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DNA topoisomerase II Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
EtoposideIC5038000.0 [1], 50400.0 [2]
3,4,5-Trihydroxy-N-[2-[(3,4,5-trihydroxybenzoyl)amino]phenyl]benzamideIC509.0 [1]
3,4,5-Trihydroxy-N-[2-[(3,4,5-trihydroxybenzoyl)amino]phenyl]benzamideKi74100.0 [1]
CholesterolIC50500000.0 [1]
AmsacrineIC501000.0 [1]
DihydrocholesterolIC50500000.0 [1]
4,4'-(1,2-Dimethyl-1,2-ethanediyl)bis-2,6-piperazinedioneIC5013900.0 [1]
Luotonin AIC5028500.0 [1]
3-(9-Acridinylamino)-5-(hydroxymethyl)anilineIC501000.0 [1]
10-[(3S)-3-Aminopyrrolidin-1-yl]-11-fluoro-14-oxo-8-oxa-1-azatetracyclo[7.7.1.02,7.013,17]heptadeca-2,4,6,9(17),10,12,15-heptaene-15-carboxylic acidIC50510.0 [1]
Luotonin BIC5025000.0 [1]
[4-[5-[4-(Diaminomethyl)phenyl]-2-furyl]phenyl]methanediamineIC50500.0 [1]
2-[4-[5-[4-(1,4,5,6-Tetrahydropyrimidin-2-yl)phenyl]furan-2-yl]phenyl]-1,4,5,6-tetrahydropyrimidine;dihydrochlorideIC50500.0 [1]
14-[(3S)-3-Aminopyrrolidin-1-yl]-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.05,10.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC50490.0 [1]
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acidIC50500000.0 [1]
Luotonin EIC5025000.0 [1]
Luotonin FIC5025000.0 [1]
14-[(3R)-3-Aminopyrrolidin-1-yl]-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.05,10.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC50240.0 [1]
(4-Acridin-9-yloxyphenyl)methyl N-propan-2-ylcarbamateIC5020000.0 [1]
N-Methylcarbamic acid 4-[(acridin-9-yl)oxy]benzyl esterIC5020000.0 [1]
N-[3-(Acridin-9-ylamino)-5-(hydroxymethyl)phenyl]-4-(dimethylamino)butanamideIC5054.0 [1]
N-Methylcarbamic acid 3-amino-5-[(acridin-9-yl)amino]benzyl esterIC50116.0 [1]
Tert-butyl N-[3-(acridin-9-ylamino)-5-(methylcarbamoyloxymethyl)phenyl]carbamateIC5020.0 [1]
[3-(Acridin-9-ylamino)-5-(methanesulfonamido)phenyl]methyl acetateIC5063.0 [1]
4-Oxopentanoic acid 3-[(1,4-dioxopentyl)amino]-5-[(acridin-9-yl)amino]benzyl esterIC501000.0 [1]
4-Oxo-4-[[3-(hydroxymethyl)-5-[(acridin-9-yl)amino]phenyl]amino]butanoic acidIC5020000.0 [1]
14-(3-Aminopyrrolidin-1-yl)-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.05,10.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC50550.0 [1]
N-[3-(Acridin-9-ylamino)-5-(hydroxymethyl)phenyl]methanesulfonamideIC5045.0 [1]
4-[3-(Acridin-9-ylamino)-5-(3-carboxypropanoyloxymethyl)anilino]-4-oxobutanoic acidIC50100000.0 [1]
4-[(Acridin-9-yl)oxy]benzene-1-methanolIC50100000.0 [1]
6-(2-Bromo-4-methylanilino)-7-chloroquinazoline-5,8-dioneIC5040500.0 [1]
(4-Acridin-9-ylsulfanylphenyl)methyl N-propan-2-ylcarbamateIC5050000.0 [1]
4-[(Acridin-9-yl)thio]benzene-1-methanolIC50100000.0 [1]
14-(3-Aminopyrrolidin-1-yl)-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.03,8.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC50770.0 [1]
14-(3-Aminopyrrolidin-1-yl)-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.04,9.017,21]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxylic acidIC50770.0 [1]
15-Fluoro-18-oxo-14-piperazin-1-yl-12-oxa-1-azapentacyclo[11.7.1.02,11.03,8.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC509600.0 [1]
N-[(7S)-2,3-Dihydroxy-1-methoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamideIC5038000.0 [1]
N-[(7S)-1,2-Dihydroxy-3-methoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamideIC50150000.0 [1]
15-Fluoro-18-oxo-14-piperazin-1-yl-12-oxa-1-azapentacyclo[11.7.1.02,11.05,10.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC501840.0 [1]
15-Fluoro-18-oxo-14-piperazin-1-yl-12-oxa-1-azapentacyclo[11.7.1.02,11.04,9.017,21]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxylic acidIC50640.0 [1]
2-Quinolin-3-yl-3H-quinazolin-4-oneIC5025000.0 [1]
2-(1-Quinolin-3-ylethenyl)-3H-quinazolin-4-oneIC5025000.0 [1]
5-(3-Fluoro-4,5-dihydroxy-6-methyloxan-2-yl)oxy-6-hydroxynaphtho[2,3-f]quinoline-7,12-dioneIC505000.0 [1]
3-[(Acridin-9-yl)amino]benzene-1-methanolIC50226.0 [1]
2-[4-[5-[4-(3a,4,5,6,7,7a-Hexahydro-1H-benzimidazol-2-yl)phenyl]furan-2-yl]phenyl]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole;dihydrochlorideIC503000.0 [1]
N-[(7S)-1,2,3-Trihydroxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamideIC509000.0 [1]
3,4,5-Trihydroxy-N-[3-[(3,4,5-trihydroxybenzoyl)amino]phenyl]benzamideIC50220.0 [1]
N-Methylcarbamic acid 4-[(4-methoxyacridin-9-yl)oxy]benzyl esterIC5050000.0 [1]
