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Dipeptidyl peptidase I Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(S)-2-Amino-N-((S)-2-biphenyl-4-yl-1-cyano-ethyl)-butyramideIC502.0 [1], 13.0 [2], 63.1 [3], 6100.0 [4], 10000.0 [5]
4-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]oxane-4-carboxamideIC500.79 [1], 1.0 [2], 5.01 [3], 7.94 [4]
(3S)-N-[(1S)-1-Cyano-2-[4-(1-methyl-2-oxo-3H-indol-6-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5032.2 [1], 52.2 [2]
CID 118253852IC503.98 [1]
N-[(2S)-1-[[(E,3S)-1-(Benzenesulfonyl)-5-phenylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamideIC502600.0 [1], 4000.0 [2]
(S)-2-Amino-N-((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)pentanamideIC5070.0 [1], 100.0 [2]
(S)-N-((S)-1-Cyano-2-phenylethyl)pyrrolidine-2-carboxamideIC504806.0 [1], 9637.0 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(3,3-difluoro-1-methyl-2-oxoindol-6-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5015.85 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-(3,7-dimethyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC507.94 [1], 10.0 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(1-methyl-2-oxoquinolin-7-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5012.59 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-(3-methyl-1,2-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5015.85 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5031.62 [1], 39.81 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(4-methyl-3-oxo-1,4-benzoxazin-6-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5012.59 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-(3-ethyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC505.01 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-[3-(2,2-difluoroethyl)-2-oxo-1,3-benzoxazol-5-yl]phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC506.31 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC50199.53 [1]
(1S,2S)-2-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamideIC50398.11 [1], 501.19 [2]
(1R,2S)-2-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclopentane-1-carboxamideIC501000.0 [1], 1258.93 [2]
(1R,2R)-2-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamideIC50158.49 [1], 316.23 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]morpholine-2-carboxamideIC50398.11 [1], 501.19 [2]
(1R,2S)-2-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamideIC5039.81 [1]
N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]azepane-3-carboxamideIC50501.19 [1], 1258.93 [2]
(1R,2S)-2-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cycloheptane-1-carboxamideIC5031.62 [1], 39.81 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]piperidine-2-carboxamideIC5010.0 [1], 39.81 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(4-cyano-3-methylsulfanylphenyl)phenyl]ethyl]piperidine-2-carboxamideIC501.0 [1], 3.98 [2]
4-Amino-N-[(1S)-1-cyano-2-[4-(1-methyl-2-oxo-3H-indol-6-yl)phenyl]ethyl]oxane-4-carboxamideIC500.25 [1], 1.58 [2]
4-Amino-N-[(1S)-1-cyano-2-[4-(3-methylsulfonylphenyl)phenyl]ethyl]oxane-4-carboxamideIC500.79 [1], 7.94 [2]
4-Amino-N-[(1S)-1-cyano-2-[4-(2-methyl-3-oxo-1H-isoindol-5-yl)phenyl]ethyl]oxane-4-carboxamideIC505.01 [1], 50.12 [2]
1-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamideIC502.51 [1], 3.16 [2]
(2S)-N-[(1S)-1-Cyano-2-(4-phenylphenyl)ethyl]piperidine-2-carboxamideIC50125.89 [1], 158.49 [2]
4-Amino-N-[(1S)-1-cyano-2-(4-phenylphenyl)ethyl]oxane-4-carboxamideIC502.0 [1], 31.62 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]piperidine-2-carboxamideIC507.94 [1], 25.12 [2]
(2S,4S)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamideIC505.01 [1], 12.59 [2]
(2S,4S)-N-[(1S)-1-Cyano-2-[4-(2-methyl-1-oxo-3H-isoindol-5-yl)phenyl]ethyl]-4-hydroxypiperidine-2-carboxamideIC503.98 [1], 39.81 [2]
(2S)-N-[(1S)-1-Cyano-2-[4-(3-methyl-2-oxo-1,3-benzothiazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC502.51 [1], 3.16 [2]
N-[(1S)-1-Cyano-2-[4-(3-cyano-4-methylsulfonylphenyl)-2-fluorophenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5027.8 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(3,4,5-trifluorophenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50243.7 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-ethylsulfonylphenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50164.4 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(2-cyanopyridin-4-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50248.5 [1]
(3S)-N-[(1S)-1-Cyano-2-[2-fluoro-4-(2-methyl-1,3-dihydroisoindol-5-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5098.0 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-cyano-3-methylsulfonylphenyl)-2-fluorophenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5030.1 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-sulfamoylphenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50102.3 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(2-oxo-1,3-dihydroindol-5-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50102.8 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-methylsulfonylphenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50110.5 [1]
(3S)-N-[(1S)-2-[4-(4-Carbamoylphenyl)phenyl]-1-cyanoethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50118.0 [1]
