![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 45.8 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_ec16eafeb8a44e2bff3dbe95aadaee0f.svg) | Selumetinib | IC50 | 9.0 [1], 14.0 [2], 31.0 [3], 80.0 [4], 3700.0 [5] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_0faee984b20109c5e446f3e6ecd1d4c6.svg) | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide | IC50 | 5.2 [1], 7.0 [2], 13.0 [3], 15.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_14396790c62cf589eeceb01f31cda776.svg) | Unii-M58joz0T53 | IC50 | 12.0 [1], 22.0 [2], 25.0 [3], 69.0 [4], 82.0 [5] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_a8ebd4976d63cfa733b87fd61eea9b5d.svg) | 4-(4-Phenoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrile | IC50 | 2.4 [1], 4.0 [2], 7.0 [3], 1000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_49a5495605b74208c838150d56407afb.svg) | 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene | IC50 | 70.0 [1], 72.0 [2], 13000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_ff90ae676fe199017b343b3e8a101a0f.svg) | Tak-733 | IC50 | 1.79 [1], 3.2 [2], 5.0 [3], 6.92 [4] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_d10507bbe5a40f1d93ef354cfb5f7cc0.svg) | 6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile | IC50 | 6.2 [1], 9.0 [2], 30.0 [3], 34.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_024edde474cd699e50f6071a083374a4.svg) | (4S,5R,6Z,9S,10S,12E)-9,10,18-Trihydroxy-4,5-dimethyl-16-(methylamino)-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione | IC50 | 2.8 [1], 10.0 [2], 70.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_de61ae1ab836dfe861d102d7e387693f.svg) | 2-[(2S)-2,3-Dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyridazin-1-one | IC50 | 1.63 [1], 1.95 [2], 35.5 [3], 58.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_18b0aaeef16b71367292d08b52874f1b.svg) | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | IC50 | 2000.0 [1], 4000.0 [2], 10000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_7b8bd8099ae8aee0413f6b58888ab23a.svg) | 5Z-7-Oxozeaenol | IC50 | 2.9 [1], 6.0 [2], 80.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_3195e9a4a73a8bc248129bfb23f4abec.svg) | 3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamide | IC50 | 2.0 [1], 13.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_fc9f48ecabafd5f654fa856beb73ec7b.svg) | 4-(3-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile | IC50 | 60.0 [1], 100.0 [2], 160.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_26f5955c1d6791a4269169be8dd4ea62.svg) | 4-(2-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrile | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_b8a80a4f6729f7d496252eb48179df86.svg) | 3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(sulfamoylamino)methyl]phenoxy}benzamide | IC50 | 1.8 [1], 8.7 [2], 21.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_93c574e9449f6876500d39366a551a51.svg) | 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide | IC50 | 2.0 [1], 130.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_5056396fd6132d5f6d9e041409ccd203.svg) | Cobimetinib | IC50 | 0.9 [1], 4.2 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_d18945e13b995914a5c9929a6b03e086.svg) | Pimasertib | IC50 | 1.81 [1], 3.39 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_8cc99367596a19949f2432708276e495.svg) | Hymenialdisine | IC50 | 6.0 [1], 2500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_0ee4cca9cb9a30297469dae72afaa1d1.svg) | CID 24866313 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_bfb385e38ab64be74c336aa4cc43502b.svg) | Ulixertinib | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_c71081a8619ec348ecd13cc61c9f2023.svg) | CID 46209401 | IC50 | 300.0 [1], 3700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_6b3b1daff6a525a896bd95908c8874e1.svg) | 4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-7-[3-(4-ethylpiperazin-1-yl)propoxy]-6-methoxyquinoline-3-carbonitrile | IC50 | 3.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_5714d9038d414dabf61f16b15b479559.svg) | 4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrile | IC50 | 2.0 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_c653f9c8167f22b1173fd534faa89712.svg) | N-[2-[2-[2-[2-[4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide | IC50 | 0.01 [1], 398.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_8d0f91312ea19acc344aa3115da9bde5.svg) | 5-(2,3-Dichlorophenylamino)-3-hydroxy-N-(1-hydroxypropan-2-yl)isothiazole-4-carboxamidine | IC50 | 38.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_58926a57a1b811db194cd558e7f0686e.svg) | [4-Methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_482caccce5577424472b4f30ef45663d.svg) | [6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate | IC50 | 7.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_61a7351d9d36e8e9922a4620e83655af.svg) | 3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one | IC50 | 97.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_d0b4f794086600befe89bd59a459fa53.svg) | 5-Acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide | IC50 | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_a058bbc7d0f80bfd4a2414688d763f71.svg) | 3-Hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidine | IC50 | 240.0 [1], 266.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_7d75699cbc234225a66c763083693dc5.svg) | 3-Hydroxy-5-(4-iodo-2-methylphenylamino)-N-isopropylisothiazole-4-carboxamidine | IC50 | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_2e5a07f68491a215695cb62483cb363b.svg) | 5-(2-Chloro-4-iodophenylamino)-3-hydroxy-N-isopropylisothiazole-4-carboxamidine | IC50 | 42.