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Dopamine transporter Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
CocaineIC50301.0 [1]
CocaineKi330.0 [1]
DuloxetineIC50870.0 [1]
DuloxetineKi240.0 [1], 251.19 [2], 370.0 [3], 435.0 [4], 240000.0 [5]
FluoxetineIC506000.0 [1]
FluoxetineKi1900.0 [1], 6000.0 [2], 6670.0 [3]
MazindolIC5013.0 [1], 22.0 [2], 43.0 [3]
MazindolKi22.1 [1], 34.6 [2], 45.0 [3], 74.2 [4]
VanoxerineIC5027.0 [1]
VanoxerineKi0.36 [1], 3.7 [2], 5.07 [3], 22.0 [4]
BupropionIC50945.0 [1]
BupropionKi441.0 [1], 821.4 [2], 871.0 [3]
Methyl (1R,2S,3S,5R)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateIC5011.0 [1], 21.0 [2]
Methyl (1R,2S,3S,5R)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateKi10.6 [1], 14.7 [2]
NomifensineIC5015.0 [1], 30.2 [2], 31.62 [3], 281.84 [4]
NomifensineKi10.0 [1], 23.5 [2], 79.0 [3], 84.0 [4]
VenlafaxineIC504430.0 [1], 7340.0 [2], 9120.11 [3], 15767.0 [4]
VenlafaxineKi890.0 [1], 5300.0 [2]
1-[1-(1-Benzothiophen-2-yl)cyclohexyl]piperidineIC5012.0 [1]
1-[1-(1-Benzothiophen-2-yl)cyclohexyl]piperidineKi2.2 [1], 6.2 [2]
Methyl (2S,3S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate;hydrochlorideIC5023.0 [1], 65.0 [2], 373.0 [3]
Methyl (2S,3S,5R)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate;hydrochlorideKi33.0 [1], 314.0 [2]
DesipramineIC509900.0 [1], 17700.0 [2], 47900.0 [3], 50500.0 [4], 82000.0 [5]
DesipramineKi0.49 [1], 3000.0 [2]
AtomoxetineIC503000.0 [1]
NisoxetineIC501150.0 [1], 2400.0 [2]
NisoxetineKi30.0 [1], 1000.0 [2]
ModafinilIC5011500.0 [1]
ModafinilKi927.0 [1], 1456.0 [2], 2000.0 [3], 3090.0 [4], 13000.0 [5]
2-[(2-Ethoxyphenoxy)-phenylmethyl]morpholineIC5025000.0 [1]
2-[(2-Ethoxyphenoxy)-phenylmethyl]morpholineKi60.0 [1], 10000.0 [2]
MidalcipranIC506100.0 [1], 10000.0 [2]
MidalcipranKi854.0 [1], 31622.78 [2]
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexaneIC5078.0 [1], 93.8 [2], 394.0 [3]
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexaneKi251.0 [1]
Rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-azabicyclo[4.1.0]heptaneIC502.0 [1], 8.0 [2]
Rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-azabicyclo[4.1.0]heptaneKi10.0 [1], 12.02 [2], 25.12 [3]
(R)-3-Benzoyloxy-2-methoxycarbonyl-8-methyl-8-azonia-bicyclo[3.2.1]octaneIC50350.0 [1], 470.0 [2], 490.0 [3], 717.0 [4], 1161.0 [5]
6-(4-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,1-a]isoindol-6-olIC503.7 [1], 4.2 [2]
6-(4-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,1-a]isoindol-6-olKi1.7 [1]
MethylphenidateIC5017.0 [1], 79.0 [2]
MethylphenidateKi34.0 [1], 110.0 [2]
Vanoxerine dihydrochlorideIC5014.0 [1], 190.0 [2]
Vanoxerine dihydrochlorideKi2.42 [1]
DexmethylphenidateIC5088.0 [1], 156.0 [2]
DexmethylphenidateKi16.0 [1], 25.0 [2]
MadamIC50100.0 [1]
MadamKi532.0 [1], 1000.0 [2], 10000.0 [3]
PyrovaleroneIC5032.0 [1], 52.0 [2]
PyrovaleroneKi8.0 [1], 21.4 [2]
AmitifadineIC5096.0 [1], 159.3 [2]
AmitifadineKi79.43 [1], 125.89 [2]
3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterIC501.4 [1], 1.7 [2], 2.4 [3]
3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterKi1.1 [1]
3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterIC501.3 [1]
3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterKi0.48 [1], 1.3 [2]
Methyl 3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateIC500.38 [1], 0.4 [2], 1.09 [3]