(3S)-N-[(1S)-2-[4-(3-Carbamoylphenyl)phenyl]-1-cyanoethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50130.7 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(1-methyl-2-oxo-3H-indol-5-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50133.7 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(1-oxo-3,4-dihydro-2H-isoquinolin-6-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50136.7 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(2-oxo-1,3-dihydroindol-6-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5050.1 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-cyano-3-fluorophenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5066.4 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-[1-(2-methoxyethyl)-2-oxo-3H-indol-6-yl]phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50159.8 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-[4-(methanesulfonamido)phenyl]phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC50123.7 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5073.0 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(3-methylsulfonylphenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5073.5 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(1-oxo-2,3-dihydroisoindol-5-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5086.7 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-cyano-3-methylsulfonylphenyl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5070.2 [1]
(3S)-N-[(1S)-1-Cyano-2-[2-fluoro-4-(2-methyl-1,1-dioxo-3H-1,2-benzothiazol-5-yl)phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5073.3 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-[3-(methanesulfonamido)phenyl]phenyl]ethyl]-2-azabicyclo[2.2.2]octane-3-carboxamideIC5097.4 [1]
e-64IC50770.0 [1]
OdanacatibIC5010.0 [1]
Morpholine-4-carboxylic acid (1-(3-benzenesulfonyl-1-phenethylallylcarbamoyl)-3-methylbutyl)-amideIC5010000.0 [1]
Pyrrolidine-1-carbonitrileIC5025118.86 [1]
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrileIC506918.31 [1]
Grassystatin AIC5010000.0 [1]
Cruzain-IN-1IC5034.67 [1]
9-(3,5-Difluorophenyl)-6-(ethylamino)-2-purinecarbonitrileIC50588.84 [1]
L-Phenylalaninamide, glycyl-Ki6200000.0 [1]
2-Amino-N-(benzyl-cyano-methyl)-acetamideKi2700.0 [1]
(2R)-2-[[(1S)-1-(4-Bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfonylpropanamideIC5010000.0 [1]
Gly-Phe-DMKIC5051.0 [1]
(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanoneIC501.0 [1]
(S)-2-Amino-N-((S)-1-cyano-3-phenylpropyl)butanamideIC50822.0 [1]
(S)-2-Amino-N-((S)-1-cyano-2-phenylethyl)butanamideIC50172.0 [1]
(S)-2-Amino-N-((S)-2-(4-chlorophenyl)-1-cyanoethyl)butanamideIC5096.0 [1]
(2R)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC506309.57 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-[4-(trifluoromethyl)phenyl]phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5039.81 [1]
(2S)-N-[(1S)-2-[4-(1,3-Benzothiazol-5-yl)phenyl]-1-cyanoethyl]-1,4-oxazepane-2-carboxamideIC5063.1 [1]
N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5063.1 [1]
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamideIC50100000.0 [1]
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamideIC50100000.0 [1]
N-[(2-Cyanopyrimidin-4-Yl)methyl]-3-[2-(3,5-Dichlorophenyl)-2-Methylpropanoyl]-4-MethoxybenzamideIC5066000.0 [1]
N-[(2-Cyanopyrimidin-4-yl)methyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamideIC5018000.0 [1]
3-[2-(3,5-Dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]benzamideIC50100000.0 [1]
(2S)-2-[[2-(3,5-Dichlorophenyl)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamideIC50100000.0 [1]
(2S)-2-[[(2S)-2-(3,5-Dichlorophenyl)-2-(ethylamino)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamideIC50100000.0 [1]
(2S)-2-(3,5-Dichlorophenyl)-N-[(3S)-1-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamideIC50100000.0 [1]
(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-olIC50100000.0 [1]
(3S)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]piperidine-3-carboxamideIC5010000.0 [1]
(1S,2R)-2-Amino-N-[(1S)-1-cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamideIC5010000.0 [1]
2-Amino-N-[(1S)-1-cyano-2-[4-(3-cyanophenyl)phenyl]ethyl]cyclohexane-1-carboxamideIC501000.0 [1]
(2S)-N-[(1S)-1-Cyano-2-[4-(4-methyl-3-oxoquinoxalin-6-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamideIC5025.12 [1]
(2R)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]morpholine-2-carboxamideIC5010000.0 [1]
(3R)-N-[(1S)-1-Cyano-2-[4-(4-cyanophenyl)phenyl]ethyl]piperidine-3-carboxamideIC5010000.0 [1]
N-[1-[[(3S)-1-Diazo-2-oxohexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-(4-iodophenyl)benzamideIC50450.0 [1]
(4S,5R)-4-(2,3-Dimethylphenoxy)-6-oxa-1-azabicyclo[3.2.1]octan-7-oneIC5018.0 [1]
cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamideIC5014.0 [1]
(4S,5S)-4-(2,3-Dimethylphenoxy)-6-oxa-1-azabicyclo[3.2.1]octan-7-oneIC501727.0 [1]
(4S,5R)-4-Phenoxy-6-oxa-1-azabicyclo[3.2.1]octan-7-oneIC5029.0 [1]
(4S,5R)-4-Phenylmethoxy-6-oxa-1-azabicyclo[3.2.1]octan-7-oneIC50403.0 [1]
(4S,5R)-4-(2-Methylpropoxy)-6-oxa-1-azabicyclo[3.2.1]octan-7-oneIC50191.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Dipeptidyl peptidase I Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/dipeptidyl-peptidase-i-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Dipeptidyl peptidase I Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dipeptidyl-peptidase-i-inhibitors-ic50-ki.
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