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DNA-(apurinic or apyrimidinic site) lyase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Aurintricarboxylic acidIC5055.0 [1], 10000.0 [2]
(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acidIC5010000.0 [1]
2,4,9-Trimethylbenzo[b][1,8]naphthyridin-5-amineIC501500.0 [1], 2100.0 [2], 32000.0 [3]
MyricetinIC50320.0 [1]
LucanthoneIC505000.0 [1]
2,5-DihydroxytyrosineIC50110.0 [1]
7-Nitro-1H-indole-2-carboxylic acidIC503000.0 [1], 3060.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamideIC502000.0 [1], 12000.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl]acetamideIC501000.0 [1], 3300.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamideIC502900.0 [1], 5000.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-7-propan-2-yl-4,5,6,8-tetrahydrothieno[2,3-c]azepin-2-yl]acetamideIC5012900.0 [1], 14000.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamideIC503800.0 [1], 5000.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]-2,2-difluoroacetamideIC503800.0 [1], 4000.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-6-propan-2-yl-4,5,7,8-tetrahydrothieno[2,3-d]azepin-2-yl]acetamideIC5013000.0 [1], 17600.0 [2]
N-[3-(1,3-Benzothiazol-2-yl)-5-propan-2-yl-4,6-dihydrothieno[2,3-c]pyrrol-2-yl]acetamideIC503100.0 [1], 4000.0 [2]
N-[3-(4-Phenyl-2-thiazolyl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamideIC502900.0 [1], 3000.0 [2]
N-[3-(1,3-Benzoxazol-2-yl)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]acetamideIC5013000.0 [1], 20400.0 [2]
SodiumIC508850.0 [1]
Mitoxantrone hydrochlorideIC502000.0 [1]
HycanthoneIC5080.0 [1]
ThiolactomycinIC501000.0 [1]
Tyrphostin AG 538IC50280.0 [1]
GalloflavinIC50400.0 [1]
3,3',4,4',5,5'-HexabromobiphenylIC50200.0 [1]
1,3,6-Trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dioneIC50200000.0 [1]
4-[Methyl(Nitroso)amino]benzene-1,2-DiolIC50500.0 [1]
3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dioneIC50200000.0 [1]
3-[3-(2-Carboxyethyl)-2-sulfanylidene-2,3-dihydro-1H-1,3-benzodiazol-1-yl]propanoic acidIC5015000.0 [1]
3-(6-Amino-9H-purin-8-ylsulfanyl)-propionic acidIC5020000.0 [1]
N-[3-[(1,1-Dioxo-1,2-benzothiazol-3-ylidene)amino]-2,2-dimethylpropyl]-2-methoxybenzamideIC50100000.0 [1]
4-(3,5-Dioxo-2,3,4,5-tetrahydro-[1,2,4]triazin-6-ylamino)-butyric acidIC50100000.0 [1]
5-({2-[(4-Carboxy-5-methyl(2-furyl))methylthio]ethylthio}methyl)-2-methylfuran-3-carboxylic acidIC505000.0 [1]
N-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)-N-[(4-sulfamoylphenyl)methyl]propanamideIC50100000.0 [1]
(2E)-3-{3-[(1,1-Dioxidotetrahydrothiophen-3-yl)sulfamoyl]-4-methoxyphenyl}prop-2-enoic acidIC50100000.0 [1]
3-(Pyridin-2-ylsulfanylmethyl)-benzofuran-2-carboxylic acidIC5027000.0 [1]
4-({[(3-Carboxy-5-methylfuran-2-yl)methyl]sulfanyl}methyl)-5-methylfuran-2-carboxylic acidIC5020000.0 [1]
1,3-Bis(1,3-benzothiazol-2-ylthio)acetoneIC503000.0 [1]
