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DNA polymerase beta Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Oleanolic acidIC503000.0 [1], 8800.0 [2], 24980.0 [3], 26250.0 [4]
Betulinic acidIC5033700.0 [1], 43600.0 [2], 46250.0 [3]
StigmasterolIC5043400.0 [1], 60280.0 [2], 250000.0 [3]
psi-7409IC50100000.0 [1], 1000000.0 [2]
EdgeworinIC5031430.0 [1], 38880.0 [2]
ZidovudineIC5020000.0 [1]
beta-SitosterolIC5026300.0 [1]
AphidicolinIC50100000.0 [1]
Ursolic acidIC5018600.0 [1]
RaltegravirIC5050000.0 [1]
Thymidine-5'-triphosphateIC501400.0 [1]
SitoglusideIC5026500.0 [1]
CombivirIC5016000.0 [1]
Pamoic acidIC509000.0 [1]
2',3'-Dideoxythymidine triphosphateIC5019000.0 [1]
Corosolic acidIC5012600.0 [1]
Calanolide AIC50205000.0 [1]
DillapiolIC5050000.0 [1]
IlimaquinoneIC5045200.0 [1]
Digallic acidKi390.0 [1]
(+)-Protolichesterinic acidIC507400.0 [1]
1-(2-Cyclopropylethyl)-3-(1,1-dioxo-4H-1lambda6,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxyquinolin-2-oneIC5050000.0 [1]
5-Methyluridine 5'-(tetrahydrogen triphosphate)IC50200000.0 [1]
N-Methylpyrimidone, 17IC5010000.0 [1]
SoulattrolideIC50495000.0 [1]
2-[2-(Dimethylamino)propan-2-yl]-N-[(4-fluorophenyl)methyl]-5-hydroxy-6-oxo-1H-pyrimidine-4-carboxamideIC5010000.0 [1]
2-[4-[[2-(4-Chlorophenyl)-5-(2-oxopyrrolidin-1-yl)phenyl]methoxy]-2-fluorophenyl]-1-cyclohexylbenzimidazole-5-carboxylic acidIC5010000.0 [1]
SwertifranchesideIC5057700.0 [1]
Remdesivir triphosphateIC50200000.0 [1]
Untenone AIC5057000.0 [1]
5-Acetyl-6-(2,4-dichlorophenyl)-9,9-dimethyl-6,8,10,11-tetrahydrobenzo[b][1,4]benzodiazepin-7-oneIC50100000.0 [1]
N-(2-Diphosphorylphosphonylmethoxyethyl)guanineIC501600.0 [1]
Hymenoic acidIC50200000.0 [1]
2-[[2-Chloro-6-methoxy-5-(trifluoromethyl)naphthalene-1-carbonyl]-methoxycarbonyl-amino]acetic acidIC50100000.0 [1]
[[(2S,3R,5S)-5-(4-Amino-5-methyl-2-oxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50200000.0 [1]
N-[2-[4-[(4-Fluorophenyl)methylcarbamoyl]-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl]propan-2-yl]-N',N'-dimethyloxamideIC5050000.0 [1]
2-[4-[Bis(4-fluorophenyl)methoxy]-2-fluoro-phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis(4-chlorophenyl)methoxy]phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-(4-Benzhydryloxyphenyl)-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis(4-fluorophenyl)methoxy]phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-(Bis-p-tolylmethoxy)phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis(3-fluorophenyl)methoxy]phenyl]-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
Plakevulin AIC50179000.0 [1]
5,7-Dimethoxy-4-prop-2-enyl-1,3-benzodioxoleIC5018600.0 [1]
alpha,beta-Methylene-dTTPKi600.0 [1]
1-Allyl-2,6-dimethoxy-3,4-methylenedioxybenzeneIC5034200.0 [1]
1-Cyclohexyl-2-[2-fluoro-4-(phenyl-pyridin-3-yl-methoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acidIC5010000.0 [1]
