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Dopamine D3 receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
HaloperidolIC500.06 [1], 10.0 [2]
HaloperidolKi4.4 [1], 4.6 [2], 10.4 [3], 18.0 [4]
ClozapineIC50450.0 [1]
ClozapineKi240.0 [1], 242.0 [2], 319.0 [3], 513.0 [4]
QuinpiroleKi23.99 [1], 24.0 [2], 420.0 [3]
2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridineKi5300.0 [1]
2-Naphthalenecarboxamide, N-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-IC503.0 [1], 13.0 [2], 56.0 [3]
2-Naphthalenecarboxamide, N-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-Ki0.92 [1]
N-[4-[2-(6-Cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamideKi11.2 [1]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamideIC504.94 [1]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamideKi0.5 [1], 0.8 [2], 2.6 [3]
OlanzapineKi39.0 [1], 43.0 [2]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamideIC505.0 [1], 14.4 [2]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamideKi2.0 [1], 2.7 [2]
RisperidoneKi16.0 [1], 31.0 [2]
3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridineKi2310.0 [1]
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridineKi5000.0 [1]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamideIC509.01 [1]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamideKi0.8 [1], 1.5 [2], 4.3 [3]
SpiperoneIC500.36 [1], 93.2 [2], 97.0 [3]
SpiperoneKi1.31 [1]
US8748608, 34 Enantiomer AIC5029.9 [1], 30.0 [2], 495.0 [3]
N-[4-[4-[2-Tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]butyl]imidazo[1,2-a]pyridine-2-carboxamideIC500.6 [1], 1.3 [2], 157.0 [3]
PramipexoleKi0.72 [1], 0.88 [2], 38.0 [3]
7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-olKi1.4 [1], 2.9 [2]
3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indoleIC5090.4 [1]
CID 11477180IC503.0 [1], 3.01 [2]
CID 11477180Ki0.7 [1], 2.11 [2]
7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-olKi0.79 [1]
N-[4-[4-[2-Tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]butyl]-5-[(dimethylamino)methyl]imidazo[1,2-a]pyridine-2-carboxamideIC5029.0 [1]
N-[4-[4-[2-Tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]butyl]-3-[(dimethylamino)methyl]imidazo[1,2-a]pyridine-2-carboxamideIC507.2 [1]
N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzo[b]thiophene-2-carboxamideIC500.22 [1]
N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzo[b]thiophene-2-carboxamideKi0.19 [1], 0.23 [2], 0.27 [3]
(R)-N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamideIC5018.2 [1]
(R)-N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamideKi0.53 [1], 1.12 [2], 2.9 [3]
4-[3-(4-Chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-(4-fluorophenyl)butan-1-oneKi0.71 [1]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)but-2-enyl)-9H-fluorene-2-carboxamideIC50173.0 [1]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)but-2-enyl)-9H-fluorene-2-carboxamideKi1.5 [1], 5.0 [2], 5.9 [3]
(S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-3-carbaldehydeKi5.25 [1], 5.3 [2], 150.0 [3]
N-[(E)-4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]but-2-enyl]-1-benzothiophene-2-carboxamideIC509.62 [1]
N-[(E)-4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]but-2-enyl]-1-benzothiophene-2-carboxamideKi1.1 [1], 1.11 [2], 3.3 [3], 1770.0 [4]
N-[(E)-4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]but-2-enyl]-1-benzofuran-2-carboxamideIC5018.7 [1]
N-[(E)-4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]but-2-enyl]-1-benzofuran-2-carboxamideKi2.1 [1], 2.11 [2], 7.11 [3]
SulpirideIC5066.22 [1], 560.0 [2]
SulpirideKi8.0 [1], 57.0 [2], 120.0 [3]
ZiprasidoneKi6.31 [1], 7.2 [2], 7.5 [3], 10.0 [4]
(+)-ButaclamolIC501.6 [1], 16.0 [2]
(+)-ButaclamolKi0.04 [1]
ButaclamolIC501.2 [1], 1.9 [2], 6.6 [3], 10.0 [4]
ButaclamolKi6.39 [1]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamideIC506.31 [1]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamideKi0.4 [1], 0.5 [2], 2.33 [3]
N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamideIC502.39 [1]
N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamideKi0.92 [1], 1.1 [2], 1.12 [3]
N-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-benzamideIC507.71 [1], 7.72 [2]
N-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-benzamideKi0.8 [1], 6.02 [2]
N-[4-[(4-Ethynylcyclohex-3-en-1-yl)-propylamino]butyl]-4-phenylbenzamideKi0.2 [1], 0.21 [2], 0.78 [3], 20.0 [4], 870.0 [5]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]quinoxaline-2-carboxamideIC5026.8 [1], 26.9 [2]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]quinoxaline-2-carboxamideKi1.4 [1], 10.6 [2]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]-3-fluorobutyl]-1-benzofuran-2-carboxamideIC50430.0 [1]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]-3-fluorobutyl]-1-benzofuran-2-carboxamideKi5.4 [1], 6.1 [2], 10.0 [3], 31.5 [4]
2-[5-[4-(4-Chlorophenyl)piperazin-1-yl]pentyl]pyrazolo[1,5-a]pyridineKi220.0 [1], 370.0 [2], 530.0 [3], 1100.0 [4], 1900.0 [5]
ApomorphineKi2.6 [1], 7.8 [2], 10.0 [3], 17.0 [4]
RopiniroleKi2.9 [1], 19.0 [2], 36.31 [3], 61.0 [4]
PreclamolKi25.0 [1], 25.12 [2], 132.0 [3]
CariprazineKi0.09 [1], 0.1 [2], 0.27 [3]
5-OH-DpatKi0.66 [1], 1.36 [2], 4.4 [3]
(1S,2R)-5-Methoxy-1-methyl-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amineKi4.0 [1], 4.2 [2], 12.59 [3]
SumaniroleKi546.0 [1], 573.0 [2], 2333.0 [3], 6330.0 [4]
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazoleKi480.0 [1], 770.0 [2]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-1H-indole-2-carboxamideKi0.66 [1], 1.4 [2]
11-Methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-olKi47.0 [1], 47.5 [2]
4-Methyl-5-[4-methyl-5-[3-[1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazoleKi0.5 [1]
N-[(3S)-4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]-3-hydroxybutyl]-1H-indole-2-carboxamideIC506.6 [1]
N-[(3S)-4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]-3-hydroxybutyl]-1H-indole-2-carboxamideKi3.9 [1], 16.6 [2]
N-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-butyl}-4-iodo-benzamideIC5031.7 [1]
N-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-butyl}-4-iodo-benzamideKi1.6 [1], 3.0 [2]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-5-fluoro-1H-indole-2-carboxamideIC5052.0 [1], 52.4 [2]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-5-fluoro-1H-indole-2-carboxamideKi0.28 [1], 0.52 [2]
Items per page: 1 - 10 of 79
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dopamine D3 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Dec. 2024, https://www.aatbio.com/data-sets/dopamine-d3-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 20). Quest Database™ Dopamine D3 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dopamine-d3-receptor-inhibitors-ic50-ki.
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