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DNA topoisomerase II alpha Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
EtoposideIC5056000.0 [1]
DoxorubicinIC50880.0 [1], 1000.0 [2], 3000.0 [3]
MerbaroneIC5032000.0 [1], 40000.0 [2], 120000.0 [3]
3-[(E)-4-Hydroxybenzylidene]-6-hydroxybenzofuran-2(3H)-oneIC50400000.0 [1]
3-[3-[3-(4-Aminobutylamino)propylamino]-2-hydroxypropoxy]-1-hydroxyxanthen-9-one;2,2,2-trifluoroacetic acidIC502500.0 [1], 10000.0 [2]
CamptothecinIC50300000.0 [1]
Methyl 2'-(2-hydroxyphenyl)-(2,4'-bibenzoxazole)-4-carboxylateIC5032000.0 [1], 50000.0 [2]
TopostatinIC504000.0 [1]
6-Chloro-14-[2-[2-hydroxyethyl(methyl)amino]ethyl]-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-oneIC507200.0 [1], 10000.0 [2]
1-[(2R,4S,5S)-5-[[Tert-butyl(dimethyl)silyl]oxymethyl]-4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]oxolan-2-yl]-5-methylpyrimidine-2,4-dioneIC508100.0 [1], 19100.0 [2]
4-[3-(Tert-Butylamino)imidazo[1,2-a]pyridine-2-yl]benzoic acidIC5052660.0 [1]
4-[3-(Tert-Butylamino)imidazo[1,2-a]pyridine-2-yl]benzoic acidKi75000.0 [1]
3-[3-(Butylamino)-2-hydroxypropoxy]-1-hydroxyxanthen-9-oneIC509000.0 [1], 100000.0 [2]
6-Amino-7-(1H-benzimidazol-2-yl)-5-[4-(dimethylamino)butyl]pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrileIC50900.0 [1], 16500.0 [2]
2-[4-(1,3-Benzoxazol-2-yl)-1,3-benzoxazol-2-yl]phenolIC5020000.0 [1]
3-[3-[3-[4-(3-Aminopropylamino)butylamino]propylamino]-2-hydroxypropoxy]-1-hydroxyxanthen-9-one;tetrahydrochlorideIC501000.0 [1], 10000.0 [2]
CiprofloxacinIC50256000.0 [1]
SpermineIC501000000.0 [1]
SpermidineIC501000000.0 [1]
MitoxantroneIC505300.0 [1]
NovobiocinIC50256000.0 [1]
PibenzimolIC5028920.0 [1]
MyricetinIC50390.0 [1]
AmsacrineIC509940.0 [1]
LupeolIC50250000.0 [1]
EllipticineIC503300.0 [1]
Ginsenoside rb1IC50250000.0 [1]
Ginsenoside Rg3IC50250000.0 [1]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC5015000.0 [1]
4,4'-(1,2-Dimethyl-1,2-ethanediyl)bis-2,6-piperazinedioneIC5013900.0 [1]
Ginsenoside ReIC50250000.0 [1]
Gypenoside VIIIIC50250000.0 [1]
alpha-AmyrinIC50250000.0 [1]
PiroxantroneIC504600.0 [1]
LosoxantroneIC507300.0 [1]
Ginsenoside F2IC50250000.0 [1]
AscidideminIC501376.0 [1]
2-Pyridinecarboxaldehyde thiosemicarbazoneIC50100000.0 [1]
N-[(Benzyloxy)carbonyl]-L-aspartic acidIC5026950.0 [1]
1,3-Dihydroxy-9H-xanthen-9-oneIC50100000.0 [1]
Ganoderiol FIC5017000.0 [1]
Mansonone EIC5018600.0 [1]
Olivetolic acidIC501000000.0 [1]
(20R)-Ginsenoside Rg3IC50250000.0 [1]
4-Methyl-1-(1-(2-pyridyl)ethylidene)-3-thiosemicarbazideIC5092000.0 [1]
Unii-W6V49A8fjqIC50250000.0 [1]
{4-Amino-6-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}methyl morpholine-4-carbodithioateIC50229000.0 [1]
5,7-Dioxa-12-azoniapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-1(18),2,4(8),9,11,15(19),16-heptaen-17-olateIC5025800.0 [1]
4-Allyl-1-(1-(2-pyridyl)ethylidene)-3-thio-semicarbazideIC50100000.0 [1]
Gypenoside XVIIIC50250000.0 [1]
{4-Amino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}methyl 4-methylpiperazine-1-carbodithioateIC501000000.0 [1]
{4-Amino-6-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}methyl piperidine-1-carbodithioateIC501000000.0 [1]
{4-Amino-6-[(4-fluorophenyl)amino]-1,3,5-triazin-2-yl}methyl morpholine-4-carbodithioateIC50139000.0 [1]
N-[[4-(3,4-Dichlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3-methoxybenzamideIC501000000.0 [1]
N-Cyclohexyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amineIC50680.0 [1]
DemethylzeylasteroneIC5017600.0 [1]
Kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranosideIC50600000.0 [1]
6-Phenyl-4-sulfanylidene-1H-1,3,5-triazin-2-oneIC501000000.0 [1]
BakuchicinIC50404000.0 [1]
Dehydrotrametenonic acidIC5037500.0 [1]
Ginsenoside F3IC50250000.0 [1]
1-Methyl-3-[(E)-1-pyrazin-2-ylethylideneamino]thioureaIC50100000.0 [1]
