Dihydroorotate dehydrogenase Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Brequinar	IC50	8.0 [1]
	Brequinar	Ki	12.0 [1]
	Teriflunomide	IC50	356.0 [1]
	Teriflunomide	Ki	30.0 [1], 2700.0 [2]
	Brequinar sodium	IC50	8.0 [1], 15.0 [2]
	Brequinar sodium	Ki	12.0 [1]
	2-({2,6-Difluoro-4-[3-(trifluoromethoxy)phenyl]phenyl}carbamoyl)cyclopent-1-ene-1-carboxylic acid	IC50	33.0 [1]
	2-[2,3,5,6-Tetrafluoro-3'-(trifluoromethoxy)-4-biphenylylcarbamoyl]-1-cyclopentene-1-carboxylic acid	IC50	7.0 [1]
	2-(1,1-Difluoroethyl)-5-Methyl-N-[4-(Trifluoromethyl)phenyl][1,2,4]triazolo[1,5-A]pyrimidin-7-Amine	IC50	100000.0 [1]
	2-(4-Biphenylylcarbamoyl)-1-cyclopentene-1-carboxylic acid	IC50	410.0 [1]
	Leflunomide	IC50	10000.0 [1], 13000.0 [2]
	Vidofludimus	IC50	134.0 [1]
	5-Methyl-n-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	200000.0 [1]
	5-Methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	100000.0 [1]
	CID 51347103	IC50	100000.0 [1]
	CID 51347104	IC50	30000.0 [1], 100000.0 [2]
	2-(2,3,5,6-Tetrafluoro-2'-methoxy-4-biphenylylcarbamoyl)-1-cyclopentene-1-carboxylic acid	IC50	8.0 [1]
	3-{[(3-Fluoro-3'-Methoxybiphenyl-4-Yl)amino]carbonyl}thiophene-2-Carboxylic Acid	IC50	44.0 [1]
	Diethyl 2-[(dibenzothiophen-2-ylamino)methylidene]propanedioate	IC50	30000.0 [1]
	Diethyl 2-[(dibenzothiophen-2-ylamino)methylidene]propanedioate	Ki	3630.0 [1]
	Ethyl (Z)-2-cyano-3-[(9-ethylcarbazol-3-yl)amino]prop-2-enoate	IC50	491000.0 [1]
	Ethyl (Z)-2-cyano-3-[(9-ethylcarbazol-3-yl)amino]prop-2-enoate	Ki	60400.0 [1]
	N-[3,5-Difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	1600.0 [1], 2100.0 [2]
	2-(1,1-Difluoroethyl)-N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	2100.0 [1], 2700.0 [2]
	(E)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide	IC50	200.0 [1], 435.0 [2]
	1-{2-[(3-Chloro-4-methylphenyl)amino]-4-methyl-1,3-thiazol-5-yl}ethanone	IC50	930.0 [1], 3937.0 [2]
	2-({[3-Fluoro-3'-(trifluoromethoxy)biphenyl-4-YL]amino}carbonyl)cyclopent-1-ene-1-carboxylic acid	IC50	280.0 [1]
	3-N-Benzyl-1-(4-methoxyphenyl)-5-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide	Ki	26.0 [1], 50000.0 [2]
	1-(4-Chlorophenyl)-5-N-phenyl-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide	Ki	4.0 [1], 50000.0 [2]
	3-Carbamoyl-5-{3-[4-(trifluoromethyl)phenyl]phenyl}benzoic acid	Ki	6000.0 [1], 90000.0 [2]
	3-Carbamoyl-5-[3-(3-methylphenyl)phenyl]benzoic Acid	Ki	3700.0 [1], 50000.0 [2]
	3-[3-(4-Tert-butylphenyl)phenyl]-5-carbamoylbenzoic acid	Ki	4000.0 [1], 90000.0 [2]
	1-(4-Chlorophenyl)-3-N-[(4-methylphenyl)methyl]-5-N-phenylpyrazole-3,5-dicarboxamide	Ki	32.0 [1], 50000.0 [2]
	1-(4-Methoxyphenyl)-3-N-(oxolan-2-ylmethyl)-5-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide	Ki	331.0 [1], 50000.0 [2]
	1-(4-Methoxyphenyl)-5-N-phenyl-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide	Ki	12.0 [1], 5000.0 [2]
