![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_93c574e9449f6876500d39366a551a51.svg) | 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide | IC50 | 16.0 [1], 46.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_3195e9a4a73a8bc248129bfb23f4abec.svg) | 3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamide | IC50 | 1.2 [1], 2.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_d6da00e34bbfe7a4e7c83873173795a9.svg) | 4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxopyridine-3-carboxamide | IC50 | 4.0 [1], 23.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_2af1039425aea87cba576adaa6de4353.svg) | 3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide | IC50 | 17.4 [1], 30.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_ea9357727e772a1284d72c575ef1f9e2.svg) | 4-(2-Fluoro-4-iodoanilino)-6-oxo-1-propylpyridine-3-carboxamide | IC50 | 430.0 [1], 2540.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_890adf9236766d8df057bf655a3aa7b8.svg) | 4-(2-Fluoro-4-iodoanilino)-N-(3-hydroxypropyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 61.0 [1], 95.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_b5fa8edcd934cfc2c9bc568d4979730d.svg) | 4-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 180.0 [1], 206.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_9852388975dbc4561d32440ce192f62f.svg) | 4-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 5.0 [1], 18.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_118b2ebbcb7ef48387cc61e815f9738a.svg) | 4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid | IC50 | 425.0 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_3f4f9cc46f1386ed32412b7b6070be3d.svg) | 4-(3,4-Dichloro-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide | IC50 | 3900.0 [1], 5720.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_523e9ba230ef918fc22c1482a4e32ee5.svg) | Ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate | IC50 | 63.0 [1], 669.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_999d7f7899219b4cdfd930700069738a.svg) | 4-(4-Ethynyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 21.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_5b814820a6c7ca63819bc37c144df910.svg) | 4-(2-Fluoro-4-methylsulfanylanilino)-1-methyl-6-oxopyridine-3-carboxamide | IC50 | 150.0 [1], 356.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_b789a6fcfc7db006624a2431391a44af.svg) | 4-(2-Fluoro-4-iodoanilino)-6-oxo-1H-pyridine-3-carboxamide | IC50 | 100.0 [1], 630.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_bee7043a3596ac3f8571a501dafc0825.svg) | 4-(4-Ethyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 110.0 [1], 2620.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_bf5b214ae6d5f8ad8f5a8f54b5826964.svg) | 4-(4-Bromo-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 93.0 [1], 1910.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_1e845306afa5a035b8c28c831903dd6e.svg) | 4-(2-Fluoro-4-iodoanilino)-1-(2-hydroxyethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 2540.0 [1], 5000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_f5042833cc08c0b7a36acaad949ca78b.svg) | 3,4-Difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)benzamide | IC50 | 68.0 [1], 84.2 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_a64e003d94496f76f51d1fde2e38797b.svg) | 4-(4-Bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-6-oxo-1H-pyridine-3-carboxamide | IC50 | 120.0 [1], 3630.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_b96c95589239aa5fc9b995c3e9055da0.svg) | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole | IC50 | 61000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_986db0437f20070dfb14143a9f1b018d.svg) | Dasatinib | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_b0f6535d633b24658defe8380c006aae.svg) | Vemurafenib | IC50 | 1500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_55635e1e49159e77f5424d0e58fcfe56.svg) | Dabrafenib | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_86afa169fbf5024375ee5d399dedddf5.svg) | Saracatinib | IC50 | 14000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_5056396fd6132d5f6d9e041409ccd203.svg) | Cobimetinib | IC50 | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_94feb385cecaa610e1d68d9fb9d55ef3.svg) | Pyridone 6 | IC50 | 