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dUTP pyrophosphatase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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▼
Standard Type
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▼
Standard Values (in nM)
▲
▼
5'-O-Trityl-2'-deoxyuridineKi18000.0 [1]
2',5'-Dideoxy-5'-(Tritylamino)uridineKi46000.0 [1]
1-[2-(Trityloxy)ethoxymethyl]uracilIC50100000.0 [1], 185000.0 [2]
1-[2-(Trityloxy)ethoxymethyl]uracilKi17000.0 [1]
N-[(1R)-1-[3-(Cyclopropylmethoxy)phenyl]ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC5040.0 [1], 50.0 [2]
1-(6-Tritylaminohexyl)uracilKi1000000.0 [1]
N-{5-[(2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)methoxy]-2-Methylpentan-2-Yl}benzenesulfonamideIC503900.0 [1], 9480.0 [2]
3-(Cyclopropylmethoxy)-N-[5-[(2,4-dioxopyrimidin-1-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamideIC5035.0 [1], 260.0 [2]
N-[2-[3-(Cyclopropylmethoxy)phenyl]propan-2-yl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC50340.0 [1], 520.0 [2]
N-[(1R)-1-[3-(Cyclopropylmethoxy)-4-fluorophenyl]ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC5021.0 [1], 90.0 [2]
N-[1-[3-(Cyclopropylmethoxy)phenyl]ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC5062.0 [1], 490.0 [2]
(E)-N-[(1R)-1-[3-(Cyclopropylmethoxy)phenyl]ethyl]-5-(2,4-dioxopyrimidin-1-yl)pent-3-ene-1-sulfonamideIC5039.0 [1], 50.0 [2], 38200.0 [3]
1-(3-Tritylaminopropyl)uracilKi1400.0 [1]
1-(5-Tritylaminopentyl)uracilKi1000000.0 [1]
CID 57385739IC5030000.0 [1]
CID 57385739Ki1000000.0 [1]
1-[(E)-4-Trityloxy-2-butenyl]uracilKi1000000.0 [1]
1-[2-[Tert-butyl(dimethyl)silyl]oxyethoxymethyl]pyrimidine-2,4-dioneIC50100000.0 [1]
1-[2-[Tert-butyl(dimethyl)silyl]oxyethoxymethyl]pyrimidine-2,4-dioneKi63000.0 [1]
1-[4-Hydroxy-3-(tritylaminomethyl)butyl]uracilKi5700.0 [1]
1-[(2R,4S,5R)-5-[[Tert-butyl(diphenyl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dioneKi806000.0 [1]
1-{(2S,5S)-4-Fluoro-5-[(trityloxy)methyl]tetrahydrofuran-2-YL}pyrimidine-2,4(1H,3H)-dioneKi457000.0 [1]
1-[(2R,4S,5R)-4-Hydroxy-5-(triphenylsilyloxymethyl)oxolan-2-yl]pyrimidine-2,4-dioneKi909000.0 [1]
4-(2,4-Dioxopyrimidin-1-yl)-N-(2,2-diphenylethyl)-N-methylbutanamideIC501300.0 [1]
2'-Deoxyuridine 5'-alpha,beta-imido-triphosphateIC5015000.0 [1], 15200.0 [2]
1-[3-({(2r)-2-[Hydroxy(Diphenyl)methyl]pyrrolidin-1-Yl}sulfonyl)propyl]pyrimidine-2,4(1h,3h)-DioneIC50320.0 [1]
N-[(1R)-1-(3-Cyclopentyloxyphenyl)ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC5060.0 [1]
N-[5-[(2,4-Dioxopyrimidin-1-yl)methoxy]-2-methylpentan-2-yl]-3-methoxybenzenesulfonamideIC501120.0 [1], 1200.0 [2]
2-Chloro-N-[5-[(2,4-dioxopyrimidin-1-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamideIC507640.0 [1], 9400.0 [2]
3-Chloro-N-[5-[(2,4-dioxopyrimidin-1-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamideIC502770.0 [1], 4500.0 [2]
4-Chloro-N-[5-[(2,4-dioxopyrimidin-1-yl)methoxy]-2-methylpentan-2-yl]benzenesulfonamideIC503940.0 [1], 5700.0 [2]
