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Dual specificity mitogen-activated protein kinase kinase; MEK1/2 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
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▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamideIC5016.0 [1], 46.0 [2]
3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamideIC501.2 [1], 2.0 [2]
4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxopyridine-3-carboxamideIC504.0 [1], 23.0 [2]
3,4-Difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamideIC5017.4 [1], 30.0 [2]
4-(2-Fluoro-4-iodoanilino)-6-oxo-1-propylpyridine-3-carboxamideIC50430.0 [1], 2540.0 [2]
4-(2-Fluoro-4-iodoanilino)-N-(3-hydroxypropyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC5061.0 [1], 95.0 [2]
4-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC50180.0 [1], 206.0 [2]
4-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC505.0 [1], 18.0 [2]
4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acidIC50425.0 [1], 5000.0 [2]
4-(3,4-Dichloro-phenylamino)-1-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amideIC503900.0 [1], 5720.0 [2]
Ethyl 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylateIC5063.0 [1], 669.0 [2]
4-(4-Ethynyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC5021.0 [1], 100.0 [2]
4-(2-Fluoro-4-methylsulfanylanilino)-1-methyl-6-oxopyridine-3-carboxamideIC50150.0 [1], 356.0 [2]
4-(2-Fluoro-4-iodoanilino)-6-oxo-1H-pyridine-3-carboxamideIC50100.0 [1], 630.0 [2]
4-(4-Ethyl-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC50110.0 [1], 2620.0 [2]
4-(4-Bromo-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC5093.0 [1], 1910.0 [2]
4-(2-Fluoro-4-iodoanilino)-1-(2-hydroxyethyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC502540.0 [1], 5000.0 [2]
3,4-Difluoro-2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethyl)benzamideIC5068.0 [1], 84.2 [2]
4-(4-Bromo-2-fluoroanilino)-N-(2-hydroxyethoxy)-6-oxo-1H-pyridine-3-carboxamideIC50120.0 [1], 3630.0 [2]
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC5061000.0 [1]
DasatinibIC501700.0 [1]
VemurafenibIC501500.0 [1]
DabrafenibIC5020000.0 [1]
SaracatinibIC5014000.0 [1]
CobimetinibIC500.2 [1]
Pyridone 6IC50160.0 [1]
Azd-1152hqpaKi10000.0 [1]
N6,N6-Dimethyl-N4-[1-(phenylmethyl)-5-indazolyl]pyrido[3,4-d]pyrimidine-4,6-diamineIC509700.0 [1]
LY-3009120IC5020000.0 [1]
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amineIC5010000.0 [1]
4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenolIC50100000.0 [1]
N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamideIC500.9 [1]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyridin-2-amineIC5010000.0 [1]
4-[3-Methyl-2-piperidin-4-yl-5-[3-(trifluoromethyl)phenyl]imidazol-4-yl]-N-[(1S)-1-phenylethyl]pyrimidin-2-amineIC5010000.0 [1]
3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acidIC50102.0 [1]
Vandetanib hydrochlorideIC5020000.0 [1]
4-(4-Cyano-2-fluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC5010000.0 [1]
(5-(Aminocarbonyl)-4-(2-fluoro-4-iodoanilino)-2-oxo-1(2H)-pyridinyl)acetic acidIC5010000.0 [1]
1-Allyl-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC5091.0 [1]
1-(2,3-Dihydroxypropyl)-4-(2-fluoro-4-iodoanilino)-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC5010000.0 [1]
4-[2-Fluoro-4-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)anilino]-1-methyl-6-oxopyridine-3-carboxamideIC5010000.0 [1]
4-(2-Fluoro-4-iodoanilino)-N,N,1-trimethyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC50627.0 [1]
4-(2-Fluoro-4-iodoanilino)-N,1-dimethyl-6-oxopyridine-3-carboxamideIC50195.0 [1]
1-(3-Cyanopropyl)-4-(2-fluoro-4-iodoanilino)-6-oxopyridine-3-carboxamideIC504890.0 [1]
4-(2-Fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxopyridine-3-carboxamideIC501130.0 [1]
1-Ethyl-4-(2-fluoro-4-iodoanilino)-6-oxopyridine-3-carboxamideIC501000.0 [1]
4-[2-Fluoro-4-(3-hydroxypropyl)anilino]-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC5010000.0 [1]
4-(2-Fluoro-4-iodoanilino)-1-(3-hydroxypropyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC503000.0 [1]
4-(2-Fluoro-4-methylanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC502970.0 [1]
1-Methyl-4-(2-naphthylamino)-6-oxo-1,6-dihydro-3-pyridinecarboxamideIC503000.0 [1]
N-[(R)-Cyclopropyl(pyridin-2-yl)methyl]-3-[4-[(1S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]phenyl]-1H-indazole-5-carboxamideIC5057.0 [1]
1-(3-Tert-butyl-1,2-oxazol-5-yl)-3-[2-fluoro-5-[7-(methylamino)-2-oxo-1-[(3S)-oxolan-3-yl]-1,6-naphthyridin-3-yl]phenyl]ureaIC502900.0 [1]
1-(3,3-Dimethylbutyl)-3-[5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluoro-4-methylphenyl]ureaIC502500.0 [1]
Tert-butyl N-[2-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-2-oxoethyl]carbamateIC507350.0 [1]
Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamateIC50100000.0 [1]