	1-(4-Chlorophenyl)-5-N-(4-piperidin-1-ylphenyl)-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide	Ki	8.0 [1], 50000.0 [2]
	5-N-Benzyl-1-(4-methoxyphenyl)-3-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide	Ki	1500.0 [1], 50000.0 [2]
	3-N-Benzyl-5-N-(4-carbamoylphenyl)-1-(4-chlorophenyl)pyrazole-3,5-dicarboxamide	Ki	6.0 [1], 50000.0 [2]
	3-N-Benzhydryl-5-N-benzyl-1-(4-methoxyphenyl)pyrazole-3,5-dicarboxamide	Ki	2400.0 [1], 50000.0 [2]
	1-(4-Methoxyphenyl)-3-N-(2-methylpropyl)-5-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide	Ki	138.0 [1], 50000.0 [2]
	3-N-Benzyl-1-(4-chlorophenyl)-5-N-(2-methylpropyl)pyrazole-3,5-dicarboxamide	Ki	91.0 [1], 50000.0 [2]
	4-Quinolinecarboxylic acid, 2-[1,1'-biphenyl]-4-yl-6-fluoro-3-hydroxy-	IC50	5.0 [1]
	4-Quinolinecarboxylic acid, 2-[1,1'-biphenyl]-4-yl-6-fluoro-3-hydroxy-	Ki	40.0 [1]
	Aslan003	IC50	15.0 [1]
	2-([1,1'-Biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid	IC50	75.4 [1]
	2-([1,1'-Biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid	Ki	1.7 [1]
	5-(Benzimidazol-1-yl)-N-propylthiophene-2-carboxamide	IC50	30000.0 [1]
	2-Biphenyl-4-yl-1H-benzoimidazole-4-carboxylic acid	IC50	750.0 [1], 795.0 [2]
	2-(1,1-Difluoroethyl)-N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	17000.0 [1], 45000.0 [2]
	3-N-Benzyl-1-(4-chlorophenyl)-5-N-phenylpyrazole-3,5-dicarboxamide	Ki	4.0 [1], 50000.0 [2]
	2-[2,3,5,6-Tetrafluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid	IC50	3.0 [1]
	2-[2,5-Difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid	IC50	87.9 [1], 88.0 [2]
	2-[4-(3-Ethoxyphenyl)-2,6-difluoroanilino]pyridine-3-carboxylic acid	IC50	19.0 [1], 19.01 [2]
	2-[4-(3-Cyclobutyloxyphenyl)-2,6-difluoroanilino]pyridine-3-carboxylic acid	IC50	89.95 [1], 90.0 [2]
	2-[2-Chloro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid	IC50	149.97 [1], 150.0 [2]
	3-[4-(3-Ethoxyphenyl)-2-fluoroanilino]pyridine-4-carboxylic acid	IC50	19.0 [1], 19.01 [2]
	3-[4-(3-Methoxyphenyl)-2-(trifluoromethoxy)anilino]pyridine-4-carboxylic acid	IC50	14.0 [1]
	3-[2-Fluoro-4-[3-(trifluoromethoxy)phenyl]anilino]pyridine-4-carboxylic acid	IC50	199.99 [1], 200.0 [2]
	2-[2,6-Difluoro-4-(3-methoxyphenyl)anilino]-5-ethylpyridine-3-carboxylic acid	IC50	11.99 [1], 12.0 [2]
	2-[2-Fluoro-4-(3-methoxyphenyl)-5-methylanilino]pyridine-3-carboxylic acid	IC50	99.0 [1], 99.08 [2]
	2-[2-Fluoro-4-[3-(trifluoromethoxy)phenyl]anilino]-5-methylpyridine-3-carboxylic acid	IC50	109.9 [1], 110.0 [2]
	2-[2,6-Difluoro-4-(3-methoxyphenyl)anilino]-5-methylpyridine-3-carboxylic acid	IC50	11.99 [1], 12.0 [2]
	5-Cyclopropyl-2-[2-fluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid	IC50	32.96 [1], 33.0 [2]
	5-Cyclopropyl-2-[4-(3-cyclopropyloxyphenyl)-2,6-difluoroanilino]pyridine-3-carboxylic acid	IC50	6.0 [1]
	2-(2,6-Difluoro-3-methyl-4-phenylanilino)pyridine-3-carboxylic acid	IC50	5.0 [1]
