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Dopamine D1 receptor Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
(R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-olIC500.66 [1], 0.74 [2], 0.82 [3], 1.4 [4], 520.0 [5]
(R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-olKi0.15 [1]
HaloperidolKi107.0 [1]
7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecineKi60.4 [1]
Sch-23390 maleateIC500.22 [1], 0.27 [2], 1.7 [3], 30.0 [4]
Sch-23390 maleateKi0.1 [1]
11-Methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-olKi1.35 [1]
(13As)-3,9,11-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olIC509.85 [1], 1380.0 [2], 1400.0 [3]
(13As)-3,9,11-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olKi2.5 [1], 2.53 [2]
QuetiapineKi214.6 [1], 390.0 [2], 1000.0 [3], 1300.0 [4], 4240.0 [5]
7-Chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-olIC500.31 [1], 2.52 [2], 740.0 [3]
7-Chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-olKi1.2 [1]
l-StepholidineKi3.4 [1], 5.9 [2], 6.23 [3], 12.29 [4]
(+)-DihydrexidineKi6.2 [1], 33.0 [2], 35.7 [3], 1200.0 [4]
1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, (1R)-Ki5.1 [1], 56.0 [2], 73.0 [3], 130.0 [4], 320.0 [5]
6-Methoxy-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaeneKi22.91 [1], 24.1 [2], 28.5 [3]
11-Methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3,5,7,14,16-hexaeneKi3.47 [1], 4.5 [2], 40.4 [3]
EcopipamKi1.2 [1], 1.9 [2]
(13As)-3-methoxy-9,11-dimethyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olIC5056.37 [1]
(13As)-3-methoxy-9,11-dimethyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olKi28.9 [1], 28.91 [2]
ZiprasidoneKi9.5 [1], 130.0 [2], 330.0 [3]
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineKi190.0 [1], 393.0 [2]
N-PropylnorapomorphineKi1.0 [1], 490.0 [2], 1510.0 [3]
(6Ar)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-olKi45.0 [1], 4300.0 [2], 10000.0 [3]
7-Chloro-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-olKi0.46 [1], 0.81 [2], 0.83 [3]
12-Methyl-12,22-diazatetracyclo[13.7.0.03,8.016,21]docosa-1(15),3,5,7,16,18,20-heptaeneKi2.04 [1], 2.2 [2], 2.8 [3]
11-Methyl-11,22-diazatetracyclo[13.7.0.03,8.016,21]docosa-1(15),3,5,7,16,18,20-heptaeneKi158.49 [1], 163.5 [2], 304.0 [3]
10-Methyl-6-thia-10-azatricyclo[11.4.0.03,7]heptadeca-1(17),3(7),4,13,15-pentaeneKi4.0 [1], 10.7 [2], 207.0 [3]
(1S)-16,18-Dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaeneIC50141.58 [1]
(1S)-16,18-Dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaeneKi64.12 [1], 74.51 [2]
(13As)-3,9,12-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olIC507.22 [1], 1900.0 [2]
(13As)-3,9,12-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olKi3.7 [1]
ChlorpromazineKi96.0 [1], 112.0 [2]
AmitriptylineKi89.0 [1], 178.0 [2]
FluphenazineKi11.0 [1], 179.0 [2]
PergolideKi339.0 [1], 2020.0 [2]
MaprotilineKi187.0 [1], 402.0 [2]
LisurideKi77.0 [1], 86.0 [2]
TetrahydropalmatineKi153.0 [1], 231.0 [2]
ZotepineKi29.0 [1], 84.0 [2]
GR-127935Ki10000.0 [1]
CariprazineKi2100.0 [1]
3-Methyl-6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(3-methylphenyl)-1H-3-benzazepineKi1.18 [1], 1.93 [2]
2-Naphthalenecarboxamide, N-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-Ki760.0 [1]
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamideIC502000.0 [1], 7000.0 [2]
(S)-CanadineKi48.6 [1], 66.0 [2]
4-Amino-5-chloro-N-((hexahydro-1H-pyrrolizin-1-yl)methyl)-2-methoxybenzamide hydrochlorideIC5010000.0 [1]
4-Amino-5-chloro-N-((hexahydro-1H-pyrrolizin-1-yl)methyl)-2-methoxybenzamide hydrochlorideKi10000.0 [1]
N-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamideKi1195.0 [1], 8800.0 [2]
Di-deacetyl adrogolideKi49.0 [1]
CorydalmineKi50.0 [1], 107.0 [2]
N-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamideKi1500.0 [1], 1600.0 [2]
N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzo[b]thiophene-2-carboxamideKi670.0 [1], 800.0 [2]
(S)-TetrahydrocolumbamineKi4.5 [1], 6.2 [2]
2-Methoxy-N-n-propylnorapomorphineKi8.1 [1], 5000.0 [2]
