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Cytochrome P450 2D6 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
QuinidineIC5020.0 [1]
QuinidineKi9.8 [1], 40.0 [2], 43.0 [3], 60.0 [4], 80.0 [5]
YohimbineIC508.4 [1]
YohimbineKi180.0 [1]
(S)-alpha-[(2R)-8-Vinylquinuclidine-2-yl]-4-quinolinemethanolKi7500.0 [1]
AjmalicineKi4.6 [1]
alpha-NaphthoflavoneIC5010000.0 [1]
QuinineIC501800.0 [1]
QuinineKi5500.0 [1], 15000.0 [2]
IndinavirIC5030000.0 [1]
DuloxetineIC501000.0 [1], 1580.0 [2], 1600.0 [3], 1995.26 [4]
(-)-Dimethyl-{2-[3-((R)-1-pyrazin-2-yl-ethyl)-1H-inden-2-yl]-ethyl}-amineIC5010000.0 [1], 50000.0 [2], 50500.0 [3], 51000.0 [4]
2-[(1-Hydroxycyclohexyl)methylamino]-1-[(1R)-6-methoxy-1-propan-2-yl-3,4-dihydro-1H-isoquinolin-2-yl]ethanoneIC502900.0 [1], 37000.0 [2], 41000.0 [3], 50000.0 [4]
QuercetinIC5018800.0 [1], 20000.0 [2]
CID 57345320IC50320.0 [1]
HydrocinchonineKi1600.0 [1], 2800.0 [2], 3200.0 [3]
AuglurantIC5030000.0 [1], 200000.0 [2]
1-[(1R,2S)-2-[[(3S)-3-[(4-Fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-[3-(1-methyltetrazol-5-yl)phenyl]ureaIC5030.0 [1], 200.0 [2], 210.0 [3]
1-((1R,2S)-2-(((S)-3-(4-Fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-acetylphenyl)ureaIC5030.0 [1], 40.0 [2], 60.0 [3]
N,N-Dimethyl-2-[3-(pyrazin-2-ylmethyl)-1H-inden-2-yl]ethanamineIC506679.0 [1], 6700.0 [2], 6800.0 [3]
Benzo[B]thiophene-2-ethanamine, N,N-dimethyl-3-[(1R)-1-(2-pyridinyl)ethyl]-IC5028000.0 [1], 28200.0 [2]
Antihistamine-1IC505219.0 [1], 5400.0 [2]
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamideIC5010000.0 [1], 50118.72 [2]
(R)-(5-Ethyl-1-azabicyclo[2.2.2]octan-2-yl)-quinolin-4-ylmethanolKi8000.0 [1], 9600.0 [2], 24000.0 [3]
PropranololIC501900.0 [1], 5011.87 [2]
VerapamilIC5030000.0 [1], 43300.0 [2]
ChlorpromazineIC501490.0 [1]
ChlorpromazineKi7000.0 [1]
HaloperidolIC503640.0 [1], 30000.0 [2]
MetoprololIC5024000.0 [1], 50000.0 [2]
Quinidine sulfate dihydrateIC5020.0 [1]
LinezolidIC5020000.0 [1]
SertralineIC501400.0 [1], 2880.0 [2]
NicardipineIC501590.0 [1], 1780.0 [2]
PentamidineIC5024800.0 [1]
NortriptylineIC502300.0 [1], 2600.0 [2]
AtomoxetineIC502000.0 [1]
DextromethorphanIC501800.0 [1], 3400.0 [2]
FluvoxamineKi8000.0 [1], 17000.0 [2]
CinacalcetIC5050.0 [1], 100.0 [2]
AmsacrineIC5010200.0 [1]
AmsacrineKi7500.0 [1]
4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydrochlorideIC506100.0 [1]
MibefradilIC5063.0 [1], 840.0 [2]
BepridilIC5030000.0 [1], 50000.0 [2]
DolutegravirIC50100000.0 [1]
DaclatasvirIC50100000.0 [1]
SaxagliptinIC5050000.0 [1]
IvacaftorIC5020000.0 [1]
6-Chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indolineIC50100000.0 [1]
ShogaolIC5087000.0 [1], 100000.0 [2]
PleconarilIC501258.93 [1], 50118.72 [2]
CinchonineIC501800.0 [1]
CinchonineKi21000.0 [1]
TraxoprodilIC504250.0 [1], 10000.0 [2]
DesethylamodiaquineIC506400.0 [1]
N-Hydroxy-N'-(4-butyl-2-methylphenyl)formamidineIC5083900.0 [1], 84500.0 [2]
(S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamineIC501600.0 [1], 1640.0 [2]
S1RAIC5010000.0 [1]
Bms-536924IC5040000.0 [1]
ParadolIC5030000.0 [1]
N-[4-(4-Chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamideIC5030000.0 [1]
TemsavirIC5025000.0 [1], 40000.0 [2]
1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexaneIC50780.0 [1], 7000.0 [2]
