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Dual specificity phosphatase Cdc25B Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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3-[7-(3-Methyl-2-butenyl)-1H-indole-3-yl]-2,5-dihydroxy-p-benzoquinoneIC5012000.0 [1]
3-[7-(3-Methyl-2-butenyl)-1H-indole-3-yl]-2,5-dihydroxy-p-benzoquinoneKi640.0 [1]
3-(1H-Indole-3-yl)-2,5-dihydroxy-p-benzoquinoneIC5050000.0 [1]
3-(1H-Indole-3-yl)-2,5-dihydroxy-p-benzoquinoneKi13000.0 [1]
2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedioneIC50100.0 [1], 125.0 [2], 3770.0 [3], 19170.0 [4], 19200.0 [5]
6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dioneIC50210.0 [1], 740.0 [2], 29200.0 [3], 100000.0 [4]
6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dioneKi95.0 [1]
(1S)-1-Methyl-7,7-dioxo-18-oxa-7lambda6-thia-10-azahexacyclo[15.6.1.02,15.04,13.06,11.020,24]tetracosa-2(15),3,6(11),13,17(24),19-hexaene-5,12,16-trioneIC5070.0 [1], 80.0 [2], 110.0 [3]
4-(N-Benzyl-C-pentadecylcarbonimidoyl)-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-oneIC508420.0 [1], 15600.0 [2], 16900.0 [3]
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-oneIC504260.0 [1], 9980.0 [2], 10900.0 [3]
3-[4,6-Dichloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC502300.0 [1], 8600.0 [2]
3-[4,6-Dichloro-7-(3-methylbut-2-enyl)-1H-indol-3-yl]-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneKi430.0 [1]
(5Z)-5-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-2-[7-[[(5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]heptylimino]-1,3-thiazolidin-4-oneIC501380.0 [1], 3100.0 [2], 3200.0 [3]
(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-[7-[[(5Z)-5-[(4-hydroxyphenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]heptylimino]-1,3-thiazolidin-4-oneIC503400.0 [1], 16500.0 [2], 20000.0 [3]
6-(3-Aminophenyl)-3-(phenylamino)isoquinoline-1(2H)-oneIC503180.0 [1], 33600.0 [2]
6-(3-Aminophenyl)-3-(phenylamino)isoquinoline-1(2H)-oneKi1900.0 [1]
MenadioneIC502200.0 [1], 3380.0 [2]
7-((2-(3,5-Dibromo-4-hydroxyphenyl)ethyl)amino)-5,8-quinolinedioneIC50640.0 [1], 35000.0 [2]
2-(3,4-Dimethylphenylamino)-5-(3-furan-2-ylallylidene)thiazol-4-oneIC501800.0 [1], 5440.0 [2]
(E)-2-((1R,7Ar)-7a-methyl-1-((R)-6-methylheptan-2-yl)-octahydroinden-4-ylidene)acetic acidIC505900.0 [1], 8000.0 [2]
2-[4-(4-Chlorophenyl)-5-p-tolyl-4H-[1,2,4]triazol-3-ylsulfanyl]-1-(3,4-dihydroxyphenyl)ethanoneIC501980.0 [1], 2000.0 [2]
4-Heptadecyl-2,5-dihydro-2,5-dioxofuran-3-propionic acidIC503600.0 [1]
(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamideIC5026000.0 [1]
(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamideKi4600.0 [1]
(E)-N-(4,5-Diphenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethenesulfonamideIC5022000.0 [1]
(E)-N-(4,5-Diphenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethenesulfonamideKi36000.0 [1]
