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Cytochrome P450 2B6 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
VoriconazoleIC501900.0 [1]
VoriconazoleKi340.0 [1], 400.0 [2]
(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amineIC506240.0 [1], 6960.0 [2]
ArtemisinineIC508400.0 [1], 12100.0 [2]
ArtemisinineKi4600.0 [1]
(5-Pyrid-3-ylthien-2-YL)methylamineIC5052200.0 [1]
(5-Pyrid-3-ylthien-2-YL)methylamineKi26100.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineIC50191000.0 [1]
(5-(Pyridin-3-YL)furan-2-YL)methanamineKi95500.0 [1]
3-(1H-Imidazol-4-yl)pyridineIC50103000.0 [1]
3-(1H-Imidazol-4-yl)pyridineKi51500.0 [1]
3-(3-Methylthiophen-2-yl)pyridineIC503900.0 [1]
3-(3-Methylthiophen-2-yl)pyridineKi1900.0 [1]
TiclopidineIC50600.0 [1], 70000.0 [2]
ParnateIC506900.0 [1], 6960.0 [2]
(1S,4S,5R,8S,9R,10S,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-olIC50125000.0 [1]
DolutegravirIC50100000.0 [1]
SaxagliptinIC5050000.0 [1]
S1RAIC5010000.0 [1]
ParadolIC506300.0 [1], 15400.0 [2]
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3,5-dihydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileIC50200000.0 [1]
2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamideIC50100000.0 [1]
(3R)-N-Isoquinolin-3-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amineIC5040000.0 [1]
MCH-1 antagonist 1IC5010000.0 [1]
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-IC50146000.0 [1]
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-Ki73000.0 [1]
3-(4-Methylthiophen-3-yl)pyridineIC506300.0 [1]
3-(4-Methylthiophen-3-yl)pyridineKi3100.0 [1]
3-(2-Methyl-1H-imidazol-1-yl)pyridineIC50300000.0 [1]
3-(2-Methyl-1H-imidazol-1-yl)pyridineKi300000.0 [1]
3-(3-Thienyl)pyridineIC5059100.0 [1]
3-(3-Thienyl)pyridineKi30000.0 [1]
1-(3-Pyridin-3-ylisoxazol-5-YL)methanamineIC5067400.0 [1]
1-(3-Pyridin-3-ylisoxazol-5-YL)methanamineKi33700.0 [1]
(3-(Pyridin-3-yl)-1H-pyrazol-5-yl)methanamineIC5066400.0 [1]
(3-(Pyridin-3-yl)-1H-pyrazol-5-yl)methanamineKi33200.0 [1]
Ethinyl estradiolKi900.0 [1]
RitonavirIC502000.0 [1]
beta-NaphthoflavoneIC5025000.0 [1]
TranylcypromineIC506900.0 [1]
ChrysinIC5025000.0 [1]
IbrutinibIC5011100.0 [1]
alpha-NaphthoflavoneIC5013000.0 [1]
AnidulafunginIC5017500.0 [1]
GingerolIC5040800.0 [1]
AlosetronIC5010000.0 [1]
(10)-GingerolIC504300.0 [1]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC5024500.0 [1]
ShogaolIC505800.0 [1]
TariquidarIC50100000.0 [1]
OrteronelIC5030000.0 [1]
HydroxybupropionIC5019200.0 [1]
RimegepantIC5020000.0 [1]
(8)-GingerolIC508100.0 [1]
6-(4-Chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thieno[3,2-d]pyrimidin-4(3H)-oneIC5010000000.0 [1]
VibegronIC50100000.0 [1]
VericiguatIC5050000.0 [1]
CID 78209992IC5050.0 [1]
3-[[(1S)-2,2-Difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrileIC5050000.0 [1]
CID 11570626IC5023000.0 [1]
3,3'-BipyridineIC50145000.0 [1]
VidupiprantIC5030000.0 [1]
6-(3-Hydroxyphenyl)-2-naphtholIC5013400.0 [1]
2-[(4-Methylbenzyl)sulfanyl]-3,5,6,7-Tetrahydro-4h-Cyclopenta[d]pyrimidin-4-OneIC5020000.0 [1]
2-[(4-Chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-oneIC5020000.0 [1]
Pyrimidine-4,6-dicarboxylic acid bis-(4-fluoro-3-methyl-benzylamide)IC5020000.0 [1]
6-(Pyridin-3-yl)-3,4-dihydroquinolin-2(1H)-oneIC5050000.0 [1]
PumosetragIC5010000.0 [1]
(2E,5E)-2,5-Bis[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]cyclopentan-1-oneIC5070000.0 [1]
1-[4-[4-Morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl]phenyl]-3-pyridin-4-ylureaIC5030000.0 [1]
N-[4-[3-(6-Methylpyridin-3-yl)-1,2,4-triazol-1-yl]phenyl]-4-(3-morpholin-4-ylphenyl)pyrimidin-2-amineIC5050000.0 [1]
3-(4-Methyl-1,3-thiazol-2-yl)pyridineKi43500.0 [1]
4-[[(4-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acid methyl esterIC5020000.0 [1]
AuglurantIC50200000.0 [1]
CYP3cideIC5088000.0 [1]
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic AcidIC502500.0 [1]
1-(4-Chlorobenzyl)-1H-imidazoleIC5012000.0 [1]
2-Amino-4-[4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxamideIC5030000.0 [1]
Bms-986142IC5040000.0 [1]
CID 91933883IC5020000.0 [1]
1,5-Bis(3,5-dimethoxy-4-hydroxyphenyl)-1,4-pentadien-3-oneIC5024800.0 [1]
pi3K|A Inhibitor C52IC5020000.0 [1]
1-Methyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-oneIC5050000.0 [1]
1-Cyano-3-(2-methyl-1-benzofuran-5-yl)-2-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidineIC5040000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC508150.0 [1]
2-((Pyridin-2-ylmethyl)thio)-1H-benzo[d]imidazoleIC5024000.0 [1]
ZuranoloneIC5030000.0 [1]
CID 91810751IC5010000.0 [1]
Methyl[3-(pyridin-3-yl)prop-2-yn-1-yl]amineKi60000.0 [1]
N-[(E)-(3-Oxido-2,1,3-benzoxadiazol-3-ium-5-yl)methylideneamino]pyridine-4-carboxamideIC5020000.0 [1]
6-(3-Hydroxyphenyl)-1-phenyl-2-naphtholIC507960.0 [1]
6-Isoquinolin-4-yl-3,4-dihydroquinolin-2(1H)-oneIC50100000.0 [1]
(3R)-N-(6-Imidazol-1-ylpyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amineIC5030000.0 [1]
1-(3-Hydroxyazetidin-1-yl)-2-(6-hydroxy-2-phenyl-2-adamantyl)ethanoneIC5040000.0 [1]
N'-[(1-Tert-butyltetrazol-5-yl)-(4-chlorophenyl)methyl]-N-(7-chloroquinolin-4-yl)ethane-1,2-diamineIC5020000.0 [1]
RelacorilantIC5010000.0 [1]
3-PhenylthiopheneKi14000.0 [1]
1-Phenethyl-1H-imidazoleIC5020000.0 [1]
Dimethyl[3-(pyridin-3-yl)prop-2-yn-1-yl]amineKi192000.0 [1]
1,5-Bis(3,5-dimethyl-4-hydroxyphenyl)-1,4-pentadien-3-oneIC5044800.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 2B6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/cytochrome-p450-2b6-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Cytochrome P450 2B6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-2b6-inhibitors-ic50-ki.
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