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Dual specificity protein kinase TTK Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N2-(2-Methoxy-4-(1-Methyl-1h-Pyrazol-4-Yl)phenyl)-N8-Neopentylpyrido[3,4-D]pyrimidine-2,8-DiamineIC508.0 [1], 18.0 [2], 140.0 [3]
N2-(2-Methoxy-4-(1-Methyl-1h-Pyrazol-4-Yl)phenyl)-N8-Neopentylpyrido[3,4-D]pyrimidine-2,8-DiamineKi0.44 [1], 0.5 [2]
CID 44556162IC507.0 [1], 8.0 [2], 160.0 [3], 182.0 [4]
N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamineIC501.8 [1], 4.0 [2], 5.0 [3]
9-Cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-oneIC507.0 [1], 35.0 [2], 720.0 [3]
Tert-butyl 6-[2-chloro-4-(3-methylimidazol-4-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC503.0 [1], 43.0 [2]
8-N-[(2S)-3,3-Dimethylbutan-2-yl]-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC505.0 [1], 11.0 [2], 59.0 [3]
8-N-[(2S)-3,3-Dimethylbutan-2-yl]-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineKi0.2 [1]
8-N-Cyclohexyl-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC509.0 [1], 12.0 [2], 220.0 [3]
8-N-Cyclohexyl-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineKi1.3 [1]
8-N-(Cyclopropylmethyl)-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC506.0 [1], 11.0 [2], 430.0 [3]
8-N-(Cyclopropylmethyl)-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineKi2.8 [1]
8-N-[(2R)-3,3-Dimethylbutan-2-yl]-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC509.0 [1], 22.0 [2], 190.0 [3]
8-N-[(2R)-3,3-Dimethylbutan-2-yl]-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineKi4.2 [1]
2-N-[2-Methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-N-(2-methylpropyl)pyrido[3,4-d]pyrimidine-2,8-diamineIC508.0 [1], 16.0 [2], 650.0 [3]
2-N-[2-Methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-N-(2-methylpropyl)pyrido[3,4-d]pyrimidine-2,8-diamineKi3.7 [1]
N-[2-Methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-pyrrolidin-1-ylpyrido[3,4-d]pyrimidin-2-amineIC508.0 [1], 10.0 [2], 2200.0 [3]
N-[2-Methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-pyrrolidin-1-ylpyrido[3,4-d]pyrimidin-2-amineKi3.3 [1]
8-N-(2,2-Dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC503.0 [1], 63.0 [2]
8-N-(2,2-Dimethylpropyl)-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.11 [1]
3-[3-(Aminosulfonyl)phenyl]-5-(cyclohexylamino)-6-(1-methyl-1H-pyrazole-4-yl)-1H-indazoleIC5010.0 [1], 10.4 [2], 20.5 [3]
N-(2,4-Dimethoxyphenyl)-5-(1-methylpyrazol-4-yl)isoquinolin-3-amineIC5074.0 [1], 99.0 [2], 2770.0 [3]
N-[2-Methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amineIC508.0 [1], 600.0 [2]
8-N-(2,2-Dimethylpropyl)-2-N-[4-(1,3-dimethylpyrazol-4-yl)-2-methoxyphenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC505.0 [1], 230.0 [2]
8-N-(2,2-Dimethylpropyl)-2-N-[4-(1,3-dimethylpyrazol-4-yl)-2-methoxyphenyl]pyrido[3,4-d]pyrimidine-2,8-diamineKi24.0 [1]
N-[2-Methoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-phenylpyrido[3,4-d]pyrimidin-2-amineIC5014.0 [1], 18.0 [2], 480.0 [3]
8-Cyclopropyl-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidin-2-amineIC5096.0 [1], 110.0 [2], 7810.0 [3]
N-[2-Methyl-4-(1-methylpyrazol-4-yl)phenyl]-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amineIC5021.0 [1], 24.0 [2], 2540.0 [3]
8-N-(Cyclohexylmethyl)-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC5046.0 [1], 61.0 [2], 1000.0 [3]
8-N-(2,2-Dimethylpropyl)-2-N-[2-methoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC502.0 [1], 3.5 [2]
8-N-(2,2-Dimethylpropyl)-2-N-[2-methoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineKi0.07 [1]
2-N-[4-(2,3-Dimethylimidazol-4-yl)-2-methoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC505.0 [1], 170.0 [2]
2-N-[4-(2,3-Dimethylimidazol-4-yl)-2-methoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.09 [1]