2-(4-Benzhydryloxy-2-fluoro-phenyl)-1-cyclohexyl-benzimidazole-5-carboxylic acidIC5010000.0 [1]
2-[4-[Bis[4-(dimethylcarbamoyl)phenyl]methoxy]-2-fluorophenyl]-1-cyclohexylbenzimidazole-5-carboxylic acidIC5010000.0 [1]
1-Cyclohexyl-2-[4-(di-pyridin-3-yl-methoxy)-2-fluoro-phenyl]-1H-benzoimidazole-5-carboxylic acidIC5010000.0 [1]
3-(p-Coumaroyl)ursolic acidIC5050000.0 [1]
[[(2R,3R,4R,5S)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50100000.0 [1]
(4As,6aS,6bR,8aS,10S,12R,12aR,14aS,14bR)-12-hydroxy-10-(4-hydroxybenzoyl)oxy-2,2,6b,9,9,12a,14a-heptamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a-carboxylic acidIC502200.0 [1]
2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylamino]-benzoic acidIC5020000.0 [1]
5-Acetyl-6-(4-methoxy-3-phenylmethoxyphenyl)-9,9-dimethyl-6,8,10,11-tetrahydrobenzo[b][1,4]benzodiazepin-7-oneIC50100000.0 [1]
[[(2S,3R,5S)-3-Fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50200000.0 [1]
[[(2S,3R,5S)-5-(2,4-Dioxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50100000.0 [1]
[[(2S,3R,5S)-5-(4-Amino-2-oxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50100000.0 [1]
2-(8-Chloro-5-ethyl-1-propyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acidIC50100000.0 [1]
1-[(2-Amino-4-chloro-5-methylphenyl)sulfonyl]-L-prolineIC50100000.0 [1]
(3As,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC503200.0 [1]
(3As,4S,7R,7aR)-1,6-diethyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC5050000.0 [1]
(1S,5S,6R,7S,8R)-7-(1,3-Benzodioxol-5-yl)-1,3,8-trihydroxy-6-methyl-5-prop-2-enylbicyclo[3.2.1]oct-3-en-2-oneIC5050000.0 [1]
(4Ar,5S,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-5,10-diacetyloxy-9-(acetyloxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acidIC5013000.0 [1]
2,6-Dimethoxy-3,4-methylenedioxycinnamyl alcoholIC5043500.0 [1]
(1S,5S,6R,7S,8R)-7-(1,3-Benzodioxol-5-yl)-1,8-dihydroxy-3-methoxy-6-methyl-5-prop-2-enylbicyclo[3.2.1]oct-3-en-2-oneIC5015300.0 [1]
[[(2R,3R,4S,5R)-4-Chloro-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateIC50100000.0 [1]
2'-Deoxy-5'-O-[(R)-Hydroxy{[(S)-Hydroxy(Phosphonooxy)phosphoryl]methyl}phosphoryl]guanosineKi1000.0 [1]
2-(2-Amino-6-oxo-1H-purin-9-yl)ethoxymethyl-phosphonooxyphosphinic acidIC5013500.0 [1]
2'-Deoxy-5'-O-[(S)-Hydroxy{[(S)-Hydroxy(Phosphonooxy)phosphoryl]methyl}phosphoryl]adenosineKi5000.0 [1]
3-O-Acetylcorosolic acidIC5021500.0 [1]
Armenin-BIC5012300.0 [1]
Trimethyl (1aR,1bR,2R,5S,5aS,6aS)-1a,3-dihexadecyl-6-oxo-1b,2,5,5a-tetrahydro-1H-cyclopropa[a]indene-2,5,6a-tricarboxylateIC5012500.0 [1]
Ddctp SODIUMIC501300.0 [1]
2'-Deoxy-5'-O-[(S)-Hydroxy{[(S)-Hydroxy(Phosphonooxy)phosphoryl]methyl}phosphoryl]cytidineKi900.0 [1]
(3As,4S,7R,7aR)-1,6-didodecyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC502300.0 [1]
(3As,4S,7R,7aR)-1,6-dihexadecyl-3-oxo-2,7-bis(propan-2-yloxycarbonyl)-3a,4,7,7a-tetrahydroindene-4-carboxylic acidIC504400.0 [1]
Methyl (2S,3S,4R,5E)-2-ethyl-4-hydroxy-5-(2-oxononadecylidene)-1-(2-phenylethyl)pyrrolidine-3-carboxylateIC508700.0 [1]
