bis-(4-methoxy-phenyl)-5H-furan-2-one | IC50 | 190.0 [1], 310.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_96126e17129d627a3e28475c51c39d49.svg) | 3-(3,4-Dichlorophenyl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(4-methoxyphenyl)methyl]furan-2-one | IC50 | 170.0 [1], 310.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_a45ad338785f556f543eb6e5d014d49f.svg) | 3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-methoxy-phenyl)-5H-furan-2-one | IC50 | 7.4 [1], 50.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_ecc2421d61b872ba00524bfff71bcb5f.svg) | 3-(1,3-Benzodioxol-5-yl)-4-[(4-chlorophenyl)methyl]-5-hydroxy-5-(4-methoxyphenyl)furan-2-one | IC50 | 110.0 [1], 140.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_ec506469095af94e9e53ae9b85b8502a.svg) | (3S)-3-[[(2S)-2-[[(2R)-2-Acetamido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 1800.0 [1], 2800.0 [2], 10000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_3ebb9142356f01204247d61378426695.svg) | 3-[(3-Carboxyphenyl)methyl]-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-4-oxo-6-propoxyquinoline-2-carboxylic acid | IC50 | 0.11 [1], 4.0 [2], 4.2 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_60b4d8581b30b6a9d806e27c83120cf7.svg) | 3-(1,3-Benzodioxol-5-yl)-4-benzyl-5-hydroxy-5-phenylfuran-2-one | IC50 | 600.0 [1], 1300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_8244a6f592d9ca47f20de718ee032e04.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-Acetamido-2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)acetyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 3.5 [1], 4.0 [2], 4.9 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_bbcfe4fcf297de51415511f7c7495c24.svg) | 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(4-methylphenyl)methyl]furan-2-one | IC50 | 50.0 [1], 51.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c8f4dfd98875ee3022c6404d3faacbfd.svg) | 3-(1,3-Benzodioxol-5-yl)-4-benzyl-5-hydroxy-5-(4-methylphenyl)furan-2-one | IC50 | 1200.0 [1], 4900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_3b8153a0d30f466081db09a51726bd66.svg) | 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-4-[(4-methoxy-3-methylphenyl)methyl]-5-(4-methoxyphenyl)furan-2-one | IC50 | 2.4 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_0b1f799f3124796b33261f949f3ed517.svg) | 2-(1,3-Benzodioxol-5-yl)-2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-2-propylphenoxy]-N-(4-propan-2-ylphenyl)sulfonylacetamide | IC50 | 24.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_36015c76893bd07617a483b493341262.svg) | 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(4-methoxyphenyl)methyl]furan-2-one | IC50 | 1.8 [1], 9.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_1c3ad05c5d1f338708a69c632e83a93a.svg) | 3-(4-Chlorophenyl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(4-methoxyphenyl)methyl]furan-2-one | IC50 | 700.0 [1], 960.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_a5fc952547980db117148ced1bed385a.svg) | Methyl 2-(1,3-benzodioxol-5-yl)-2-(1,2,3,4-tetrahydroacridin-9-yl)acetate | IC50 | 7300.0 [1], 11000.0 [2], 12000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_b8ea44e756437079ecf1726dd96cf43f.svg) | 2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-ethanol | IC50 | 900.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_50a005092c9a0b391360c6202c9d613c.svg) | 2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-acetamide | IC50 | 7900.0 [1], 8500.0 [2], 77000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_5cb477ca46ed988980439a0aacf395de.svg) | Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid methyl ester | IC50 | 2800.0 [1], 4300.0 [2], 5800.0 [3] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_0f91d5e943cbc1b906e5d3bf5b0d28a8.svg) | 1,3-Benzodioxol-5-yl 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate | IC50 | 8.9 [1], 8900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_06d1fd62fd4503094c79085141b3ae94.svg) | Endothelin-1 | IC50 | 0.02 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_e8d9ad9f0be3af1bd05741a14215df45.svg) | 2-[(3S,6R,9S,12R,15S)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid | IC50 | 22.