8-N-(2,2-Dimethylpropyl)-2-N-[2-methoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC502.0 [1], 30.0 [2]
8-N-(2,2-Dimethylpropyl)-2-N-[2-methoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.13 [1]
N-[2-Ethoxy-4-(1-methylpyrazol-4-yl)phenyl]-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amineIC508.0 [1], 10.0 [2], 2640.0 [3]
2-N-[4-(2,3-Dimethylimidazol-4-yl)-2-methoxyphenyl]-8-N-(2,2-dimethylpropyl)pyrido[3,4-d]pyrimidine-2,8-diamineIC507.0 [1], 44.0 [2]
2-N-[4-(2,3-Dimethylimidazol-4-yl)-2-methoxyphenyl]-8-N-(2,2-dimethylpropyl)pyrido[3,4-d]pyrimidine-2,8-diamineKi0.08 [1]
8-N,8-N-Diethyl-2-N-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC5062.0 [1], 69.0 [2], 1000.0 [3]
8-N-(2,2-Dimethylpropyl)-2-N-[4-(1,5-dimethylpyrazol-4-yl)-2-methoxyphenyl]pyrido[3,4-d]pyrimidine-2,8-diamineIC505.0 [1], 95.0 [2]
8-N-(2,2-Dimethylpropyl)-2-N-[4-(1,5-dimethylpyrazol-4-yl)-2-methoxyphenyl]pyrido[3,4-d]pyrimidine-2,8-diamineKi0.78 [1]
1,9-PyrazoloanthroneIC5098.0 [1], 2500.0 [2]
ReversineIC502.8 [1], 4.0 [2]
3-Phenyl-1H-indazoleIC502100.0 [1], 12000.0 [2]
TC Mps1 12IC5011.0 [1], 560.0 [2]
N-Cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]imidazo[1,2-b]pyridazin-3-yl]benzamideIC500.7 [1], 2.8 [2]
2-Pyrrolidin-1-yl-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]-2-thiophen-3-ylacetamideIC502.9 [1]
1-[3-Methoxy-4-[[4-(2-propan-2-ylsulfonylanilino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]piperidin-4-olIC50370.0 [1], 809.0 [2]
Mps BAY 2aIC501.0 [1]
N-[Cyclopropyl(phenyl)methyl]-3-(3-sulfamoylphenyl)-1H-indazole-5-carboxamideIC5016.0 [1]
N-Cyclopropyl-4-[8-(2-methylpropylamino)imidazo[1,2-a]pyrazin-3-yl]benzamideIC5014.0 [1], 55.0 [2]
6-N-Cyclohexyl-2-N-[2-methoxy-4-(4-methylsulfonylpiperazin-1-yl)phenyl]-7H-purine-2,6-diamineIC502.0 [1]
4-[[4-Cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methylbenzamideIC505.0 [1], 57.0 [2]
N-[2-Ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-8-(7-oxa-2-azaspiro[3.5]nonan-2-yl)pyrido[3,4-d]pyrimidin-2-amineIC5037.0 [1]
N-[2-Ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-8-(7-oxa-2-azaspiro[3.5]nonan-2-yl)pyrido[3,4-d]pyrimidin-2-amineKi0.11 [1]
N-[2-Ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-8-pyrrolidin-1-ylpyrido[3,4-d]pyrimidin-2-amineIC50370.0 [1]
N-[2-Ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-8-pyrrolidin-1-ylpyrido[3,4-d]pyrimidin-2-amineKi0.82 [1]
8-(3,3-Dimethylazetidin-1-yl)-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidin-2-amineIC5037.0 [1]
8-(3,3-Dimethylazetidin-1-yl)-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidin-2-amineKi0.09 [1]
8-N-(2,2-Dimethylpropyl)-2-N-[4-(4,5-dimethyl-1,2,4-triazol-3-yl)-2-ethoxyphenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC5033.0 [1]
8-N-(2,2-Dimethylpropyl)-2-N-[4-(4,5-dimethyl-1,2,4-triazol-3-yl)-2-ethoxyphenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.12 [1]
3-(4-Chloro-1H-indazol-3-yl)benzenesulfonamideIC501800.0 [1], 1900.0 [2]
N-Cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamideIC508.5 [1], 45.0 [2]
4-[6-(4-Cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamideIC506.6 [1], 12.0 [2]
4-[6-(2-Amino-4-cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamideIC501.3 [1], 2.5 [2]
N-Cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-phenoxyimidazo[1,2-b]pyridazin-3-yl]benzamideIC503.6 [1], 6.8 [2]
N-Cyclopropyl-4-[6-(4-fluorophenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamideIC505.6 [1], 7.8 [2]
N-Cyclopropyl-4-[6-(2-fluorophenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamideIC503.7 [1], 6.6 [2]
N-Cyclopropyl-4-[6-(2-hydroxyphenoxy)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]benzamideIC500.3 [1], 2.6 [2]
4-[6-Anilino-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamideIC5013.0 [1], 33.0 [2]
4-[6-(Cyclopentylamino)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamideIC504.2 [1], 5.3 [2]