	2-[4-(3-Cyclopropyloxyphenyl)-2,6-difluoroanilino]pyridine-3-carboxylic acid	IC50	17.0 [1], 17.02 [2]
	2-[2,6-Difluoro-4-(2-fluoro-3-methoxyphenyl)anilino]pyridine-3-carboxylic acid	IC50	52.97 [1], 53.0 [2]
	5-Cyclopropyl-2-[4-(3-ethoxyphenyl)-2,5-difluoroanilino]pyridine-3-carboxylic acid	IC50	23.0 [1], 23.01 [2]
	5-Cyclopropyl-2-[2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]anilino]pyridine-3-carboxylic acid	IC50	4.0 [1]
	5-Chloro-2-(2,6-difluoro-4-phenylanilino)pyridine-3-carboxylic acid	IC50	8.0 [1]
	2-[2,6-Difluoro-4-(2-methylphenyl)anilino]pyridine-3-carboxylic acid	IC50	10.99 [1], 11.0 [2]
	2-[4-(2-Chlorophenyl)-2,6-difluoro-3-methylanilino]pyridine-3-carboxylic acid	IC50	4.0 [1]
	2-[2,6-Difluoro-3-methyl-4-[3-(trifluoromethoxy)phenyl]anilino]pyridine-3-carboxylic acid	IC50	6.0 [1]
	2-[4-(2-Chlorophenyl)-2,6-difluoroanilino]-5-cyclopropylpyridine-3-carboxylic acid	IC50	5.0 [1]
	2-[4-(3-Ethoxyphenyl)-2-fluoroanilino]pyridine-3-carboxylic acid	IC50	199.99 [1], 200.0 [2]
	Cyclosporin A	IC50	50000.0 [1]
	Niflumic acid	IC50	17000.0 [1]
	Atovaquone	IC50	14500.0 [1]
	Clonixin	IC50	13000.0 [1]
	Cinchophen	IC50	144000.0 [1]
	Flunixin	IC50	8000.0 [1]
	3',4'-Dihydroxyflavone	IC50	12380.0 [1]
	CID 51347395	IC50	100000.0 [1]
	2-[(4-Chlorobenzyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one	IC50	39000.0 [1]
	N,N-Dimethyl-N'-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-benzene-1,4-diamine	IC50	100000.0 [1]
	Oxycinchophen	IC50	12000.0 [1]
	2-((4-Methoxyphenyl)amino)benzoic acid	IC50	10000.0 [1]
	N-(3-Chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	100000.0 [1]
	2-Phenylamino-4-Methyl-5-Acetyl Thiazole	IC50	10000.0 [1]
	Ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate	IC50	50000.0 [1]
	2-Benzylsulfanyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol	IC50	89000.0 [1]
	N-(4-Isopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	100000.0 [1]
	N-(3-Fluoro-4-methylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	100000.0 [1]
	N-(4-Chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	100000.0 [1]
	2-[(2-Chlorobenzyl)thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one	IC50	12000.0 [1]
	Ethyl 2-anilino-4-oxo-4,5-dihydro-3-thiophenecarboxylate	IC50	50000.0 [1]
	2-(4-Chloro-phenylamino)-nicotinic acid	IC50	400.0 [1]
	Diethyl 2-(2-toluidinomethylene)malonate	IC50	292200.0 [1]
	5-Methyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine	IC50	200000.0 [1]
	N-(1,3-Benzothiazol-2-yl)-3-methoxybenzamide	IC50	6830.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Dihydroorotate dehydrogenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/dihydroorotate-dehydrogenase-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Dihydroorotate dehydrogenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/dihydroorotate-dehydrogenase-inhibitors-ic50-ki.
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