160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_bd1c4c226d09bccaf8e1c9ed8e2ba78a.svg) | Azd-1152hqpa | Ki | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_20beeda5bb0152c29cef63a6468d977e.svg) | N6,N6-Dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamine | IC50 | 9700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_777898ba417f4e875e6f3109cad807ee.svg) | LY-3009120 | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_9c062cd6c7c1362062730d56f1c53648.svg) | N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_298939ba2bdecf0f92f08e04bb796b27.svg) | 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_638b2b9a12dd6a9a9e92a9b396e4bebf.svg) | N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide | IC50 | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_39ceed0ad4ea5af71d276a234ff375b8.svg) | 4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_0b1fcdc69956cd0cffe6717d5ac331b9.svg) | 4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_6a0c8aaa666e393f1dbca5a25041f409.svg) | 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid | IC50 | 102.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_46b256ec54d5cc122ecfb7d1e2fbe009.svg) | Vandetanib hydrochloride | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_3c8f2f9ed71a24eaf117d65935184649.svg) | 4-(4-Cyano-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_171272521f7643c934095843482e202e.svg) | (5-(Aminocarbonyl)-4-(2-fluoro-4-iodoanilino)-2-oxo-1(2H)-pyridinyl)acetic acid | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_72f9de9cc3451172087326b827c99f03.svg) | 1-Allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 91.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_74f3f617d15172b90d3203122f9ea594.svg) | 1-(2,3-Dihydroxypropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_bf5fe4755b55883dadcee24a3e2e8b06.svg) | 4-[2-Fluoro-4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)anilino]-1-methyl-6-oxopyridine-3-carboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_878ffe1f685aa9438e1fc12a7075101d.svg) | 4-(2-Fluoro-4-iodoanilino)-N,N,1-trimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 627.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_271336ac6d09f7baa0009b7367f819a8.svg) | 4-(2-Fluoro-4-iodoanilino)-N,1-dimethyl-6-oxopyridine-3-carboxamide | IC50 | 195.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_b0685435f268a724a900446e3e5c0ba6.svg) | 1-(3-Cyanopropyl)-4-(2-fluoro-4-iodoanilino)-6-oxopyridine-3-carboxamide | IC50 | 4890.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_c6177bdb922d18df7a35f0a0c0cce109.svg) | 4-(2-Fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxopyridine-3-carboxamide | IC50 | 1130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_bb49e85f8e224b6a04710ad1f7385f1a.svg) | 1-Ethyl-4-(2-fluoro-4-iodoanilino)-6-oxopyridine-3-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_e67c66c300adde7b644f3bede9bdac89.svg) | 4-[2-Fluoro-4-(3-hydroxypropyl)anilino]-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_21f0006bdfbfa5d2d78030343c5cbba8.svg) | 4-(2-Fluoro-4-iodoanilino)-1-(3-hydroxypropyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 3000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_4a21dbecf33623cf678775166241a094.svg) | 4-(2-Fluoro-4-methylanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 2970.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_f20d6e1fce3a46585947785cbcd81d76.svg) | 1-Methyl-4-(2-naphthylamino)-6-oxo-1,6-dihydro-3-pyridinecarboxamide | IC50 | 3000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_b7432d9007485dfb53c9f4ebe8a72cdb.svg) | N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamide | IC50 | 57.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_bb914cb57091324b87c50b9090f9f5b7.svg) | 1-(3-Tert-butyl-1,2-oxazol-5-yl)-3-[2-fluoro-5-[7-(methylamino)-2-oxo-1-[(3S)-oxolan-3-yl]-1,6-naphthyridin-3-yl]phenyl]urea | IC50 | 2900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_1a8d2a9baf02ce37ec22fe85b47552e3.svg) | 1-(3,3-Dimethylbutyl)-3-[5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluoro-4-methylphenyl]urea | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_d9c8f3dd3f7924e74bb28bd61288209f.svg) | Tert-butyl N-[2-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-2-oxoethyl]carbamate | IC50 | 7350.