DNA (cytosine-5)-methyltransferase 3B Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	S-Adenosyl-L-homocysteine	IC50	200.0 [1], 250.0 [2], 300.0 [3], 50000.0 [4]
	2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[2-(4-phenylphenyl)ethylamino]purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acid	IC50	600.0 [1]
	5,5'-Methylenedisalicylic acid	IC50	17000.0 [1]
	Nanafrocin	IC50	500.0 [1]
	N-(4-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide	IC50	7500.0 [1]
	S-Adenosyl-3-thiopropylamine	IC50	17000.0 [1]
	S-Tubercidinylhomocysteine	IC50	300.0 [1]
	CID 16451230	IC50	200000.0 [1]
	5'-Deoxy-5'-[2-(amino)ethylthio]adenosine	IC50	41000.0 [1]
	S-Inosyl-L-homocysteine	IC50	1000000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-phenylethylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acid	IC50	2000.0 [1]
	1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea	IC50	50000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	6800.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-[6-[(3,5-dimethoxyphenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	900.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(6-amino-2-methylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	1000.0 [1]
	(2R,3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-[[(2R)-pyrrolidin-2-yl]methylsulfanylmethyl]oxolane-3,4-diol	IC50	21000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	500000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(3-phenylpropylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acid	IC50	600.0 [1]
	(2S,4S)-4-[[(2S,3S,4R,5R)-5-(6-Amino-2-chloropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]pyrrolidine-2-carboxylic acid	IC50	1900.0 [1]
	(2R,3R,4S,5S)-2-(6-Amino-2-chloropurin-9-yl)-5-[[(3S)-pyrrolidin-3-yl]sulfanylmethyl]oxolane-3,4-diol	IC50	45000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(pyridin-4-ylmethylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acid	IC50	3600.0 [1]
	(2R,3R,4S,5S)-2-[2-Chloro-6-[2-(4-phenylphenyl)ethylamino]purin-9-yl]-5-[[(3S)-pyrrolidin-3-yl]sulfanylmethyl]oxolane-3,4-diol	IC50	27000.0 [1]
	(2S,4R)-4-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]piperidine-2-carboxylic acid	IC50	39000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(7-aminotriazolo[4,5-d]pyrimidin-3-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	3000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(6-anilinopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	2000.0 [1]
	(2S,4S)-4-[[(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-[2-(4-phenylphenyl)ethylamino]purin-9-yl]oxolan-2-yl]methylsulfanyl]pyrrolidine-2-carboxylic acid	IC50	260.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-[2-chloro-6-[2-(4-phenylphenyl)ethylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	29000.0 [1]
	(2S,4S)-4-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]piperidine-2-carboxylic acid	IC50	1500.0 [1]
	(2R,3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-[[(3S)-pyrrolidin-3-yl]sulfanylmethyl]oxolane-3,4-diol	IC50	26000.0 [1]
	(2R,3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-(azetidin-3-ylsulfanylmethyl)oxolane-3,4-diol	IC50	100000.0 [1]
	(2S,4R)-4-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]pyrrolidine-2-carboxylic acid	IC50	54000.0 [1]
	S-Nebularinehomocysteine	IC50	28000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	6800.0 [1]
	(2R,3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-[[(3R)-pyrrolidin-3-yl]sulfanylmethyl]oxolane-3,4-diol	IC50	12000.0 [1]
	(2R,3R,4S,5S)-2-[6-[2-(4-Phenylphenyl)ethylamino]purin-9-yl]-5-[[(3S)-pyrrolidin-3-yl]sulfanylmethyl]oxolane-3,4-diol	IC50	33000.0 [1]
	(2R,4S)-4-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]piperidine-2-carboxylic acid	IC50	100000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(7-aminoimidazo[4,5-b]pyridin-3-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	45000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(6-amino-2-chloropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	57200.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-(6-amino-2-iodopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	256000.0 [1]
	(2S,4S)-4-[[(2S,3S,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]-1-methylpyrrolidine-2-carboxylic acid	IC50	11000.0 [1]
	(2R,3R,4S,5S)-2-(6-Aminopurin-9-yl)-5-[[(2S)-pyrrolidin-2-yl]methylsulfanylmethyl]oxolane-3,4-diol	IC50	100000.0 [1]
	(2S,3S,4R,5R)-2-[[(1R,2S)-2-Aminocyclopentyl]sulfanylmethyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol	IC50	66000.0 [1]
	2-Amino-4-[[(2S,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid	IC50	1000.0 [1]
	(2S,4S)-4-[[(2S,3S,4R,5R)-5-[2-Chloro-6-[2-(4-phenylphenyl)ethylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]pyrrolidine-2-carboxylic acid	IC50	920.0 [1]
	(2S,4S)-4-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]pyrrolidine-2-carboxylic acid	IC50	300.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 45 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ DNA (cytosine-5)-methyltransferase 3B Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/dna-cytosine-5-methyltransferase-3b-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 20). Quest Database™ DNA (cytosine-5)-methyltransferase 3B Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-cytosine-5-methyltransferase-3b-inhibitors-ic50-ki.
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