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Diacylglycerol O-acyltransferase 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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DGAT-1 inhibitorIC5015.0 [1]
PF-04620110IC5019.0 [1]
CID 42636350IC5010.0 [1], 70.0 [2], 80.0 [3], 430.0 [4]
2-[4-[4-[[5-(3,4-Difluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenyl]cyclohexyl]acetic acidIC500.5 [1], 0.6 [2], 2.0 [3], 36.0 [4]
2-[4-[4-[(5-Benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl]cyclohexyl]acetic acidIC5029.0 [1], 36.0 [2], 578.0 [3]
CID 24768261IC507.0 [1], 7.8 [2], 20.0 [3]
N-[6-[2-Methoxyethyl(methyl)amino]pyridin-3-yl]-2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carboxamideIC5038.0 [1]
2-[4-[4-[[5-[(4-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC50130.0 [1], 131.0 [2], 600.0 [3]
4-[4-[[5-[(3,5-Difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acidIC5011.0 [1], 13.0 [2], 76.0 [3], 160.0 [4]
4-[5-[5-(6-Fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC502.0 [1], 2.5 [2], 10000.0 [3]
4-[5-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC501.7 [1], 3.0 [2], 1093.0 [3], 1232.0 [4]
4-[5-[5-(6-Chloro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC502.0 [1], 2.1 [2], 1344.0 [3], 3528.0 [4]
4-[5-[5-(1H-Benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC504.0 [1], 5.3 [2], 6065.0 [3], 8080.0 [4]
4-[5-[5-(5,6-Difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC501.3 [1], 1.4 [2], 8440.0 [3], 10000.0 [4]
4-[5-[5-(6-Cyano-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC503.2 [1], 6.0 [2], 10000.0 [3]
4-[5-[5-(6-Methylsulfonyl-1H-benzimidazol-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC50101.0 [1], 137.0 [2], 10000.0 [3]
4-[5-[5-(5-Methyl-1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC5032.0 [1], 54.0 [2], 8782.0 [3], 10000.0 [4]
4-[5-[5-(5-Methoxy-1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-yl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC5011.0 [1], 14.0 [2], 2475.0 [3], 4903.0 [4]
4-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperidine-1-carbonyl]cyclohexane-1-carboxylic acidIC5057.0 [1], 82.0 [2], 114.0 [3]
2-[4-[4-[4-(Phenylcarbamoyl)-2,3-dihydro-1,4-benzoxazin-7-yl]phenyl]cyclohexyl]acetic acidIC5052.0 [1], 65.0 [2]
4-[4-[2-(Naphthalene-2-carbonylamino)ethylcarbamoyl]phenoxy]adamantane-1-carboxylic acidIC5034.0 [1], 44.0 [2], 48.0 [3]
4-[4-[2-[(4-Phenylbenzoyl)amino]ethylcarbamoyl]phenoxy]adamantane-1-carboxylic acidIC505.0 [1], 12.0 [2], 25.0 [3]
4-[4-[(5-Benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acidIC5016.0 [1], 28.0 [2], 280.0 [3]
CID 49846226IC503.98 [1], 7.94 [2]
2-(4'-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorobiphenyl-4-yl)acetic acidIC506.31 [1]
3-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]propanoic acidIC5031.0 [1], 31.62 [2], 131.0 [3]
Unii-G3MY6fge1JIC503.0 [1], 4.0 [2]
2-(trans-4-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)cyclohexyl)acetic acidIC508.0 [1], 78.0 [2]
(1R,2R)-2-[4-[3-Fluoro-4-[(6-fluoro-1,3-benzothiazol-2-yl)amino]phenyl]benzoyl]cyclopentane-1-carboxylic acidIC5073.0 [1]
2-[4-[4-[1-(Phenylcarbamoyl)indol-5-yl]phenyl]cyclohexyl]acetic acidIC5037.0 [1]
1-Methylsulfonyl-1'-[5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]spiro[2H-indole-3,4'-piperidine]IC5068.0 [1]
1'-[5-(6-Chloro-1H-benzimidazol-2-yl)pyridin-2-yl]spiro[2-benzofuran-3,4'-piperidine]-1-oneIC5052.0 [1]
4-[1-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]piperidin-4-yl]oxycyclohexane-1-carboxylic acidIC502.5 [1], 3.9 [2]
2-[4-[4-(4-Amino-2,7,7-trimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]acetic acidIC508.0 [1], 30.0 [2]
2-[6-(4-Amino-7,7-dimethylpyrano[2,3-d]pyrimidin-6-yl)spiro[1,2-dihydroindene-3,4'-cyclohexane]-1'-yl]acetic acidIC509.0 [1], 13.0 [2]