4-[4-(4-Carboxy-phenoxy)-benzenesulfonyl]-phthalic acidIC5010000.0 [1]
3,3'-(2,4,6-Trioxo-1,3,5-triazinane-1,3-diyl)dipropanoic acidIC5033000.0 [1]
1-Phenyl-5-[(E)-4-(1-phenyltetrazol-5-yl)sulfanylbut-2-enyl]sulfanyltetrazoleIC50100000.0 [1]
2-[(5Z)-5-[1-(Carboxymethyl)-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoic acidIC503000.0 [1]
1,6-Dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dioneIC50200000.0 [1]
3,6,7-Trimethoxyphenanthrene-2,5-diolIC50400.0 [1]
3-[1-(Carboxymethyl)-5-(4-methylphenyl)pyrrol-2-yl]propanoic acidIC5012000.0 [1]
2-Chloro-5-(diethylsulfamoyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamideIC50100000.0 [1]
N-[2-Chloro-4-(toluene-4-sulfonylamino)-phenyl]-2-piperidin-1-yl-acetamideIC50100000.0 [1]
CID 1270554IC506800.0 [1]
3-[3-[3-[(2-Chlorophenyl)methyl]-7-oxo-6H-triazolo[4,5-d]pyrimidin-5-yl]piperidin-1-yl]sulfonylbenzoic acidIC5087000.0 [1]
5-(1-Benzenesulfonyl-piperidin-3-yl)-3-(4-methyl-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-olIC50100000.0 [1]
3-[3-[3-[(4-Fluorophenyl)methyl]-7-oxo-6H-triazolo[4,5-d]pyrimidin-5-yl]piperidin-1-yl]sulfonylbenzoic acidIC5033000.0 [1]
3-[(4-Fluorophenyl)methyl]-5-[1-(4-fluorophenyl)sulfonylpiperidin-3-yl]-6H-triazolo[4,5-d]pyrimidin-7-oneIC50100000.0 [1]
2-[(Furan-2-carbonyl)-amino]-4-methyl-thiazole-5-carboxylic acidIC50100000.0 [1]
N-Cyclopentyl-3-methyl-4-tetrazol-1-yl-benzenesulfonamideIC50100000.0 [1]
3-[(4-{3-[4-(Dimethylamino)phenyl]-1,2,4-oxadiazol-5-yl}piperidino)sulfonyl]benzoic acidIC5040000.0 [1]
[7-(Carboxymethyl-sulfamoyl)-9-oxo-9H-fluorene-2-sulfonylamino]-acetic acidIC5050000.0 [1]
(5E)-1-(Furan-2-ylmethyl)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trioneIC502800.0 [1]
N-[4-(5-Ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-succinamic acidIC5080000.0 [1]
Fluorene-9,9-dipropionic acidIC5050000.0 [1]
4-{4-[(4-Carboxyphenyl)sulfonyl]phenylthio}benzene-1,2-dicarboxylic acidIC506000.0 [1]
4-(3-Allyl-5-benzyl-4-oxo-thiazolidin-2-ylideneamino)-benzoic acidIC50100000.0 [1]
2-Methyl-5-[(oxolan-2-ylmethylthio)methyl]furan-3-carboxylic acidIC5016000.0 [1]
N-[5-(Diethylsulfamoyl)-2-methoxyphenyl]oxolane-2-carboxamideIC50100000.0 [1]
5-O-Methyl 2-O-(oxolan-2-ylmethyl) 3,6-dimethyl-4-oxo-1,5,6,7-tetrahydroindole-2,5-dicarboxylateIC50100000.0 [1]
2-O-Cyclohexyl 5-O-methyl 3,6-dimethyl-4-oxo-1,5,6,7-tetrahydroindole-2,5-dicarboxylateIC50100000.0 [1]
Methyl 2-(4-{ethyl[(4-methylphenyl)sulfonyl]amino}phenyl)-3,3,3-trifluoro-2-hydroxypropanoateIC50100000.0 [1]
2-[[5-(Dimethylsulfamoyl)-1H-indol-3-yl]methylidene]propanedioic acid diethyl esterIC50100000.0 [1]
3-Methoxy-N-(2-methylcyclohexyl)-4-(tetrazol-1-yl)benzenesulfonamideIC50100000.0 [1]
N-{2-[4-Methyl-5-(pyridin-3-ylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-ethyl}-benzenesulfonamideIC50100000.0 [1]
Oxolan-2-ylmethyl 6-(furan-2-yl)-3-methyl-4-oxo-1,5,6,7-tetrahydroindole-2-carboxylateIC507070.0 [1]
