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DNA excision repair protein ERCC-1/DNA repair endonuclease XPF Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50630.0 [1], 15600.0 [2]
5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acidIC503900.0 [1]
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acidIC502900.0 [1]
N-(4-Fluorobenzyl)-5,6-dihydroxy-2-thien-2-ylpyrimidine-4-carboxamideIC504200.0 [1]
3-Hydroxyquinazoline-2,4(1H,3H)-dioneIC5018100.0 [1]
N-HydroxynaphthalimideIC5030000.0 [1]
6-Chloro-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dioneIC5012000.0 [1]
5-Hydroxy-1-methyl-6-oxo-2-(2-thienyl)pyrimidine-4-carboxylic acidIC5048800.0 [1]
3-Hydroxy-1H-thieno[2,3-d]pyrimidine-2,4-dioneIC503900.0 [1]
5-Bromopyridine-2,3-diolIC5024000.0 [1]
5,6-Dihydroxy-2-(2-thienyl)pyrimidine-4-carboxamideIC501000.0 [1]
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl esterIC5027300.0 [1]
5-Hydroxy-6-methoxy-2-(2-thienyl)pyrimidine-4-carboxylic acidIC50100000.0 [1]
2(1H)-Pyridinone, 5-(4-fluorophenyl)-3-hydroxy-IC508700.0 [1]
6-(4-Fluorophenyl)-3-hydroxy-1H-pyridin-2-oneIC5055200.0 [1]
3-Hydroxy-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dioneIC501800.0 [1]
3-Hydroxy-7-(4-methylphenyl)furo[3,2-d]pyrimidine-2,4(1H,3H)-dioneIC501500.0 [1]
1-Benzyl-3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dioneIC5080400.0 [1]
2(1H)-Pyridinone, 4-(4-fluorophenyl)-3-hydroxy-IC50100000.0 [1]
2-Anilino-N-[2-(3,4-dihydroxyphenyl)ethyl]acetamideIC5015200.0 [1]
2-Anilino-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50900.0 [1]
2-Anilino-N-(3,4-dihydroxyphenyl)acetamideIC501600.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-3-phenylpropanamideIC507300.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenoxyacetamideIC5012100.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenylacetamideIC5013300.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenylpropanamideIC501800.0 [1]
2-(4-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC501000.0 [1]
2-(2-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50800.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-(4-methoxyphenyl)acetamideIC502600.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-1-phenylcyclohexane-1-carboxamideIC501600.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]cyclopentanecarboxamideIC5024600.0 [1]
2-Cyclohexyl-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC501400.0 [1]
2-(3-Cyanophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC504000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-pyridin-3-ylacetamideIC5025600.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-(4-morpholin-4-ylphenyl)acetamideIC507900.0 [1]
2-(4-Acetylpiperazin-1-yl)-N-[(3,4-dihydroxyphenyl)methyl]acetamideIC50100000.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-1-[(4-fluorophenyl)methyl]piperidine-4-carboxamideIC505800.0 [1]
2-(2,4-Dichlorophenyl)-1-(6,7-dihydroxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanoneIC501000.0 [1]
2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]-N-methylacetamideIC50800.0 [1]
N-[(2-Chloro-3,4-dihydroxyphenyl)methyl]-2-(2,4-dichlorophenyl)acetamideIC501600.0 [1]
2-(2,4-Dichlorophenyl)-N-[(2-fluoro-4,5-dihydroxyphenyl)methyl]acetamideIC501100.0 [1]
1-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]methanesulfonamideIC502900.0 [1]
N-[(2,4-Dichlorophenyl)methyl]-2-(3,4-dihydroxyphenyl)acetamideIC50740.0 [1]
1-(4-Chlorophenyl)-3-[(3,4-dihydroxyphenyl)methyl]ureaIC504800.0 [1]
1-[(4-Chlorophenyl)methyl]-3-[(3,4-dihydroxyphenyl)methyl]imidazolidin-2-oneIC504100.0 [1]
4-[[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]benzene-1,2-diolIC5012200.0 [1]
