![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_1cc257bab28d3e85f276bcae9f111347.svg) | Methotrexate | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_1cc257bab28d3e85f276bcae9f111347.svg) | Methotrexate | Ki | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_3f59bab9b954f7e2737294dc8b7f1b51.svg) | Trimethoprim | IC50 | 198000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_3f59bab9b954f7e2737294dc8b7f1b51.svg) | Trimethoprim | Ki | 1380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_567a3300d143a91f2e91ad015695c1c3.svg) | Pemetrexed | IC50 | 6600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_567a3300d143a91f2e91ad015695c1c3.svg) | Pemetrexed | Ki | 7.0 [1], 7.2 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_8055fdb52a0be4690c7a5f93e8cd44e9.svg) | Pyrimethamine | IC50 | 400.0 [1], 2600.0 [2], 4300.0 [3], 6000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_8055fdb52a0be4690c7a5f93e8cd44e9.svg) | Pyrimethamine | Ki | 98.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4487ccdc80108ece5e2c0bb95146f975.svg) | Trimetrexate | IC50 | 12.2 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4487ccdc80108ece5e2c0bb95146f975.svg) | Trimetrexate | Ki | 1.4 [1], 13.0 [2], 83.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_ae4c874a9a276c25ed7f79e6df62c297.svg) | Aminopterin | IC50 | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_ae4c874a9a276c25ed7f79e6df62c297.svg) | Aminopterin | Ki | 0.0 [1], 0.21 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4100a1643488e57996146c3e729610ab.svg) | L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl)-2-propynylamino)benzoyl)- | IC50 | 1900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_5903c60648088a0445f70a793dc35c51.svg) | Piritrexim | IC50 | 2.0 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_5903c60648088a0445f70a793dc35c51.svg) | Piritrexim | Ki | 0.03 [1], 33.0 [2], 38.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_a4bdcd797e506f643ea3e8b9a6a8f166.svg) | N-[4-[2-(2,4-Diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_21912c18acfff53d86afecd09d16be0d.svg) | (2S)-2-[[4-[(2-Amino-6-methyl-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid | IC50 | 2100.0 [1], 2200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_2e69378d2166370d16e0ba0ad150a326.svg) | Iclaprim | IC50 | 8.0 [1], 30000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_2e69378d2166370d16e0ba0ad150a326.svg) | Iclaprim | Ki | 775.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_920b81b3bbb4db433dc698c4655a05db.svg) | 2,4-Diamino-5-(3-methoxybenzyl)pyrimidine | Ki | 9.6 [1], 300.0 [2], 1000.0 [3], 2300.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_5fbf9b804a95a4c8f241ec513eec43bb.svg) | 2,4-Diamino-5-[3-benzyloxybenzyl]pyrimidine | Ki | 11.0 [1], 65.0 [2], 200.0 [3], 1000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_5c613cde25add2682109d112cb93b06f.svg) | 2,4-Diamino-5-[3-octyloxybenzyl]pyrimidine | Ki | 24.0 [1], 97.0 [2], 1130.0 [3], 2400.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_f0ca2d455e9c1e88b37642dfe5448950.svg) | 2,4-Diamino-5-[3-hexyloxybenzyl]pyrimidine | Ki | 9.8 [1], 171.0 [2], 600.0 [3], 1900.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_8ac1dff24a0851fbbbdb0d7322039aff.svg) | 2,4-Diamino-5-[3-butoxybenzyl]pyrimidine | Ki | 3.6 [1], 150.0 [2], 220.0 [3], 930.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_e99bdc9886eec096dce4ec9842a3f739.svg) | 2,4-Diamino-5-[3-heptyloxybenzyl]pyrimidine | Ki | 131.0 [1], 221.0 [2], 620.0 [3], 1330.