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Dipeptidyl peptidase II Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SitagliptinIC50100000.0 [1]
VildagliptinIC50100000.0 [1]
TalabostatIC5015.0 [1], 30.0 [2], 86.0 [3]
TalabostatKi125.0 [1], 125000.0 [2]
1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-IC5028000.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-Ki8170.0 [1]
LinagliptinIC50100000.0 [1]
(2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrileIC5026520.0 [1]
Allo-Ile-IsoindolineIC5029000.0 [1]
N4-(4-Chlorobenzyl)-2,4-diaminobutanoylpiperidineIC500.22 [1], 0.48 [2], 0.5 [3]
N4-(4-Chlorobenzyl)-2,4-diaminobutanoylpiperidineKi0.08 [1]
Chg-Pro-CNIC5039873.0 [1], 41000.0 [2], 102000.0 [3]
1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-IC50110000.0 [1]
1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-Ki24700.0 [1]
2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-oneIC50153000.0 [1], 223000.0 [2]
(S)-2-Amino-2-cyclohexyl-1-(pyrrolidin-1-YL)ethanoneIC5019000.0 [1], 42000.0 [2], 100000.0 [3]
AlogliptinIC50100000.0 [1]
N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl]-4-trifluoromethoxy-benzenesulfonamideIC501100.0 [1], 1180.0 [2]
(S)-Pyrrolidin-1-yl(pyrrolidin-2-yl)methanoneIC50500000.0 [1]
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindoleIC5020000.0 [1], 100000.0 [2]
2-Oxo-2-pyrrolidin-1-ylethanamineIC501000000.0 [1]
(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanoic acidIC50500000.0 [1]
(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-oneIC50179000.0 [1]
(2S)-1-[(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanoyl]pyrrolidine-2-carbonitrileIC50100000.0 [1]
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acidIC502700.0 [1]
CID 56658139IC5050000.0 [1], 1000000.0 [2]
(3S)-4-Oxo-4-piperidin-1-ylbutane-1,3-diamineIC50130.0 [1], 163.0 [2]
N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-2,4-difluoro-benzenesulfonamideIC508800.0 [1]
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
(S)-1-[2-((5S,7S)-3-Hydroxy-adamantan-1-ylamino)-acetyl]-pyrrolidine-2-carbonitrileIC50210000.0 [1], 500000.0 [2]
OmarigliptinIC5067000.0 [1], 100000.0 [2]
Ala-boroProIC5060.0 [1]
Ala-boroProKi125.0 [1]
Lys-Pro-CNIC50577.0 [1], 1000.0 [2]
(S)-2,6-Diamino-1-(piperidin-1-yl)hexan-1-oneIC501600.0 [1], 2100.0 [2]
3-Methyl-1-oxo-1-piperidin-1-ylpentan-2-aminiumIC5059000.0 [1], 62000.0 [2]
Ala-Pro-CNIC50110000.0 [1]
Ile-IsoindolineIC5043000.0 [1]
[(2R)-1-[(2R)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acidIC5021.0 [1], 38.0 [2]
2,5-Diamino-1-piperidin-1-yl-pentan-1-oneIC50450.0 [1]
2,6-Diamino-1-pyrrolidin-1-yl-hexan-1-oneIC509900.0 [1]
1-(3-Cyclohexylalanyl)pyrrolidineIC5042000.0 [1]
1-{2-[2-(5-Nitro-pyridin-2-ylamino)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrileIC5012000.0 [1], 16000.0 [2]
(2S)-2-Amino-4-[(2-chlorophenyl)methylamino]-1-piperidin-1-ylbutan-1-oneIC500.23 [1], 5.0 [2]
Sitagliptin HydrochlorideIC50100000.0 [1]
3-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N-(2-phenylethyl)propanamideIC5020000.0 [1], 20720.0 [2]
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acidIC50100000.0 [1]
3-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N-(3,4-dimethoxyphenyl)-3-methylbutanamideIC5020000.0 [1]
3-[2-(2-Cyanopyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-N-(1-methyl-1-phenylethyl)butyramideIC5020000.0 [1], 100000.0 [2]
N-Benzyl-3-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]propanamideIC5017400.0 [1]
3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-phenylpropionamideIC505717.6 [1], 57176.0 [2]
3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-(1-methyl-1-phenylethyl)propionamideIC5020000.0 [1], 100000.0 [2]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamideIC50100000.0 [1]
2-Amino-3-hydroxy-1-pyrrolidin-1-yl-propan-1-oneIC5065000.0 [1]
