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Egl nine homolog 1 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
N-[(1-Chloro-4-hydroxyisoquinolin-3-YL)carbonyl]glycineIC50300.0 [1]
N-OxalylglycineIC505600.0 [1], 6200.0 [2], 18500.0 [3], 20000.0 [4], 26000.0 [5]
N-OxalylglycineKi8000.0 [1]
RoxadustatIC50591.4 [1], 2100.0 [2], 5740.0 [3]
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylateIC5014000.0 [1]
VadadustatIC50390.0 [1], 410.0 [2], 1100.0 [3], 13700.0 [4]
US8722895, 4: [(3-Hydroxy-5-(4-methylphenyl)pyridine-2-carbonyl)amino]-acetic acidIC50650.0 [1], 890.4 [2]
Succinic acidIC503000.0 [1], 85300.0 [2], 10000000.0 [3]
Pyridine-2,4-dicarboxylic acidIC502000.0 [1], 6100.0 [2]
Pyridine-2,4-dicarboxylic acidKi7000.0 [1]
MolidustatIC50280.0 [1], 876.3 [2]
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acidIC500.2 [1]
1-Benzyl-3-hydroxy-4-[[(4-methylcyclohexyl)amino]methyl]pyridin-2-oneIC5011000.0 [1]
3-[(1-Benzyl-3-hydroxy-2-oxopyridin-4-yl)methylamino]azepan-2-oneIC5012000.0 [1]
1-Benzyl-4-[[4-(6-chloropyridazin-3-yl)piperazin-1-yl]methyl]-3-hydroxypyridin-2-oneIC5011000.0 [1]
3-Hydroxy-1-(4-methylphenyl)sulfonyl-4-[(4-piperidin-1-ylpiperidin-1-yl)methyl]pyridin-2-oneIC504400.0 [1]
1-Benzyl-4-[(4-benzylpiperazin-1-yl)methyl]-3-hydroxypyridin-2-oneIC5017000.0 [1]
1-Benzyl-3-hydroxy-4-[(3-imidazol-1-ylpropylamino)methyl]pyridin-2-oneIC5012000.0 [1]
4-[[4-(6-Chloropyridazin-3-yl)piperazin-1-yl]methyl]-3-hydroxy-1-(4-methylphenyl)sulfonylpyridin-2-oneIC5012000.0 [1]
1-Benzyl-3-hydroxy-4-[(2-methylsulfanylethylamino)methyl]pyridin-2-oneIC5016000.0 [1]
1-(4-Chlorobenzyl)-3-hydroxypyridin-2(1H)-oneIC501200.0 [1]
1-[(3-Chlorophenyl)methyl]-3-hydroxypyridin-2-oneIC505000.0 [1]
2-[[3-Hydroxy-1-(4-methylphenyl)sulfonyl-2-oxopyridin-4-yl]methyl-methylamino]acetic acidIC5021000.0 [1]
4-(Azepan-1-ylmethyl)-3-hydroxy-1-[[2-(hydroxymethyl)phenyl]methyl]pyridin-2-oneIC5018000.0 [1]
4-[(Benzylamino)methyl]-1-[(4-chlorophenyl)methyl]-3-hydroxypyridin-2-oneIC5012000.0 [1]
1-Benzyl-3-hydroxy-4-[(1-phenylethylamino)methyl]pyridin-2-oneIC5012000.0 [1]
Fumaric acidIC5019000.0 [1], 220000.0 [2]
4,6-Dioxoheptanoic acidIC5018000.0 [1], 100000.0 [2]
4-(Hydroxyamino)-4-oxobutanoic acidIC5019600.0 [1], 94000.0 [2]
2-[[1-[[6-(4-Chlorophenoxy)pyridin-3-yl]methyl]-4-hydroxy-6-oxo-2,3-dihydropyridine-5-carbonyl]amino]acetic acidIC5013.0 [1], 43.0 [2]
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acidIC50100000.0 [1]
2-[(6-Naphthalen-2-ylimidazo[1,2-a]pyridine-2-carbonyl)amino]acetic acidIC503600.0 [1]
2-[(1-Chloro-4-hydroxy-[1]benzothiolo[3,2-c]pyridine-3-carbonyl)amino]acetic acidIC500.0 [1], 1500.0 [2]
2-[(8-Hydroxyquinoline-7-carbonyl)amino]acetic acidIC505000.0 [1]
1'-[(3-Methylpyridin-2-yl)methyl]-1-(4-phenylphenyl)spiro[indole-3,4'-piperidine]-2-oneIC500.5 [1], 4.0 [2]
1'-[(1-Methylimidazol-2-yl)methyl]-1-thiophen-3-ylspiro[indole-3,4'-piperidine]-2-oneIC501000.0 [1], 1200.0 [2]
8-[(3-Methylpyridin-2-yl)methyl]-2-(4-phenylphenyl)-2,8-diazaspiro[4.5]decan-1-oneIC5025.12 [1], 98.0 [2]
Prolyl Hydroxylase inhibitor 1IC5062.23 [1], 1310.0 [2]