3-Hydroxy-5-(3-pyrazol-1-ylphenyl)-1H-pyridin-2-oneIC505200.0 [1]
5-(3-Chloro-4-fluorophenyl)-3-hydroxy-1H-pyridin-2-oneIC5013100.0 [1]
N-[4-(5-Hydroxy-6-oxo-1H-pyridin-3-yl)phenyl]acetamideIC5013500.0 [1]
3-Hydroxy-5-(1-methylindazol-6-yl)-1H-pyridin-2-oneIC5014600.0 [1]
5-(4-Fluorophenyl)-3-hydroxy-1-methylpyridin-2-oneIC50100000.0 [1]
2-(2,4-Dichlorophenyl)-N-[(5-hydroxy-6-oxo-1H-pyridin-3-yl)methyl]acetamideIC50100000.0 [1]
7-Anilino-3-hydroxy-1H-quinazoline-2,4-dioneIC503900.0 [1]
3-Hydroxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dioneIC509100.0 [1]
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-8-yl)acetamideIC506100.0 [1]
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-6-yl)acetamideIC506600.0 [1]
3-Hydroxy-6-phenyl-1H-pyrimidine-2,4-dioneIC501500.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]benzamideIC5024500.0 [1]
N-[(E)-(2,5-Dibromo-3,4-dihydroxyphenyl)methylideneamino]-2-(3-methylanilino)acetamideIC5033000.0 [1]
Methyl 5,6-dihydroxy-2-phenylpyrimidine-4-carboxylateIC5016400.0 [1]
2-Anilino-N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]acetamideIC502000.0 [1]
4-[3-[(4-Chlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]benzene-1,2-diolIC507800.0 [1]
5-Hydroxy-N-methyl-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC50600.0 [1]
5-Hydroxy-6-oxo-N-propyl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC502700.0 [1]
5-Hydroxy-N-(2-hydroxyethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC50700.0 [1]
5-Hydroxy-4-(pyrrolidine-1-carbonyl)-2-thiophen-2-yl-1H-pyrimidin-6-oneIC504600.0 [1]
N-Butan-2-yl-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC50600.0 [1]
5-Hydroxy-N-(3-methylbutyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC50500.0 [1]
N-(2-Acetamidoethyl)-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC50800.0 [1]
N-(4-Fluorophenyl)-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC50800.0 [1]
5-Hydroxy-6-oxo-N-pyridin-3-yl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC50700.0 [1]
5-Hydroxy-N-(2-morpholin-4-ylethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamideIC501000.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-[4-(morpholin-4-ylmethyl)phenyl]-6-oxo-1H-pyrimidine-4-carboxamideIC50800.0 [1]
2-[4-[(Dimethylamino)methyl]phenyl]-5-hydroxy-N-(3-methylbutyl)-6-oxo-1H-pyrimidine-4-carboxamideIC501700.0 [1]
5-Hydroxy-N-(3-methylbutyl)-6-oxo-2-piperidin-2-yl-1H-pyrimidine-4-carboxamideIC506300.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-3-yl)-6-oxo-1H-pyrimidine-4-carboxamideIC5025300.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-4-yl)-6-oxo-1H-pyrimidine-4-carboxamideIC506900.0 [1]
5-Hydroxy-N-(3-methylbutyl)-2-(1-methylpiperidin-2-yl)-6-oxo-1H-pyrimidine-4-carboxamideIC508400.0 [1]
3-Hydroxy-1-methylquinazoline-2,4(1H,3H)-dioneIC5096200.0 [1]
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-7-yl)acetamideIC506400.0 [1]
N-[(3,4-Dihydroxyphenyl)methyl]-2-methylpropanamideIC5024000.0 [1]
Items per page: 1 - 10 of 81
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References

This online tool may be cited as follows

MLA

"Quest Database™ DNA excision repair protein ERCC-1/DNA repair endonuclease XPF Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/dna-excision-repair-protein-ercc-1-dna-repair-endonuclease-xpf-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ DNA excision repair protein ERCC-1/DNA repair endonuclease XPF Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-excision-repair-protein-ercc-1-dna-repair-endonuclease-xpf-inhibitors-ic50-ki.
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