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_03781c6e4a489df8ad995ca9674a9d93.svg) | Dpmabg | IC50 | 220.0 [1], 450.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4019f8436b1ad1d5d714d47f0c5172bb.svg) | 5-(4-Propoxybenzyl)pyrimidine-2,4-diamine | Ki | 6.4 [1], 230.0 [2], 330.0 [3], 2900.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_e7d520438a653f605e58a1ed4279c96b.svg) | 5-(4-Ethoxybenzyl)pyrimidine-2,4-diamine | Ki | 9.8 [1], 130.0 [2], 210.0 [3], 6000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_b9728eeaf0e56b224276ad70de940d18.svg) | 5-[3-(Nonyloxy)benzyl]pyrimidine-2,4-diamine | Ki | 36.0 [1], 360.0 [2], 990.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_9761d2a003464dda1468b7ec237d48f9.svg) | 5-[3-(Decyloxy)benzyl]pyrimidine-2,4-diamine | Ki | 52.0 [1], 750.0 [2], 2220.0 [3], 3110.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_cc2f646acae0d983cc98394d915ed0f6.svg) | 5-[3-(Heptyloxy)benzyl]-6-methylpyrimidine-2,4-diamine | Ki | 75.0 [1], 370.0 [2], 1000.0 [3], 1500.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_642900592b3fa61eb8248da287565788.svg) | 5-(3-Pentyloxy-benzyl)-pyrimidine-2,4-diamine | Ki | 7.1 [1], 140.0 [2], 210.0 [3], 1100.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_a1d6609a3efe40590deb4d194930c3c2.svg) | 5-(3-Ethoxybenzyl)pyrimidine-2,4-diamine | Ki | 8.6 [1], 156.0 [2], 430.0 [3], 1600.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_ca5f8ae9bc4f3660f0630409a28191c2.svg) | 5-(3-Propoxybenzyl)pyrimidine-2,4-diamine | Ki | 10.5 [1], 130.0 [2], 510.0 [3], 2400.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_71aaeb6944391e9d3dfdd6a16a3bd338.svg) | 5-(3-Isopropoxybenzyl)pyrimidine-2,4-diamine | Ki | 8.8 [1], 23.0 [2], 160.0 [3], 1400.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_12598ff58c47e68b02938c69a838d3d1.svg) | 5-[3-(Tetrahydro-pyran-2-yloxy)-benzyl]-pyrimidine-2,4-diamine | Ki | 13.0 [1], 93.0 [2], 360.0 [3], 1300.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_b2a7ea41316ae8ba3c5ae0d15aa80c04.svg) | 5-[3-(Heptyloxy)benzyl]-6-ethylpyrimidine-2,4-diamine | Ki | 19.0 [1], 48.0 [2], 400.0 [3], 710.0 [4] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_e34a3d0fc9333e4e60b6d0dd8fcf4cff.svg) | 5-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]pyrimidine-2,4-diamine | IC50 | 10.0 [1], 210.0 [2], 30000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_2f807ce3cdf247617b0e9b5411fcc2cf.svg) | Cycloguanil | Ki | 55.6 [1], 410.0 [2], 43000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_617f5a080009c3a412ea5d41fed1f529.svg) | 10-Propargyl-5,8-dideazafolic acid | IC50 | 1900.0 [1], 11000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_9bcc7e03ee41dde7b998baa7d9c957b5.svg) | Epiroprim | IC50 | 200.0 [1], 600000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_9bcc7e03ee41dde7b998baa7d9c957b5.svg) | Epiroprim | Ki | 58.88 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_c204158d3974723f1c05071fdf6b0961.svg) | 2-[[4-Carboxy-4-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid | IC50 | 1.1 [1], 12.2 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_c204158d3974723f1c05071fdf6b0961.svg) | 2-[[4-Carboxy-4-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid | Ki | 0.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_1bb42af0b53c4fc9d34d87146c98b76e.svg) | 2,4-Diamino-5-[3-hydroxybenzyl]pyrimidine | Ki | 750.0 [1], 990.0 [2], 3300.