(8)-GingerolIC5042700.0 [1], 74500.0 [2]
MK-7246IC5030000.0 [1], 100000.0 [2]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amineIC50660.0 [1], 1000.0 [2]
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3,5-dihydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileIC50200000.0 [1]
4-(8-Fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamideIC501600.0 [1], 25000.0 [2]
IsoquineIC507000.0 [1]
(S)-7-Hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-oneIC5020000.0 [1]
2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamideIC50100000.0 [1]
SB 221284IC50110.0 [1]
2,3-Dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamideIC509200.0 [1]
Unii-pon9ofp69GIC502600.0 [1]
Unii-pon9ofp69GKi2600.0 [1]
N-[2-(Diethylamino)ethyl]-2-[2-[(4-fluorophenyl)methylsulfanyl]-5-[(1-methylpyrazol-4-yl)methyl]-4-oxopyrimidin-1-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamideIC5037000.0 [1]
4-Methoxy-3-(1-methylpiperidin-4-yl)oxy-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]benzamideIC5030000.0 [1]
N-(4-(Trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamideIC5030000.0 [1]
(3R)-N-Isoquinolin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amineIC5040000.0 [1]
2-(2-(4-Tert-Butylphenylthio)ethyl)-1H-imidazoleIC50680.0 [1]
CID 46244454IC5010000.0 [1]
1-Cyclohexyl-2-(furan-3-yl)-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]benzimidazole-5-carboxamideIC504000.0 [1]
3-(1-Naphthyl)-1-(4-pyridinyl)-2-propen-1-oneIC5010000.0 [1], 18000.0 [2]
5-(4-Chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamideIC5020000.0 [1]
(E)-3-(2-Chlorophenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-oneIC5010000.0 [1], 12000.0 [2]
Benzamide, 2,3-dichloro-N-(2-methylpropyl)-N-(3S)-3-pyrrolidinyl-IC5030000.0 [1]
1-Cyano-3-(2-methyl-1-benzofuran-5-yl)-2-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidineIC5040000.0 [1], 200000.0 [2]
2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]acetamideIC502200.0 [1]
Bms-344577IC5040000.0 [1], 200000.0 [2]
2-(4-Fluorophenyl)-N-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-1-methylbenzimidazol-4-amineIC503600.0 [1]
(2S)-2-[2-Methyl-4-(2-oxa-8-azatricyclo[7.3.1.05,13]trideca-1(13),5,7,9,11-pentaen-10-yl)quinolin-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acidIC5030000.0 [1]
N-[4-[(1R,2R)-2-(Dimethylamino)-1-imidazol-1-ylpropyl]phenyl]-1,3-benzothiazol-2-amineIC503900.0 [1]
LinaprazanIC5046000.0 [1], 58000.0 [2]
(5-Pyrid-3-ylthien-2-YL)methylamineIC50168000.0 [1]
(5-Pyrid-3-ylthien-2-YL)methylamineKi84500.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineIC5011300.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineKi5700.0 [1]
(S)-N-(2,3-Dichlorobenzyl)-N-(pyrrolidin-3-yl)isobutyramideIC503000.0 [1], 27100.0 [2]
3-[(E)-[3-[(E)-2-[4-[(Dimethylamino)methyl]phenyl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-olIC508900.0 [1], 9000.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 2D6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/cytochrome-p450-2d6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Cytochrome P450 2D6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-2d6-inhibitors-ic50-ki.
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