2-[4-[4-(4-Amino-7,7-dimethylpyrano[2,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acidIC508.0 [1], 50.0 [2]
2-[(2R)-2-Ethyl-1-oxo-6-[4-[[3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-3,4-dihydronaphthalen-2-yl]acetic acidIC50126.0 [1], 251.0 [2]
4-[4-[(5-Anilino-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acidIC503.0 [1], 4.0 [2]
2-[(2S)-6-[4-[(4-Chlorophenyl)carbamoylamino]phenyl]-2-ethyl-1-oxo-3,4-dihydronaphthalen-2-yl]acetic acidIC502.0 [1], 8.0 [2]
4-[4-[4-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperazine-1-carbonyl]cyclohexane-1-carboxylic acidIC5077.0 [1], 277.0 [2]
2-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetonitrileIC5041.0 [1], 64.0 [2]
6-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)spiro[1,2-dihydroindene-3,4'-cyclohexane]-1'-carboxylic acidIC50170.0 [1], 240.0 [2]
2-[4-[4-[[5-(2-Phenylethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5070.0 [1], 590.0 [2]
2-[4-[4-[[5-[2-(4-Fluorophenyl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5066.0 [1], 173.0 [2]
2-[4-[4-[[5-[3-(4-Fluorophenyl)propyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5050.0 [1], 181.0 [2]
2-[4-[4-[[5-[(4-Fluorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5044.0 [1], 91.0 [2]
2-[4-[4-[[5-(Cyclopentylmethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5024.0 [1], 33.0 [2]
2-[4-[4-[[5-(Cyclopentyloxymethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5038.0 [1], 66.0 [2]
4-Amino-6-(4-tert-butylphenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5043.0 [1], 134.0 [2]
2-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acidIC5060.0 [1], 71.0 [2]
2-[4-[4-[[5-[(4-Methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC50142.0 [1], 728.0 [2]
2-[4-[4-[[5-(2-Cyclopentylethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5012.0 [1], 19.0 [2]
2-[4-[4-[[5-(Phenoxymethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5047.0 [1], 107.0 [2]
2-[4-[4-[(5-Phenyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl]cyclohexyl]acetic acidIC5085.0 [1], 588.0 [2]
4-[5-[(5-Benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC5045.0 [1], 135.0 [2]
4-[5-[[5-[(3-Chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]pyridin-2-yl]oxycyclohexane-1-carboxylic acidIC5055.0 [1], 85.0 [2]
4-[4-[[5-(Cyclopentyloxymethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acidIC5012.0 [1], 17.0 [2]
4-[4-[[5-(Cyclopentylamino)-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acidIC509.0 [1], 22.0 [2]
3-[5-[2-Ethyl-4-(phenylcarbamoyl)-2,3-dihydro-1,4-benzoxazin-7-yl]pyridin-2-yl]oxy-2,2-dimethylpropanoic acidIC50100.0 [1], 131.0 [2]
2,2-Dimethyl-3-(5-(2-methyl-4-(phenylcarbamoyl)quinolin-7-yl)pyridin-2-yloxy)propanoic acidIC50275.0 [1]
Ethyl 6-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylateIC5019.0 [1], 48.0 [2]
Ethyl 6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylateIC5030.0 [1], 48.0 [2]
Methyl 4-[4-[[2-phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]phenyl]piperidine-1-carboxylateIC5084.0 [1], 500.0 [2]
Ethyl 6-(3-cyclohexyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylateIC5031.0 [1], 56.0 [2]
Ethyl 7-(2-hydroxyethyl)-6-[3-(2-hydroxyethyl)-1,2,4-oxadiazol-5-yl]-2-morpholin-4-yl-4-phenylpyrrolo[1,2-b]pyridazine-5-carboxylateIC50180.0 [1], 260.0 [2]
Ethyl 2-morpholin-4-yl-4-phenyl-6-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylateIC5051.0 [1], 57.0 [2]
Ethyl 6-(3-butyl-1,2,4-oxadiazol-5-yl)-2-morpholin-4-yl-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylateIC5069.0 [1], 73.0 [2]
Ethyl 2-morpholin-4-yl-4-phenyl-6-(3-phenyl-1,2,4-oxadiazol-5-yl)-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylateIC50180.0 [1], 200.0 [2]
Ethyl 2-morpholin-4-yl-4-phenyl-7-propyl-6-(3-pyrrolidin-1-yl-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazine-5-carboxylateIC50100.0 [1]