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_b8bd3238a152166a01851e8be5cb0096.svg) | 2,4-Diamino-5-[2-Methoxy-5-(4-Carboxybutyloxy)benzyl]pyrimidine | IC50 | 5000.0 [1], 8000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_3a74d793b6eb50a49dd35340948d3562.svg) | 2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | IC50 | 4.5 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_3a74d793b6eb50a49dd35340948d3562.svg) | 2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | Ki | 0.0 [1], 0.01 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_7ad709930bad7d85c536c140cd005ff3.svg) | 2-(4-((2-Amino-4-hydroxyquinazolin-6-yl) methylthio)benzamido)pentanedioic acid | IC50 | 330.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_e4f31b8b18d5fb12628f02b20bf72002.svg) | 5-[3-(3-Methoxy-5-phenyl-phenyl)but-1-ynyl]-6-methyl-pyrimidine-2,4-diamine | IC50 | 1700.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_ea6ca18e16f6469f80093b814be3b081.svg) | 5-[3-(3-Methoxy-4-phenyl-phenyl)but-1-ynyl]-6-methyl-pyrimidine-2,4-diamine | IC50 | 1420.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_91c3174344e7d7a9a13d254e8b1e0152.svg) | 2-[[4-[(2-Amino-4-oxo-3H-quinazolin-6-yl)methoxy]benzoyl]amino]pentanedioic acid | IC50 | 170.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_96ea36f944afe356955fb9b936d62a21.svg) | Furo[2,3d]pyrimidine antifolate | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_b2aed14e197fd0799db16462677f9291.svg) | 5-[3-(2,5-Dimethoxyphenyl)prop-1-Yn-1-Yl]-6-Ethylpyrimidine-2,4-Diamine | IC50 | 1280.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_c525c4fe26300c10372e953e0210b7bb.svg) | 5-[3-[3-Methoxy-5-(p-tolyl)phenyl]but-1-ynyl]-6-methyl-pyrimidine-2,4-diamine | IC50 | 1400.0 [1], 1410.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_b9b93c51997fc7ea00d9a8a0dc6501d6.svg) | 5-Amino-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanoic acid | IC50 | 1.0 [1], 2.5 [2], 160.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_5111be973896917bbe580032ec3c68d3.svg) | 2,4-Diamino-5-[3-(3-methoxy-5-(2-methylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine | IC50 | 1360.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_bd8e03749a453d7d9062b7a86633d96e.svg) | 5-[3-[3-(2,6-Dimethylphenyl)-5-methoxy-phenyl]but-1-ynyl]-6-methyl-pyrimidine-2,4-diamine | IC50 | 1250.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_3b2a638cd8f8dd0d5d472964bf50f999.svg) | 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-diisopropylphenyl)phenyl)-but-1-ynyl]-6-methylpyrimidine | IC50 | 7200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_e4cad10ed5c2178f2636aef14bb9e20d.svg) | 5-[(3r)-3-(5-Methoxybiphenyl-3-Yl)but-1-Yn-1-Yl]-6-Methylpyrimidine-2,4-Diamine | IC50 | 1360.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_c764e931e62b1911c100ae2005917952.svg) | 2-(4-{[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl)-amino]-methyl}-benzoylamino)-pentanedioic acid | IC50 | 10000.0 [1], 30500.0 [2], 200000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_63f5c5ece76d8bef769849f5ea4d2888.svg) | 5-[(3S)-3-(3-Methoxy-5-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine | IC50 | 1380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_fbf596436e7f11eb4ac997f6634eb41d.svg) | 5-[[(9R)-4-Methoxy-9-methyl-7,9-dihydro-6H-[1,3]dioxolo[4,5-h]isoquinolin-8-yl]methyl]pyrimidine-2,4-diamine | IC50 | 2.8 [1], 9.8 [2], 1200.