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Dual specificity mitogen-activated protein kinase kinase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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StaurosporineIC5045.8 [1]
SelumetinibIC509.0 [1], 14.0 [2], 31.0 [3], 80.0 [4], 3700.0 [5]
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamideIC505.2 [1], 7.0 [2], 13.0 [3], 15.0 [4]
Unii-M58joz0T53IC5012.0 [1], 22.0 [2], 25.0 [3], 69.0 [4], 82.0 [5]
4-(4-Phenoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)-3-quinolinecarbonitrileIC502.4 [1], 4.0 [2], 7.0 [3], 1000.0 [4]
1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadieneIC5070.0 [1], 72.0 [2], 13000.0 [3]
Tak-733IC501.79 [1], 3.2 [2], 5.0 [3], 6.92 [4]
6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrileIC506.2 [1], 9.0 [2], 30.0 [3], 34.0 [4]
(4S,5R,6Z,9S,10S,12E)-9,10,18-Trihydroxy-4,5-dimethyl-16-(methylamino)-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dioneIC502.8 [1], 10.0 [2], 70.0 [3]
2-[(2S)-2,3-Dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyridazin-1-oneIC501.63 [1], 1.95 [2], 35.5 [3], 58.0 [4]
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneIC502000.0 [1], 4000.0 [2], 10000.0 [3]
5Z-7-OxozeaenolIC502.9 [1], 6.0 [2], 80.0 [3]
3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)benzamideIC502.0 [1], 13.0 [2]
4-(3-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrileIC5060.0 [1], 100.0 [2], 160.0 [3]
4-(2-Phenoxyanilino)-6,7-dimethoxy-3-quinolinecarbonitrileIC5010000.0 [1]
3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-{3-[(sulfamoylamino)methyl]phenoxy}benzamideIC501.8 [1], 8.7 [2], 21.0 [3]
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamideIC502.0 [1], 130.0 [2]
CobimetinibIC500.9 [1], 4.2 [2]
PimasertibIC501.81 [1], 3.39 [2]
HymenialdisineIC506.0 [1], 2500.0 [2]
CID 24866313IC5010000.0 [1]
UlixertinibIC5010000.0 [1]
CID 46209401IC50300.0 [1], 3700.0 [2]
4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-7-[3-(4-ethylpiperazin-1-yl)propoxy]-6-methoxyquinoline-3-carbonitrileIC503.0 [1]
4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrileIC502.0 [1], 8.0 [2]
N-[2-[2-[2-[2-[4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamideIC500.01 [1], 398.0 [2]
5-(2,3-Dichlorophenylamino)-3-hydroxy-N-(1-hydroxypropan-2-yl)isothiazole-4-carboxamidineIC5038.0 [1]
[4-Methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC50110.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC507.0 [1]
3-[[2-Fluoro-3-(methylsulfamoylamino)phenyl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-oneIC5097.0 [1]
5-Acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamideIC5018.0 [1]
3-Hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidineIC50240.0 [1], 266.0 [2]
3-Hydroxy-5-(4-iodo-2-methylphenylamino)-N-isopropylisothiazole-4-carboxamidineIC5062.0 [1]
5-(2-Chloro-4-iodophenylamino)-3-hydroxy-N-isopropylisothiazole-4-carboxamidineIC5042.0 [1]
3-Hydroxy-5-(4-iodophenylamino)-N-isopropylisothiazole-4-carboxamidineIC50510.0 [1]
2-[3-[[(Dimethylamino)sulfonyl]amino]phenoxy]-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]-benzamideIC5021.0 [1]
4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-(sulfamoylmethyl)phenoxy]benzamideIC5032.0 [1]
7-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,2-benzothiazole-6-carboxamideIC5012.0 [1], 15.0 [2]
4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-(sulfamoylamino)phenoxy]benzamideIC5014.0 [1]
[4,6-Dimethyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5029.0 [1]
(+/-)-HymeninIC506.0 [1], 2500.0 [2]
4-[4-(4-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC50190.0 [1], 650.0 [2]
4-[4-(2-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC5018.0 [1], 72.0 [2]
4-[4-(3-Furanylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC5014.0 [1], 43.0 [2]
4-[4-(3-Pyridinylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC5029.0 [1], 100.0 [2]
4-[4-(2-Furanylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC5020.0 [1], 66.0 [2]
4-(4-Benzylphenylamino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC502.7 [1], 14.0 [2]
4-[4-(4-Pyridinyloxy)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC5026.0 [1], 81.0 [2]
4-[4-(3-Thienylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC504.2 [1], 23.0 [2]
6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenethyl-phenylamino)-quinoline-3-carbonitrileIC5033.0 [1], 150.0 [2]
4-[4-(2-Thienylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC504.4 [1], 20.0 [2]
6,7-Dimethoxy-4-(4-methylsulfanyl-phenylamino)-quinoline-3-carbonitrileIC50280.0 [1], 1300.0 [2]