3-(Cyclopropylmethoxy)-N-[2-[4-[(2,4-dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamideIC5073.0 [1], 240.0 [2]
(E)-N-[(1R)-1-(3-Cyclopentyloxyphenyl)ethyl]-5-(2,4-dioxopyrimidin-1-yl)pent-3-ene-1-sulfonamideIC5041.0 [1], 170.0 [2]
N-[2-[4-[(2,4-Dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]benzenesulfonamideIC501800.0 [1], 2690.0 [2]
N-[2-[4-[(2,4-Dioxopyrimidin-1-yl)methyl]phenyl]propan-2-yl]-3-methoxybenzenesulfonamideIC501270.0 [1], 2570.0 [2]
N-[[3-(Cyclopropylmethoxy)phenyl]methyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC50330.0 [1]
N-[[3-(Cyclopropylmethoxy)-4-fluorophenyl]methyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC50640.0 [1]
N-[(3-Cyclopentyloxyphenyl)methyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC50270.0 [1]
N-[(1R)-1-[3-(Cyclopropylmethoxy)-4-fluorophenyl]propyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC5030.0 [1]
N-[(1R)-1-(3-Cyclopentyloxy-4-fluorophenyl)ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC5040.0 [1]
N-[(1R)-1-[3-(2,2-Difluoroethoxy)phenyl]ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC50140.0 [1]
3-[(2,4-Dioxopyrimidin-1-yl)methoxy]-N-[(1R)-1-(3-prop-2-enoxyphenyl)ethyl]propane-1-sulfonamideIC50740.0 [1]
N-[(1R)-1-[3-(2,2-Difluoroethoxy)-4-fluorophenyl]ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamideIC50110.0 [1]
3-(Cyclopropylmethoxy)-N-[1-[3-[(2,4-dioxopyrimidin-1-yl)methoxy]propyl]cyclopropyl]benzenesulfonamideIC50130.0 [1]
3-[(2,4-Dioxopyrimidin-1-yl)methoxy]-N-[(1R)-1-[3-(2-methylpropoxy)phenyl]ethyl]propane-1-sulfonamideIC50310.0 [1]
3-[(2,4-Dioxopyrimidin-1-yl)methoxy]-N-[(1R)-1-[3-(oxolan-3-yloxy)phenyl]ethyl]propane-1-sulfonamideIC50460.0 [1], 940.0 [2]
3-[(2,4-Dioxopyrimidin-1-yl)methoxy]-N-[(1R)-1-[4-fluoro-3-(2,2,2-trifluoroethoxy)phenyl]ethyl]propane-1-sulfonamideIC50230.0 [1]
3-[(2,4-Dioxopyrimidin-1-yl)methoxy]-N-[(1R)-1-[3-[(2S)-2-methylbutoxy]phenyl]ethyl]propane-1-sulfonamideIC50720.0 [1]
3-[(2,4-Dioxopyrimidin-1-yl)methoxy]-N-[(1R)-1-[3-(oxan-4-yloxy)phenyl]ethyl]propane-1-sulfonamideIC50210.0 [1]
3-[(2,4-Dioxopyrimidin-1-yl)methoxy]-N-[(1R)-1-[3-(2,2,2-trifluoroethoxy)phenyl]ethyl]propane-1-sulfonamideIC50230.0 [1]
2',3'-Didehydro-2',3'-dideoxyuridineKi1000000.0 [1]
TriphenylmethanolKi1000000.0 [1]
TriphenylsilanolKi1000000.0 [1]
1-(4-Trityloxybutyl)uracilKi1000000.0 [1]
1-(6-Trityloxyhexyl)uracilKi476000.0 [1]
1-(3-Trityloxypropyl)pyrimidine-2,4-dioneKi313000.0 [1]
1-(5-Trityloxypentyl)uracilKi1000000.0 [1]
1-[2-(Benzoyloxyethoxy)methyl]uracilKi311000.0 [1]
1-(4-Tritylaminobutyl)uracilKi1000000.0 [1]
5'-O-Acetyl-2'-deoxyuridineKi1000000.0 [1]
1-[2-(Hydroxymethyl)-4-(trityloxy)butyl]uracilKi260000.0 [1]
N-(3-Hydroxypropyl)-2,2-diphenylacetamideKi1000000.0 [1]
4-(2,4-Dioxopyrimidin-1-yl)butanoic acidKi1000000.0 [1]
1-(5-Aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dioneKi1000000.0 [1]
2',5'-Dideoxy-5'-[(Diphenylmethyl)amino]uridineKi100000.0 [1]
