Dual specificity protein phosphatase 3 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	IC50	1600.0 [1], 1630.0 [2], 100000.0 [3]
	(5R)-3-Hexadecanoyl-4-hydroxy-5-(hydroxymethyl)furan-2(5H)-one	IC50	10200.0 [1], 11700.0 [2]
	2-[(5Z)-5-[[3-[4-[(2-Fluorophenyl)methoxy]phenyl]-1-phenylpyrazol-4-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid	IC50	74.0 [1]
	5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one	IC50	1900.0 [1], 20100.0 [2]
	1-Methanesulfonyl-5-[2-(3-methylphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indole	IC50	8000.0 [1], 40100.0 [2]
	4-{2,5-Dimethyl-1-[(oxolan-2-yl)methyl]-1H-pyrrol-3-yl}-2-(4-methoxyphenyl)-1,3-thiazole	IC50	8300.0 [1], 33300.0 [2]
	2-(4-Ethoxyphenyl)-4-(naphthalen-2-yl)-1,3-thiazole	IC50	4400.0 [1], 61000.0 [2]
	N-[3-(2-Phenyl-1,3-thiazol-4-yl)phenyl]-2-furamide	IC50	26100.0 [1], 100000.0 [2]
	N-{3-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]phenyl}cyclopropanecarboxamide	IC50	8900.0 [1], 100000.0 [2]
	2-(4-Methoxyphenyl)-4-(1-methylsulfonyl-2,3-dihydroindol-5-yl)-1,3-thiazole	IC50	8100.0 [1], 45400.0 [2]
	1-Methanesulfonyl-5-[2-(2-methoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indole	IC50	2700.0 [1], 40200.0 [2]
	5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-1-methyl-2,3-dihydro-1H-indol-2-one	IC50	10600.0 [1], 64500.0 [2]
	Linoleic acid	IC50	100000.0 [1]
	Oleanolic acid	IC50	5400.0 [1]
	Caffeic acid	IC50	100000.0 [1]
	Imperatorin	IC50	100000.0 [1]
	2,3-Dihydroxypropyl decanoate	IC50	98200.0 [1]
	6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione	IC50	4000.0 [1]
	Sanggenon C	IC50	80000.0 [1]
	7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedione	IC50	8500.0 [1]
	Stigmasterol glucoside	IC50	60700.0 [1]
	6,7-Dichloroquinoline-5,8-dione	IC50	10000.0 [1]
	Dotriacontanoic acid	IC50	100000.0 [1]
	5,8-Quinolinedione	IC50	10000.0 [1]
	5-[(6R)-6-Hydroxy-7,7-dimethyl-5,6-dihydrofuro[3,2-g]chromen-2-yl]benzene-1,3-diol	IC50	80000.0 [1]
	cis-12-Octadecenoic acid	IC50	51800.0 [1]
	Moracin O	IC50	80000.0 [1]
	Streptonigrin methyl ester	IC50	5100.0 [1]
	CID 25262525	IC50	103000.0 [1]
	Cefsulodin sodium salt	IC50	200000.0 [1]
	4-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid	Ki	12800.0 [1]
	6-Hydroxy-1-methyl-3-[1-[3-oxo-3-(4-phenylanilino)propyl]triazol-4-yl]-2-phenylindole-5-carboxylic acid	IC50	50000.0 [1]
	Brunsvicamide A	IC50	100000.0 [1]
	5,8-Phthalazinedione, 6,7-dichloro-	IC50	10000.0 [1]
	2-[4-[(Z)-[5-(4-Chlorophenyl)-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid	IC50	4200.0 [1]
	CID 71734765	IC50	5900.0 [1]
	N-(4-Methoxybenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine	IC50	2680.0 [1]
	6-(Hydroxymethyl)pyridin-3-ol	IC50	100000.0 [1]
	N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamide	IC50	100000.0 [1]
	2-Methoxy-4-(piperidylthioxomethyl)phenol	IC50	370.0 [1]
