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Dual specificity protein kinase CLK2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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4-[[4-Cyclopentyloxy-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methylbenzamideIC506.0 [1], 15.0 [2], 549.0 [3]
SilmitasertibIC503.8 [1]
9H-Purine-2,6-diamine, N2-(2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-, cis-IC50111.0 [1]
CID 53246941IC50112.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(thiophen-2-ylmethyl)-4-quinazolinamineIC501902.0 [1]
CID 59604787IC5010000.0 [1]
CID 46926514IC50231.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(2-furanylmethyl)-N-methyl-4-quinazolinamineIC50692.0 [1]
[5-[4-[(5-Methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanolIC501648.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi8753.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamideIC50211.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamineIC501327.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(2-methyl-4-thiazolyl)methyl]-4-quinazolinamineIC50186.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(1,3-thiazol-2-ylmethyl)quinazolin-4-amineIC50589.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-methyl-N-(thiophen-2-ylmethyl)-4-quinazolinamineIC50173.0 [1]
6-(Benzo[d][1,3]dioxol-5-yl)-N-(furan-3-ylmethyl)quinazolin-4-amineIC50877.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(3-oxolanylmethyl)-4-quinazolinamineIC501055.0 [1]
CID 46926513IC5023.0 [1]
(Z)-3-Pyridin-3-yl-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-enenitrileIC504600.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC501012.0 [1]
11H-Pyrido[3,4-a]carbazole-6-carbonitrileIC501100.0 [1]
Clk1-IN-1IC5031.0 [1]
N-(4-Morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amineIC505.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(3R)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamineIC5034.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC5016.0 [1]
N-[3-[[2-[[(1R,2S)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamideIC5013.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2S)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC5014.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1R,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC50163.0 [1]
N-[3-[[2-[[(1S,2R)-2-Aminocyclohexyl]amino]-9-propan-2-ylpurin-6-yl]amino]-5-chlorophenyl]acetamideIC5017.0 [1]
2-N-[(1S,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC5026.0 [1]
2-N-[(1R,2R)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC50120.0 [1]
2-N-[(1S,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC5016.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(1S,2R)-2-aminocyclohexyl]-9-propan-2-ylpurine-2,6-diamineIC5026.0 [1]
2-N-[(1R,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-propan-2-ylpurine-2,6-diamineIC5011.0 [1]
6-N-(3-Amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3S)-pyrrolidin-3-yl]purine-2,6-diamineIC5028.0 [1]
6-N-(3-Amino-5-chlorophenyl)-2-N-[(3S)-piperidin-3-yl]-9-propan-2-ylpurine-2,6-diamineIC5026.0 [1]
6-N-(3-Amino-5-chlorophenyl)-9-propan-2-yl-2-N-[(3R)-pyrrolidin-3-yl]purine-2,6-diamineIC5092.0 [1]
5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-oneIC5010000.0 [1]
Methyl 2-(2-chloroanilino)-4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]furan-3-carboxylateIC505.3 [1]
1-[4-[4-[[5-(Oxan-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]cyclohexyl]piperazin-1-yl]ethanoneIC5039.0 [1]
1-[4-[4-[(5-Propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]piperazin-1-yl]ethanoneIC50175.0 [1]
(5E)-2-Amino-5-(1,3-benzodioxol-5-ylmethylidene)-3-methylimidazol-4-oneIC50910.0 [1]
5-(1,3-Benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amineIC5010000.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-[(3-methylthiophen-2-yl)methyl]quinazolin-4-amineIC502163.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-[2-(1H-imidazol-5-yl)ethyl]quinazolin-4-amineIC502219.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(2-oxolanylmethyl)-4-quinazolinamineIC501810.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]quinazolin-4-amineIC503118.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-[2-(2-furanyl)ethyl]-4-quinazolinamineIC50801.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-[(5-methylfuran-2-yl)methyl]quinazolin-4-amineIC50651.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(1H-imidazol-2-ylmethyl)quinazolin-4-amineIC503594.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-[(5-methylthiophen-2-yl)methyl]quinazolin-4-amineIC5010000.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-[(2-methyl-3-furanyl)methyl]-4-quinazolinamineIC502725.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(3-methylthiophen-2-yl)methyl]quinazolin-4-amineIC50962.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-ethyl-N-(thiophen-2-ylmethyl)-4-quinazolinamineIC50447.0 [1]
