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DNA topoisomerase I Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
CamptothecinIC503750.0 [1]
TopotecanIC501100.0 [1]
DoxorubicinIC5020000.0 [1], 200000.0 [2]
3-[(E)-4-Hydroxybenzylidene]-6-hydroxybenzofuran-2(3H)-oneIC50307000.0 [1], 400000.0 [2]
9-AminocamptothecinIC50110.0 [1], 1800.0 [2], 4200.0 [3]
10,11-Methylenedioxy-20S-camptothecinIC5027.0 [1], 30.0 [2], 78.0 [3]
TopostatinIC5029000.0 [1], 50000.0 [2], 55000.0 [3]
Chebulagic acidIC5050.0 [1], 100.0 [2]
10,11-Methylenedioxy-20(RS)-camptothecinIC5038.0 [1], 67.0 [2]
9-Amino-20-camptothecinIC50440.0 [1], 840.0 [2]
(+)-CamptothecinIC501400.0 [1], 1600.0 [2]
(19S)-7-Bromo-19-ethyl-19-hydroxy-10-methyl-17-oxa-3,6,13-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dioneIC5028.0 [1]
(19S)-19-Ethyl-19-hydroxy-10-methyl-14,18-dioxo-17-oxa-3,6,13-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-7-carbonitrileIC50143.0 [1]
6,20-Dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dioneIC5030.0 [1], 2300.0 [2]
4-(Furan-2-yl)-2-[(E)-2-(furan-2-yl)ethenyl]-6-thiophen-2-ylpyridineIC5010000.0 [1], 200000.0 [2]
Aesculioside IV-23D1IC5023800.0 [1], 27100.0 [2]
AesculiosideIV-23C1IC5023800.0 [1], 53000.0 [2]
Aesculioside IV-23EIC5023800.0 [1], 32700.0 [2]
2,4,6-Tris(furan-2-yl)pyridineIC50500000.0 [1], 1000000.0 [2]
(5-Ethyl-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(13),2,4(9),14,16,21,23-heptaen-5-yl) 2-aminoacetate;hydrochlorideIC50430.0 [1], 2500.0 [2]
(8-Amino-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl) 2-aminoacetate;hydrochlorideIC505500.0 [1], 6800.0 [2]
2-Amino-N-(5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-16-yl)acetamide;hydrochlorideIC50260.0 [1], 30000.0 [2]
Aesculioside IVaIC5023800.0 [1], 51800.0 [2]
Aesculioside IVcIC5023800.0 [1], 49700.0 [2]
Aesculioside IVbIC5023800.0 [1], 36000.0 [2]
Aesculioside IIIbIC5023800.0 [1], 160000.0 [2]
Aesculioside IIIaIC5023800.0 [1], 118700.0 [2]
Aesculioside IIcIC5023800.0 [1], 110500.0 [2]
Aesculioside IIdIC5023800.0 [1]
3,4,5-Trihydroxy-N-[2-[(3,4,5-trihydroxybenzoyl)amino]phenyl]benzamideIC50900.0 [1]
3,4,5-Trihydroxy-N-[2-[(3,4,5-trihydroxybenzoyl)amino]phenyl]benzamideKi400.0 [1]
16-Amino-5-ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaene-6,10-dioneIC5069.0 [1], 76.0 [2]
2-Amino-N-(19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-8-yl)acetamideIC50570.0 [1], 30000.0 [2]
EtoposideIC501000000.0 [1]
ReserpineIC50160000.0 [1]
RibavirinIC5065880.0 [1]
Oleic acidIC5031000.0 [1]
7-Ethyl-10-hydroxycamptothecinIC505500.0 [1]
PibenzimolIC5022860.0 [1]
Hoechst 33342IC5050000.0 [1]
NetropsinIC5062000.0 [1]
10-HydroxycamptothecinIC50110.0 [1]
ShikoninIC50208000.0 [1]
Ginsenoside rb1IC50250000.0 [1]
StallimycinIC502700.0 [1]
Ginsenoside Rg3IC50250000.0 [1]
CorilaginIC5040000.0 [1]
Elaidic acidIC501000000.0 [1]
Ginsenoside ReIC50250000.0 [1]
Gypenoside VIIIIC50250000.0 [1]
alpha-AmyrinIC50250000.0 [1]
Unii-ST04094S3XIC5045000.0 [1]
Simocyclinone D8IC5060000.0 [1]
Ginsenoside F2IC50250000.0 [1]
beta,beta-DimethylacrylshikoninIC5077000.0 [1]
20R-CamptothecinIC5030000.0 [1]
3-[[4-[Bis(4-hydroxy-2-oxochromen-3-yl)methyl]phenyl]-(4-hydroxy-2-oxochromen-3-yl)methyl]-4-hydroxychromen-2-oneIC5010000.0 [1]
Ganoderiol FIC50106000.0 [1]
(5R)-5-Ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(13),2,4(9),14,16,21,23-heptaene-6,10-dioneIC5030000.0 [1]
(20R)-Ginsenoside Rg3IC50250000.0 [1]
Unii-W6V49A8fjqIC50250000.0 [1]
5,7-Dioxa-12-azoniapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-1(18),2,4(8),9,11,15(19),16-heptaen-17-olateIC506100.0 [1]
Acetic acid 4-[2-(4-acetoxy-benzoylamino)-phenylcarbamoyl]-phenyl esterIC50100000.0 [1]
GallanilideIC50100000.0 [1]
6H-Purin-6-one, 2-((3,4-dichlorophenyl)amino)-1,9-dihydro-IC50200000.0 [1]