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_6a22c0caa47e3d324bb8cf29cf04b83e.svg) | 5-[[7-Methoxy-4-(3-nitrophenyl)-3,4-dihydro-1H-isoquinolin-2-yl]methyl]pyrimidine-2,4-diamine | IC50 | 6.0 [1], 56.0 [2], 100000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_85b82f80541aa4df2c1063731bdb0ff8.svg) | 5-[(4,11-Dimethyl-2,4-dihydro-1H-pyrido[4,3-a]carbazol-3-yl)methyl]pyrimidine-2,4-diamine | IC50 | 4.0 [1], 10.0 [2], 85.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_22e351dd15ed27dde040e08cbee69072.svg) | 5-[(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]pyrimidine-2,4-diamine | IC50 | 44.0 [1], 53.0 [2], 670.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_bdbc843e1166c15f6dcffcd4147cc542.svg) | 5-[(7-Chloro-10-methylsulfanyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)methyl]pyrimidine-2,4-diamine | IC50 | 2.0 [1], 31.0 [2], 5200.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_2dc8dff7724e2a76e47c3e4c9868ed50.svg) | 5-[(7-Benzyl-1-methyl-6-phenyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)methyl]pyrimidine-2,4-diamine | IC50 | 450.0 [1], 550.0 [2], 18000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_fe528a70f92ddfcf9691c19c53ba2957.svg) | 5-[[(9S)-4-Methoxy-9-methyl-7,9-dihydro-6H-[1,3]dioxolo[4,5-h]isoquinolin-8-yl]methyl]pyrimidine-2,4-diamine | IC50 | 21.0 [1], 29.0 [2], 520.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_ebd43a9a6d087fe1bb342a8cbdf5e6da.svg) | 5-[[4-(2,4-Dichlorophenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]methyl]pyrimidine-2,4-diamine | IC50 | 7.0 [1], 31.0 [2], 1700.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4220acdf58ad199e11e17a0bba7a30a4.svg) | 5-(1,3,4,9-Tetrahydropyrido[3,4-b]indol-2-ylmethyl)pyrimidine-2,4-diamine | IC50 | 4.0 [1], 47.0 [2], 180000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4aa0c28484a7150de8f22470a8935001.svg) | 2,4-Pyrimidinediamine, 5-[(3,4-dihydro-2(1H)-isoquinolinyl)methyl]- | IC50 | 1100.0 [1], 5500.0 [2], 100000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_1240b95cb8218b3a53e28f7c830fd3da.svg) | 5-[(4-Methoxy-9-methyl-7,9-dihydro-6H-[1,3]dioxolo[4,5-h]isoquinolin-8-yl)methyl]pyrimidine-2,4-diamine | IC50 | 12.0 [1], 24.0 [2], 1400.0 [3] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_3f53ada1766cdeccc391487c0352c435.svg) | Raltitrexed | IC50 | 21000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_a4452a98265632f65b541f104ca7119c.svg) | Edatrexato | IC50 | 2.6 [1], 4.4 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_b87fbeb84bc8dc1082f47dff56d415fd.svg) | 1,3,5-Triazine-2,4-diamine, 1-(3-chlorophenyl)-1,6-dihydro-6,6-dimethyl- | Ki | 93.33 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_246b5db9aa13124f9d3c96193f30ba1d.svg) | 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | Ki | 1.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_49fe5ff748642df2f503ca916d439778.svg) | N6-(2,5-Dimethoxy-benzyl)-N6-methyl-pyrido[2,3-D]pyrimidine-2,4,6-triamine | IC50 | 8500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_cf4a75735019f7bf7084ff3905190fb7.svg) | 5-Methyl-6-(1-naphthylaminomethyl)pyrido[2,3-d]pyrimidine-2,4-diamine | IC50 | 4.3 [1], 100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_5b0fafd26bbca0203bf2f9eb416a0796.svg) | 6-Methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-ynyl]pyrimidine-2,4-diamine | IC50 | 1380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_19e245eef688f87a39575e358f912a4d.svg) | 2-[[4-[[(2-Amino-4-oxo-3H-quinazolin-6-yl)amino]methyl]benzoyl]amino]pentanedioic acid | IC50 | 110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_61d8e97689e81ccdadf80a4775c70a2a.svg) | 3-(2,4-Diamino-6-methylpyrimidin-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol | IC50 | 5710.