	(2S,3S)-2-[[(3S,6S,9S,12S,15S)-3-Benzyl-12-[(2S)-butan-2-yl]-6-(1H-indol-3-ylmethyl)-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acid	IC50	100000.0 [1]
	1,4-Dimethoxyanthraquinone	Ki	3070.0 [1]
	7-[(1-Hydroxy-1-phenylpropan-2-yl)amino]quinoline-5,8-dione	IC50	16000.0 [1]
	Furospongin-1	IC50	11000.0 [1]
	{[4-(2,5-Dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl}acetic acid	Ki	2090.0 [1]
	5,7-Dichloro-4-((3-(4-methoxyphenylthio)benzyl)(methyl)amino)quinoline-2-carboxylic acid	IC50	50700.0 [1]
	5-(13-(3-Furanyl)-2,6,10-trimethyl-6,10-tridecadienylidene)-4-hydroxy-3-methyl-2(5H)-furanone	IC50	6000.0 [1]
	CID 5777336	IC50	19500.0 [1]
	(9Z)-Heptadeca-1,9-dien-4,6-diyne-3,8,11-triol	IC50	100000.0 [1]
	(2S)-2-[4'-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid	IC50	15900.0 [1]
	3-Hexadecanoyl-5-hydroxymethyl-4-methoxy-5H-furan-2-one	IC50	250000.0 [1]
	6,7-Dichloro-5,8-isoquinolinedione	IC50	10000.0 [1]
	4-[(5Z)-5-Benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-YL]benzoic acid	IC50	200000.0 [1]
	Mulberrofuran C	IC50	80000.0 [1]
	4-[5-[(E)-(2-Amino-3,7-dicyano-4,6-dimethylcyclopenta[b]pyridin-5-ylidene)methyl]furan-2-yl]-2-chlorobenzoic acid	Ki	3870.0 [1]
	N-(4-Butylphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide	IC50	50000.0 [1]
	(Phenoxymethyl)phosphonic acid	Ki	26000000.0 [1]
	[(4As,5R,6S,8aR)-5-[(E)-5-(6-amino-9-methylpurin-9-ium-7-yl)-3-methylpent-3-enyl]-5,6,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]methyl 4-bromo-1H-pyrrole-2-carboxylate	IC50	13000.0 [1]
	4-(Biphenyl-4-yl)thiazole-2-ylmethyl 2-furylmethyl sulfone	IC50	26000.0 [1]
	(2-Naphthyloxymethyl)phosphonic acid	Ki	5700000.0 [1]
	[4-(Phosphonomethoxy)phenyl]acetic acid	Ki	2600000.0 [1]
	[3-[3-[(3S)-3-(Methylcarbamoyl)-7-(sulfoamino)-3,4-dihydro-1H-isoquinolin-2-yl]-3-oxopropyl]phenyl]sulfamic acid	IC50	4000.0 [1]
	3-[5-[(E)-[(5-Nitro-2-pyridyl)hydrazono]methyl]-2-furyl]benzoic acid	Ki	13800.0 [1]
	2-(4-Oxo-5-(3-phenylallylidene)-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid	Ki	2010.0 [1]
	(3Z)-3-(1-Hydroxyhexadecylidene)oxolane-2,4-dione	IC50	14400.0 [1]
	3-Hexadecanoyl-4-hydroxy-5-methylenefuran-2(5H)-one	IC50	9500.0 [1]
	(12E,20Z,18S)-8-Hydroxyvariabilin	IC50	9400.0 [1]
	6-Hydroxy-2-phenyl-3-[2-[3-(trifluoromethyl)phenyl]ethynyl]benzofuran-5-carboxylic acid	IC50	1900.0 [1]
	3-[2-(3,5-Difluorophenyl)ethynyl]-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid	IC50	5300.0 [1]
	6-Hydroxy-2-phenyl-3-[2-[4-(trifluoromethoxy)phenyl]ethynyl]benzofuran-5-carboxylic acid	IC50	2100.0 [1]
	6-Hydroxy-2-phenyl-3-(2-phenylethynyl)benzofuran-5-carboxylic acid	IC50	5000.0 [1]
	3-[2-(3-Fluorophenyl)ethynyl]-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid	IC50	4100.0 [1]
	3-[2-(3-Chlorophenyl)ethynyl]-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid	IC50	16000.0 [1]
	6-Hydroxy-3-[2-(3-methoxyphenyl)ethynyl]-2-phenyl-benzofuran-5-carboxylic acid	IC50	30000.0 [1]