2-[[5-[1-[(4-Chlorophenyl)methyl]triazol-4-yl]-3-hydroxypyridine-2-carbonyl]amino]acetic acidIC50228.2 [1], 8130.0 [2]
2-[[5-[1-[1-(4-Chlorophenyl)propyl]triazol-4-yl]-3-hydroxypyridine-2-carbonyl]amino]acetic acidIC5075.82 [1], 6880.0 [2]
2-[[5-[1-[1-(4-Chlorophenyl)ethyl]triazol-4-yl]-3-hydroxypyridine-2-carbonyl]amino]acetic acidIC5061.08 [1], 6110.0 [2]
2-[[5-[1-[2-(4-Chlorophenoxy)ethyl]triazol-4-yl]-3-hydroxypyridine-2-carbonyl]amino]acetic acidIC5079.69 [1], 6430.0 [2]
2-[[5-[1-[3-(4-Chlorophenoxy)propyl]triazol-4-yl]-3-hydroxypyridine-2-carbonyl]amino]acetic acidIC5067.58 [1], 5340.0 [2]
2-[[5-[1-[2-(4-Chlorophenyl)ethyl]triazol-4-yl]-3-hydroxypyridine-2-carbonyl]amino]acetic acidIC5052.84 [1], 2750.0 [2]
2-[[6-(1-Benzyltriazol-4-yl)quinoline-2-carbonyl]amino]acetic acidIC50853.8 [1], 17060.0 [2]
2-[[4-Hydroxy-6-oxo-1-[[6-(4-propan-2-ylphenoxy)pyridin-3-yl]methyl]-2,3-dihydropyridine-5-carbonyl]amino]acetic acidIC5014.0 [1]
2-[[4-Hydroxy-1-[[6-(4-methylphenoxy)pyridin-3-yl]methyl]-6-oxo-2,3-dihydropyridine-5-carbonyl]amino]acetic acidIC5039.0 [1]
2-[[4-Hydroxy-1-[[4-(4-methylphenoxy)phenyl]methyl]-6-oxo-2,3-dihydropyridine-5-carbonyl]amino]acetic acidIC5049.0 [1]
3-[[1-Cyano-4-hydroxy-7-(4-methoxyphenoxy)isoquinoline-3-carbonyl]amino]-3-methylbutanoic acidIC509400.0 [1]
2-[[3-Hydroxy-5-[3-(pyrrolidine-1-carbonyl)phenyl]pyridine-2-carbonyl]amino]acetic acidIC50300.0 [1]
US8722895, 24: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)phenyl]-pyridine-2-carbonyl}-amino)-acetic acidIC50400.0 [1]
US8722895, 15: {[5-(4-Isopropoxyphenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC501600.0 [1]
US8722895, 5: [(3-Hydroxy-4'-methyl-biphenyl-4-carbonyl)-amino]-acetic acidIC5020000.0 [1]
US8722895, 17: 5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxypyridin-2-yl amideIC501200.0 [1]
US8722895, 7: {[5-(2-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl esterIC506800.0 [1]
{[5-(3-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl esterIC502800.0 [1]
US8722895, 2: {[5-(4-Chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl esterIC503700.0 [1]
US8722895, 6: [(3-Hydroxy-5-(4-methylphenyl)-pyridine-2-carbonyl)-amino]-acetic acid methyl esterIC504100.0 [1]
Methyl 2-[[5-(3-carbamoylphenyl)-3-hydroxypyridine-2-carbonyl]amino]acetateIC5011200.0 [1]
Methyl 2-[[3-hydroxy-5-[3-(pyrrolidine-1-carbonyl)phenyl]pyridine-2-carbonyl]amino]acetateIC502500.0 [1]
Methyl 2-[[3-hydroxy-5-[3-(2H-tetrazol-5-yl)phenyl]pyridine-2-carbonyl]amino]acetateIC502600.0 [1]
Methyl 2-[[5-[3-(cyclopropanecarbonylamino)phenyl]-3-hydroxypyridine-2-carbonyl]amino]acetateIC509200.0 [1]
US8722895, 9: {[5-(4-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC50240.0 [1]
US8722895, 14: {[5-(4-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC50300.0 [1]
US8722895, 12: {[5-(2-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC501100.0 [1]
US8722895, 13: {[5-(4-Isopropylphenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC50440.0 [1]
US8722895, 16: {[5-(2-Methyl-5-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acidIC502500.0 [1]