Methyl (2R,3S,4R,5E)-4-hydroxy-5-(2-oxononadecylidene)-2-phenyl-1-(2-phenylethyl)pyrrolidine-3-carboxylateIC508800.0 [1]
7-O-Ethyl 2-O,4-O-dimethyl (3aR,4R,7S,7aS)-3,5-dihexadecyl-1-oxo-3a,4,7,7a-tetrahydroindene-2,4,7-tricarboxylateIC501900.0 [1]
7-O-Ethyl 2-O,4-O-dimethyl (3aR,4S,7S,7aS)-3,5-dihexadecyl-1-oxo-3a,4,7,7a-tetrahydroindene-2,4,7-tricarboxylateIC502400.0 [1]
Methyl (2S,3S,4R,5E)-2-ethyl-4-hydroxy-5-(2-oxotetradecylidene)-1-(2-phenylethyl)pyrrolidine-3-carboxylateIC5022000.0 [1]
Methyl (2S,3S,4R,5E)-1-benzyl-2-ethyl-4-hydroxy-5-(2-oxotetradecylidene)pyrrolidine-3-carboxylateIC5030000.0 [1]
Methyl (2S,3S,4S,5E)-1-benzyl-2-ethyl-4-hydroxy-5-(2-oxotetradecylidene)pyrrolidine-3-carboxylateIC5027100.0 [1]
Dimethyl (3aR,4R,7S,7aS)-3,5-dihexadecyl-1-oxo-7-(2-phenylethylcarbamoyl)-3a,4,7,7a-tetrahydroindene-2,4-dicarboxylateIC508700.0 [1]
Methyl (2R,3S,4R,5E)-4-hydroxy-1-[2-(1H-indol-3-yl)ethyl]-5-(2-oxotetradecylidene)-2-phenylpyrrolidine-3-carboxylateIC5010000.0 [1]
(E)-Methyl-3,6-dioxo-4-docosenoateIC508800.0 [1]
Canellin AIC5026500.0 [1]
Canellin CIC5032400.0 [1]
3'-MethoxyguianinIC5050000.0 [1]
(1S,5S,6R,7S,8R)-7-(1,3-Benzodioxol-5-yl)-3,8-dihydroxy-1-methoxy-6-methyl-5-prop-2-enylbicyclo[3.2.1]oct-3-en-2-oneIC5021600.0 [1]
2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylamino]-4-fluoro-benzoic acidIC5020000.0 [1]
4-Fluoro-2-[[3-[1-(naphthalen-2-ylmethyl)pyrazol-4-yl]phenyl]sulfonylamino]benzoic acidIC5020000.0 [1]
[[(R)-[(2S,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)oxolan-2-yl]-fluoromethoxy]-hydroxyphosphoryl] phosphono hydrogen phosphateIC5010000.0 [1]
2-[2-Amino-6-(cyclopropylamino)purin-9-yl]ethoxymethyl-phosphonooxyphosphinic acidIC5033000.0 [1]
2-[2-Amino-6-(cyclopropylamino)purin-9-yl]ethoxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acidIC5023000.0 [1]
3-[4-Hydroxy-7,7-dimethyl-3-(2-methylbutanoyl)-4a,6-bis(3-methylbut-2-enyl)-2-oxo-5,6-dihydrochromen-8-yl]hexanoic acidIC50342000.0 [1]
3-[4-Hydroxy-7,7-dimethyl-3-(2-methylbutanoyl)-4a,6-bis(3-methylbut-2-enyl)-2-oxo-5,6-dihydrochromen-8-yl]-3-phenylpropanoic acidIC5073000.0 [1]
3-[4-Hydroxy-7,7-dimethyl-3-(3-methylbutanoyl)-4a,6-bis(3-methylbut-2-enyl)-2-oxo-5,6-dihydrochromen-8-yl]-3-phenylpropanoic acidIC5028000.0 [1]
3-[4-Hydroxy-7,7-dimethyl-3-(3-methylbutanoyl)-4a,6-bis(3-methylbut-2-enyl)-2-oxo-5,6-dihydrochromen-8-yl]hexanoic acidIC5012000.0 [1]
Items per page: 1 - 10 of 100
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References

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MLA

"Quest Database™ DNA polymerase beta Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/dna-polymerase-beta-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ DNA polymerase beta Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-polymerase-beta-inhibitors-ic50-ki.
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