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D-3-phosphoglycerate dehydrogenase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
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▼
Standard Values (in nM)
▲
▼
Ethanone, 2-(morpholin-4-yl)-1-phenyl-2-thioxo-IC5030900.0 [1]
Ethanone, 2-(morpholin-4-yl)-1-phenyl-2-thioxo-Ki27000.0 [1], 40000.0 [2]
1-(4-Fluorophenyl)-2-morpholino-2-thioxoethanoneIC5043300.0 [1], 64400.0 [2], 68900.0 [3], 100000.0 [4]
2-Morpholino-1-(4-nitrophenyl)-2-thioxoethanoneIC506000.0 [1], 7600.0 [2], 17600.0 [3], 22800.0 [4], 35100.0 [5]
1-(4-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC507100.0 [1], 9300.0 [2], 19600.0 [3], 25700.0 [4], 177700.0 [5]
1-(3-Chlorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50100000.0 [1], 200000.0 [2]
1-(2-Chlorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50100000.0 [1], 200000.0 [2]
1-(4-Chlorophenyl)-2-morpholino-2-thioxoethan-1-oneIC506600.0 [1], 8700.0 [2], 15500.0 [3], 21000.0 [4], 50500.0 [5]
4-Chloro-N-(2-nitrophenyl)benzamideIC5057500.0 [1], 75200.0 [2], 83000.0 [3], 100000.0 [4]
1-(4-Bromophenyl)-2-morpholino-2-thioxoethanoneIC507900.0 [1], 16900.0 [2], 20400.0 [3], 37200.0 [4], 130700.0 [5]
(3,4-Dichlorophenyl)(morpholino)methanethioneIC505600.0 [1], 7000.0 [2], 16000.0 [3], 19100.0 [4], 24300.0 [5]
N-(4-Methylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC505400.0 [1], 14100.0 [2], 15300.0 [3], 17200.0 [4]
Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylateIC507000.0 [1], 33000.0 [2]
CID 118796328IC502500.0 [1]
N-(4,6-Dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamideIC503700.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC506300.0 [1], 6500.0 [2]
3-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC5050000.0 [1]
5-(2-Hydroxyphenyl)-N-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxamideIC50100000.0 [1]
PHGDH-inactiveIC5057000.0 [1]
N-(3-Methylphenyl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC5057000.0 [1]
4-[(1S)-1-[[5-Chloro-6-[2-(2-hydroxyethylamino)-2-oxoethoxy]-1H-indole-2-carbonyl]amino]-2-hydroxyethyl]benzoic acidIC501400.0 [1]
N-Pyridin-2-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC506800.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[6-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamideIC5011000.0 [1]
4-[3-(Trifluoromethyl)phenyl]-N-[4-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamideIC506400.0 [1]
N-Pyridin-4-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC5014000.0 [1]
N-Quinolin-2-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC5010000.0 [1]
Methyl 2-[[4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioyl]amino]pyridine-4-carboxylateIC5013000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine-1-carbothioamideIC505300.0 [1]
5-(2-Hydroxyphenyl)-N-[4-(piperidin-1-ylsulfonyl)phenyl]-1H-pyrazole-3-carboxamideIC50100000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-pyridin-2-ylpiperazine-1-carbothioamideIC5037000.0 [1]
N-Pyridin-3-yl-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC508900.0 [1]
N-(4-Methylpyrimidin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC5037000.0 [1]
N-(4-Methylquinolin-2-yl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC5021000.0 [1]
N-[4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl]-3-phenyl-1H-pyrazole-5-carboxamideIC5050000.0 [1]
4-Methyl-3-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC50100000.0 [1]
3-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1,2-oxazole-5-carboxamideIC50100000.0 [1]
3-(2-Aminopyridin-3-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC50100000.0 [1]
N-[4-[Methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-3-phenyl-1H-pyrazole-5-carboxamideIC50100000.0 [1]
2-[5-[[4-(Pyrimidin-2-ylsulfamoyl)phenyl]carbamoyl]-1H-pyrazol-3-yl]benzoic acidIC50100000.0 [1]
3-Phenyl-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC5050000.0 [1]
