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DNA (cytosine-5)-methyltransferase 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
N-(4-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamideIC506000.0 [1]
S-Adenosyl-L-homocysteineIC50941.0 [1]
Unc-0638IC501287.0 [1], 2010.0 [2]
N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamideIC50120.0 [1], 9000.0 [2]
2-Cyclohexyl-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50619.0 [1], 1400.0 [2]
N-Phthalyl-L-tryptophanIC50390000.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50382.0 [1]
N,N-Dimethyl-1-[3-(4-nitrophenyl)-4,5-dihydro-1,2-oxazol-5-yl]methanamineIC50150000.0 [1]
2-(5-Ethylfuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50234.0 [1]
2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[2-(4-phenylphenyl)ethylamino]purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acidIC505400.0 [1]
N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamideIC50370.0 [1], 52000.0 [2]
N-[4-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamideIC504110.0 [1], 265000.0 [2]
4-[(2-Amino-6-methylpyrimidin-4-yl)amino]-N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]benzamideIC502230.0 [1], 68000.0 [2]
4-(Quinolin-4-ylamino)-N-[4-(quinolin-4-ylamino)phenyl]benzamideIC50650.0 [1], 33000.0 [2]
GenisteinIC5030000.0 [1]
AzacitidineIC50300.0 [1]
(-)-Epigallocatechin gallateIC50500.0 [1]
DecitabineIC5030.0 [1]
ProcainamideIC50500000.0 [1]
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amineIC5010000.0 [1]
DichloneIC501600.0 [1]
Psammaplin AIC5018.6 [1]
CID 71268957IC50100000.0 [1]
5,5'-Methylenedisalicylic acidIC5092000.0 [1]
CID 53315878IC5050000.0 [1]
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(1H-indol-3-yl)-propionic acidIC5050000.0 [1]
S-Adenosyl-3-thiopropylamineIC5045000.0 [1]
S-TubercidinylhomocysteineIC501500.0 [1]
N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acidIC50302000.0 [1]
7-Methyl-3-[2-(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl]-[1,2,4]triazolo[4,3-a]pyridineIC50100000.0 [1]
Bromo-deaza-SAHIC501900.0 [1]
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amineIC50100000.0 [1]
(5S)-2-(4-Nitrophenyl)-5-(pyrrolidin-1-ylmethyl)-4,5-dihydro-1,3-oxazoleIC50150000.0 [1]
5'-Deoxy-5'-[2-(amino)ethylthio]adenosineIC5018000.0 [1]
S-Inosyl-L-homocysteineIC501000000.0 [1]
(2S)-2-(2,5-Dioxopyrrol-1-yl)-3-(1H-indol-3-yl)propanoic acidIC5020000.0 [1]
4-Chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamideIC5012000.0 [1]
PRMT5 Inhibitor C17IC50100000.0 [1]
4-[2-(1,3-Benzothiazol-2-yl)vinyl]-N,N-diethylbenzenesulfonamideIC50100000.0 [1]
2-Amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-phenylethylamino)purin-9-yl]oxolan-2-yl]methylsulfanyl]butanoic acidIC5027000.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(piperidin-4-ylmethoxy)quinolin-4-amineIC5073.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-(oxan-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC504420.0 [1]
6,7-Dimethoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)quinolin-4-amineIC50750.0 [1]
2-(5-Methylfuran-2-yl)-4-[(1-methylpiperidin-4-yl)amino]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-6-olIC50645.0 [1]
2-(Cyclohexen-1-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50494.0 [1]
6-Methoxy-2-(5-methyloxolan-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501370.0 [1]
2-Cyclohexyl-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50497.0 [1]
2-(5-Methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50950.0 [1]
2-(1-Benzofuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501070.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-(2-methylpyrazol-3-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC5010000.0 [1]
2-(Furan-3-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50978.0 [1]
N-(1-Cyclopropylpiperidin-4-yl)-6-methoxy-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50413.0 [1]
4-[[6-Methoxy-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]amino]-1-methylpiperidin-2-oneIC50297.0 [1]
3-[[6-Methoxy-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]amino]-N-methylpropanamideIC501080.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-(5-phenylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501050.0 [1]
6-Methoxy-2-(2-methylphenyl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50582.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-(1-methylpyrazol-3-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50969.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-(5-methylthiophen-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50230.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-phenyl-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501050.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-pyridin-3-yl-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501410.0 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-2-(5-methyl-1H-pyrrol-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50232.0 [1]