5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-oneIC508900.0 [1], 17900.0 [2]
1-Methanesulfonyl-5-[2-(3-methylphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indoleIC5019000.0 [1], 34400.0 [2]
4-{2,5-Dimethyl-1-[(oxolan-2-yl)methyl]-1H-pyrrol-3-yl}-2-(4-methoxyphenyl)-1,3-thiazoleIC5012100.0 [1], 23600.0 [2]
2-(4-Ethoxyphenyl)-4-(naphthalen-2-yl)-1,3-thiazoleIC5013600.0 [1], 100000.0 [2]
N-[3-(2-Phenyl-1,3-thiazol-4-yl)phenyl]-2-furamideIC50100000.0 [1]
N-{3-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]phenyl}cyclopropanecarboxamideIC5014900.0 [1], 100000.0 [2]
2-(4-Methoxyphenyl)-4-(1-methylsulfonyl-2,3-dihydroindol-5-yl)-1,3-thiazoleIC5017500.0 [1], 26100.0 [2]
1-Methanesulfonyl-5-[2-(2-methoxyphenyl)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indoleIC5010100.0 [1], 31300.0 [2]
5-[2-(4-Ethoxyphenyl)-1,3-thiazol-4-yl]-1-methyl-2,3-dihydro-1H-indol-2-oneIC5022700.0 [1], 50000.0 [2]
1,4-BenzoquinoneIC5050000.0 [1]
Oleanolic acidIC50980.0 [1]
AnthraquinoneIC509510.0 [1]
1,4-NaphthoquinoneIC502760.0 [1]
JugloneIC501980.0 [1]
alpha-TocopherolquinoneIC5023230.0 [1]
5,8-Dihydroxy-1,4-naphthoquinoneIC501000.0 [1]
IlimaquinoneIC5092000.0 [1]
DysidiolideIC5087000.0 [1]
3-(2-PYRIDYL)-5,6-bis-[2-(5-FURYL-SULFONIC ACID)]-1,2,4-TRIAZINEKi159000.0 [1]
2-((2-Hydroxyethyl)thio)-3-methylnaphthalene-1,4-dioneIC5023630.0 [1]
RK-682, Streptomyces sp.IC5012400.0 [1]
6,7-Dichloroquinoline-5,8-dioneIC504600.0 [1]
5,8-QuinolinedioneIC503000.0 [1]
3-Anilinoisoquinolin-1(2H)-oneIC503300.0 [1]
Streptonigrin methyl esterIC50370.0 [1]
o-(4-Biphenylylcarbonyl)benzoic acidIC5023100.0 [1]
2-[[5-(3-Chlorophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]-1-(3,4-dihydroxyphenyl)ethanoneIC504670.0 [1]
5,8-Phthalazinedione, 6,7-dichloro-IC508900.0 [1]
2-[4-(Methylamino)-3-nitrobenzoyl]benzoic acidIC507900.0 [1]
5,5'-Methylenedianthranilic acidIC5023800.0 [1]
5-((1H-Indol-3-yl)methylene)-2-(2,4-dichlorophenylamino)thiazol-4(5H)-oneIC502600.0 [1]
3-Benzoylnaphtho[1,2-b]furan-4,5-dioneIC505000.0 [1]
2-Benzylidene-1,3-dioxo-2,3-dihydro-1H-indene-5-carboxylic acidIC508600.0 [1]
3-(4-Fluoroanilino)-2H-isoquinolin-1-oneIC50830.0 [1]
1-(Biphenyl-4-yl)-2-(5-(furan-2-yl)-4-methyl-4H-1,2,4-triazol-3-ylthio)ethanoneIC502000.0 [1]
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]pyrazine-2-carboxamideIC5016000.0 [1]
3-Anilino-6-bromo-isocarbostyrilIC501160.0 [1]
3-(2-Pyridylamino)isocarbostyrilIC503310.0 [1]
3-(2-Chloroanilino)isocarbostyrilIC504190.0 [1]
3-(2,5-Dimethoxyanilino)isocarbostyrilIC505250.0 [1]
3-(Morpholin-4-yl)-1,2-dihydroisoquinolin-1-oneIC503370.0 [1]
7-[(1-Hydroxy-1-phenylpropan-2-yl)amino]quinoline-5,8-dioneIC50510.0 [1]
Ethyl 4-[(1-oxo-2H-isoquinolin-3-yl)amino]benzoateIC5010750.0 [1]
1,4-Dioxo-3-methyl-2-naphthalenebutyric acidIC50100000.0 [1]
2-Methoxy-5-((4-methyl-2-oxo-1,2-dihydro-quinolin-6-yl)methyl)benzenesulfonic acidKi84000.0 [1]