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(3-methoxyphenyl)-N-phenyl-3,4-dihydropyrazole-2-carbothioamideIC50195000.0 [1]
5-(4-Bromophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-phenyl-3,4-dihydropyrazole-2-carbothioamideIC50188000.0 [1]
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-phenyl-5-(4-phenylmethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamideIC50176000.0 [1]
[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-(pyrrolidin-1-ylmethyl)azetidin-1-yl]methanoneIC5050.0 [1]
[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-[(dimethylamino)methyl]-3-hydroxyazetidin-1-yl]methanoneIC5014.0 [1]
[3-(Aminomethyl)-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanoneIC5057.0 [1]
3-[(1S)-1-Aminoethyl]-1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)azetidin-3-olIC5046.0 [1]
[3-[(1R)-1-Aminoethyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanoneIC50164.0 [1]
[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-(morpholin-4-ylmethyl)azetidin-1-yl]methanoneIC50331.0 [1]
[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(propan-2-ylamino)methyl]azetidin-1-yl]methanoneIC503.7 [1]
1-[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)benzoyl]-3-hydroxyazetidine-3-carboxamideIC5081.0 [1]
[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-(ethylaminomethyl)-3-hydroxyazetidin-1-yl]methanoneIC506.9 [1]
[3-[(Tert-butylamino)methyl]-3-hydroxyazetidin-1-yl]-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanoneIC5011.0 [1]
1-({3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)azetidin-3-olIC5029.0 [1]
Azetidin-1-yl-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]methanoneIC50111.0 [1]
1-({3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-(hydroxymethyl)azetidin-3-olIC5029.0 [1]
[3,4-Difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-(3-hydroxy-3-methylazetidin-1-yl)methanoneIC5051.0 [1]
(2Z,3Z)-2,3-Bis[amino-(2-methoxyphenyl)sulfanylmethylidene]butanedinitrileIC5016500.0 [1]
(2Z,3Z)-2,3-Bis[amino-(2-chlorophenyl)sulfanylmethylidene]butanedinitrileIC506600.0 [1]
(2Z,3Z)-2,3-Bis[amino-(2-fluorophenyl)sulfanylmethylidene]butanedinitrileIC507600.0 [1]
(2Z,3Z)-2,3-Bis[amino-(2-hydroxyphenyl)sulfanylmethylidene]butanedinitrileIC50400.0 [1]
(2Z,3Z)-2,3-Bis[amino-(4-aminophenyl)sulfanylmethylidene]butanedinitrileIC5010500.0 [1]
2-Amino-5-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-dicarbonitrileIC5025100.0 [1]
(2Z,3Z)-2,3-Bis[amino(thiophen-2-ylsulfanyl)methylidene]butanedinitrileIC501200.0 [1]
(2Z,3Z)-2,3-Bis[amino-(2,6-dichlorophenyl)sulfanylmethylidene]butanedinitrileIC506500.0 [1]
(2Z,3Z)-2,3-Bis(3H-1,3-benzothiazol-2-ylidene)butanedinitrileIC5042500.0 [1]
(2Z,3Z)-2,3-Bis[amino-(4-chlorophenyl)sulfanylmethylidene]butanedinitrileIC5021700.0 [1]
(2Z,3Z)-2,3-Bis[amino-(3-chlorophenyl)sulfanylmethylidene]butanedinitrileIC5018400.0 [1]
(2Z,3Z)-2,3-Bis[amino-(2-bromophenyl)sulfanylmethylidene]butanedinitrileIC507900.0 [1]
2,5-Bis-(naphthalen-2-ylsulfanyl)-1H-pyrrole-3,4-dicarbonitrileIC5028900.0 [1]
N-[3,4-Dicyano-5-(naphthalen-2-ylsulfanyl)-1H-pyrrol-2-yl]-benzenesulfonamideIC508000.0 [1]
2-Amino-5-(2-amino-phenylsulfanyl)-1H-pyrrole-3,4-dicarbonitrileIC5026200.0 [1]
(2Z,3Z)-2,3-Bis[amino-(2-methylphenyl)sulfanylmethylidene]butanedinitrileIC5013300.0 [1]
(2Z,3Z)-2-[Amino-(2-aminophenyl)sulfanylmethylidene]-3-(3H-1,3-benzothiazol-2-ylidene)butanedinitrileIC5018700.0 [1]
10,11-Difluoro-12-(2-fluoro-4-iodoanilino)-2,2-dioxospiro[4,5,6,7-tetrahydro-1H-8,2lambda6,1-benzoxathiazecine-3,1'-cyclopropane]-5,6-diolIC5016.0 [1]
2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamideIC5022.0 [1]
N-(2-Amino-2-methylpropyl)-2-(2-fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamideIC5014.0 [1]
2-(2-Chloro-4-iodoanilino)-N-[(3R)-3,4-dihydroxybutyl]-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamideIC50200.0 [1]
2-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamideIC507.0 [1]
2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[[(2R)-pyrrolidin-2-yl]methyl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamideIC5042.0 [1]
2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxylic acidIC5014.0 [1]
2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamideIC509.0 [1]
2-(2-Fluoro-4-iodoanilino)-5,5-dimethyl-8-oxo-N-[(3R)-pyrrolidin-3-yl]-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxamideIC508.0 [1]
2-(2-Fluoro-4-iodoanilino)-7,7-dimethyl-6,8-dihydro-5H-[1,3]thiazolo[5,4-c]azepin-4-oneIC50946.0 [1]
Ethyl 2-(2-chloro-4-iodoanilino)-5,5-dimethyl-8-oxo-6,7-dihydro-4H-thieno[2,3-c]azepine-3-carboxylateIC502617.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dual specificity mitogen-activated protein kinase kinase; MEK1/2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Dual specificity mitogen-activated protein kinase kinase; MEK1/2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-mek1-2-inhibitors-ic50-ki.
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