6-(4-Methylpiperazin-1-yl)-2-[2-(4-prop-2-ynoxyphenyl)-3H-benzimidazol-5-yl]-1H-benzimidazoleIC5051600.0 [1]
4-Ethyl-1-(1-(2-pyridyl)ethylidene)-3-thiosemicarbazideIC5079000.0 [1]
6-Phenethylsulfanyl-7H-purin-2-amineIC5085000.0 [1]
N2-(2-(Diethylamino)ethyl)-N9-phenylthiazolo[5,4-b]quinoline-2,9-diamineIC50168900.0 [1]
BengacarbolineIC50100000.0 [1]
6-Methyl-5-methylidene-2-[(5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]heptanoic acidIC504600.0 [1]
Anziaic acidIC5035000.0 [1]
(2R,3S,4S,5R,6S)-2-[[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[(2S)-6-methyl-2-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,6,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-en-2-yl]oxyoxane-3,4,5-triolIC50250000.0 [1]
1-Benzyl-3-[(E)-2-pyridylmethyleneamino]thioureaIC50100000.0 [1]
(E,6R)-6-[(3S,5R,10S,13R,14R,15S,17R)-15-Acetyloxy-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acidIC5025000.0 [1]
N-(3-(2-(Methylthio)thiazolo[5,4-b]quinolin-9-ylamino)phenyl)acetamideIC5029560.0 [1]
4,6-Dichloro-[1,3,5]triazin-2-yl-4-methoxy-benzyl-amineIC501000000.0 [1]
N1-(2-(Methylthio)thiazolo[5,4-b]quinolin-9-yl)benzene-1,3-diamineIC5016740.0 [1]
(3-Amino-5-(2-(methylthio)thiazolo[5,4-b]quinolin-9-ylamino)phenyl)methanolIC5018040.0 [1]
(3E)-3-[(3-Hydroxy-4-methoxyphenyl)methylidene]-1-benzofuran-2-oneIC50400000.0 [1]
Indeno[1,2-c]cinnolin-11-oneIC50100000.0 [1]
6-(4-Methylphenyl)-4-sulfanylidene-1H-1,3,5-triazin-2-oneIC501000000.0 [1]
20(S)-Ginsenoside Rg2IC50250000.0 [1]
4-Methylamino-[1,2,4]triazolo[4,3-a]quinoxalineIC502090.0 [1]
5-[3-(Dimethylamino)propyl]quinolino[4,3-b]quinoxalin-6-oneIC50100000.0 [1]
Quinovic acid 3-O-beta-D-glucosideIC50250000.0 [1]
(1S,2R,4As,6aR,6aR,6bR,8aR,10S,12aR,14bS)-1,2,6b,9,9,12a-hexamethyl-10-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-6a-carboxylic acidIC50250000.0 [1]
Bis[2-[2-(6-chloro-8-oxo-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-14-yl)ethyl-methylamino]ethyl] pentanedioateIC5032000.0 [1]
N-(2-Ethylphenyl)-2-amino-4,6-dichloro-1,3,5-triazineIC501000000.0 [1]
(3E)-3-[(4-Methoxyphenyl)methylidene]-1-benzofuran-2-oneIC50400000.0 [1]
N,N'-Bis[2-[2-(6-chloro-8-oxo-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-14-yl)ethyl-methylamino]ethyl]heptanediamideIC5022000.0 [1]
N-(2-Bromophenyl)-4,6-dichloro-1,3,5-triazin-2-amineIC501000000.0 [1]
18-[(3S)-3-Aminopyrrolidin-1-yl]-19-fluoro-22-oxo-16-oxa-1-azahexacyclo[15.7.1.02,15.05,14.06,11.021,25]pentacosa-2(15),3,5(14),6,8,10,12,17(25),18,20,23-undecaene-23-carboxylic acidIC50700.0 [1]
18-[(3R)-3-Aminopyrrolidin-1-yl]-19-fluoro-22-oxo-16-oxa-1-azahexacyclo[15.7.1.02,15.05,14.06,11.021,25]pentacosa-2(15),3,5(14),6,8,10,12,17(25),18,20,23-undecaene-23-carboxylic acidIC5060.0 [1]
2-(4,6-Dimethoxy-1,3,5-triazine-2-yloxy)benzoic acid methyl esterIC501000000.0 [1]
N-[(4-Phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]-2-(trifluoromethyl)benzamideIC501000000.0 [1]
3-[(E)-4-Hydroxybenzylidene]benzofuran-2(3H)-oneIC50327000.0 [1]
9-[[(4-Chloro)phenyl]amino]-2-(methylthio)thiazolo[5,4-b]quinolineIC5020490.0 [1]
9-[[(3-N-Methylamino)phenyl]amino]-2-(methylthio)-thiazolo[5,4-b]quinolineIC5012270.0 [1]
3-(2-(Methylthio)thiazolo[5,4-b]quinolin-9-ylamino)phenolIC5064340.0 [1]
2-Methylsulfanyl-N-[3-(trifluoromethyl)phenyl]-[1,3]thiazolo[5,4-b]quinolin-9-amineIC5015420.0 [1]
9-[[(3-Chloro)phenyl]amino]-2-(methylthio)thiazolo[5,4-b]quinolineIC5021200.0 [1]
9-N-(3-Chlorophenyl)-2-N-[3-(diethylamino)propyl]-[1,3]thiazolo[5,4-b]quinoline-2,9-diamineIC5040950.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ DNA topoisomerase II alpha Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/dna-topoisomerase-ii-alpha-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ DNA topoisomerase II alpha Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-topoisomerase-ii-alpha-inhibitors-ic50-ki.
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