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_4b8766df7c256ae2da7dd593b3598a19.svg) | Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_48a16770dd3c7acdef8833047553db5b.svg) | 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(3-methoxyphenyl)-N-phenyl-3,4-dihydropyrazole-2-carbothioamide | IC50 | 195000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_d8bca89e8d46be301aae0976eb62e15f.svg) | 5-(4-Bromophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-phenyl-3,4-dihydropyrazole-2-carbothioamide | IC50 | 188000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_9b8e823af5cabe365acc9a8d34406550.svg) | 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-phenyl-5-(4-phenylmethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide | IC50 | 176000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_772619541247cd173079f6785e585010.svg) | [3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-(pyrrolidin-1-ylmethyl)azetidin-1-yl]methanone | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_4f6ba1654e084e063e33f7d6bd8c9671.svg) | [3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-[(dimethylamino)methyl]-3-hydroxyazetidin-1-yl]methanone | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_1506aa5574b911785556b89f78a6dc90.svg) | [3-(Aminomethyl)-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone | IC50 | 57.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_56050d114c0d6d308edba50a972792d1.svg) | 3-[(1S)-1-Aminoethyl]-1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)azetidin-3-ol | IC50 | 46.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_ecd00a4eef9de102aab3af83025fe59b.svg) | [3-[(1R)-1-Aminoethyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone | IC50 | 164.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_75e1cfe13f703d9e5fe137b59c1d92d2.svg) | [3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-(morpholin-4-ylmethyl)azetidin-1-yl]methanone | IC50 | 331.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_400e82b9e1dddf4f9457aed6bf5ec2db.svg) | [3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(propan-2-ylamino)methyl]azetidin-1-yl]methanone | IC50 | 3.7 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_ca8440701eb01761cccc129001f4ef71.svg) | 1-[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)benzoyl]-3-hydroxyazetidine-3-carboxamide | IC50 | 81.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_181d155c1103fdfda3f1129f5eab218a.svg) | [3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-(ethylaminomethyl)-3-hydroxyazetidin-1-yl]methanone | IC50 | 6.9 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_edd2276ff9db330dadb4526bffa2abc8.svg) | [3-[(Tert-butylamino)methyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone | IC50 | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_98cc2ae3f22be1bab7c07134621e3417.svg) | 1-({3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)azetidin-3-ol | IC50 | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_4688288f3cb7b01fba04dd67aef8f8e4.svg) | Azetidin-1-yl-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanone | IC50 | 111.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_3cd9589db1fe4d1dfe9f79002908e314.svg) | 1-({3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(hydroxymethyl)azetidin-3-ol | IC50 | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_622d8f70eea1bc09b8d6e4fc66845dad.svg) | [3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-(3-hydroxy-3-methylazetidin-1-yl)methanone | IC50 | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_d0d6611cb1484a8d83d19cc12bec7ee5.svg) | (2Z,3Z)-2,3-Bis[amino-(2-methoxyphenyl)sulfanylmethylidene]butanedinitrile | IC50 | 16500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_c5531f091a0c174021513dfaa191010b.svg) | (2Z,3Z)-2,3-Bis[amino-(2-chlorophenyl)sulfanylmethylidene]butanedinitrile | IC50 | 6600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_0364e1f12fbbd61eb53c02ee62a2174b.svg) | (2Z,3Z)-2,3-Bis[amino-(2-fluorophenyl)sulfanylmethylidene]butanedinitrile | IC50 | 7600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_c949356a040e37bf9351e16416a85384.svg) | (2Z,3Z)-2,3-Bis[amino-(2-hydroxyphenyl)sulfanylmethylidene]butanedinitrile | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_7951d20fca551676f33ebca708038593.svg) | (2Z,3Z)-2,3-Bis[amino-(4-aminophenyl)sulfanylmethylidene]butanedinitrile | IC50 | 10500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_20d5a1f69d56bbe3cef556bc3f8f2a52.svg) | 2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-dicarbonitrile | IC50 | 25100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_6376c6ca446f79f9aa0bbda832fd5e13.svg) | (2Z,3Z)-2,3-Bis[amino(thiophen-2-ylsulfanyl)methylidene]butanedinitrile | IC50 | 1200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_d63029834edc1b0a354989fc3a517949.svg) | (2Z,3Z)-2,3-Bis[amino-(2,6-dichlorophenyl)sulfanylmethylidene]butanedinitrile | IC50 | 6500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_4b4b3df3df7341aaf2406074ea69dd22.svg) | (2Z,3Z)-2,3-Bis(3H-1,3-benzothiazol-2-ylidene)butanedinitrile | IC50 | 42500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_32585b03de47204a54db1347f501e2bb.svg) | (2Z,3Z)-2,3-Bis[amino-(4-chlorophenyl)sulfanylmethylidene]butanedinitrile | IC50 | 21700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_3cd4d9e946b6a93a407a0455058cc6e5.svg) | (2Z,3Z)-2,3-Bis[amino-(3-chlorophenyl)sulfanylmethylidene]butanedinitrile | IC50 | 18400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_78c893d05fcbd5cde0805bdfe37a4c0a.svg) | (2Z,3Z)-2,3-Bis[amino-(2-bromophenyl)sulfanylmethylidene]butanedinitrile | IC50 | 7900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_e6db83118da53f854cf4e587ae0f29cc.svg) | 2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-dicarbonitrile | IC50 | 28900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_44418a032568f2e7b44e594b9c8542a9.svg) | N-[3,4-Dicyano-5-(naphthalen-2-ylsulfanyl)-1H-pyrrol-2-yl]-benzenesulfonamide | IC50 | 8000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_ff6985a1ee642ce7c40ad4a720b7bbbb.svg) | 2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-dicarbonitrile | IC50 | 26200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_436baf7e39f7d2bf9d29c0dce37d9b19.svg) | (2Z,3Z)-2,3-Bis[amino-(2-methylphenyl)sulfanylmethylidene]butanedinitrile | IC50 | 13300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_3ed49a2083b9674a65cac8a0f01adeee.svg) | (2Z,3Z)-2-[Amino-(2-aminophenyl)sulfanylmethylidene]-3-(3H-1,3-benzothiazol-2-ylidene)butanedinitrile | IC50 | 18700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_69483f0036c6270f6c31a74e77a6fdd0.svg) | 10,11-Difluoro-12-(2-fluoro-4-iodoanilino)-2,2-dioxospiro[4,5,6,7-tetrahydro-1H-8,2lambda6,1-benzoxathiazecine-3,1'-cyclopropane]-5,6-diol | IC50 | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_bece046ceedb33489ab7346393fcfc1f.svg) | 2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide | IC50 | 22.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_cbcc5f5a0c734dc44037270af8f931f9.svg) | N-(2-Amino-2-methylpropyl)-2-(2-fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_7044179de9d55aa15c089e4ea94b8183.svg) | 2-(2-Chloro-4-iodoanilino)-N-[(3R)-3,4-dihydroxybutyl]-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide | IC50 | 200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_a2f0de34704f08f8c55e1eb979cd619b.svg) | 2-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_55ef1eedb18387cab80d463c51490b26.svg) | 2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[[(2R)-pyrrolidin-2-yl]methyl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide | IC50 | 42.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_71d14363d058a548425d823ba92c5154.svg) | 2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxylic acid | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_8c49335aae2df396964d8f07ed8ed00d.svg) | 2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide | IC50 | 9.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_1fd5de598ee36206c437aa8f17beac2f.svg) | 2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[(3R)-pyrrolidin-3-yl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamide | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_4dab65189b4a9ab43ff1f5de0fce0d03.svg) | 2-(2-Fluoro-4-iodoanilino)-7,7-dimethyl-6,8-dihydro-5H-[1,3]thiazolo[5,4-c]azepin-4-one | IC50 | 946.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2_8641300bd3beafc02884ff88b686b96c.svg) | Ethyl 2-(2-chloro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxylate | IC50 | 2617.0 [1] |