1-(4-Benzhydryloxybutyl)pyrimidine-2,4-dioneKi49000.0 [1]
N-[3-(3-Benzoyl-2,4-dioxopyrimidin-1-yl)propyl]-2,2,2-triphenylacetamideKi1000000.0 [1]
N-[3-(2,4-Dioxopyrimidin-1-yl)propyl]-2,2-diphenylacetamideKi286000.0 [1]
N-[3-(2,4-Dioxopyrimidin-1-yl)propyl]-2,2,2-triphenylacetamideKi1000000.0 [1]
4-(2,4-Dioxopyrimidin-1-yl)-N-tritylbutanamideKi1000000.0 [1]
1-[4-(Benzhydrylamino)butyl]pyrimidine-2,4-dioneKi63000.0 [1]
1-[3-(Benzhydrylamino)propyl]pyrimidine-2,4-dioneKi10000.0 [1]
N-(3-Hydroxypropyl)-2,2,2-triphenylacetamideKi1000000.0 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-[[hydroxy-[hydroxy(phenylmethoxy)phosphoryl]oxyphosphoryl]methyl]phosphinic acidKi300.0 [1]
1-[4-(Tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dioneKi119000.0 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl diethyl phosphateKi1000000.0 [1]
5'-O-(Dimethoxytrityl)-5-(propargyloxy)-2'-deoxyuridineKi1000000.0 [1]
1-[(2R,5S)-5-(Trityloxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dioneKi157000.0 [1]
1-(4-Triphenylsilyloxybutyl)uracilKi1000000.0 [1]
1-[4-Hydroxy-2-(trityloxymethyl)butyl]uracilKi21000.0 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl N-sulfamoylcarbamateKi1000000.0 [1]
1-(5-Hydroxypentyl)uracilKi1000000.0 [1]
1-[2-(Azidomethyl)-4-(trityloxy)butyl]uracilKi1000000.0 [1]
Tert-butyl N-[4-(2,4-dioxopyrimidin-1-yl)butyl]carbamateKi1000000.0 [1]
1-(3-Hydroxypropyl)-2,4(1H,3H)-pyrimidinedioneKi1000000.0 [1]
1-(6-Benzoyloxyhexyl)uracilKi1000000.0 [1]
[(2R,3S,5R)-3-[Tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl N-sulfamoylcarbamateKi1000000.0 [1]
[(2R,3S,5R)-3-[Tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl diethyl phosphateKi1000000.0 [1]
1-(3-Triphenylsilyloxypropyl)uracilKi25000.0 [1]
1-[4-Acetyloxy-3-(tritylaminomethyl)butyl]uracilKi74000.0 [1]
1-(4-Tert-butyldiphenylsilyloxyhexyl)uracilKi1000000.0 [1]
1-(3-Tert-butyldimethylsilyloxypropyl)uracilKi73000.0 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl 2-diethoxyphosphorylacetateKi1000000.0 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl sulfamateKi1000000.0 [1]
1-[(2R,4S,5R)-4-[Tert-butyl(dimethyl)silyl]oxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dioneKi1000000.0 [1]
1-(6-Triphenylsilyloxyhexyl)uracilKi383000.0 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl pentanoateKi1000000.0 [1]
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl diphenyl phosphateKi135000.0 [1]
[(2R,3S,5R)-3-[Tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl diphenyl phosphateKi1000000.0 [1]
Methyl N-[4-(2,4-dioxopyrimidin-1-yl)-2-(trityloxymethyl)butyl]carbamateKi1000000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ dUTP pyrophosphatase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/dutp-pyrophosphatase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ dUTP pyrophosphatase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dutp-pyrophosphatase-inhibitors-ic50-ki.
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