Disintegrin and metalloproteinase domain-containing protein 8 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Unii-Q56UE7E40Y	IC50	1000.0 [1]
	2-[(2S,5S,8S,11S,14S)-2,8-Bis(4-aminobutyl)-14-butyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	378.0 [1]
	2-[(2S,5S,8S,11S,14S)-2,8-Bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,19-hexaoxo-14-propyl-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	452.0 [1]
	2-[(2S,5S,8S,11S,14S)-2-(4-Aminobutyl)-8-(aminomethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	5000.0 [1]
	2-[(2S,5S,8S,11S,14S)-2-(4-Aminobutyl)-8-(2-aminoethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	5000.0 [1]
	2-[(2S,5S,8S,11S,14S,17R)-2,8-Bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	157.0 [1]
	2-[(2S,5S,8S,11S,14S)-2,8-Bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	1645.0 [1]
	(2S,5S,8S,11S,14S,17S)-2,8-Bis(4-aminobutyl)-5-(carboxymethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadecane-17-carboxylic acid	IC50	420.0 [1]
	2-[(2S,5S,8S,11S,14S)-2,8-Bis(4-aminobutyl)-11-[3-[[amino(nitramido)methylidene]amino]propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	2345.0 [1]
	2-[(2S,5S,8S,11S,14S)-2,8-Bis(4-aminobutyl)-11-[3-(carbamoylamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	890.0 [1]
	2-[(2S,5S,8S,11S,14S,17R)-2,8-Bis(4-aminobutyl)-11-[3-(carbamoylamino)propyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	192.0 [1]
	2-[(2S,5S,8S,11S,14S,17R)-2,8-Bis(4-aminobutyl)-11-[4-(diaminomethylideneamino)butyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	368.0 [1]
	2-[(2S,5S,8S,11S,14S)-2,8-Bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2,2-dimethylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	256.0 [1]
	2-[(2S,5S,8S,11S,14S)-2,8-Bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-14-(3-methylbutyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	220.0 [1]
	2-[(2S,5S,8S,11S,14S,17R)-2,8-Bis(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-17-(hydroxymethyl)-14-(3-methylbutyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	142.0 [1]
	2-[(2S,5S,8S,11S,14R,17S)-5,17-Bis(4-aminobutyl)-8-[3-(diaminomethylideneamino)propyl]-14-(hydroxymethyl)-11-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetic acid	IC50	182.0 [1]
	2-[(2S,5S,8S,11S,14S)-2-(4-Aminobutyl)-8-(3-aminopropyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	5000.0 [1]
	4-[(2S,5S,8S,11S,14S)-2-(4-Aminobutyl)-5-(carboxymethyl)-11-[3-(diaminomethylideneamino)propyl]-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-8-yl]butyl-trimethylazanium	IC50	10000.0 [1]
	2-[(2S,5S,8S,11S,14S,17R)-2,8-Bis(4-aminobutyl)-11-[3-[[amino(nitramido)methylidene]amino]propyl]-17-(hydroxymethyl)-14-(2-methylpropyl)-3,6,9,12,15,19-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-5-yl]acetic acid	IC50	1245.0 [1]
	2-[(2S,5S,8S,11S,14S,17S)-5,17-Bis(4-aminobutyl)-8-[3-(diaminomethylideneamino)propyl]-14-(hydroxymethyl)-11-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetic acid	IC50	240.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

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References

This online tool may be cited as follows

MLA	"Quest Database™ Disintegrin and metalloproteinase domain-containing protein 8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/disintegrin-and-metalloproteinase-domain-containing-protein-8-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Disintegrin and metalloproteinase domain-containing protein 8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/disintegrin-and-metalloproteinase-domain-containing-protein-8-inhibitors-ic50-ki.
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