[4-(4-Methoxyacridin-9-yl)oxyphenyl]methyl N-propan-2-ylcarbamateIC50100000.0 [1]
4-[(4-Methoxyacridin-9-yl)oxy]benzene-1-methanolIC5020000.0 [1]
[4-(4-Methoxyacridin-9-yl)sulfanylphenyl]methyl N-propan-2-ylcarbamateIC50100000.0 [1]
N-Methylcarbamic acid 4-[(4-methoxyacridin-9-yl)thio]benzyl esterIC50100000.0 [1]
4-[(4-Methoxyacridin-9-yl)thio]benzene-1-methanolIC5050000.0 [1]
6-(2-Bromoanilino)-7-chloroquinazoline-5,8-dioneIC5017300.0 [1]
6-(4-Bromoanilino)-7-chloroquinazoline-5,8-dioneIC5015100.0 [1]
14-[(3S)-3-Aminopyrrolidin-1-yl]-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.03,8.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC50720.0 [1]
14-[(3S)-3-Aminopyrrolidin-1-yl]-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.04,9.017,21]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxylic acidIC50440.0 [1]
14-[(3R)-3-Aminopyrrolidin-1-yl]-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.03,8.017,21]henicosa-2(11),3,5,7,9,13(21),14,16,19-nonaene-19-carboxylic acidIC501220.0 [1]
14-[(3R)-3-Aminopyrrolidin-1-yl]-15-fluoro-18-oxo-12-oxa-1-azapentacyclo[11.7.1.02,11.04,9.017,21]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxylic acidIC50420.0 [1]
2-[[(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetic acidIC50500000.0 [1]
2-[[(3S,10R,13R,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetic acidIC50500000.0 [1]
2-[[(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethanolIC50500000.0 [1]
1-[[(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diolIC50500000.0 [1]
1-[[(3S,10R,13R,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diolIC50500000.0 [1]
(3S,10R,13R,17R)-17-[(E,2R,5S)-5-Ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-olIC50500000.0 [1]
Methyl (10S,13R,14R,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carboxylateIC5066510.0 [1]
(10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-oneIC50149970.0 [1]
(10R,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-2-methoxy-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-oneIC5022700.0 [1]
(10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carboxylic acidIC5023800.0 [1]
(10R,13R,14R,17R)-2-Bromo-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-oneIC5018270.0 [1]
(10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carbonitrileIC5083230.0 [1]
(10R,13R,14R,17R)-2-Chloro-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-oneIC50106800.0 [1]
(10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carbaldehydeIC501860.0 [1]
2-[4-[5-[4-(4,5-Dihydro-1H-imidazol-2-yl)phenyl]furan-2-yl]phenyl]-4,5-dihydro-1H-imidazole;hydrochlorideIC503000.0 [1]
2-[4-[5-[4-(4,5,6,7-Tetrahydro-1H-1,3-diazepin-2-yl)phenyl]furan-2-yl]phenyl]-4,5,6,7-tetrahydro-1H-1,3-diazepine;dihydrochlorideIC501500.0 [1]
2-[2-[4-[5-[4-[1-(2-Hydroxyethyl)-4,5-dihydroimidazol-2-yl]phenyl]furan-2-yl]phenyl]-4,5-dihydroimidazol-1-yl]ethanol;dihydrochlorideIC5020000.0 [1]
1-Ethyl-2-[4-[5-[4-(1-ethyl-4,5-dihydroimidazol-2-yl)phenyl]furan-2-yl]phenyl]-4,5-dihydroimidazole;dihydrochlorideIC5025000.0 [1]
2-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethanolIC50500000.0 [1]
(4S)-4-[(5R,8S,9S,10R,13R,14S,17R)-3-Hydroxy-5,10,13-trimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acidIC5062000.0 [1]
1-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diolIC50500000.0 [1]
2-[[(3S,10R,13R,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethanolIC50500000.0 [1]
3,4,5-Trihydroxy-N-[4-[(3,4,5-trihydroxybenzoyl)amino]phenyl]benzamideIC50150.0 [1]
N-Methylcarbamic acid 4-[(acridin-9-yl)thio]benzyl esterIC5020000.0 [1]
N-[3-(Acridin-9-ylamino)-5-(hydroxymethyl)phenyl]-4-oxopentanamideIC501000.0 [1]
N-(10-Oxo-3,11,21-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,13,15,17,19-nonaen-12-yl)acetamideIC5025000.0 [1]
1-[3-[(Methylsulfonyl)amino]-5-[(acridin-9-yl)amino]benzyl]pyridiniumIC502970.0 [1]
Items per page: 1 - 10 of 86
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References

This online tool may be cited as follows

MLA

"Quest Database™ DNA topoisomerase II Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/dna-topoisomerase-ii-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ DNA topoisomerase II Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-topoisomerase-ii-inhibitors-ic50-ki.
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