N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamideKi1100.0 [1], 2000.0 [2]
CorypalmineKi199.0 [1], 310.0 [2]
N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamideKi2100.0 [1], 2900.0 [2]
7-[4-[4-(2,3-Dichlorophenyl)-1,4-diazepan-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-oneKi340.0 [1], 825.0 [2]
(6S)-6-[2-Phenylethyl(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-olKi230.0 [1], 1200.0 [2]
5-[2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]ethyl]-2H-benzotriazoleKi4677.35 [1]
(1R,11S)-5-Chloro-10-methyl-10-azatetracyclo[9.7.0.02,7.013,18]octadeca-2,4,6,13,15,17-hexaen-4-olKi7.0 [1]
2-Chloro-N-[3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]benzamideKi4.0 [1], 4.1 [2]
11-Methyl-11-azatricyclo[13.4.0.03,8]nonadeca-1(19),3(8),4,6,15,17-hexaen-6-olKi2.67 [1], 3.2 [2]
17-Methoxy-11-methyl-11-azatricyclo[13.4.0.03,8]nonadeca-1(15),3,5,7,16,18-hexaeneKi28.18 [1], 29.4 [2]
6-Methoxy-11-methyl-11-azatricyclo[13.4.0.03,8]nonadeca-1(19),3(8),4,6,15,17-hexaeneKi18.5 [1], 21.88 [2]
5'-Chloro-N,N-dimethylspiro[cyclohex-2-ene-4,2'-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaene]-1-amineKi0.3 [1], 3.1 [2]
(1S)-16-Methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-17-olKi6.3 [1], 6.5 [2]
10-[2-[(2R)-1-Methylpiperidin-2-yl]ethyl]-2-methylsulfinylphenothiazineIC50137.0 [1]
10-[2-[(2R)-1-Methylpiperidin-2-yl]ethyl]-2-methylsulfinylphenothiazineKi103.0 [1]
N-[3-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]-4-methoxybenzamideKi47.0 [1]
N-[3-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]benzamideKi157.0 [1]
N-[3-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]-2,6-dimethoxybenzamideKi1.6 [1]
N-[3-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]-2,6-dimethylbenzamideKi3.0 [1]
11-Methyl-11,21-diazatetracyclo[12.7.0.03,8.015,20]henicosa-1(14),3,5,7,15(20),16,18-heptaen-17-olKi0.56 [1]
(4As,5R,10bR)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diolKi47.0 [1], 18000.0 [2]
2-[[(2R)-2-Phenethylmorpholino]methyl]-1H-benzoimidazoleIC50100000.0 [1]
2-[[(2R)-2-Phenethylmorpholino]methyl]-1H-benzoimidazoleKi100000.0 [1]
(13As)-3,11-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olKi35.79 [1], 35.8 [2]
(13As)-12-(hydroxymethyl)-3,9,11-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-olKi17.29 [1], 17.3 [2]
6,10-Dimethyl-6,10-diazatricyclo[11.4.0.03,7]heptadeca-1(17),3(7),4,13,15-pentaeneKi61.0 [1], 1000.0 [2]
4-[2-(1H-Benzotriazol-5-yl)ethyl]-1-(2-methoxyphenyl)piperazineKi812.83 [1]
4-[2-(1H-Benzotriazol-5-yl)ethyl]-1-(1-naphthyl)piperazineKi5754.4 [1]
5,7-Dichloro-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3,5,7,14,16-hexaen-6-olKi3.2 [1], 3.8 [2]
5-Methoxy-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaeneKi82.0 [1], 567.0 [2]
11-Methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaen-4-olKi8.7 [1], 64.1 [2]
4-Methoxy-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaeneKi7.6 [1], 37.6 [2]
5-Amino-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3,5,7,14,16-hexaen-6-olKi9.3 [1], 20.9 [2]
6-Chloro-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3,5,7,14,16-hexaen-5-olKi3.1 [1], 10.8 [2]
6,16-Dimethoxy-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(14),3(8),4,6,15,17-hexaeneKi9.4 [1], 26.9 [2]
4-Chloro-11-methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaen-5-olKi0.46 [1], 6.8 [2]
11-Methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(14),3(8),4,6,15,17-hexaene-6,16-diolKi2.0 [1], 3.3 [2]
11-Methyl-11-azatricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaen-5-olKi2.6 [1], 8.9 [2]



References

This online tool may be cited as follows

MLA

"Quest Database™ Dopamine D1 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc.22 Dec2024https://www.aatbio.com/data-sets/dopamine-d1-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 22). Quest Database™ Dopamine D1 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dopamine-d1-receptor-inhibitors-ic50-ki.
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