4-[6-Methoxy-4-[(1-methylpiperidin-4-yl)amino]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-2-yl]-1H-pyridin-2-oneIC501250.0 [1]
6-Methoxy-N-(6-methyl-6-azaspiro[3.4]octan-2-yl)-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50201.0 [1]
6-Methoxy-N-(6-methyl-6-azaspiro[3.4]octan-3-yl)-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50316.23 [1]
6-Methoxy-N-(7-methyl-7-azaspiro[3.5]nonan-2-yl)-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50140.0 [1]
6-Methoxy-N-(7-methyl-7-azaspiro[3.5]nonan-3-yl)-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50316.23 [1]
2-(3,6-Dihydro-2H-pyran-4-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50957.0 [1]
2-(5-Ethylfuran-2-yl)-6-methoxy-N-(7-methyl-7-azaspiro[3.5]nonan-3-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50316.23 [1]
6-Methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)-2-(trifluoromethyl)quinolin-4-amineIC5010000.0 [1]
2-[5-(Ethylaminomethyl)furan-2-yl]-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50618.0 [1]
[5-[6-Methoxy-4-[(1-methylpiperidin-4-yl)amino]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-2-yl]furan-2-yl]methanolIC50759.0 [1]
5-[6-Methoxy-4-[(1-methylpiperidin-4-yl)amino]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-2-yl]furan-2-carbonitrileIC501600.0 [1]
6-Methoxy-2-(4-methylpiperazin-1-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50945.0 [1]
2,6-Dimethoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC502290.0 [1]
6-Methoxy-2-methyl-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50929.0 [1]
2-[5-[(Dimethylamino)methyl]furan-2-yl]-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501270.0 [1]
N-Benzyl-6-methoxy-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50624.0 [1]
2-[[6-Methoxy-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]amino]ethanolIC50781.0 [1]
N-Cyclopropyl-6-methoxy-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501030.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-N-piperidin-4-yl-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50137.0 [1]
N-Cyclopentyl-6-methoxy-2-(5-methylfuran-2-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501790.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-N-[(1-methylpiperidin-4-yl)methyl]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC5032.0 [1]
7-[5-(2-Acetamidoethyl)-2-hydroxyphenyl]-3,5,6-trihydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acidIC5019000.0 [1]
6-Methoxy-7-[(2-methyl-2-azaspiro[3.3]heptan-6-yl)oxy]-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)quinolin-4-amineIC5021.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-[(1-methylpiperidin-4-yl)methoxy]quinolin-4-amineIC5083.0 [1]
2-(5-Methylfuran-2-yl)-4-[(1-methylpiperidin-4-yl)amino]-7-(3-pyrrolidin-1-ylpropoxy)quinoline-6-carbonitrileIC50588.0 [1]
2-(5-Ethylfuran-2-yl)-6-methoxy-N-[(1-methylpiperidin-4-yl)methyl]-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC5040.0 [1]
2-(5-Methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)-6-(trifluoromethoxy)quinolin-4-amineIC502080.0 [1]
6-Chloro-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50298.0 [1]
N-(1-Cyclopropylpiperidin-4-yl)-2-(5-ethylfuran-2-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50274.0 [1]
2-(5-Ethylfuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-piperidin-1-ylpropoxy)quinolin-4-amineIC50247.0 [1]
7-[3-(Dimethylamino)propoxy]-2-(5-ethylfuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)quinolin-4-amineIC50425.0 [1]
7-[3-(5-Azaspiro[2.4]heptan-5-yl)propoxy]-2-(5-ethylfuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)quinolin-4-amineIC50212.0 [1]
2-(5-Ethylfuran-2-yl)-6-methoxy-N-(1-methylpiperidin-4-yl)-7-(3-morpholin-4-ylpropoxy)quinolin-4-amineIC50446.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-piperidin-4-yloxyquinolin-4-amineIC50414.0 [1]
6-Methoxy-N-(7-methyl-7-azaspiro[3.5]nonan-2-yl)-2-(5-methylfuran-2-yl)-7-[(1-methylpiperidin-4-yl)methoxy]quinolin-4-amineIC50200.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-4-(1-methylpiperidin-4-yl)oxy-7-(3-pyrrolidin-1-ylpropoxy)quinolineIC501870.0 [1]
6-Methoxy-N-methyl-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC501320.0 [1]
6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50231.0 [1]
2-(5-Ethylfuran-2-yl)-6-methoxy-N-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amineIC50284.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ DNA (cytosine-5)-methyltransferase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/dna-cytosine-5-methyltransferase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ DNA (cytosine-5)-methyltransferase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-cytosine-5-methyltransferase-1-inhibitors-ic50-ki.
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