	3-[2-(2,4-Difluorophenyl)ethynyl]-6-hydroxy-2-phenyl-1-benzofuran-5-carboxylic acid	IC50	3900.0 [1]
	6-Hydroxy-3-[2-(4-phenoxyphenyl)ethynyl]-2-phenyl-benzofuran-5-carboxylic acid	IC50	800.0 [1]
	3-Ethynyl-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid	IC50	50000.0 [1]
	(2R)-2-[2,6-Dibromo-4-(6-bromonaphtho[3,2-b][1]benzofuran-11-yl)phenoxy]-3-phenylpropanoic acid	IC50	11000.0 [1]
	3-(1,3-Benzodioxol-5-yl)-N-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]acrylamide	IC50	65700.0 [1]
	2-(3-Bromoanilino)-5-hydroxybenzothiazole-6-carboxylic acid	IC50	43000.0 [1]
	(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	IC50	32000.0 [1]
	Ageline B	IC50	19000.0 [1]
	[4-(4-Hydroxybenzyl)phenoxymethyl]phosphonic acid	Ki	1300000.0 [1]
	(E)-2-(3,4-Difluorophenyl)-N-[5-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]ethenesulfonamide	IC50	31000.0 [1]
	2-[2,6-Dibromo-4-(6-bromonaphtho[3,2-b][1]benzothiol-11-yl)phenoxy]acetic acid	IC50	7900.0 [1]
	6-Chloro-7-[2-(1H-indol-3-yl)ethylamino]quinoline-5,8-dione	IC50	10000.0 [1]
	(1E,4E)-1-[5-(3,4-Dichlorophenyl)furan-2-yl]-5-(furan-2-yl)penta-1,4-dien-3-one	Ki	15900.0 [1]
	2-[(6-Chloro-5,8-dioxoquinolin-7-yl)amino]-3-(1H-indol-3-yl)propanoic acid	IC50	10000.0 [1]
	5-Hydroxymethyl-4-methoxy-2-oxo-2,5-dihydro-furan-3-carboxylic acid tetradecyl ester	IC50	100000.0 [1]
	2-(4-(7-(4-Methoxybenzoyl)cyclopenta[d][1,2]oxazin-4-yl)phenoxy)acetic acid	IC50	181200.0 [1]
	3-[[(2S)-2-(3-Benzoyl-1-cyanoindolizin-5-yl)oxy-4-methylpentanoyl]amino]-3-phenylpropanoic acid	IC50	82900.0 [1]
	6-Chloro-7-(2-morpholin-4-ylethylamino)isoquinoline-5,8-dione	IC50	10000.0 [1]
	4-[[4-[(E)-[5-[4-(Dimethylamino)phenyl]-6-ethoxycarbonyl-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]methyl]benzoic acid	IC50	7600.0 [1]
	2-Hydroxy-4-[1-(cyclohexylcarbamoyl)pentyloxy]-5-[2-(trifluoromethoxy)phenylethynyl]benzoic acid	IC50	6000.0 [1]
	3-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-3-yl}-benzoic acid	IC50	100000.0 [1]
	2-[4-[[2-(4-Iodoanilino)-2-oxoacetyl]amino]anilino]-2-oxo-1-phenylethanesulfonic acid	IC50	50000.0 [1]
	2-Oxo-2-[4-[[2-oxo-2-(4-phenylanilino)acetyl]amino]anilino]-1-phenylethanesulfonic acid	IC50	50000.0 [1]
	2-Oxo-2-[4-[[2-oxo-2-(4-propan-2-ylanilino)acetyl]amino]anilino]-1-phenylethanesulfonic acid	IC50	50000.0 [1]
	S-Tetradecyl (2R)-3-hydroxy-2-(hydroxymethyl)-5-oxo-2H-furan-4-carbothioate	IC50	11500.0 [1]
	1-(3-Chlorophenyl)-6-hydroxy-5-[(E)-pyrrol-2-ylidenemethyl]-2-sulfanylidenepyrimidin-4-one	Ki	3490.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dual specificity protein phosphatase 3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/dual-specificity-protein-phosphatase-3-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 21). Quest Database™ Dual specificity protein phosphatase 3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-protein-phosphatase-3-inhibitors-ic50-ki.
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