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Cytochrome P450 3A4 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
KetoconazoleIC5057.0 [1]
KetoconazoleKi25.12 [1]
DiltiazemIC5080000.0 [1]
DiltiazemKi100.0 [1]
Amg-487IC509200.0 [1]
RitonavirIC50100.0 [1]
RitonavirKi100.0 [1], 170.0 [2]
XolegelIC50136.0 [1]
NizoralIC501260.0 [1]
Bms-536924IC50500.0 [1]
Cyclosporin AIC506500.0 [1], 6600.0 [2], 10000.0 [3]
Cyclosporin AKi300.0 [1], 890.0 [2], 7600.0 [3]
FluconazoleIC5010000.0 [1]
alpha-NaphthoflavoneIC5010000.0 [1]
AbirateroneIC502700.0 [1]
(S)-N-[1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamideIC5033000.0 [1]
N-[(1R)-1-[3-(4-Hydroxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamideIC5027.0 [1], 68.0 [2], 650.0 [3], 2100.0 [4]
N-[(1R)-1-[3-(4-Hydroxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamideKi730.0 [1], 740.0 [2]
VerapamilIC504700.0 [1], 8193.0 [2], 12000.0 [3], 17600.0 [4], 76032.63 [5]
ClotrimazoleIC5020.0 [1], 50.0 [2], 100.0 [3], 300.0 [4], 500000.0 [5]
TroleandomycinIC507998.34 [1], 16000.0 [2], 20000.0 [3], 33000.0 [4], 61000.0 [5]
GingerolIC5021800.0 [1], 32000.0 [2], 37400.0 [3], 42900.0 [4], 73400.0 [5]
SaxagliptinIC5050000.0 [1], 100000.0 [2]
4-(8-Fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC506700.0 [1], 7800.0 [2], 26000.0 [3], 40000.0 [4]
3-[5-[(4Ar,7aR)-2-amino-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxo-5,7-dihydro-4aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophen-3-yl]benzonitrileIC501200.0 [1], 1900.0 [2], 30000.0 [3]
NifedipineIC505620.0 [1], 10000.0 [2], 11000.0 [3], 46989.41 [4]
ErythromycinIC50190.0 [1], 1900.0 [2], 33000.0 [3], 132129.56 [4]
CimetidineIC5010000.0 [1], 15000.0 [2], 1000000.0 [3]
IndinavirIC50150.0 [1]
MiconazoleIC50180.0 [1], 851.14 [2], 5000.0 [3]
PosaconazoleIC5050.0 [1], 75.0 [2], 82.0 [3], 350.0 [4]
4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydrochlorideIC5028000.0 [1], 100000.0 [2]
MibefradilIC50130.0 [1], 300.0 [2], 470.0 [3], 140000.0 [4]
NefazodoneIC5015.0 [1], 1500.0 [2], 10000.0 [3]
DolutegravirIC5033000.0 [1], 54000.0 [2], 65000.0 [3], 100000.0 [4]
(10)-GingerolIC507100.0 [1], 20800.0 [2], 21800.0 [3], 24900.0 [4]
ShogaolIC504000.0 [1], 8300.0 [2], 65200.0 [3], 77700.0 [4]
DesethylamodiaquineIC5024000.0 [1], 100000.0 [2]
2-PhenylimidazoleIC5010000.0 [1], 500000.0 [2]
4-PhenylimidazoleIC501500.0 [1], 58800.0 [2]
1-PhenylimidazoleIC501000.0 [1], 52500.0 [2]
ClimbazoleIC50100.0 [1], 47500.0 [2]
ParadolIC5030000.0 [1]
(8)-GingerolIC508100.0 [1], 8700.0 [2], 10500.0 [3], 11600.0 [4]
MK-7246IC507000.0 [1], 34000.0 [2]
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3,5-dihydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileIC50200000.0 [1]
VericiguatIC5050000.0 [1]
2,3-Dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamideIC503800.0 [1], 3900.0 [2]
7-Methoxy-N-[[6-(3-methyl-1,2-thiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-1,5-naphthyridin-4-amineIC5026000.0 [1], 50000.0 [2]
AuglurantIC5030000.0 [1], 133000.0 [2], 200000.0 [3]
(3R)-N-Isoquinolin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amineIC5040000.0 [1]
6-[2-[4-(2-Methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamideIC509000.0 [1], 88000.0 [2], 100000.0 [3]
7-Methoxy-4-[[6-(3,4,5-trifluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methoxy]quinolineIC502000.0 [1], 29000.0 [2]
2-(4-Fluorophenyl)-N-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-1-methylbenzimidazol-4-amineIC502900.0 [1], 8700.0 [2]
LinaprazanIC508400.0 [1], 9000.0 [2], 12000.0 [3], 14000.0 [4]
[3-[4-[[(3S,5R)-3,5-Dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanoneIC501400.0 [1], 20000.0 [2], 100000.0 [3]
N-[(2R)-3-(1H-Indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC504000.0 [1], 40000.0 [2]