3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterIC501.1 [1]
3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl esterKi0.2 [1], 2.3 [2]
(R)-Sila-VenlafaxineIC504900.0 [1], 5270.0 [2]
4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneIC50100000.0 [1]
4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneKi100000.0 [1]
(S)-N-(2,3-Dimethylbenzyl)-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amineIC50727.0 [1]
(1S,5S,6S)-1-(3,4-Dichlorophenyl)-6-(ethoxymethyl)-3-azabicyclo[3.1.0]hexaneIC505.01 [1]
(1S,5S,6S)-1-(3,4-Dichlorophenyl)-6-(ethoxymethyl)-3-azabicyclo[3.1.0]hexaneKi7.94 [1], 25.12 [2]
2-[5-[3-(5-Fluoro-2-methoxyphenyl)propyl]oxolan-2-yl]ethanamineIC5016987.0 [1], 41260.0 [2]
2-[5-[3-(5-Fluoro-2-methoxyphenyl)propyl]oxolan-2-yl]ethanamineKi7307.0 [1], 21190.0 [2]
Dimethyl-((2S,3S)-3-naphthalen-2-yl-bicyclo[2.2.1]hept-2-ylmethyl)-amineIC5076.0 [1]
Dimethyl-((2S,3S)-3-naphthalen-2-yl-bicyclo[2.2.1]hept-2-ylmethyl)-amineKi25.0 [1]
Methyl 2-(3,4-dichlorophenyl)cyclopent-1-enecarboxylateKi1900.0 [1], 5500.0 [2], 512861383991366.0 [3]
(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-oneIC50100000.0 [1]
(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-oneKi100000.0 [1]
3-(4-Chloro-phenyl)-2-(2-chloro-vinyl)-8-methyl-8-aza-bicyclo[3.2.1]octaneIC500.73 [1], 1.3 [2]
3-(4-Chloro-phenyl)-2-(2-chloro-vinyl)-8-methyl-8-aza-bicyclo[3.2.1]octaneKi0.22 [1], 0.88 [2]
Cocaine hydrochlorideIC5089.1 [1]
Cocaine hydrochlorideKi46.3 [1]
3,4-MethylenedioxymethamphetamineIC501442.0 [1], 2398.83 [2]
SertralineIC50310.0 [1]
SertralineKi25.8 [1]
TenamfetamineIC50890.0 [1], 6165.95 [2]
BenztropineIC50312.0 [1]
BenztropineKi193.0 [1]
1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;hydrochlorideIC501.7 [1], 5.0 [2]
1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;hydrochlorideKi16.2 [1]
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazineIC5018.0 [1]
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazineKi3.7 [1], 73.0 [2]
ReboxetineIC5010000.0 [1]
ReboxetineKi2000.0 [1], 19952.62 [2]
2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamineKi840.0 [1], 10000.0 [2]
Benzonitrile, 3-amino-4-((2-((dimethylamino)methyl)phenyl)thio)-Ki1000.0 [1], 1423.0 [2], 10000.0 [3]
N,N-Diallyl-5-methoxytryptamineIC5032359.37 [1]
N,N-Diallyl-5-methoxytryptamineKi3162.28 [1], 10000.0 [2]
Methyl (3S,5R)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylateIC501.1 [1], 1.7 [2], 3.2 [3]
(S)-VenlafaxineIC504430.0 [1], 6670.0 [2]
3-Amino-4-[[2-[(dimethylamino)methyl]phenyl]thio]benzenemethanolKi1000.0 [1], 3608.0 [2]
BMS-505130 free baseIC504200.0 [1]
BMS-505130 free baseKi2100.0 [1]
5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindoleIC506.0 [1], 29.7 [2]
5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindoleKi23.0 [1]
(1S,5R)-1-(3,4-Dichlorophenyl)-3-azabicyclo(3.1.0)hexaneIC50129.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dopamine transporter Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 31 Mar. 2025, https://www.aatbio.com/data-sets/dopamine-transporter-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, March 31). Quest Database™ Dopamine transporter Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dopamine-transporter-inhibitors-ic50-ki.
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