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Elongation of very long chain fatty acids protein 6 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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6,6-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50290.0 [1]
1-(3-Chlorophenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50245.0 [1]
3-[2-(4-Chlorophenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5012.0 [1]
1,6,6-Trimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50520.0 [1]
1-Ethyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50550.0 [1]
6,6-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-propyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50185.0 [1]
1-(4-Chlorophenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50603.0 [1]
1-(3-Methoxyphenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50226.0 [1]
4-Fluoro-N-[[(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC502.6 [1]
1-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-3-(4-fluorophenyl)ureaIC5019.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-4-methylbenzamideIC5038.0 [1]
N-{[6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamideIC5010000.0 [1]
4-Fluoro-N-[[2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC504.0 [1]
4-Fluoro-N-[[2-oxo-6-(2-oxopyrrolidin-1-yl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC5039.0 [1]
1-(4-Methoxyphenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50566.0 [1]
6,6-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydro-1H-indole-2,4-dioneIC501710.0 [1]
6,6-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-propan-2-yl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50600.0 [1]
1-Cyclopropyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50144.0 [1]
1-Cyclobutyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50271.0 [1]
1-Cyclopentyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50411.0 [1]
1-Cyclohexyl-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50210.0 [1]
1-(2-Methoxyphenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC506340.0 [1]
1-(2-Chlorophenyl)-6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC506520.0 [1]
3-(5-Ethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5099.0 [1]
6,6-Dimethyl-3-(3-oxo-2-phenyl-5-propan-2-yl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5010000.0 [1]
3-(5-Methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-6,7-dihydro-5H-indole-2,4-dioneIC504500.0 [1]
6-Methyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-6,7-dihydro-5H-indole-2,4-dioneIC50704.0 [1]
3-(5-Methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1,6-diphenyl-3-(trifluoromethyl)-6,7-dihydro-5H-indole-2,4-dioneIC506260.0 [1]
3-(5-Methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)spiro[5,7-dihydroindole-6,1'-cyclobutane]-2,4-dioneIC50123.0 [1]
3-(2,5-Dimethyl-3-oxo-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC502020.0 [1]
6,6-Dimethyl-3-(5-methyl-3-oxo-2-propan-2-yl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5010000.0 [1]
3-(2-Cyclohexyl-5-methyl-3-oxo-1H-pyrazol-4-yl)-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5010000.0 [1]
3-[2-(2-Chlorophenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC504330.0 [1]
3-[2-(3-Chlorophenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5044.0 [1]
3-[2-(2-Methoxyphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5058.0 [1]
3-[2-(3-Methoxyphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5043.0 [1]
3-[2-(4-Methoxyphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5017.0 [1]
3-[2-(4-Fluorophenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5044.0 [1]
4-[4-[6,6-Dimethyl-2,4-dioxo-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-5-methyl-3-oxo-1H-pyrazol-2-yl]benzonitrileIC5014.0 [1]
6,6-Dimethyl-3-[5-methyl-3-oxo-2-(4-propan-2-ylphenyl)-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC5010.0 [1]
6,6-Dimethyl-3-[5-methyl-2-(4-methylphenyl)-3-oxo-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC508.7 [1]
6,6-Dimethyl-3-[5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC508.9 [1]
6,6-Dimethyl-3-[5-methyl-3-oxo-2-(4-phenoxyphenyl)-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dioneIC50196.0 [1]
(1S,4S,6R)-2-(1-Methylimidazol-4-yl)sulfonyl-N-(4-propan-2-yloxyphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamideIC50230.0 [1]
(1S,5R)-3-(2-Methoxyphenyl)sulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC507970.0 [1]
(1S,5R)-3-(3-Methoxyphenyl)sulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC50840.0 [1]
(1R,5S)-3-(4-Methoxyphenyl)sulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC505630.0 [1]
(1R,5S)-3-(2-Chlorophenyl)sulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC503390.0 [1]
(1S,5R)-3-(3-Chlorophenyl)sulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC50600.0 [1]
(1S,5R)-3-(4-Chlorophenyl)sulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC502850.0 [1]
(1S,5R)-3-Pyridin-2-ylsulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC5079.0 [1]
(1R,5S)-3-Pyridin-3-ylsulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC50560.0 [1]