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_e181c63fc4526373d037d8e8c046a1ae.svg) | 2,4-Diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine | IC50 | 400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_28d315998f3b0a46bc0813fab09db4df.svg) | 2,4-Diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine | IC50 | 1220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_edb225a8db7c7c11cd3f9e223af8b87f.svg) | 5-[(4-Methylphenyl)sulfanyl]-2,4-quinazolinediamine | IC50 | 940.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_e6cd340726464609b473a20f7e01c29a.svg) | 2,4-Diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)pyrimidine | IC50 | 1460.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_342ef2763a6e9ae93e2c99c2d4114f93.svg) | 2,4-Diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)pyrimidine | IC50 | 1160.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_7638d3b489c179cee01beb494f443e32.svg) | 2,4-Diamino-5-(3-(3,4,5-trimethoxyphenyl)but-1-ynyl)pyrimidine | IC50 | 1460.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_fa0dfcc8a2b07fe52214bed58a89bc7a.svg) | 3-(2,4-Diaminopyrimidin-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol | IC50 | 14300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_0d73acb84be8e13d0e96c17eb8613b8e.svg) | 1,3-Diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo(3,2-f)quinazoline | Ki | 0.0 [1], 0.3 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_23d2f983d11a96a03bbfdf31ed3bb544.svg) | 6-Ethyl-5-[3-(3,4,5-Trimethoxyphenyl)prop-1-Yn-1-Yl]pyrimidine-2,4-Diamine | IC50 | 57.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_1e27abf686b544cdd19b4fcde3460fcd.svg) | 5-Phenylsulfanyl-2,4-quinazolinediamine | IC50 | 620.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_2f9884fe4acf2d1bce77b112c27d4938.svg) | 6-N-[(2,5-Dimethoxyphenyl)methyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine | IC50 | 13000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_c7477a7cd0c1dc6e05e4fb39b11be5e9.svg) | 5-[3-[(2,4-Diaminopyrimidin-5-yl)methyl]-4-methoxy-phenyl]pent-4-ynoic acid | IC50 | 5000.0 [1], 30000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_3fe7179eec2b11117ef78c34af2fe6dc.svg) | 6-Methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-ynyl]pyrimidine-2,4-diamine | IC50 | 1380.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_8b1c30c78e88fe930ddb95cd8acbebb7.svg) | 5-[3-(2,5-Dimethoxyphenyl)prop-1-ynyl]-6-methyl-pyrimidine-2,4-diamine | IC50 | 1300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4b8da7a1bb004975af922191167a87e9.svg) | 2-[[4-[(2,4-Diamino-5-chloroquinazolin-6-yl)methylamino]benzoyl]amino]pentanedioic acid | IC50 | 3.8 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_35c41fae9a5c8280317dd9aebd1da397.svg) | 6-N-[(3,4,5-Trimethoxyphenyl)methyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine | IC50 | 76000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_4f409c4e8306fd3bf8a9222a1c1c5aa4.svg) | (2S)-2-[[4-[(2,4-Diamino-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoyl]amino]pentanedioic acid | IC50 | 210.0 [1] |
![](https://images.aatbio.com/dataset/ic50/dihydrofolate-reductase_86a175a32a0307c3d948d8bce5128a5a.svg) | 5-Amino-2-[[4-[(2-amino-5-chloro-4-oxo-3H-quinazolin-6-yl)methylamino]benzoyl]amino]pentanoic acid | IC50 | 430.0 [1] |