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Cytochrome P450 2C8 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Gemfibrozil 1-O-beta-GlucuronideIC501800.0 [1], 24000.0 [2], 28000.0 [3]
Gemfibrozil 1-O-beta-GlucuronideKi52000.0 [1]
QuercetinIC501200.0 [1], 1390.0 [2], 3500.0 [3]
VidupiprantIC505400.0 [1]
VidupiprantKi1100.0 [1], 1800.0 [2], 6000.0 [3]
GemfibrozilIC504100.0 [1], 95000.0 [2]
2-{3-[1-(4-Hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl]propanamido}benzoic acidIC5019000.0 [1], 28000.0 [2]
(2S,3S,4S,5R,6S)-6-[2-[4-[4-(Tert-butylcarbamoyl)-2-[(2-chloro-4-cyclopropylphenyl)sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]acetyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acidKi2700.0 [1], 6900.0 [2], 7300.0 [3]
4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydrochlorideIC502700.0 [1]
AnidulafunginIC5012000.0 [1], 17500.0 [2]
DolutegravirIC50100000.0 [1]
SaxagliptinIC5050000.0 [1]
DesethylamodiaquineIC5020000.0 [1]
S1RAIC5010000.0 [1]
ParadolIC505100.0 [1], 8300.0 [2]
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3,5-dihydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileIC50200000.0 [1]
IsoquineIC5013000.0 [1]
2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamideIC50100000.0 [1]
(3R)-N-Isoquinolin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amineIC5040000.0 [1]
CID 58282870IC503500.0 [1], 5000.0 [2]
2-{3-[4-(2-Chloro-4-hydroxyphenyl)phenyl]propanamido}benzoic acidIC50400.0 [1]
2-[(2R,4R)-1-[4-[[4-(2-Fluoro-5-methoxyphenyl)-2-methylphenyl]methyl]phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acidIC502100.0 [1], 3800.0 [2]
1-[(2-Chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1H-pyridin-3-yl)indole-2-carboxylic acidIC5021000.0 [1], 30000.0 [2]
PropranololIC5010000.0 [1]
VerapamilIC5030000.0 [1]
TamoxifenIC5014300.0 [1]
HaloperidolIC5030000.0 [1]
SimvastatinIC503700.0 [1]
KetoconazoleIC502450.0 [1]
AlbendazoleIC5030000.0 [1]
MifepristoneIC501500.0 [1]
Paroxetine hydrochlorideIC5030000.0 [1]
DanazolIC501950.0 [1]
ClotrimazoleIC50803.0 [1]
NicardipineIC501560.0 [1]
LansoprazoleIC505750.0 [1]
(-)-MefloquineIC5030000.0 [1]
PimozideIC5030000.0 [1]
LoratadineIC502950.0 [1]
MontelukastIC501000.0 [1]
Montelukast sodiumKi11000.0 [1]
IsradipineIC505000.0 [1]
IbrutinibIC507900.0 [1]
BepridilIC5030000.0 [1]
AstemizoleIC5030000.0 [1]
GingerolIC5022100.0 [1]
OrphenadrineIC5030000.0 [1]
CarfilzomibIC5010000.0 [1]
SulfaphenazoleIC50130000.0 [1]
(10)-GingerolIC502000.0 [1]
ShogaolIC502900.0 [1]
TariquidarIC5045300.0 [1]
CID 53469448IC50890.0 [1]
IvermectineIC5030000.0 [1]
OrteronelIC5030000.0 [1]
GlasdegibIC5030000.0 [1]
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanolIC5030000.0 [1]
2-(1-((6-Chloroimidazo(2,1-b)(1,3)thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethylamineIC50500000.0 [1]
CID 53469059IC5025000.0 [1]
6alpha-HydroxypaclitaxelIC5021600.0 [1]
FilibuvirIC5030000.0 [1]
VoxelotorIC507900.0 [1]
(8)-GingerolIC502200.0 [1]
BrilanestrantIC50100.0 [1]
VibegronIC50100000.0 [1]
VericiguatIC5050000.0 [1]
CID 78209992IC5050.0 [1]
1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanoneIC50200000.0 [1]
3-[[(1S)-2,2-Difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrileIC5050000.0 [1]
CID 11570626IC502700.0 [1]
LemborexantIC5020000.0 [1]
N-Tert-butyl isoquineIC5023000.0 [1]
2-[(4-Methylbenzyl)sulfanyl]-3,5,6,7-Tetrahydro-4h-Cyclopenta[d]pyrimidin-4-OneIC5020000.0 [1]
MitoglitazoneIC5026000.0 [1]
2-[(4-Chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-oneIC5020000.0 [1]
SerlopitantIC5058000.0 [1]
Pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)IC5020000.0 [1]
4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-OneIC5050000.0 [1]
Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-IC5040000.0 [1]
1-Benzyl-4-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]piperazineIC5020000.0 [1]
1-[4-[4-Morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl]phenyl]-3-pyridin-4-ylureaIC503000.0 [1]
N-[4-[3-(6-Methylpyridin-3-yl)-1,2,4-triazol-1-yl]phenyl]-4-(3-morpholin-4-ylphenyl)pyrimidin-2-amineIC5050000.0 [1]
MK-6892IC50100000.0 [1]
4-[[(4-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acid methyl esterIC5020000.0 [1]
AuglurantIC50200000.0 [1]
CYP3cideIC5078000.0 [1]
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic AcidIC502500.0 [1]
2-(3,4-Dimethoxyphenyl)-5-(3-methoxypropyl)benzofuranIC5031400.0 [1]
2-Amino-4-[4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxamideIC5030000.0 [1]
CID 73670548IC50100000.0 [1]
Unii-ais8N3O50BIC5010000.0 [1]
Bms-986142IC502600.0 [1]
3-Chloro-5-[6-(5-Fluoropyridin-2-Yl)pyrimidin-4-Yl]benzonitrileIC5015848.93 [1]
[2-Chloro-3-(trifluoromethyl)phenyl]-[(4R)-1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]methanoneIC509600.0 [1]
CID 91933883IC5020000.0 [1]
N-[3-[(Tert-butylamino)methyl]-4-fluorophenyl]-7-chloroquinolin-4-amineIC509800.0 [1]
3-[[(2S)-2-Carbamoylpyrrolidin-1-yl]methyl]-1-[(4-fluorophenyl)methyl]-N-hydroxy-N-methylpyrrolo[2,3-c]pyridine-5-carboxamideIC5030000.0 [1]
CID 118572065IC5030000.0 [1]
4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-OneIC5050000.0 [1]
pi3K|A Inhibitor C52IC5020000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 2C8 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/cytochrome-p450-2c8-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Cytochrome P450 2C8 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-2c8-inhibitors-ic50-ki.
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