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Delta(24)-sterol reductase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(4R)-4-[(3S,8S,9S,10R,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-N,N-dimethylpentanamideIC500.7 [1]
Chembl4174848IC502.5 [1]
[(2S)-2-[(3S,5S,9R,10S,13R,14R,17R)-3-Acetyloxy-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl] (E)-2-methylbut-2-enoateIC50203.0 [1]
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-(Methoxyamino)-1-oxopropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetateIC50805.0 [1]
[(3S,5S,9R,10S,13R,14R,17R)-10,13-Dimethyl-17-[(2S)-1-(propanoylamino)propan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetateIC5016900.0 [1]
(3S,5S,9R,10S,13R,14R,17R)-10,13-Dimethyl-17-[(E,2R)-4-(1-methylpyridin-1-ium-4-yl)but-3-en-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;iodideIC502.9 [1]
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-Formyloxypropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetateIC504.2 [1]
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-Aminopropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetateIC50198.0 [1]
[(2S)-2-[(3S,5S,9R,10S,13R,14R,17R)-3-Acetyloxy-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl] (E)-but-2-enoateIC506.3 [1]
(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-Hydroxypropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-olIC500.1 [1]
[(3S,5S,9R,10S,13R,14R,17R)-17-[(2S)-1-Hydroxypropan-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetateIC503.3 [1]
[(2S)-2-[(3S,5S,9R,10S,13R,14R,17R)-3-Acetyloxy-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl] 2-(dimethylamino)acetateIC505.5 [1]
[(3S,5S,9R,10S,13R,14R,17R)-10,13-Dimethyl-17-[(2S)-1-(methylamino)-1-oxopropan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetateIC50823.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Delta(24)-sterol reductase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/delta-24-sterol-reductase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Delta(24)-sterol reductase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/delta-24-sterol-reductase-inhibitors-ic50-ki.
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