![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_49a5495605b74208c838150d56407afb.svg) | 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene | IC50 | 58.0 [1], 60.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_fe739739798d5a426922dc4c74a41375.svg) | (4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione | IC50 | 8.16 [1], 15.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_18b0aaeef16b71367292d08b52874f1b.svg) | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_3bec64f6fedd364af9d0c2cdf7c3ba05.svg) | Trametinib | IC50 | 1.6 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_b33d647a5a347bfb173a0ed912563556.svg) | (Z)-3-Amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_18980e80bb4f780d18f7977ab0e250d6.svg) | Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans- | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_6ad94dc26455bcde818c72b352ccec47.svg) | 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine | IC50 | 50.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_543dd3929ca0b9edf0d71c14cc494ac3.svg) | 6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_d6022885b5cae2ce542ee4d76db87270.svg) | 5-Amino-6-[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-(4-hydroxyphenyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_b076cdaba7bb8b7d9a4e8120c86a34a8.svg) | N-Propyl-4-({4-[(2,2,2-trifluoroethyl)amino]-1H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)benzamide | IC50 | 391.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_3dcac6cd4103c4e201c7b5b6cd031cff.svg) | 4-Methyl-N-(1,2-oxazol-3-yl)-3-[(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | IC50 | 30000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_bf510744cb83a77fbc98859859fc334a.svg) | 2-[3-[(Dimethylamino)methyl]phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]thieno[2,3-b]pyridine-5-carbonitrile | IC50 | 20000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_a7ee75d4a7ce2e8d7ffa73cb444c324f.svg) | 5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_6d6e8191e03576a6f692f0ab8cbd4d38.svg) | N-Benzyl-2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]propanamide | Ki | 710.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_66d70e901d77bad74b1ac5f3c38e2fd7.svg) | N-[(1R)-1-(3,5-Difluorophenyl)ethyl]-2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]propanamide | Ki | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_056aae54a9b0570d9f31dd2c1e76aa8d.svg) | (4S,6Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione | IC50 | 6840.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_51153882d3ab9f3566d96aeaf5c3eeab.svg) | 6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_9d109cefe6f21cc70e74499a7c9999ec.svg) | 3-(5-Cyclopropyl-1,2-oxazol-3-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine | IC50 | 82.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_43448187fad0a0db3095c2031784e2a3.svg) | (4S,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione | IC50 | 186.7 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_0b43927816ebbc9be13e6e44e4f9f2e1.svg) | 5,5-Dimethyl-8-[[4-(2,2,2-trifluoroethylamino)furo[3,2-d]pyrimidin-2-yl]amino]-1H-4,1-benzoxazepin-2-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_1d1c37ceddd89948deb4e9db26d41314.svg) | N-[(3-Methoxyphenyl)methyl]-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]propanamide | Ki | 9700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_22bb07b8a5ce610dcf496ca87417e292.svg) | N-[(3-Cyanophenyl)methyl]-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]propanamide | Ki | 13000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_468fa2c075c902b624e9d4daef6b07f5.svg) | 2,2-Dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide | Ki | 6200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_c6b8270b2830fe895011a5e743bc6123.svg) | N-[(3,5-Difluorophenyl)methyl]-2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]propanamide | Ki | 2400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_59bff5defe49bf38bc191906a9d1b0c0.svg) | N-[(3-Fluorophenyl)methyl]-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]propanamide | Ki | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_194d1b2e77adc59d6d58b0d54496617d.svg) | N-[(3-Chloro-5-fluorophenyl)methyl]-2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]propanamide | Ki | 1800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_a874b779c94c674487d4157bc394ad7b.svg) | N-[(4-Fluorophenyl)methyl]-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]propanamide | Ki | 3700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_2d3ffdb9bd155642e72b149bcf9b849f.svg) | N-[(3-Chlorophenyl)methyl]-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]propanamide | Ki | 1400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_e8ea4851f0a892706328e09c2ba60611.svg) | 2,2-Dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]-N-[(3-methylphenyl)methyl]propanamide | Ki | 1800.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_9fae5067a8bfdeec0e4e0efb55a7c92b.svg) | N-[(3,5-Dichlorophenyl)methyl]-2,2-dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]propanamide | Ki | 2100.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_c7ed842f51a427ae8f21c5e8b57a137f.svg) | 2,2-Dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]-N-[(1S)-1-phenylethyl]propanamide | Ki | 16000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_bd983439cb06d004b4874b3c83d9d44b.svg) | 2,2-Dimethyl-N-[2-[[(2S)-1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl]amino]-2-oxoethyl]-N-[(1R)-1-phenylethyl]propanamide | Ki | 670.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_f980e35cc5a89e33324ed62d29bf7e45.svg) | 2-N-(1H-Indazol-6-yl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_ea7d68d5631badf4d76195468cfe148a.svg) | N~4~-Cyclopropyl-N~2~-(3-Methyl-1h-Indazol-6-Yl)furo[3,2-D]pyrimidine-2,4-Diamine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-2_f8ee55f6cac6bc1babf9b394bab747fe.svg) | 2-N-(3-Chloro-4-morpholin-4-ylphenyl)-4-N-(2,2,2-trifluoroethyl)furo[3,2-d]pyrimidine-2,4-diamine | IC50 | 10000.0 [1] |