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_57f52adf92c655ca2fc69c47800138d4.svg) | 3-Hydroxy-5-(4-iodophenylamino)-N-isopropylisothiazole-4-carboxamidine | IC50 | 510.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_aaf3385c71a11daac1a4710941977974.svg) | 2-[3-[[(Dimethylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamide | IC50 | 21.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_a327bebb186e57a994d35f2e20b30b57.svg) | 4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-(sulfamoylmethyl)phenoxy]benzamide | IC50 | 32.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_cfc609e3ad899de98b6f6e7bd7859e08.svg) | 7-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,2-benzothiazole-6-carboxamide | IC50 | 12.0 [1], 15.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_5713455ee0a346924706c6d02c8aa6e3.svg) | 4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-(sulfamoylamino)phenoxy]benzamide | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_57475d1cfbc10d9df4a50fa1a8da8229.svg) | [4,6-Dimethyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate | IC50 | 29.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_f216c35fc3f00580cf9c1e73745b89d8.svg) | (+/-)-Hymenin | IC50 | 6.0 [1], 2500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_8fa8420c6fffe0ace277a1de82b5bfba.svg) | 4-[4-(4-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 190.0 [1], 650.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_7f72fefffe79cec1148f50013cb2ffc8.svg) | 4-[4-(2-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 18.0 [1], 72.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_98f17d12e0a7e923b8a7610716aa5d97.svg) | 4-[4-(3-Furanylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 14.0 [1], 43.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_35c3aab68805a7ef4c24b431593783ea.svg) | 4-[4-(3-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 29.0 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_fc8bb31f19b4bbc7b9ce938e9e064a08.svg) | 4-[4-(2-Furanylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 20.0 [1], 66.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_808e72312bf0f0a59c140e724010b8cb.svg) | 4-(4-Benzylphenylamino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 2.7 [1], 14.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_8dee320d4581cec9f7e70dcce98f5401.svg) | 4-[4-(4-Pyridinyloxy)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 26.0 [1], 81.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_986b15cb950201bb8425d98860d9a5f6.svg) | 4-[4-(3-Thienylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 4.2 [1], 23.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_a9c6140d09e588a425ff05ea44495aee.svg) | 6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenethyl-phenylamino)-quinoline-3-carbonitrile | IC50 | 33.0 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_2dce4b30a98fa23a049885507c977c33.svg) | 4-[4-(2-Thienylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 4.4 [1], 20.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_f4ad112d00157857a75f74182927b69f.svg) | 6,7-Dimethoxy-4-(4-methylsulfanyl-phenylamino)-quinoline-3-carbonitrile | IC50 | 280.0 [1], 1300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_a41aa821c385a1ff35e131986fc5660a.svg) | 3-[(2R)-2,3-Dihydroxypropyl]-5-(4-ethynyl-2-fluoroanilino)-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 4.8 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_014d188497f714296a89ee7604f3dc23.svg) | 5-(4-Bromo-2-fluoroanilino)-3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_af17dced71b83c042ddefb8cb0522b12.svg) | 3-[(2S)-2,3-Dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 3.2 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_ebe85a6d2570b055ee2db8faf86d433e.svg) | 6-Fluoro-5-(2-fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 8.6 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_2f1adda590aac64e09f513f4858bf7d4.svg) | 5-(2-Fluoro-4-iodophenylamino)-3,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | IC50 | 16.0 [1], 26.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_d766969892ba1049f55afdab5bf29d8a.svg) | 5-(2-Fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 9.8 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_5fedfec7bc81ffee8a15ed7ee3cbe8fb.svg) | 3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 8.3 [1], 10.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_bd50413bf85522ee7e2e707fe2bdec39.svg) | 3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 3.8 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_7e082630a9de433605d8413fd86d0232.svg) | 3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_075f4b6589d240b39f4f825bc0811763.svg) | 5-(2-Fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 4.0 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_51a2516462fdf9196891c7e08e2d2fd3.svg) | 3-[(2S)-2,4-Dihydroxybutyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 16.0 [1], 53.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_c99a8f9e31c37d5aa6a009e0010486fa.svg) | 3-[2-(Dimethylamino)ethyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 16.0 [1], 740.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_f83d7d0c282b7e609ddd8e898390313e.svg) | 5-(2-Fluoro-4-iodophenylamino)-3-(3-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3h,8h)-dione | IC50 | 4.9 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_efb13e3a85d7314323886de4561fedb3.svg) | 3-[(2R)-2,3-Dihydroxypropoxy]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 3.1 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_f3507305d872c25ec9aaa76b56bdf180.svg) | 3-(1,3-Dihydroxypropan-2-yl)-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 3.3 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_bb5666bb19da36e78b1f3d05eb4358cd.svg) | 4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-7-[(E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile | IC50 | 12.0 [1], 225.