N-Cyclopropyl-4-[8-(oxan-4-ylmethylamino)-6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamideIC505.5 [1], 8.4 [2]
N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC502.7 [1]
N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideKi0.7 [1]
N-(2,4-Dimethoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amineIC5046.0 [1], 4840.0 [2]
8-N-[(2S)-3,3-Dimethylbutan-2-yl]-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC5023.0 [1]
8-N-[(2S)-3,3-Dimethylbutan-2-yl]-2-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.05 [1]
1-[2-[2-Ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)anilino]-6-methylpyrido[3,4-d]pyrimidin-8-yl]-3-methylazetidine-3-carbonitrileIC50110.0 [1]
1-[2-[2-Ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)anilino]-6-methylpyrido[3,4-d]pyrimidin-8-yl]-3-methylazetidine-3-carbonitrileKi0.2 [1]
8-(2,2-Dimethylazetidin-1-yl)-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidin-2-amineIC503800.0 [1]
8-(2,2-Dimethylazetidin-1-yl)-N-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methylpyrido[3,4-d]pyrimidin-2-amineKi4.0 [1]
N-(4-Methoxyphenyl)-8-(1-methylpyrazol-4-yl)pyrido[3,4-d]pyrimidin-2-amineIC50140.0 [1], 10000.0 [2]
2-N-[4-(6,7-Dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)-2-ethoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC50250.0 [1]
2-N-[4-(6,7-Dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)-2-ethoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.38 [1]
2-N-[4-(6,7-Dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)-2-methoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC50240.0 [1]
2-N-[4-(6,7-Dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)-2-methoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.19 [1]
2-N-[4-[5-[2-(Dimethylamino)ethyl]-4-methyl-1,2,4-triazol-3-yl]-2-ethoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineIC50230.0 [1]
2-N-[4-[5-[2-(Dimethylamino)ethyl]-4-methyl-1,2,4-triazol-3-yl]-2-ethoxyphenyl]-8-N-(2,2-dimethylpropyl)-6-methylpyrido[3,4-d]pyrimidine-2,8-diamineKi0.12 [1]
N-Cyclopropyl-4-[8-(oxan-4-ylmethylamino)imidazo[1,2-a]pyrazin-3-yl]benzamideIC5035.0 [1], 380.0 [2]
3-(1H-Indazol-3-yl)benzenesulfonamideIC501600.0 [1], 2600.0 [2]
3-[5-Cyclohexyloxy-6-(1-methylpyrazol-4-yl)-1H-indazol-3-yl]benzenesulfonamideIC507.93 [1], 74.0 [2]
3-[5-Ethoxy-6-(1-methylpyrazol-4-yl)-1H-indazol-3-yl]benzenesulfonamideIC503.06 [1], 85.8 [2]
Tert-butyl 6-[2-chloro-4-(1,3-oxazol-5-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC5019.0 [1], 260.0 [2]
Tert-butyl 6-(2-chloro-4-pyridin-3-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC5028.0 [1], 710.0 [2]
Tert-butyl 6-[2-chloro-4-[4-(dimethylamino)piperidine-1-carbonyl]anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC504.0 [1], 1100.0 [2]
Tert-butyl 6-[2-chloro-4-(1-methylpyrazol-3-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC5020.0 [1], 2500.0 [2]
Tert-butyl 6-[2-chloro-4-(1,1-dioxo-1,4-thiazinane-4-carbonyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC505.0 [1], 860.0 [2]
Tert-butyl 6-[2-chloro-4-(dimethylcarbamoyl)anilino]-2-(1,3-oxazol-5-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC5022.0 [1], 5600.0 [2]
Tert-butyl 6-[2-chloro-4-(dimethylsulfamoyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylateIC5092.0 [1], 840.0 [2]
4-[6-(4-Cyanophenyl)-8-(oxan-4-ylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-cyclopropylbenzamideIC504.2 [1], 9.6 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dual specificity protein kinase TTK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-ttk-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Dual specificity protein kinase TTK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-ttk-inhibitors-ic50-ki.
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