(1S,5R)-3-Pyridin-4-ylsulfonyl-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC50510.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
3-(Phenylsulfonyl)-N-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamideIC5010000.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-8-carboxamideIC501750.0 [1]
(1R,5S)-3-(Benzenesulfonyl)-N-phenyl-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
(1R,5S)-3-(Benzenesulfonyl)-N-pyridin-2-yl-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
(1R,5S)-3-(Benzenesulfonyl)-N-pyridin-3-yl-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
(1R,5S)-3-(Benzenesulfonyl)-N-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-(4-fluorophenyl)-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-(4-methoxyphenyl)-8-azabicyclo[3.2.1]octane-8-carboxamideIC505070.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-(4-chlorophenyl)-8-azabicyclo[3.2.1]octane-8-carboxamideIC50970.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-(4-propan-2-ylphenyl)-8-azabicyclo[3.2.1]octane-8-carboxamideIC5032.0 [1]
(1R,5S)-3-(Benzenesulfonyl)-N-(4-phenylphenyl)-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-[3-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC501400.0 [1]
(1S,5R)-3-(Benzenesulfonyl)-N-[2-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
[(1S,5R)-3-(Benzenesulfonyl)-8-azabicyclo[3.2.1]octan-8-yl]-[4-(trifluoromethyl)phenyl]methanoneIC501750.0 [1]
1-[(1S,5R)-3-(Benzenesulfonyl)-8-azabicyclo[3.2.1]octan-8-yl]-2-[4-(trifluoromethyl)phenyl]ethanoneIC5010000.0 [1]
(1S,5R)-3-(Benzenesulfinyl)-N-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxamideIC5010000.0 [1]
[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl N-(4-fluorophenyl)carbamateIC50142.0 [1]
(6-Chloro-4-methyl-2-oxo-1H-3,1-benzoxazin-4-yl)methyl N-(4-fluorophenyl)carbamateIC501364.0 [1]
(6-Chloro-4-ethyl-2-oxo-1H-3,1-benzoxazin-4-yl)methyl N-(4-fluorophenyl)carbamateIC502255.0 [1]
(6-Chloro-2-oxo-4-propan-2-yl-1H-3,1-benzoxazin-4-yl)methyl N-(4-fluorophenyl)carbamateIC505031.0 [1]
(6-Chloro-4-cyclopropyl-2-oxo-1H-3,1-benzoxazin-4-yl)methyl N-(4-fluorophenyl)carbamateIC501414.0 [1]
(6-Chloro-2-oxo-4-phenyl-1H-3,1-benzoxazin-4-yl)methyl N-(4-fluorophenyl)carbamateIC5010000.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-2-(4-fluorophenyl)acetamideIC50648.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-3-fluorobenzamideIC50261.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-2-fluorobenzamideIC50539.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-3-methylbenzamideIC50437.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-2-methylbenzamideIC50971.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-4-methoxybenzamideIC50558.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-4-(trifluoromethyl)benzamideIC50813.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-4-propan-2-ylbenzamideIC501869.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-4-phenylbenzamideIC5010000.0 [1]
N-[[6-Chloro-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]-4-methylsulfonylbenzamideIC5010000.0 [1]
4-Fluoro-N-{[2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamideIC5095.0 [1]
4-Fluoro-N-[[2-oxo-6-phenyl-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC501479.0 [1]
4-Fluoro-N-[[2-oxo-6-(2-oxopyridin-1-yl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC50106.0 [1]
4-Fluoro-N-[[2-oxo-6-(1H-pyrazol-4-yl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC5010.0 [1]
4-Fluoro-N-[[2-oxo-6-pyrazol-1-yl-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC5013.0 [1]
4-Fluoro-N-[[2-oxo-6-(1H-1,2,4-triazol-5-yl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC5097.0 [1]
4-Fluoro-N-[[2-oxo-6-(1,2,4-triazol-1-yl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC50572.0 [1]
4-Fluoro-N-[[6-(1H-imidazol-2-yl)-2-oxo-4-(trifluoromethyl)-1H-3,1-benzoxazin-4-yl]methyl]benzamideIC50537.0 [1]
(1S,4S,6R)-2-Butylsulfonyl-N-(4-methoxyphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamideIC501710.0 [1]
(1S,4S,6R)-2-Butylsulfonyl-N-(4-propan-2-yloxyphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamideIC50120.0 [1]
1-Butylsulfonyl-N-(4-propan-2-yloxyphenyl)piperidine-3-carboxamideIC50930.0 [1]
(1R,2R,5R)-8-Butylsulfonyl-N-(4-propan-2-yloxyphenyl)-8-azabicyclo[3.2.1]octane-2-carboxamideIC505950.0 [1]
(1S,4S,6R)-2-(4-Methoxyphenyl)sulfonyl-N-(4-propan-2-yloxyphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamideIC50610.0 [1]
(1S,4S,6R)-2-(3-Methoxyphenyl)sulfonyl-N-(4-propan-2-yloxyphenyl)-2-azabicyclo[2.2.2]octane-6-carboxamideIC50600.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Elongation of very long chain fatty acids protein 6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/elongation-of-very-long-chain-fatty-acids-protein-6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Elongation of very long chain fatty acids protein 6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/elongation-of-very-long-chain-fatty-acids-protein-6-inhibitors-ic50-ki.
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