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_f6652d22b97fc8d506426751b7db499a.svg) | 4-(4-Biphenylylamino)-6,7-dimethoxyquinoline-3-carbonitrile | IC50 | 1100.0 [1], 9500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_beec2a095f83953cba67b4c637df2800.svg) | 4-[4-(Phenylamino)phenylamino]-6,7-dimethoxyquinoline-3-carbonitrile | IC50 | 160.0 [1], 1200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_379b60eaa60b8f2fdfcc1b9ddf7dce10.svg) | 4-(4-Benzylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | IC50 | 3.6 [1], 36.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_1a1a217b6c2b068ae35a49d06db60aae.svg) | 4-[4-(4-Chlorophenoxy)phenylamino]-6,7-dimethoxyquinoline-3-carbonitrile | IC50 | 43.0 [1], 210.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_0f63c11270122c5c6efd82b4538a0621.svg) | 4-(4-Hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | IC50 | 550.0 [1], 2200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_24138a4ae017da85d9f6338148a397a2.svg) | 4-(4-Methoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | IC50 | 520.0 [1], 3000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_7e85479aff19ea75c62925f0365c23a3.svg) | 4-(4-Cyclohexyloxyanilino)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrile | IC50 | 110.0 [1], 320.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_c3e27e886ee4b4b25cc97de224570a50.svg) | 4-(4-Methoxyphenylamino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 99.0 [1], 250.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_e9ec767de0292ec630eac20f6f10cf57.svg) | 4-[4-(Cyclohexylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 200.0 [1], 3300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_0c4538eb613aea03ad65c79e7a55680e.svg) | 4-[4-(Cyclohexylthio)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile | IC50 | 21.0 [1], 300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_639782ddb407ba7af337dcc5e41681df.svg) | N'-(1-Hydroxypropan-2-yl)-3-oxo-5-(4-phenoxyanilino)-1,2-thiazole-4-carboximidamide | IC50 | 26.0 [1], 33.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_c7beaee7e15f86eb91b14f5fd7e3c638.svg) | 3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione | IC50 | 4.6 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_d3e691082bdd5157243617ac060ef5ac.svg) | N-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide | IC50 | 30.2 [1], 56.6 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_c882ff52ebef94df6078e4fa2c5f7324.svg) | N-(1,3-Dihydroxypropan-2-yl)-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide | IC50 | 31.3 [1], 55.2 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_c49d6934e116bbdf257a0076a1c93c81.svg) | 3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-one | IC50 | 33.6 [1], 142.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_8829585a7edbc51dbee03e45e27edfcc.svg) | 5-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethyl)pyrimidine-4-carboxamide | IC50 | 49.6 [1], 101.6 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_618dd16a7a59e3cc909a94226dd22843.svg) | 5-(2-Fluoro-4-iodoanilino)-N-(3-hydroxypropyl)pyrimidine-4-carboxamide | IC50 | 60.1 [1], 101.4 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_dd65ee2f14e6edb8079f0aedc4ccf3a8.svg) | N-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide | IC50 | 3.41 [1], 5.37 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_d0c99153922e2a6a5df044c39db76c79.svg) | 2-[(2S)-2,3-Dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)-4-methylpyrido[3,4-d]pyridazin-1-one | IC50 | 11.4 [1], 13.9 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_16002a5fde0695ec3cdc571eb8bc4f89.svg) | 2-Chloro-N-[(2S)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamide | IC50 | 13.0 [1], 44.3 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_a7ca9e2795f7944558b33fedfbc0fac7.svg) | 3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-one | IC50 | 12.3 [1], 108.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_32a99c737b98bca4adc8bf58358063dc.svg) | 6-Methoxy-7-[3-(morpholin-4-yl)propoxy]-4-{[4-(phenylsulfanyl)phenyl]amino}quinoline-3-carbonitrile | IC50 | 1.1 [1], 5.7 [2] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_2016e1fb48c552930d228a3e7f6e1433.svg) | Quercetin | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_3745b8510effa74ecd8f0d51ff80c3d6.svg) | U0126 | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_60d2309f9dd49902f395a788164cb728.svg) | 1,4-Naphthoquinone | IC50 | 380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_3bec64f6fedd364af9d0c2cdf7c3ba05.svg) | Trametinib | IC50 | 3.4 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_b5f9e60dc2b2b7e76e07307c1d8f7888.svg) | Bosutinib | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_e0fe681fa2f1e71ee414f0f588b2ab69.svg) | Arctigenin | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_a59db47f5f7aa063c6007dcf79b51cfe.svg) | PD173074 | IC50 | 50000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_1970071dd3288d1434749caa6fc51ef1.svg) | 4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine | IC50 | 10500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_27ca4e0730f60781e1d36a4449f9874b.svg) | Oroidin | IC50 | 2500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dual-specificity-mitogen-activated-protein-kinase-kinase-1_9fb851793aa73d9e3bfe985893b8e689.svg) | 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide | IC50 | 10000.0 [1] |