3-[(2R)-2,3-Dihydroxypropyl]-5-(4-ethynyl-2-fluoroanilino)-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC504.8 [1], 5.0 [2]
5-(4-Bromo-2-fluoroanilino)-3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC5016.0 [1]
3-[(2S)-2,3-Dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC503.2 [1], 5.0 [2]
6-Fluoro-5-(2-fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC508.6 [1], 10.0 [2]
5-(2-Fluoro-4-iodophenylamino)-3,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dioneIC5016.0 [1], 26.0 [2]
5-(2-Fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC509.8 [1], 10.0 [2]
3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC508.3 [1], 10.0 [2]
3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dioneIC503.8 [1], 5.0 [2]
3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dioneIC505.0 [1]
5-(2-Fluoro-4-iodoanilino)-3-(2-hydroxyethyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7-dioneIC504.0 [1], 5.0 [2]
3-[(2S)-2,4-Dihydroxybutyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC5016.0 [1], 53.0 [2]
3-[2-(Dimethylamino)ethyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC5016.0 [1], 740.0 [2]
5-(2-Fluoro-4-iodophenylamino)-3-(3-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3h,8h)-dioneIC504.9 [1], 5.0 [2]
3-[(2R)-2,3-Dihydroxypropoxy]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC503.1 [1], 5.0 [2]
3-(1,3-Dihydroxypropan-2-yl)-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC503.3 [1], 5.0 [2]
4-[3-Chloro-4-(1-methylimidazol-2-yl)sulfanylanilino]-7-[(E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrileIC5012.0 [1], 225.0 [2]
4-(4-Biphenylylamino)-6,7-dimethoxyquinoline-3-carbonitrileIC501100.0 [1], 9500.0 [2]
4-[4-(Phenylamino)phenylamino]-6,7-dimethoxyquinoline-3-carbonitrileIC50160.0 [1], 1200.0 [2]
4-(4-Benzylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrileIC503.6 [1], 36.0 [2]
4-[4-(4-Chlorophenoxy)phenylamino]-6,7-dimethoxyquinoline-3-carbonitrileIC5043.0 [1], 210.0 [2]
4-(4-Hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrileIC50550.0 [1], 2200.0 [2]
4-(4-Methoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrileIC50520.0 [1], 3000.0 [2]
4-(4-Cyclohexyloxyanilino)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinoline-3-carbonitrileIC50110.0 [1], 320.0 [2]
4-(4-Methoxyphenylamino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC5099.0 [1], 250.0 [2]
4-[4-(Cyclohexylmethyl)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC50200.0 [1], 3300.0 [2]
4-[4-(Cyclohexylthio)phenylamino]-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrileIC5021.0 [1], 300.0 [2]
N'-(1-Hydroxypropan-2-yl)-3-oxo-5-(4-phenoxyanilino)-1,2-thiazole-4-carboximidamideIC5026.0 [1], 33.0 [2]
3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dioneIC504.6 [1], 5.0 [2]
N-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamideIC5030.2 [1], 56.6 [2]
N-(1,3-Dihydroxypropan-2-yl)-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamideIC5031.3 [1], 55.2 [2]
3-[(2R)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-oneIC5033.6 [1], 142.0 [2]
5-(2-Fluoro-4-iodoanilino)-N-(2-hydroxyethyl)pyrimidine-4-carboxamideIC5049.6 [1], 101.6 [2]
5-(2-Fluoro-4-iodoanilino)-N-(3-hydroxypropyl)pyrimidine-4-carboxamideIC5060.1 [1], 101.4 [2]
N-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamideIC503.41 [1], 5.37 [2]
2-[(2S)-2,3-Dihydroxypropyl]-8-(2-fluoro-4-iodoanilino)-4-methylpyrido[3,4-d]pyridazin-1-oneIC5011.4 [1], 13.9 [2]
2-Chloro-N-[(2S)-2,3-dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrimidine-4-carboxamideIC5013.0 [1], 44.3 [2]
3-[(2S)-2,3-Dihydroxypropyl]-5-(2-fluoro-4-iodoanilino)pyrido[3,4-d]pyrimidin-4-oneIC5012.3 [1], 108.0 [2]
6-Methoxy-7-[3-(morpholin-4-yl)propoxy]-4-{[4-(phenylsulfanyl)phenyl]amino}quinoline-3-carbonitrileIC501.1 [1], 5.7 [2]
QuercetinIC5010000.0 [1]
U0126IC50500.0 [1]
1,4-NaphthoquinoneIC50380.0 [1]
TrametinibIC503.4 [1]
BosutinibIC501.0 [1]
ArctigeninIC501.0 [1]
PD173074IC5050000.0 [1]
4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amineIC5010500.0 [1]
OroidinIC502500.0 [1]
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamideIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dual specificity mitogen-activated protein kinase kinase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Dual specificity mitogen-activated protein kinase kinase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dual-specificity-mitogen-activated-protein-kinase-kinase-1-inhibitors-ic50-ki.
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