1-Benzyl-3-hydroxy-4-[[(2R)-2-(2-hydroxyethyl)pyrrolidin-1-yl]methyl]pyridin-2-oneIC509000.0 [1]
Methyl 2-[[3-hydroxy-5-(4-isocyanophenyl)pyridine-2-carbonyl]amino]acetateIC505800.0 [1]
Methyl 2-[[3-hydroxy-5-(3-isocyanophenyl)pyridine-2-carbonyl]amino]acetateIC505100.0 [1]
2-[[3-Hydroxy-5-(3-isocyanophenyl)pyridine-2-carbonyl]amino]acetic acidIC50190.0 [1]
2-[[3-Hydroxy-5-(4-isocyanophenyl)pyridine-2-carbonyl]amino]acetic acidIC5099.0 [1], 99000.0 [2]
Isocitric acidIC5010000000.0 [1]
DaminozideIC50100000.0 [1]
2,5-Pyridinedicarboxylic acidKi300000.0 [1]
8-Hydroxy-5-quinolinecarboxylic acidIC5015000.0 [1]
8-Hydroxyquinoline-7-carboxylic acidIC50100000.0 [1]
Jnj-42041935IC50100.0 [1]
(2s)-2-{[(1-Chloro-4-Hydroxyisoquinolin-3-Yl)carbonyl]amino}propanoic AcidIC50512.0 [1]
PicolinoylglycineIC50100000.0 [1]
(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)propanoic acidIC50230000.0 [1]
(S)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acidIC50400000.0 [1]
(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acidIC50400000.0 [1]
4-Oxo-4-[4-[4-(1-naphthylcarbamoyloxymethyl)benzylamino]butylhydroxyamino]-2-butenoic acidIC5083000.0 [1]
3,4-Dehydro-L-prolineIC508500.0 [1]
8-Hydroxyquinoline-4-carboxylic acidIC5014000.0 [1]
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-[4-(1H-pyrazol-5-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneIC500.2 [1]
Glycine, N-(2-methoxy-2-oxoacetyl)-IC5095000.0 [1]
(2R)-2-(Oxaloamino)-4-phenylbutanoic acidIC501000000.0 [1]
3-(2-Fluoroanilino)pyridine-2,4-dicarboxylic acidIC50400000.0 [1]
[[3-Hydroxy-5-(2-naphthyl)pyridine-2-yl]carbonylamino]acetic acidIC5017.0 [1]
N-[(4-Chlorophenyl)methyl]-8-hydroxyquinoline-7-carboxamideIC504800.0 [1]
Glycine, N-[(1-chloro-4-hydroxy-7-phenoxy-3-isoquinolinyl)carbonyl]-IC502400.0 [1]
2-[[4-Hydroxy-2-oxo-1-[4-(trifluoromethyl)phenyl]-5,7-dihydrofuro[3,4-b]pyridine-3-carbonyl]amino]acetic acidIC505.8 [1]
2-[[4-Hydroxy-2-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carbonyl]amino]acetic acidIC5022.9 [1]
2-[[4-Hydroxy-2-oxo-1-[[4-(trifluoromethyl)phenyl]methyl]-5,6,7,8-tetrahydroquinoline-3-carbonyl]amino]acetic acidIC5066.0 [1]
2-[[1-(1,3-Benzothiazol-2-ylmethyl)-4-hydroxy-2-oxo-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonyl]amino]acetic acidIC505.4 [1]
2-[[1-[(4-Chlorophenyl)methyl]-4-hydroxy-7-methyl-2,6-dioxo-5,8-dihydro-1,7-naphthyridine-3-carbonyl]amino]acetic acidIC507.3 [1]
2-[(10-Hydroxy-12-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),10-tetraene-11-carbonyl)amino]acetic acidIC5021.0 [1]
2-[[7-Cyano-10-hydroxy-12-oxo-3-[4-(trifluoromethyl)phenyl]-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),10-tetraene-11-carbonyl]amino]acetic acidIC501.3 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Egl nine homolog 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/egl-nine-homolog-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Egl nine homolog 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/egl-nine-homolog-1-inhibitors-ic50-ki.
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