DNA-dependent protein kinase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	IC50	1400.0 [1]
	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	Ki	6000.0 [1]
	8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one	IC50	28.0 [1]
	8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one	Ki	0.65 [1]
	2-(Morpholin-4-yl)-benzo[h]chromen-4-one	IC50	230.0 [1]
	CID 11964036	IC50	5.0 [1]
	2-(4-Morpholinyl)-4H-1-benzopyran-4-one	IC50	1260.0 [1], 1300.0 [2], 4300.0 [3], 10000.0 [4]
	2-(4-Methoxyphenyl)-6-morpholino-4H-pyran-4-one	IC50	220.0 [1]
	3-Morpholino-1H-benzo[f]chromen-1-one	IC50	1250.0 [1], 4000.0 [2]
	2-Morpholino-6-(4-methoxyphenyl)-4H-thiopyran-4-one	IC50	280.0 [1]
	PI-103	IC50	2.0 [1], 14.0 [2], 48.5 [3]
	6-[(E)-Hydrazinylidenemethyl]-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile	IC50	8000.0 [1], 100000.0 [2]
	2-Morpholino-4H-benzo[g]chromen-4-one	IC50	390.0 [1], 400.0 [2]
	2-(4-Chlorophenyl)-6-morpholin-4-yl-thiopyran-4-one	IC50	530.0 [1]
	2-(4-Chlorophenyl)-6-morpholino-4H-pyran-4-one	IC50	180.0 [1]
	2-Morpholino-6-phenyl-4H-pyran-4-one	IC50	1100.0 [1], 1300.0 [2]
	6-Methoxy-4-morpholin-4-yl-chromen-2-one	IC50	1200.0 [1], 1700.0 [2], 1750.0 [3]
	8-Dibenzofuran-4-yl-2-morpholin-4-ylchromen-4-one	IC50	40.0 [1], 41.0 [2]
	8-(Biphenyl-3-yl)-2-morpholino-4H-chromen-4-one	IC50	180.0 [1]
	2-Morpholino-6-phenyl-4H-thiopyran-4-one	IC50	650.0 [1], 720.0 [2]
	Wortmannin	Ki	120.0 [1]
	Idelalisib	IC50	6700.0 [1]
	2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one	IC50	1800.0 [1], 2500.0 [2]
	3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide	IC50	26.0 [1], 4400.0 [2]
	N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide	IC50	64.0 [1]
	N-(7,8-Dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide	IC50	13.0 [1]
	2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one	IC50	280.0 [1]
	4-Morpholin-4-yl-chromen-2-one	IC50	4800.0 [1], 4820.0 [2]
	CID 46244454	IC50	30000.0 [1]
	2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one	IC50	190.0 [1]
	8-Methoxy-2-morpholin-4-yl-chromen-4-one	IC50	1200.0 [1], 1800.0 [2]
	3-Amino-n,6-diphenylpyrazine-2-carboxamide	IC50	620.0 [1], 8000.0 [2]
	2-(4-Fluorophenyl)-6-morpholino-4H-pyran-4-one	IC50	350.0 [1]
	2-Thiomorpholino-4H-benzo[h]chromen-4-one	IC50	1380.0 [1]
	7-Methoxy-4-morpholin-4-yl-chromen-2-one	IC50	5400.0 [1], 11310.0 [2]
	CID 11508681	IC50	800.0 [1]
	8-Benzo[b]thiophen-2-yl-2-morpholin-4-yl-chromen-4-one	IC50	800.0 [1]
	2-Morpholin-4-yl-8-thiophen-2-ylchromen-4-one	IC50	700.0 [1]
	2-Morpholin-4-yl-8-thiophen-3-ylchromen-4-one	IC50	300.0 [1]
	8-(4-Hydroxymethylphenyl)-2-morpholin-4-ylchromen-4-one	IC50	600.0 [1]
	2-(4-(Benzo[b]thiophen-3-yl)phenyl)-6-morpholino-4H-thiopyran-4-one	IC50	160.0 [1], 330.0 [2]
	2-Morpholino-6-[4-(4-methyl-1-naphthyl)phenyl]-4H-thiopyran-4-one	IC50	260.0 [1]
	2-Morpholino-6-(3'-hydroxy-3-biphenylyl)-4H-thiopyran-4-one	IC50	920.0 [1]
	2-Morpholino-6-(3-bromophenyl)-4H-thiopyran-4-one	IC50	700.0 [1], 800.0 [2]
	2-Morpholino-6-(4-tert-butylphenyl)-4H-thiopyran-4-one	IC50	920.0 [1], 1100.0 [2]
	2-Morpholino-6-(4-bromophenyl)-4H-thiopyran-4-one	IC50	680.0 [1]
	6-(4-Methoxyphenyl)-2-morpholin-4-ylpyridin-4-ol	IC50	100000.0 [1]
	Methyl (E)-3-[2-[3-(6-morpholin-4-yl-4-oxothiopyran-2-yl)phenyl]phenyl]prop-2-enoate	IC50	840.0 [1]