2-Methyl-5-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]pyrazole-3-carboxamideIC5050000.0 [1]
3-(2-Methoxyphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC5050000.0 [1]
3-(2-Fluorophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC5050000.0 [1]
Chembl4128162IC5050000.0 [1]
Chembl4125915IC5010000.0 [1]
Chembl4128958IC5021000.0 [1]
Chembl4125786IC508700.0 [1]
Chembl4127077IC5033000.0 [1]
2-Morpholin-4-yl-1-(3-nitrophenyl)-2-sulfanylideneethanoneIC5088100.0 [1]
1-(2-Bromophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50160700.0 [1]
1-(3-Fluorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50200000.0 [1]
2-Morpholin-4-yl-1-(2-nitrophenyl)-2-sulfanylideneethanoneIC50200000.0 [1]
1-(3-Bromophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50200000.0 [1]
1-(2-Fluorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50200000.0 [1]
2-Morpholin-4-yl-1-(4-phenylphenyl)-2-sulfanylideneethanoneIC50200000.0 [1]
1-(3-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50200000.0 [1]
1-(2-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanoneIC50200000.0 [1]
Chembl4127715IC5031000.0 [1]
Chembl4127154IC508300.0 [1]
Chembl4125702IC505800.0 [1]
Chembl4126631IC509900.0 [1]
Chembl4128967IC5012000.0 [1]
Chembl4127244IC5019000.0 [1]
Chembl4129229IC505700.0 [1]
Chembl4125871IC506300.0 [1]
Chembl4129573IC5041000.0 [1]
Chembl4128626IC5022000.0 [1]
Chembl4126125IC5030000.0 [1]
Chembl4128755IC5020000.0 [1]
Chembl4130080IC5020000.0 [1]
Chembl4126815IC5017000.0 [1]
Chembl4126283IC5026000.0 [1]
Chembl4127255IC5015000.0 [1]
Chembl4125843IC5040000.0 [1]
Chembl4129970IC5039000.0 [1]
Chembl4128606IC5038000.0 [1]
Chembl4128309IC509200.0 [1]
Chembl4127362IC5011000.0 [1]
Chembl4128834IC5011000.0 [1]
Chembl4127018IC506500.0 [1]
Chembl4128252IC5011000.0 [1]
Chembl4129623IC5010000.0 [1]
Chembl4126002IC507200.0 [1]
Chembl4128391IC507700.0 [1]
Chembl4130136IC5017000.0 [1]
2,4-Dihydroxy-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylidene]benzohydrazideIC5034800.0 [1]
3-(2-Hydroxyphenyl)-N-[4-[methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-1H-pyrazole-5-carboxamideIC50100000.0 [1]
1-(3-Phenyl-1H-pyrazole-5-carbonyl)-N-pyrimidin-2-yl-2,3,3a,7a-tetrahydroindole-5-sulfonamideIC50100000.0 [1]
3-(2-Hydroxyphenyl)-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC50100000.0 [1]
N-[4-(Furan-2-ylmethylsulfamoyl)phenyl]-3-(2-hydroxyphenyl)-1H-pyrazole-5-carboxamideIC50100000.0 [1]
3-(2-Hydroxyphenyl)-N-[4-(3-morpholin-4-ylpropylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamideIC50100000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[1-[4-(trifluoromethyl)phenyl]ethyl]piperazine-1-carbothioamideIC508000.0 [1]
1-(4,6-Dimethylpyridin-2-yl)-3-[2-[[4-(trifluoromethyl)phenyl]methylamino]ethyl]thioureaIC509700.0 [1]
1-(4,6-Dimethylpyridin-2-yl)-3-[2-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]ethyl]thioureaIC5021000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[4-(trifluoromethyl)phenyl]piperazine-1-carbothioamideIC504300.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[2-[4-(trifluoromethyl)phenyl]ethyl]piperazine-1-carbothioamideIC5023000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-pyridin-3-ylpiperazine-1-carbothioamideIC5050000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methylamino]piperidine-1-carbothioamideIC5015000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-(4-methoxyphenyl)piperazine-1-carbothioamideIC5016000.0 [1]
N-(4,6-Dimethylpyridin-2-yl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-diazepane-1-carbothioamideIC507300.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ D-3-phosphoglycerate dehydrogenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/d-3-phosphoglycerate-dehydrogenase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ D-3-phosphoglycerate dehydrogenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/d-3-phosphoglycerate-dehydrogenase-inhibitors-ic50-ki.
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