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Cytochrome P450 3A4/3A5 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
N-[4-(Aminomethyl)-1,3-thiazol-2-yl]-2-benzyl-5-tert-butylpyrazole-3-carboxamideIC5030000.0 [1]
alpha-(4-Chlorophenyl)-alpha-(2-chlorophenyl)pyridine-3-methanolIC50600.0 [1]
4-[4-(Trifluoromethyl)-alpha-hydroxy-alpha-(3-pyridyl)benzyl]benzonitrileIC507600.0 [1]
1-[(4-Chloro-2-fluorophenyl)-pyridin-3-ylmethyl]-4-methylsulfonylpiperazineIC501300.0 [1]
3-Fluoro-4-[hydroxy-pyridin-3-yl-[4-(trifluoromethyl)phenyl]methyl]benzonitrileIC504100.0 [1]
2-[4-[(3S)-3-[[(1R)-1-Naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid;dihydrochlorideIC5050000.0 [1]
2-[[4-(2-Methoxyphenyl)piperazin-1-yl]-[4-(trifluoromethyl)phenyl]methyl]pyrazineIC5025000.0 [1]
Tert-butyl 4-[(4-chloro-2-fluorophenyl)-pyrimidin-5-ylmethyl]piperazine-1-carboxylateIC502900.0 [1]
1-[4-[(4-Chloro-2-fluorophenyl)-pyrimidin-5-ylmethyl]piperazin-1-yl]-2,2-dimethylpropan-1-oneIC507000.0 [1]
1-[4-[(4-Chlorophenyl)-pyridin-3-ylmethyl]piperazin-1-yl]ethanoneIC507400.0 [1]
(4-Chlorophenyl)-(4-propan-2-yloxyphenyl)-pyridin-3-ylmethanolIC501900.0 [1]
[4-[(4-Chloro-2-fluorophenyl)-pyridin-3-ylmethyl]piperazin-1-yl]-cyclohexylmethanoneIC503900.0 [1]
1-[(4-Chlorophenyl)-pyridin-3-ylmethyl]-4-propan-2-ylsulfonylpiperazineIC50810.0 [1]
1-[[2-Fluoro-4-(trifluoromethyl)phenyl]-pyridin-3-ylmethyl]-4-methylsulfonylpiperazineIC501000.0 [1]
(4-Propan-2-yloxyphenyl)-pyridin-3-yl-[4-(trifluoromethyl)phenyl]methanolIC501400.0 [1]
[4-[(4-Chloro-2-fluorophenyl)-pyridin-3-ylmethyl]piperazin-1-yl]-cyclopropylmethanoneIC501800.0 [1]
Tert-butyl 4-[(4-chloro-2-fluorophenyl)-pyridin-3-ylmethyl]piperazine-1-carboxylateIC501900.0 [1]
(4-Chloro-2-fluorophenyl)-(2-propan-2-yloxypyrimidin-5-yl)-pyridin-3-ylmethanolIC504400.0 [1]
1-[(4-Chlorophenyl)-pyridin-3-ylmethyl]-4-methylsulfonylpiperazineIC503600.0 [1]
4-[(4-Chloro-2-fluorophenyl)-pyrimidin-5-ylmethyl]-N-(4-chlorophenyl)piperazine-1-carboxamideIC50300.0 [1]
3-[(4-Chlorophenyl)-hydroxy-pyridin-3-ylmethyl]benzamideIC502600.0 [1]
2,2-Dimethyl-1-[4-[pyridin-3-yl-[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]propan-1-oneIC502300.0 [1]
1-(Benzenesulfonyl)-4-[(4-chlorophenyl)-pyridin-3-ylmethyl]piperazineIC501900.0 [1]
1-[4-[(4-Chloro-2-fluorophenyl)-pyridin-3-ylmethyl]piperazin-1-yl]-2,2-dimethylpropan-1-oneIC501000.0 [1]
1-[4-[[2-Fluoro-4-(trifluoromethyl)phenyl]-pyridin-3-ylmethyl]piperazin-1-yl]-2,2-dimethylpropan-1-oneIC503900.0 [1]
(4-Chloro-2-fluorophenyl)-(4-propan-2-yloxyphenyl)-pyridin-3-ylmethanolIC501100.0 [1]
(4-Chloro-2-fluorophenyl)-pyridin-3-yl-[4-(trifluoromethyl)phenyl]methanolIC501400.0 [1]
(4-Chloro-2-fluorophenyl)-(4-chlorophenyl)-pyridin-3-ylmethanolIC50900.0 [1]
(4-Chlorophenyl)-pyridin-3-yl-pyrimidin-5-ylmethanolIC505000.0 [1]
3-[(4-Chloro-2-fluorophenyl)-hydroxy-pyridin-3-ylmethyl]benzamideIC503900.0 [1]
N-Tert-butyl-4-[(4-chloro-2-fluorophenyl)-pyrimidin-5-ylmethyl]piperazine-1-carboxamideIC506900.0 [1]
5-[[2-Fluoro-4-(trifluoromethyl)phenyl]-(4-methylsulfonylpiperazin-1-yl)methyl]pyrimidineIC505600.0 [1]
[4-[(4-Chloro-2-fluorophenyl)-pyridin-3-ylmethyl]piperazin-1-yl]-(4-methyl-1,3-thiazol-2-yl)methanoneIC502800.0 [1]
1-(Benzenesulfonyl)-4-[(4-chloro-2-fluorophenyl)-pyridin-3-ylmethyl]piperazineIC50600.0 [1]
6-(4-Tert-butylphenyl)pyridine-3-carbonitrileIC5050000.0 [1]
6-[4-(3-Methyloxetan-3-yl)phenyl]pyridine-3-carbonitrileIC5050000.0 [1]
6-(4-Propan-2-ylphenyl)pyridine-3-carbonitrileIC5050000.0 [1]
6-[4-[1-(Trifluoromethyl)cyclopropyl]phenyl]pyridine-3-carbonitrileIC5050000.0 [1]
4-Tert-butyl-N-[6-(trifluoromethyl)pyridin-3-yl]benzamideIC5050000.0 [1]
4-[1-(Trifluoromethyl)cyclopropyl]-N-[6-(trifluoromethyl)pyridin-3-yl]benzamideIC5050000.0 [1]
2-(4-Tert-butylphenyl)-5-fluoropyridineIC5050000.0 [1]
5-Fluoro-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]pyridineIC5050000.0 [1]
Items per page: 1 - 10 of 42
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 3A4/3A5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/cytochrome-p450-3a4-3a5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Cytochrome P450 3A4/3A5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-3a4-3a5-inhibitors-ic50-ki.
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