4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-oneIC50100000.0 [1]
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amineIC5034000.0 [1], 42000.0 [2]
2-Amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-oneIC5079000.0 [1]
2-Amino-3-(4-hydroxy-phenyl)-1-pyrrolidin-1-yl-propan-1-oneIC50150000.0 [1]
(S)-2-Amino-1-thiazolidin-3-yl-propane-1-thioneKi277.0 [1]
(S)-2-Amino-1-pyrrolidin-1-yl-propane-1-thioneKi1430.0 [1]
2-Amino-3-(1H-imidazol-4-yl)-1-piperidin-1-yl-propan-1-oneIC50328.0 [1], 330.0 [2]
N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-4-trifluoromethoxy-benzenesulfonamideIC506400.0 [1]
[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-carbamic acid benzyl esterIC504100.0 [1]
N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-3,4-difluoro-benzamideIC505000.0 [1]
N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl]-3,4-difluoro-benzamideIC50690.0 [1]
N-[4-[(1S)-1-Amino-2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]cyclohexyl]-4-(trifluoromethoxy)benzamideIC50360.0 [1], 690.0 [2]
[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl]-carbamic acid benzyl esterIC50900.0 [1]
(2S,4S)-1-[(2S,3R)-2-Amino-3-methylpentanoyl]-4-azidopyrrolidine-2-carbonitrileIC5024000.0 [1]
(S)-2,6-Diamino-1-(isoindolin-2-yl)hexan-1-oneIC501780.0 [1]
(S)-Benzyl 5-amino-6-(isoindolin-2-yl)-6-oxohexylcarbamateIC502500.0 [1]
(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]-4,4-difluoropyrrolidine-2-carbonitrileIC50100000.0 [1]
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acidIC5045000.0 [1]
(2S,3S)-2-Amino-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acidIC501400.0 [1]
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acidIC503500.0 [1]
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acidIC501700.0 [1], 17000.0 [2]
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-hydroxypentan-1-one;2,2,2-trifluoroacetic acidIC5044800.0 [1], 45000.0 [2]
(2S)-3-[3-(2-Chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-cyclopentylidene-1-fluorobutan-2-amine;2,2,2-trifluoroacetic acidIC50330.0 [1]
3-Amino-4-oxo-4-pyrrolidin-1-yl-butyramideIC50152000.0 [1]
2-Amino-3-(1H-imidazol-4-yl)-1-pyrrolidin-1-yl-propan-1-oneIC501160.0 [1], 1200.0 [2]
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylacetamideIC5083000.0 [1], 100000.0 [2]
(1R)-2-(2,5-Difluorophenyl)-1-[4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]cyclohexyl]ethanamineIC5018000.0 [1], 100000.0 [2]
1-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]piperidine-3-carboxamideIC5054000.0 [1], 62000.0 [2]
(1R)-2-(2,5-Difluorophenyl)-1-[4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl]ethanamineIC5016000.0 [1], 31000.0 [2]
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamineIC5017000.0 [1], 77000.0 [2]
N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamideIC50100000.0 [1]
5-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-5-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-methylquinoline-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-8-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-fluoroquinoline-4-carboxamideIC50100000.0 [1]
6-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-(trifluoromethoxy)quinoline-4-carboxamideIC50100000.0 [1]
8-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
8-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-methoxyquinoline-4-carboxamideIC50100000.0 [1]
7-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamideIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dipeptidyl peptidase II Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/dipeptidyl-peptidase-ii-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Dipeptidyl peptidase II Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dipeptidyl-peptidase-ii-inhibitors-ic50-ki.
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