2-[4-[4-[(6S)-4-Amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetic acidIC5010.0 [1], 34.0 [2]
4-[4-[[3-[(3,5-Difluorophenyl)methyl]-1,2,4-oxadiazol-5-yl]carbamoyl]phenoxy]cyclohexane-1-carboxylic acidIC50120.0 [1], 310.0 [2]
2-[4-[4-[(6S)-4-Amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetonitrileIC50175.0 [1], 249.0 [2]
2-[4-[4-(4-Amino-6-methyl-7H-[1,4]dioxino[2,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acidIC50245.0 [1], 735.0 [2]
2-[4-[4-[(6R)-4-Amino-6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidin-6-yl]phenyl]cyclohexyl]acetic acidIC5018.0 [1], 77.0 [2]
2-[4-[4-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]phenyl]cyclohexyl]acetic acidIC503.5 [1], 293.0 [2]
2-[4-[4-[5-(6-Chloro-1H-benzimidazol-2-yl)pyridin-2-yl]phenyl]cyclohexyl]acetic acidIC501.1 [1], 167.0 [2]
2-[4-[4-[[5-[(3-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5030.0 [1], 46.0 [2]
2-[4-[4-[[5-[(2-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5035.0 [1], 45.0 [2]
2-[4-[4-[[5-[(3-Chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl]cyclohexyl]acetic acidIC5030.0 [1], 57.0 [2]
2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]cyclohexyl]acetic acidIC5060.0 [1], 120.0 [2]
2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorophenyl]cyclohexyl]acetic acidIC5030.0 [1], 70.0 [2]
2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]phenyl]acetic acidIC50630.96 [1]
2-[4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorophenyl]phenyl]acetic acidIC50100.0 [1]
[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]methanesulfonamideIC5020.0 [1], 90.0 [2]
7,7-Dimethyl-6-[4-[4-(2H-tetrazol-5-ylmethyl)cyclohexyl]phenyl]pyrimido[4,5-b][1,4]oxazin-4-amineIC507.0 [1], 2500.0 [2]
2-[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]acetamideIC5015.0 [1], 70.0 [2]
2-[4-[4-(4-Amino-2,7,7-trimethylpyrano[2,3-d]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acidIC5050.0 [1], 1000.0 [2]
3-[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]propanoic acidIC506.0 [1], 100.0 [2]
4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexan-1-olIC5050.0 [1], 180.0 [2]
2-[4-[4-[4-Amino-7,7-dimethyl-2-(trifluoromethyl)pyrimido[4,5-b][1,4]oxazin-6-yl]phenyl]cyclohexyl]acetic acidIC505.0 [1], 60.0 [2]
2-[4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]phenyl]acetic acidIC506.0 [1], 3000.0 [2]
6-(4-Cyclohexylphenyl)-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-4-amineIC5060.0 [1], 390.0 [2]
4-[4-(4-Amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexane-1-carboxylic acidIC5010.0 [1], 120.0 [2]
6-[4-(4,4-Difluorocyclohexyl)phenyl]-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-4-amineIC5060.0 [1], 470.0 [2]
4-Amino-6-[4-[4-(2H-tetrazol-5-ylmethyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5076.0 [1], 774.0 [2]
2-[4-[4-[(8R)-4-Amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl]phenyl]cyclohexyl]acetic acidIC508.0 [1], 19.0 [2]
4-Amino-6-[4-[4-(2-hydroxy-2-methylpropyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5025.0 [1], 54.0 [2]
4-Amino-6-[4-[4-(2-amino-2-methylpropyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5040.0 [1], 70.0 [2]
4-Amino-6-[4-[4-(2-oxo-2-pyrrolidin-1-ylethyl)cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5045.0 [1], 110.0 [2]
4-Amino-6-[4-[4-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]cyclohexyl]phenyl]-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-oneIC5023.0 [1], 60.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Diacylglycerol O-acyltransferase 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/diacylglycerol-o-acyltransferase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Diacylglycerol O-acyltransferase 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/diacylglycerol-o-acyltransferase-1-inhibitors-ic50-ki.
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