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_e8d9ad9f0be3af1bd05741a14215df45.svg) | 2-[(3S,6R,9S,12R,15S)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid | Ki | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_81c8bb16d94199e71bcf651f30bbd302.svg) | Sodium;(Z)-2-(1,3-benzodioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-[(3,4,5-trimethoxyphenyl)methyl]but-2-enoate | IC50 | 0.31 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_81c8bb16d94199e71bcf651f30bbd302.svg) | Sodium;(Z)-2-(1,3-benzodioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-[(3,4,5-trimethoxyphenyl)methyl]but-2-enoate | Ki | 0.17 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_e6551d3d687fc7b6bf575cba515922b5.svg) | Acetyldiphenylalanyl-leucyl-aspartyl-isoleucyl-isoleucyl-tryptophan | IC50 | 3500.0 [1], 4400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_ad1dd7ff9c21c0e6e167cd17809bdb35.svg) | Enrasentan | Ki | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_8558ea5d66c663d3c4dbb9bebfc044cc.svg) | Histidyl-leucyl-aspartyl-isoleucyl-isoleucyl-tryptophan | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_4c2952593d79fb80b43da0fa8f319e60.svg) | 3-[(3-Carboxyphenyl)methyl]-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-6-hydroxy-4-oxoquinoline-2-carboxylic acid | IC50 | 37.01 [1], 38.9 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c8bfdb3f7a4435c87c1823cd5b601e1c.svg) | N-(2-Acetyl-4,6-dimethylphenyl)-3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide | IC50 | 0.04 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_75056e08a400a6daaac2fad41d416d4d.svg) | Sparsentan | Ki | 9.3 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_d124e2cd913004c6a3db01fc1cf1e12e.svg) | 4-[1-(1,3-Benzodioxol-5-yl)-2-oxo-2-[(4-propan-2-ylphenyl)sulfonylamino]ethoxy]-3-propylbenzoic acid | IC50 | 0.26 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_d124e2cd913004c6a3db01fc1cf1e12e.svg) | 4-[1-(1,3-Benzodioxol-5-yl)-2-oxo-2-[(4-propan-2-ylphenyl)sulfonylamino]ethoxy]-3-propylbenzoic acid | Ki | 0.13 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c86ee3230288fb2e606692e4786e781b.svg) | N-(3,4-Dimethyl-1,2-oxazol-5-yl)naphthalene-1-sulfonamide | IC50 | 440.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_011ed57321a7cb1a28b7c730781d10d4.svg) | N-[[2-[2-[(3,4-Dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-5-(1,3-oxazol-2-yl)phenyl]methyl]acetamide | Ki | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_64b75d826da1d08cb21a9a81d807271b.svg) | 2-[2-(1,3-Benzodioxol-5-yl)acetyl]-N-(4-chloro-3-methyl-1,2-oxazol-5-yl)thiophene-3-sulfonamide | IC50 | 18.0 [1], 21.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_f343160d7034f9a42cdecc6387d22984.svg) | (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-[butylsulfonyl(propyl)amino]ethyl]-2-(3-fluoro-4-methoxyphenyl)pyrrolidine-3-carboxylic acid | IC50 | 0.04 [1], 0.38 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c2f47eff24457e9503d1948c36038c8d.svg) | 3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(6-cyano-1,3-benzodioxol-5-yl)thiophene-2-carboxamide | IC50 | 3.4 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_154bc9bc4da9cc7dbc4d7fb5dcdb68f2.svg) | N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide | IC50 | 3.3 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_377caa42f3a3d088d7b173bf8474ea8f.svg) | 3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(4-methoxy-2-methylphenyl)thiophene-2-carboxamide | IC50 | 2.6 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c3ca6ec27e2781de6d41e1aab91a5d07.svg) | N-(6-Acetyl-1,3-benzodioxol-5-yl)-3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_5d98b47ace9492356b86724642ab77b2.svg) | (3S)-3-[[(2S)-2-[[(2R)-2-Acetamido-3-naphthalen-2-ylpropanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_683299dcfa741a060988676e41a81c3e.svg) | 3-[(3-Carboxyphenyl)methyl]-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-4-oxo-6-prop-2-enoxyquinoline-2-carboxylic acid | IC50 | 38.1 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_d8388f1b1692fc896ee7cfed18519626.svg) | 3-[(3-Carboxyphenyl)methyl]-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-6-(methoxymethoxy)-4-oxoquinoline-2-carboxylic acid | IC50 | 24.4 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_c1e0ab32f3a2f2587eefe94b3d6066e5.svg) | 6-Butoxy-3-[(3-carboxyphenyl)methyl]-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-4-oxoquinoline-2-carboxylic acid | IC50 | 1.44 [1], 1.88 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_75bed0282402884896f7466c7090625e.svg) | 3-(1,3-Benzodioxol-5-yl)-1-(1,3-benzodioxol-5-ylmethyl)-5-propoxyindole-2-carboxylic acid | IC50 | 80.0 [1], 250.