3-[(3,4-Dimethylphenoxy)methyl]-2-furoic acidIC5011000.0 [1]
2-[2-Methyl-4-(morpholine-4-sulfonyl)-phenoxy]-1-pyrrolidin-1-yl-ethanoneIC50100000.0 [1]
3-[1-(Carboxymethyl)-5-(4-fluorophenyl)-1H-pyrrol-2-yl]propanoic acidIC509000.0 [1]
N-[(1,1-Dioxobenzo[d]1,2-thiazolin-3-yl)methylamino]-2-phenoxyacetamideIC50100000.0 [1]
3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]benzoic acidIC50100000.0 [1]
3-[1-(Carboxymethyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]propanoic acidIC504000.0 [1]
3-{4-Methoxy-3-[(pyridin-3-ylmethyl)-sulfamoyl]-phenyl}-acrylic acidIC50100000.0 [1]
4-[3-[(2-Methylphenyl)carbamoyl]anilino]-4-oxobutanoic acidIC5035000.0 [1]
10-Methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dioneIC50200000.0 [1]
Walrycin BIC50200000.0 [1]
5-Bromo-2-[(2-carboxyethyl)amino]benzoic acidIC5032000.0 [1]
2-({3-[(Diethylamino)sulfonyl]benzoyl}amino)benzoic acidIC50100000.0 [1]
1H-Benzimidazole-2-propanoic acid, 6-carboxy-IC5080000.0 [1]
Methyl [2-methyl-4-(piperidin-1-ylsulfonyl)phenoxy]acetateIC50100000.0 [1]
(2E)-2-[(E)-4-(1,3-Benzodioxol-5-yl)butan-2-ylidenehydrazinylidene]-4-oxo-1,3-thiazinane-6-carboxylic acidIC5050000.0 [1]
N-[2,5-Diethoxy-4-(tetrazol-1-yl)phenyl]-8-methoxy-2-oxochromene-3-carboxamideIC50100000.0 [1]
2-{[1-(1-Carboxyethoxy)-6-oxo-6H-benzo[c]chromen-3-yl]oxy}propanoic acidIC508000.0 [1]
Dibenzofuran-2,8-disulfonic acid bis-tert-butylamideIC50100000.0 [1]
Unii-M50YL7zlbcIC50250.0 [1]
3-[(2-Carboxycyclohexyl)carbonylamino]benzoic acidIC5055000.0 [1]
3-[4-Ethyl-5-(2-pyrrolidin-1-ylethylsulfanyl)-1,2,4-triazol-3-yl]-1-methylsulfonylpiperidineIC50100000.0 [1]
[2-Methyl-4-(morpholin-4-ylsulfonyl)phenoxy]acetic acidIC50100000.0 [1]
2,7-Naphthalenedisulfonic acid, 4-(benzoylamino)-5-hydroxy-IC5027000.0 [1]
2,4-Dioxo-10-[3-(1h-Tetrazol-5-Yl)phenyl]-2,3,4,10-Tetrahydropyrimido[4,5-B]quinoline-8-CarbonitrileIC50200000.0 [1]
N-(2-Hydroxy-phenyl)-3-(pyrrolidine-1-sulfonyl)-benzamideIC50100000.0 [1]
3,3'-(2-Oxo-cyclohexylidene)-di-propionic acidIC50100000.0 [1]
4-[(5-Carboxy-2-methylfuran-3-yl)methylsulfanylmethyl]-5-methylfuran-2-carboxylic acidIC5040000.0 [1]
N-[(E)-1,3-Benzodioxol-5-ylmethylideneamino]-6-methyl-[1,3]dioxolo[4,5-g]quinolin-8-amineIC502900.0 [1]
2-[(3Z)-3-[3-(Carboxymethyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]-2-oxoindol-1-yl]acetic acidIC5013000.0 [1]
[3-(Carboxymethyl)-2-oxo-2,3-dihydro-1h-benzimidazol-1-yl]acetic acidIC5016000.0 [1]
2-Aminobenzene-1,3,5-trisulfonamideIC501400.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ DNA-(apurinic or apyrimidinic site) lyase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/dna-apurinic-or-apyrimidinic-site-lyase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ DNA-(apurinic or apyrimidinic site) lyase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dna-apurinic-or-apyrimidinic-site-lyase-inhibitors-ic50-ki.
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