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Disks large homolog 4 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-cyclohexylethylamino)-5-oxopentanoic acidKi450.0 [1], 630.0 [2], 940.0 [3], 11000.0 [4]
Tat-NR2B9cKi4400.0 [1], 9800.0 [2], 14000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(methylamino)-5-oxopentanoic acidKi8900.0 [1], 9650.0 [2], 11000.0 [3], 78000.0 [4]
Ksg-ldtknykqtsvKi2100.0 [1], 25000.0 [2], 45000.0 [3], 97000.0 [4]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-naphthalen-2-ylethylamino)-5-oxopentanoic acidKi950.0 [1], 1000.0 [2], 10000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[2-(3,4-dichlorophenyl)ethylamino]-5-oxopentanoic acidKi1100.0 [1], 2400.0 [2], 6700.0 [3]
(4S)-4-Amino-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi22000.0 [1], 29000.0 [2], 260000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(ethylamino)-5-oxopentanoic acidKi9300.0 [1], 9600.0 [2], 69000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-(propylamino)pentanoic acidKi4200.0 [1], 7000.0 [2], 35000.0 [3]
(4S)-4-(Butylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi4000.0 [1], 8400.0 [2], 35000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(cyclohexylmethylamino)-5-oxopentanoic acidKi1000.0 [1], 1300.0 [2], 21000.0 [3]
(4S)-4-(Benzylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi5200.0 [1], 7200.0 [2], 63000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-(2-phenylethylamino)pentanoic acidKi1600.0 [1], 4400.0 [2], 14000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-(3-phenylpropylamino)pentanoic acidKi2100.0 [1], 3100.0 [2], 44000.0 [3]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[2-(3,4-difluorophenyl)ethylamino]-5-oxopentanoic acidKi980.0 [1], 1000.0 [2], 7800.0 [3]
Ksg-yeklssiesdvKi4100.0 [1], 7000.0 [2], 18000.0 [3]
(4S)-4-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi2300.0 [1], 6300.0 [2], 35000.0 [3]
(4S)-4-Amino-5-[[(2S,3R)-1-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi16000.0 [1], 22000.0 [2]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi28000.0 [1], 56000.0 [2]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-4-carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi29000.0 [1], 67000.0 [2]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi100000.0 [1], 130000.0 [2]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]-methylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi78000.0 [1], 87000.0 [2]
(4S)-5-[[(2S)-1-[[(2S)-3-Carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-(methylamino)-5-oxopentanoic acidKi15000.0 [1], 24000.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3,3-dimethylbutanoic acidKi76000.0 [1], 160000.0 [2]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-5-amino-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi29000.0 [1], 57000.0 [2]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-4-amino-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi67000.0 [1], 88000.0 [2]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2,5-Diamino-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi110000.0 [1], 400000.0 [2]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-Aminopropanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi73000.0 [1], 400000.0 [2]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-Amino-2-(2-cyclohexylethylamino)-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi12000.0 [1], 141000.0 [2]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-(2-Cyclohexylethylamino)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi8100.0 [1], 89000.0 [2]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S,3R)-2-[[(2S)-2-(2-cyclohexylethylamino)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi3600.0 [1], 400000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-3-Carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-naphthalen-2-ylethylamino)-5-oxopentanoic acidKi1800.0 [1], 210000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-3-Carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[2-(3,4-dichlorophenyl)ethylamino]-5-oxopentanoic acidKi1200.0 [1], 130000.0 [2]
(2S)-2-[[(2S)-2-[[(2S,3R)-3-Hydroxy-2-[[(2S)-2-(2-naphthalen-2-ylethylamino)propanoyl]amino]butanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi56000.0 [1], 280000.0 [2]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[2-(3,4-Dichlorophenyl)ethylamino]propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi13000.0 [1], 64000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(cycloheptylmethylamino)-5-oxopentanoic acidKi1400.0 [1], 16000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-cycloheptylethylamino)-5-oxopentanoic acidKi1200.0 [1], 9400.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-[2-(2,3,4-trifluorophenyl)ethylamino]pentanoic acidKi1800.0 [1], 8800.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-[3-(2,3,4-trifluorophenyl)propylamino]pentanoic acidKi4200.0 [1], 44000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(3-naphthalen-2-ylpropylamino)-5-oxopentanoic acidKi5000.0 [1], 53000.0 [2]
(4S)-4-(2-Anthracen-9-ylethylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi9700.0 [1], 39000.0 [2]
(4S)-4-(3-Anthracen-9-ylpropylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi9000.0 [1], 95000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-(2-pyren-1-ylethylamino)pentanoic acidKi16000.0 [1], 51000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-(4-pyren-1-ylbutylamino)pentanoic acidKi33000.0 [1], 76000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-sulfanylidenepropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-cyclohexylethylamino)-5-oxopentanoic acidKi630.0 [1], 11000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-sulfanylidenepropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-naphthalen-2-ylethylamino)-5-oxopentanoic acidKi1100.0 [1], 11000.0 [2]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-sulfanylidenepropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[2-(3,4-dichlorophenyl)ethylamino]-5-oxopentanoic acidKi1000.0 [1], 8300.0 [2]
(4S)-4-[2-(2-Bicyclo[2.2.1]heptanyl)ethylamino]-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi1500.0 [1], 14000.0 [2]
(4S)-4-(1-Adamantylmethylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi2100.0 [1], 6700.0 [2]
(4S)-4-(2-Bicyclo[2.2.1]heptanylmethylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acidKi1300.0 [1], 20000.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi229000.0 [1], 480000.0 [2]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-Amino-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi38000.0 [1], 74000.0 [2]
1-(3-Carboxypropyl)-3-methyl-5-phenylmethoxyindole-2,6-dicarboxylic acidKi500000.0 [1], 1000000.0 [2]
5-Hydroxy-3-methyl-1H-indole-2,6-dicarboxylic acidKi530000.0 [1], 1000000.0 [2]
(2S)-2-[[(2S)-2-[4-[(1R,2R)-1-Amino-2-hydroxypropyl]triazol-1-yl]propanoyl]amino]-3-methylbutanoic acidKi289000.0 [1], 500000.0 [2]
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(1S)-1-carboxypropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acidKi230000.0 [1]
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S,3R)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acidKi60000.0 [1]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-Aminopropanoyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acidKi38000.0 [1]
(4S)-5-[[(2S,3R)-1-[[(2S)-3-Carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-cyclohexylethylamino)-5-oxopentanoic acidKi750.0 [1]
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-Amino-2-(2-cyclohexylethylamino)-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acidKi4400.0 [1]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-sulfanylidenepropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(methylamino)-5-oxopentanoic acidKi10800.0 [1]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-sulfanylidenebutan-2-yl]amino]-4-(methylamino)-5-oxopentanoic acidKi220000.0 [1]
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(methylamino)-5-sulfanylidenepentanoic acidKi32000.0 [1]
(2S)-2-[[1-[(1S)-1-Carboxy-2-methylpropyl]triazole-4-carbonyl]amino]-3-methylbutanoic acidKi500000.0 [1]
(2S)-2-[4-[(1S)-1-[[(2S,3R)-2-Amino-3-hydroxybutanoyl]amino]ethyl]triazol-1-yl]-3-methylbutanoic acidKi500000.0 [1]
Items per page: 1 - 10 of 65
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References

This online tool may be cited as follows

MLA

"Quest Database™ Disks large homolog 4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/disks-large-homolog-4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Disks large homolog 4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/disks-large-homolog-4-inhibitors-ic50-ki.
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