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_24154545457565905660000d0ce12892.svg) | 3-(1,3-Benzodioxol-5-yl)-1-(1,3-benzodioxol-5-ylmethyl)-5,6-dimethoxyindole-2-carboxylic acid | IC50 | 60.0 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_68f3ff7594bd60ab8fbef8b16a28edd2.svg) | (3S)-3-[[(2S)-2-[[(2R)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 400.0 [1], 7000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_e7244f65d60462d5732a5b27f7a34f70.svg) | 3-[(3-Carboxyphenyl)methyl]-6-ethoxy-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-4-oxoquinoline-2-carboxylic acid | IC50 | 6.6 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_8a7a2cd1564d03b0763abaed0eddf324.svg) | 3-[(3-Carboxyphenyl)methyl]-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-6-(2-methylpropoxy)-4-oxoquinoline-2-carboxylic acid | IC50 | 6.3 [1], 9.9 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_921f35befb0f23e8738eaa7bc1ee93df.svg) | 3-[(3-Carboxyphenyl)methyl]-6-(cyclopropylmethoxy)-1-[(6-ethyl-1,3-benzodioxol-5-yl)methyl]-4-oxoquinoline-2-carboxylic acid | IC50 | 115.9 [1], 121.3 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_d2d5c2a805590839ea93265830c511d5.svg) | N-[(2R)-1-[[(2S)-1-(Butylsulfonylamino)-3-methyl-1-oxobutan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide | Ki | 1.5 [1], 1.8 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_103101d95a3924f06940b41d5ddfecf5.svg) | Darusentan, (+/-)- | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_9d8373decd54ac4056d1268b6241cca6.svg) | (2S)-2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-Acetamido-3,3-diphenylpropanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid | IC50 | 430.0 [1], 480.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_3394dfe3839920ddc9b5405794aeacc9.svg) | N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[2-(hydroxymethyl)-4-[(4-oxo-2-propyl-5,6,7,8-tetrahydrocyclohepta[d]imidazol-3-yl)methyl]phenyl]benzenesulfonamide | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_3394dfe3839920ddc9b5405794aeacc9.svg) | N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[2-(hydroxymethyl)-4-[(4-oxo-2-propyl-5,6,7,8-tetrahydrocyclohepta[d]imidazol-3-yl)methyl]phenyl]benzenesulfonamide | Ki | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_2f1bf273093269f32da30ba0a1dc5136.svg) | N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[2-methyl-4-[(4-oxo-2-propyl-5,6,7,8-tetrahydrocyclohepta[d]imidazol-3-yl)methyl]phenyl]benzenesulfonamide | IC50 | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_2f1bf273093269f32da30ba0a1dc5136.svg) | N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[2-methyl-4-[(4-oxo-2-propyl-5,6,7,8-tetrahydrocyclohepta[d]imidazol-3-yl)methyl]phenyl]benzenesulfonamide | Ki | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_19f0dd835dee5ff60898704ddaaac288.svg) | (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-2-(3-fluoro-4-methoxyphenyl)-1-[2-[hexylsulfonyl(propyl)amino]ethyl]pyrrolidine-3-carboxylic acid | IC50 | 0.08 [1], 0.14 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_486366e99d2a0604f236c94063ac963f.svg) | 2-Butyl-5-chloro-3-[[4-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]phenyl]methyl]imidazole-4-carboxamide | IC50 | 415.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_486366e99d2a0604f236c94063ac963f.svg) | 2-Butyl-5-chloro-3-[[4-[2-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]phenyl]methyl]imidazole-4-carboxamide | Ki | 415.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_14938ecf1be583799515365a4d19735d.svg) | 3-[1-(1,3-Benzodioxol-5-yl)-2-[(2-methoxy-4-methylphenyl)sulfonylamino]-2-oxoethyl]-1-methylindole-6-carboxamide | IC50 | 1.1 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_8d1d49ea38cb04043a9d8881a502749b.svg) | (3S)-3-[[(2S)-2-[[(2S)-2-Acetamido-3,3-diphenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid | IC50 | 4.0 [1], 14.0 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_136418a2d22b8d52d2bd34b83fb01f21.svg) | 3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-phenylthiophene-2-carboxamide | IC50 | 166.0 [1] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_3827ba8825ea5e99347fad88e021892f.svg) | (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-[3-chloropropylsulfonyl(propyl)amino]ethyl]-2-(3-fluoro-4-methoxyphenyl)pyrrolidine-3-carboxylic acid | IC50 | 0.07 [1], 0.55 [2] |
![](https://images.aatbio.com/dataset/ic50/endothelin-receptor-et-a_10f400f9d2c883778dd9e5a5a1449283.svg) | (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-2-(3-fluoro-4-methoxyphenyl)-1-[2-[propyl(4,4,4-trifluorobutylsulfonyl)amino]ethyl]pyrrolidine-3-carboxylic acid | IC50 | 0.06 [1], 1.66 [2] |