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Egl nine homolog 3 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
▲
▼
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC501.6 [1]
VadadustatIC50390.0 [1]
3-Aminoisonicotinic acidIC5050118.72 [1]
N-[(4-Chlorophenyl)methyl]-3-(5,6-dimethoxypyridin-2-yl)-4-oxo-2-sulfanylidene-1H-thieno[3,2-d]pyrimidine-6-carboxamideIC501.0 [1]
US8722895, 4: [(3-Hydroxy-5-(4-methylphenyl)pyridine-2-carbonyl)amino]-acetic acidIC50180.0 [1]
US8722895, 17: 5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxypyridin-2-yl amideIC501300.0 [1]
US8722895, 7: {[5-(2-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl esterIC5037500.0 [1]
{[5-(3-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl esterIC5021400.0 [1]
US8722895, 6: [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2-carbonyl)-amino]-acetic acid methyl esterIC5052300.0 [1]
US8722895, 9: {[5-(4-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC5083.0 [1]
US8722895, 12: {[5-(2-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC50390.0 [1]
2-[[3-Hydroxy-5-(4-isocyanophenyl)pyridine-2-carbonyl]amino]acetic acidIC50560.0 [1]
BenzimidazoleIC50100000.0 [1]
1H-BenzotriazoleIC50100000.0 [1]
Pyridine-2,4-dicarboxylic acidKi7000.0 [1]
2,5-Pyridinedicarboxylic acidKi300000.0 [1]
MolidustatIC50450.0 [1]
3-(1H-Imidazol-1-yl)propanoic acidIC5025800.0 [1]
3-Benzotriazol-1-yl-propionic acidIC502290.0 [1]
N-[(4-Chlorophenyl)methyl]-3-(5,6-dimethoxypyridin-2-yl)-2,4-dioxo-1H-thieno[3,2-d]pyrimidine-6-carboxamideIC501.0 [1]
4-Oxo-4-[4-[4-(1-naphthylcarbamoyloxymethyl)benzylamino]butylhydroxyamino]-2-butenoic acidIC5031000.0 [1]
3-(1H-Benzimidazol-1-yl)propanoic acidIC5010200.0 [1]
2-[(1-Benzyl-1h-Pyrazol-4-Yl)oxy]pyrido[3,4-D]pyrimidin-4(3h)-OneIC50100000.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-[4-(1H-pyrazol-5-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC503.5 [1]
[[3-Hydroxy-5-(2-naphthyl)pyridine-2-yl]carbonylamino]acetic acidIC5017.0 [1]
6-[4-[2-(Azetidin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]-5-hydroxypyridine-3-carbonitrileIC500.0 [1]
2-[(6-Hydroxy-7-pyridin-3-ylquinoxaline-5-carbonyl)amino]acetic acidIC501.0 [1]
2-[(7-Hydroxy-3-phenylquinoline-8-carbonyl)amino]acetic acidIC501.0 [1]
2-[[1-[(4-Tert-butylphenyl)methyl]-2-(2,6-dichlorophenyl)-4-hydroxy-6-oxopyrimidine-5-carbonyl]amino]acetic acidIC500.8 [1]
2-[1-(Cyclohexylmethyl)pyrazol-4-yl]oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50100000.0 [1]
2-(1-Cyclopentylpyrazol-4-yl)oxy-3H-pyrido[3,4-d]pyrimidin-4-oneIC50100000.0 [1]
2-(4-Chloro-3-hydroxyphenoxy)-3H-pyrido[3,4-d]pyrimidin-4-oneIC50100000.0 [1]
3-[4-(1,3-Benzothiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC501.6 [1]
3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acidIC5026.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5011.0 [1]
3-(4-Cyclohexylphenyl)-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC50120.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(2-oxoazetidin-1-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5061.0 [1]
3-[4-[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC50340.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrazol-1-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC50320.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5076.0 [1]
3-[4-(2,4-Dimethyl-1,3-thiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC505.9 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrimidin-5-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5061.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5021.0 [1]
4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC507.2 [1]
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(4-morpholin-4-ylphenyl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC509.8 [1]
2-(1-Benzylpyrazol-4-yl)oxy-3H-pyrido[2,3-d]pyrimidin-4-oneIC50100000.0 [1]
1-[1-[2-(6-Ethylnaphthalen-2-yl)ethyl]-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl]pyrazole-4-carboxylic acidIC50180.0 [1]
1-[1-[Bis(4-chlorophenyl)methyl]-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl]pyrazole-4-carboxylic acidIC502600.0 [1]
N-[(1,3-Dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycineIC505.5 [1]
2-[(1,7-Dibenzylimidazo[4,5-f]benzimidazole-4-carbonyl)amino]acetic acidIC501.0 [1]
2-[(1-Benzyl-6-bromo-5-hydroxybenzimidazole-4-carbonyl)amino]acetic acidIC501.0 [1]
N-[(4-Chlorophenyl)methyl]-3-(5,6-dimethoxypyridin-2-yl)-2,4-dioxo-1H-pyrido[4,3-d]pyrimidine-7-carboxamideIC501.0 [1]