Sodium camptothecinIC5012000.0 [1]
Gypenoside XVIIIC50250000.0 [1]
(11E)-9-Methoxy-11-(2-pyrrolidin-1-ylethoxyimino)-5H-indeno[1,2-c]quinolin-6-oneIC503760.0 [1]
3-[[4-[Bis(1-hydroxy-3,4-dioxonaphthalen-2-yl)methyl]phenyl]-(1-hydroxy-3,4-dioxonaphthalen-2-yl)methyl]-4-hydroxynaphthalene-1,2-dioneIC5060000.0 [1]
(5S)-14-(Chloromethyl)-5-ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaene-6,10-dioneIC5015.0 [1]
(10S)-10-Ethyl-10-hydroxy-23-pentyl-8-oxa-4,15,21,23-tetrazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16(24),17,19,21-octaene-5,9-dioneIC502300.0 [1]
ButylshikoninIC50144000.0 [1]
9-HydroxycamptothecineIC50870.0 [1]
[(1R)-1-(1,4-Dihydroxy-5,8-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] 2-methylpropanoateIC5084000.0 [1]
Kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranosideIC50110000.0 [1]
2,4-Pyrimidinediamine, 6-chloro-N4-(3,4-dichlorophenyl)-IC50200000.0 [1]
Ginsenoside F3IC50250000.0 [1]
N~2~-(3,4-Dichlorophenyl)-9H-purine-2,6-diamineIC50200000.0 [1]
6-(4-Methylpiperazin-1-yl)-2-[2-(4-prop-2-ynoxyphenyl)-3H-benzimidazol-5-yl]-1H-benzimidazoleIC5025410.0 [1]
10-AminocamptothecinIC50140.0 [1]
2-(4-Hex-5-ynoxyphenyl)-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazoleIC5050000.0 [1]
6-(4-Methylpiperazin-1-yl)-2-[2-[4-(4-prop-2-ynoxybutoxy)phenyl]-3H-benzimidazol-5-yl]-1H-benzimidazoleIC5050000.0 [1]
6-(4-Methylpiperazin-1-yl)-2-[2-(4-undec-10-ynoxyphenyl)-3H-benzimidazol-5-yl]-1H-benzimidazoleIC5050000.0 [1]
PropionylshikoninIC5044000.0 [1]
N-(2-Benzamidophenyl)benzamideIC50100000.0 [1]
9-Methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one O-3-(dimethylamino)propyl oximeIC506600.0 [1]
9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneIC50100000.0 [1]
(2R,3S,4S,5R,6S)-2-[[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[(2S)-6-methyl-2-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,6,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-en-2-yl]oxyoxane-3,4,5-triolIC50250000.0 [1]
(5S)-16-Amino-5-ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaene-6,10-dioneIC5048.0 [1]
(E,6R)-6-[(3S,5R,10S,13R,14R,15S,17R)-15-Acetyloxy-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acidIC5055000.0 [1]
(19S)-19-Ethyl-19-hydroxy-8-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dioneIC5038.0 [1]
(18S)-2-(Chloromethyl)-18-ethyl-18-hydroxy-6,9,20-trioxa-13,24-diazahexacyclo[12.11.0.03,12.05,10.015,24.017,22]pentacosa-1,3,5(10),11,13,15,17(22)-heptaene-19,23-dioneIC5011.0 [1]
[(1R)-1-(5,8-Dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] pentanoateIC50161000.0 [1]
2-[(R)-1-(Benzoyloxy)-4-methyl-3-pentenyl]-5,8-dihydroxy-1,4-naphthoquinoneIC50153000.0 [1]
(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,6,13-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-7-carboximidamideIC5033.0 [1]
(3E)-3-[(3-Hydroxy-4-methoxyphenyl)methylidene]-1-benzofuran-2-oneIC50800000.0 [1]
(19S)-7-(Aminomethyl)-19-ethyl-19-hydroxy-10-methyl-17-oxa-3,6,13-triazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dioneIC50232.0 [1]
20(S)-Ginsenoside Rg2IC50250000.0 [1]
6-(4-Methylpiperazin-1-yl)-2-[2-[4-(8-prop-2-ynoxyoctoxy)phenyl]-3H-benzimidazol-5-yl]-1H-benzimidazoleIC5050000.0 [1]
6-(4-Methylpiperazin-1-yl)-2-[2-[4-(12-prop-2-ynoxydodecoxy)phenyl]-3H-benzimidazol-5-yl]-1H-benzimidazoleIC5050000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ DNA topoisomerase I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 19 Feb. 2025, https://www.aatbio.com/data-sets/dna-topoisomerase-i-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 19). Quest Database™ DNA topoisomerase I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-topoisomerase-i-inhibitors-ic50-ki.
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