	2-(2-Methoxyphenyl)-6-morpholino-4H-pyran-4-one	IC50	310.0 [1], 380.0 [2]
	2-(3-Methoxyphenyl)-6-morpholino-4H-pyran-4-one	IC50	540.0 [1]
	2-Morpholino-6-(4-tert-butylphenyl)-4H-pyran-4-one	IC50	480.0 [1]
	4H-Naphtho(1,2-b)pyran-4-one, 2-(1-piperidinyl)-	IC50	3810.0 [1]
	8-(4-Methoxyphenyl)-2-(morpholin-4-yl)-4H-1-benzopyran-4-one	IC50	900.0 [1]
	4-Morpholino-7-(thiophen-2-yl)-2H-chromen-2-one	IC50	600.0 [1]
	3-Amino-6-[4-[1-(dimethylamino)propan-2-ylsulfonyl]phenyl]-N-phenylpyrazine-2-carboxamide	IC50	8000.0 [1]
	3-Amino-6-[4-[1-(dimethylamino)propan-2-ylsulfonyl]phenyl]-N-phenylpyrazine-2-carboxamide	Ki	6.0 [1]
	2-Hydroxy-4-morpholin-4-yl-benzaldehyde	IC50	400.0 [1]
	2-Morpholino-6-(3-fluorophenyl)-4H-pyran-4-one	IC50	530.0 [1], 690.0 [2]
	2-Morpholino-6-[4-(1-naphthyl)phenyl]-4H-thiopyran-4-one	IC50	160.0 [1], 190.0 [2]
	[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-Hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-19-[5-(2-morpholin-4-yl-4-oxochromen-7-yl)oxypentylamino]-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate	IC50	5000.0 [1], 10000.0 [2]
	Caffeine	IC50	10000000.0 [1]
	Gefitinib	IC50	50000.0 [1]
	Sorafenib	IC50	50000.0 [1]
	Suramin	IC50	1700.0 [1]
	Trifluoperazine	IC50	100000.0 [1]
	Sunitinib	IC50	50000.0 [1]
	Dasatinib	IC50	50000.0 [1]
	Vanillin	IC50	1500000.0 [1]
	Flavone	IC50	10000.0 [1]
	alpha-Naphthoflavone	IC50	4980.0 [1]
	Tanespimycin	IC50	40000.0 [1]
	Schisandrin B	IC50	1000000000.0 [1]
	Pictilisib	IC50	1230.0 [1]
	Buparlisib	IC50	6917.0 [1]
	Torin 1	IC50	6.34 [1]
	Alpelisib	IC50	9100.0 [1]
	2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol	IC50	410.0 [1]
	Ku-0063794	IC50	10000.0 [1]
	Torin 2	IC50	0.5 [1]
	N-[4-({3-[(3,5-Dimethoxyphenyl)amino]quinoxalin-2-yl}sulfamoyl)phenyl]-3-methoxy-4-methylbenzamide	IC50	150.0 [1]
	Isogranulatimide	IC50	10000.0 [1]
	Taselisib	IC50	4800.0 [1]
	Imino-methyl-[1-[6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]cyclopropyl]-oxo-lambda6-sulfane	IC50	30000.0 [1]
	Pilaralisib	IC50	4800.0 [1]
	DNA-PK Inhibitor III	IC50	120.0 [1]
	CB-5083	IC50	500.0 [1]
	1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	IC50	60.0 [1]
	Leniolisib	IC50	880.0 [1]
	N-[6-[6-Chloro-5-[[(4-fluorophenyl)sulfonyl]amino]-3-pyridinyl]-1,3-benzothiazol-2-yl]acetamide	IC50	3.0 [1]
	2-[[4-Amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one	IC50	48000.0 [1]
	1-Tert-Butyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine	IC50	420.0 [1]
	CID 59604787	IC50	8831.0 [1]
	2-Methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile	IC50	36.0 [1]
	6-Nitroveratraldehyde	IC50	15000.0 [1]
	(S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-morpholinopyrimidin-4(3H)-one	IC50	2000.0 [1]
	DNA-PK Inhibitor V	IC50	270.0 [1]
	3-Morpholino-5-phenylcyclohex-2-enone	IC50	10000.0 [1]
	2-Pyridin-4-yl-benzo[h]chromen-4-one	IC50	10000.0 [1]
	4-[2-[(6-Methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine	IC50	10000.0 [1]
	CID 118502708	IC50	140.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ DNA-dependent protein kinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/dna-dependent-protein-kinase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ DNA-dependent protein kinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-dependent-protein-kinase-inhibitors-ic50-ki.
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