3-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)propanoic acidKi80.0 [1]
1-(3,4-Dichlorophenyl)-3-[7-(furan-2-yl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]ureaIC5013700.0 [1]
4-Ethoxynaphthalene-1,2-dioneIC50270.0 [1]
1,4-Naphthalenedione, 2-[(2-hydroxyethyl)amino]-IC5050000.0 [1]
Benzimidazo[1,2-b]isoquinolin-11(5H)-oneIC505300.0 [1]
4-Phenyl-[1,2]naphthoquinoneIC509520.0 [1]
Maleimide analogIC5010000.0 [1]
3-[5-[(E)-(2-Amino-3,7-dicyano-4,6-dimethylcyclopenta[b]pyridin-5-ylidene)methyl]furan-2-yl]benzoic acidIC5019000.0 [1]
1,1-Dioxo-3,4-dihydro-2H-benzo[g][1,4]benzothiazine-5,10-dioneIC50940.0 [1]
2-[(7-Methoxy-2-oxochromen-4-yl)methylsulfanyl]naphthalene-1,4-dioneIC509000.0 [1]
2-[(3,4-Dioxonaphthalen-1-yl)amino]-6-oxo-1H-pyrimidine-4-carboxylic acidIC509900.0 [1]
3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-oneIC50100000.0 [1]
3-Isopropylnaphthalene-1,2-dioneIC5024100.0 [1]
6,7-Dichloro-5,8-isoquinolinedioneIC501500.0 [1]
4-(2-Carboxybenzoyl)phthalic acidKi5300.0 [1]
4-(Biphenyl-4-yl)thiazole-2-ylmethyl 2-furylmethyl sulfoneIC501700.0 [1]
3-Hexadecanoyl-4-hydroxy-5-methylenefuran-2(5H)-oneIC507400.0 [1]
2-[(E)-2-[5-(4-Chlorophenyl)furan-2-yl]ethenyl]-6-oxo-3-phenyl-4-sulfanyl-1,2-dihydropyrimidine-5-carbonitrileIC5012640.0 [1]
2-(Cyclopentanecarbonyl)-7-[(2,6-dichlorophenyl)methoxy]-6,8-diiodo-3,4-dihydro-1H-isoquinoline-3-carboxylic acidIC50100000.0 [1]
3-(1,3-Benzodioxol-5-yl)-N-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]acrylamideIC502690.0 [1]
3-[(1S)-2-[(1R,4S,7Ar)-4,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-oneIC501900.0 [1]
2-(2-Hydroxyethylamino)-3-methyl-1,4-naphthoquinoneIC5050000.0 [1]
3-[(1S)-2-[(1S,2R,5S,8As)-1,2,5-trimethyl-5-(4-methylpent-4-enyl)-2,3,6,7,8,8a-hexahydronaphthalen-1-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-oneIC5018000.0 [1]
(3S)-7-[(2,4-Dichlorophenyl)methoxy]-6,8-diiodo-2-[(E)-3-[3-(trifluoromethyl)phenyl]prop-2-enoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acidIC5015000.0 [1]
(2R,5R,6R)-6,10-Dimethyl-5-[(2R)-6-methylheptan-2-yl]-13-oxotricyclo[13.2.2.02,6]nonadeca-1(17),15,18-triene-17-carboxylic acidIC503400.0 [1]
4-Cyclohexyl-1,2-naphthoquinoneIC503000.0 [1]
(E)-2-(3,4-Difluorophenyl)-N-[5-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]ethenesulfonamideIC5025000.0 [1]
3-[(1R)-2-[(1R,4R,7Ar)-4,7a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-oneIC501440.0 [1]
3-(1H-Benzo[g]indol-3-yl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dioneIC5024000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dual specificity phosphatase Cdc25B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25b-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Dual specificity phosphatase Cdc25B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-phosphatase-cdc25b-inhibitors-ic50-ki.
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