(S,E)-N-(1-(4-Fluoro-3-morpholinophenyl)ethyl)-3-(4-fluorophenyl)acrylamideIC5018000.0 [1], 19000.0 [2], 21000.0 [3]
1-(3-(2-(4-(2-Methyl-5-quinolinyl)-1-piperazinyl)ethyl)phenyl)-2-imidazolidinoneIC5021000.0 [1], 67000.0 [2]
(2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamideIC505000.0 [1], 31000.0 [2], 62000.0 [3], 89000.0 [4]
N-[(2R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamideIC506000.0 [1], 36000.0 [2]
(1s,2s)-N-[4-(Phenylsulfonyl)phenyl]-2-(Pyridin-3-Yl)cyclopropanecarboxamideIC5090.0 [1], 680.0 [2]
N-[[4-(6-Methylpyridin-3-yl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamideIC5010000.0 [1]
N-[[5-(1-Propan-2-ylpyrazol-4-yl)sulfonylpyridin-2-yl]methyl]furo[2,3-c]pyridine-2-carboxamideIC5010000.0 [1]
N-Methyl-6-[2-[4-(2-methylquinolin-5-yl)piperazin-1-yl]ethyl]-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamideIC509000.0 [1], 82000.0 [2], 100000.0 [3]
Ethyl 4-[10-[4-[2-[(6S,10R,17S)-17-hydroxy-10-methyl-3-oxo-2,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]acetyl]oxybutyl]-2,4-dioxopyrimido[4,5-b]quinolin-3-yl]butanoateIC501000.0 [1], 1100.0 [2], 2500.0 [3], 4100.0 [4]
2-(3-Pyridyl)-2-(4-chlorophenyl)-1-[4-[4-(trifluoromethyl)phenyl]piperazino]ethanoneIC501200.0 [1], 7400.0 [2], 16000.0 [3], 20000.0 [4]
QuercetinIC502110.0 [1], 20000.0 [2]
VoriconazoleIC5013000.0 [1]
SporanoxIC5032.6 [1], 50.4 [2], 70.0 [3]
MetyraponeIC503000.0 [1], 4931.74 [2]
ArtemisinineIC5050000.0 [1]
ArtemisinineKi25000.0 [1]
NicardipineIC50380.0 [1], 420.0 [2], 30000.0 [3]
AlosetronIC50600.0 [1]
1-MethylimidazoleIC5010000.0 [1], 2697739.43 [2]
2-MethylimidazoleIC5010000.0 [1], 1253141.17 [2]
LiarozoleIC50100.0 [1], 690.0 [2]
BrivanibIC5018000.0 [1], 40000.0 [2]
MetaproKi58000.0 [1], 287000.0 [2], 403000.0 [3]
CID 57345320IC5012000.0 [1], 20000.0 [2]
7-(4-Fluorobenzyloxy)-2,3-dimethyl-1-[(1S,2S)-2-methylcyclopropylmethyl]pyrrolo[2,3-d]pyridazineIC5056.23 [1], 6000.0 [2], 14000.0 [3]
[1-[(2R,6R)-1-(4-Chlorophenyl)sulfonyl-6-ethylpiperidin-2-yl]cyclopropyl] 4-(1-hydroxy-2-methylpropan-2-yl)piperazine-1-carboxylateIC502000.0 [1], 2200.0 [2]
3-[(2R)-2-Amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dioneIC50100.0 [1]
Benzamide, 2,3-dichloro-N-(2-methylpropyl)-N-(3S)-3-pyrrolidinyl-IC5030000.0 [1]
1-Cyano-3-(2-methyl-1-benzofuran-5-yl)-2-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidineIC5018500.0 [1], 40000.0 [2], 200000.0 [3]
Bms-344577IC5039000.0 [1], 40000.0 [2], 200000.0 [3]
(5-Pyrid-3-ylthien-2-YL)methylamineIC5056990.0 [1], 58700.0 [2]
(5-Pyrid-3-ylthien-2-YL)methylamineKi29400.0 [1]
4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acidIC5036000.0 [1], 39810.72 [2]
(5-(Pyridin-3-YL)furan-2-YL)methanamineIC5047100.0 [1], 47170.0 [2]
(5-(Pyridin-3-YL)furan-2-YL)methanamineKi23600.0 [1]
4-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-(6-imidazol-1-yl-4-methyl-1H-benzimidazol-2-yl)-1H-pyridin-2-oneIC5018.0 [1], 46.0 [2]
Unii-37IS6K16XEIC504600.0 [1], 7200.0 [2], 8800.0 [3]
3-(1H-Imidazol-4-yl)pyridineIC50139900.0 [1]
3-(1H-Imidazol-4-yl)pyridineKi70000.0 [1]
(3R,4S)-N-[[3-Bromo-5-(3-methoxypropyl)-4-methylphenyl]methyl]-N-cyclopropyl-4-(1-methyl-2-oxopyridin-4-yl)piperidine-3-carboxamideIC506500.0 [1], 16000.0 [2], 20000.0 [3]
Antihistamine-1IC505000.0 [1]
N-[(6Ar,8R,10aS)-10a-(4-chlorophenyl)sulfonyl-1,4-difluoro-6,6a,7,8,9,10-hexahydrobenzo[c]chromen-8-yl]-1,1,1-trifluoromethanesulfonamideIC503500.0 [1], 9600.0 [2], 30000.0 [3]
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-IC50261900.0 [1], 262000.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 3A4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/cytochrome-p450-3a4-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Cytochrome P450 3A4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-3a4-inhibitors-ic50-ki.
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