N-(1,3-Benzodioxol-5-ylmethyl)-3-(5,6-dimethoxypyridin-2-yl)-2,4-dioxo-1H-thieno[3,2-d]pyrimidine-6-carboxamideIC501.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-2-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5020.0 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-1-(2-methylpyrimidin-4-yl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC507.7 [1]
4-[5-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acidIC5020.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(2-oxo-1H-pyrimidin-6-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5044.0 [1]
4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC5010.0 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC502.1 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-2-methylbenzoic acidIC505.8 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-3-methylbenzoic acidIC501.9 [1]
4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC502.1 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyridin-2-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5097.0 [1]
3-Fluoro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC503.6 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC500.8 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyridazin-3-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5059.0 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-1-(6-methylpyrimidin-4-yl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC503.2 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-[6-(trifluoromethyl)pyrimidin-4-yl]-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC504.1 [1]
1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-3-[4-[4-(1H-pyrazol-5-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC50130.0 [1]
2-[[1-[(2-Chlorophenyl)methyl]-7-fluoro-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic acidIC5020.0 [1]
2-[[2-[(4-Tert-butylphenyl)methyl]-6-(4-chlorophenyl)-5-hydroxy-3-oxopyridazine-4-carbonyl]amino]acetic acidIC500.8 [1]
3-(1H-1,2,4-Triazol-1-yl)propanoic acidIC5033500.0 [1]
1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-3-[4-[4-(5-oxo-1,2-dihydropyrazol-3-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5038.0 [1]
3-[4-(1H-Indazol-6-yl)phenyl]-1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5048.0 [1]
3-[4-(1H-Indazol-5-yl)phenyl]-1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5047.0 [1]
3-[4-(3H-Benzimidazol-5-yl)phenyl]-1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5024.0 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzonitrileIC5017.0 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzamideIC5015.0 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-N-methylbenzamideIC5014.0 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-N,N-dimethylbenzamideIC5049.0 [1]
4-[5-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]-3-methylbenzoic acidIC5036.0 [1]
CID 57386523IC5011.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(4-oxo-1H-pyridin-2-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC5097.0 [1]
1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-6-carboxylic acidIC503.5 [1]
3-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC501.7 [1]
2-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC5095.0 [1]
3-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC5027.0 [1]
2-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC508.4 [1]
5-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]thiophene-2-carboxylic acidIC502.0 [1]
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]thiophene-2-carboxylic acidIC506.4 [1]
4-[4-[1-(3-Methoxypyrazin-2-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-3-methylbenzoic acidIC502.0 [1]
3-Methyl-4-[4-[1-(3-methylpyrazin-2-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC504.9 [1]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC502.9 [1]
4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC504.8 [1]
3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acidIC5043.0 [1]
3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acidIC5022.0 [1]
3-(3-Phenylpropanamido)isonicotinic acidIC5031622.78 [1]
3-Benzamidopyridine-4-carboxylic acidIC5050118.72 [1]
3-(4-Phenylbutanoylamino)pyridine-4-carboxylic acidIC5050118.72 [1]
3-[(2-Phenylacetyl)amino]pyridine-4-carboxylic acidIC5050118.72 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Egl nine homolog 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/egl-nine-homolog-3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Egl nine homolog 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/egl-nine-homolog-3-inhibitors-ic50-ki.
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