Ethyl 5-(4-(thiophen-2-ylmethylamino)quinazolin-6-yl)furan-2-carboxylateIC508510.0 [1]
Ethyl 5-(4-((5-methylfuran-2-yl)methylamino)quinazolin-6-yl)furan-2-carboxylateIC506181.0 [1]
6-(3-Furanyl)-N-methyl-N-[(3-methyl-2-thiophenyl)methyl]-4-quinazolinamineIC501209.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(1H-imidazol-2-ylmethyl)-N-methylquinazolin-4-amineIC503331.0 [1]
(5-(4-(Methyl((3-methylthiophen-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanolIC50889.0 [1]
N-[(3,4-Dichlorophenyl)methyl]-4-(3-methoxyphenyl)pyrimidin-2-amineIC5010000.0 [1]
N-[(4-Chlorophenyl)methyl]-4-(3-methoxyphenyl)pyrimidin-2-amineIC5010000.0 [1]
N-[(3,4-Dichlorophenyl)methyl]-4-(4-methoxyphenyl)pyrimidin-2-amineIC50409.0 [1]
N-[(4-Chlorophenyl)methyl]-4-(4-methoxyphenyl)pyrimidin-2-amineIC501092.0 [1]
5-(4-((5-Methylfuran-2-yl)methylamino)quinazolin-6-yl)furan-2-carboxylic acidIC501361.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(2-thiazolylmethyl)-4-quinazolinamineIC50414.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-methyl-N-[(4-methyl-1,3-thiazol-2-yl)methyl]quinazolin-4-amineIC50195.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(2,2-dimethylpropyl)quinazolin-4-amineIC50584.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(furan-2-ylmethyl)quinazolin-4-amineIC50301.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(cyclopentylmethyl)-4-quinazolinamineIC50486.0 [1]
6-(1,3-Benzodioxol-5-yl)-N-(3-oxanylmethyl)-4-quinazolinamineIC50882.0 [1]
4-(1,3-Benzodioxol-5-yl)-N-[3-bromo-5-(trifluoromethyl)phenyl]pyrimidin-2-amineIC50345.0 [1]
4-(1,3-Benzodioxol-5-yl)-N-[3-(trifluoromethyl)phenyl]pyrimidin-2-amineIC5052.0 [1]
4-(1,3-Benzodioxol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amineIC5060.0 [1]
N-[(3,4-Dichlorophenyl)methyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amineIC5039.0 [1]
5-(1,3-Benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-4-amineIC501557.0 [1]
N,4-Bis(1,3-benzodioxol-5-yl)pyrimidin-2-amineIC50259.0 [1]
4-(1,3-Benzodioxol-5-yl)-N-[(3,5-dibromophenyl)methyl]pyrimidin-2-amineIC5041.0 [1]
4-(1,3-Benzodioxol-5-yl)-N-[(3,4-dichlorophenyl)methyl]pyrimidin-2-amineIC5020.0 [1]
5-(1,3-Benzodioxol-5-yl)-N-[(4-chlorophenyl)methyl]pyrimidin-4-amineIC508791.0 [1]
4-(1,3-Benzodioxol-5-yl)-N-(4-chlorophenyl)pyrimidin-2-amineIC5010000.0 [1]
4-(1,3-Benzodioxol-5-yl)-N-[(3,4-dibromophenyl)methyl]pyrimidin-2-amineIC5030.0 [1]
N-[(3,4-Dichlorophenyl)methyl]-4-(1H-indazol-6-yl)pyrimidin-2-amineIC50429.0 [1]
N-[(3,4-Dichlorophenyl)methyl]-2-(1H-indazol-5-yl)pyrimidin-4-amineIC50238.0 [1]
2-(1H-Indazol-6-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amineIC501903.0 [1]
4-(1H-Indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-2-amineIC50462.0 [1]
N-[(3,4-Dichlorophenyl)methyl]-4-(1H-indazol-5-yl)pyrimidin-2-amineIC50190.0 [1]
2-(1H-Indazol-5-yl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amineIC50665.0 [1]
N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamineIC50498.0 [1]
N-(2,2-Dimethylpropyl)-6-[5-(ethylaminomethyl)furan-2-yl]quinazolin-4-amineIC508480.0 [1]
1-[2-(2-Ethyltetrazol-5-yl)ethyl]-3-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]ureaIC50117.0 [1]
2-N-[(1S,2S)-2-Aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamineIC50190.0 [1]
2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC506440.0 [1]
N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-DiamineIC5010000.0 [1]
2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamineIC5010000.0 [1]
(9-Methoxy-11H-pyrido[4,3-a]carbazol-6-yl)methanamineIC501600.0 [1]
(Z)-2-(6-Methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-pyridin-3-ylprop-2-enenitrileIC502300.0 [1]
9-Methoxy-11H-pyrido[4,3-a]carbazole-6-carbonitrileIC5080.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dual specificity protein kinase CLK2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-clk2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Dual specificity protein kinase CLK2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-protein-kinase-clk2-inhibitors-ic50-ki.
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