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Cytochrome P450 21 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
KetoconazoleIC504300.0 [1], 9010.0 [2]
AbirateroneIC5032.4 [1], 296.0 [2]
GaleteroneIC5077.2 [1], 248.0 [2]
(3S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthrene-6-carboxamideIC50673.0 [1], 8700.0 [2]
(3S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthrene-6-carbonitrileIC5023.9 [1], 537.0 [2]
(3S,5S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-17-pyridin-3-yl-1,2,3,4,5,7,8,9,11,12,14,15-dodecahydrocyclopenta[a]phenanthren-6-oneIC50440.0 [1], 831.0 [2]
4-[4-[[2-(2-Chlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]morpholineIC50960.0 [1], 4760.0 [2]
2-Methoxyethyl 4-[4-[[2-(2-chlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]piperazine-1-carboxylateIC50570.0 [1], 800.0 [2]
1-[4-[[2-(2-Chlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]-4-methylsulfonylpiperazineIC501520.0 [1], 2500.0 [2]
1-[4-[4-[[2-(2-Chlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]piperazin-1-yl]ethanoneIC501480.0 [1], 10000.0 [2]
Ethyl 2-[[4-[4-[[2-(2-chlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]piperazine-1-carbonyl]amino]acetateIC502800.0 [1], 10000.0 [2]
1-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]piperazin-1-yl]ethanoneIC50208.0 [1], 10000.0 [2]
OrteronelIC504870.0 [1]
Androsta-4,16-dien-3-one, 17-(3-pyridinyl)-IC500.7 [1]
Cyp11B2-IN-1IC5010000.0 [1]
4-(4-Methylpyridin-3-yl)-1-(2,2,2-trifluoroethyl)benzimidazoleIC507500.0 [1]
(2S,4S)-KetoconazoleIC504460.0 [1]
2-[5-(4-Fluoro-3-methylindazol-1-yl)pyridin-3-yl]propan-2-olIC5010000.0 [1]
(3S,8R,10R,13S)-10,13-Dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-olIC501050.0 [1]
(1S,2R,5S,7S,11S,12S,16S)-5-Hydroxy-2,16-dimethyl-15-pyridin-3-yl-8-azatetracyclo[9.7.0.02,7.012,16]octadec-14-en-9-oneIC503605.0 [1]
Chembl4127656IC50190.0 [1]
1-[4-[(E)-2-(3-Fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]-4-methylsulfonylpiperazineIC50740.0 [1]
Chembl4126996IC50393.0 [1]
Chembl4127240IC5010000.0 [1]
Chembl4127399IC501100.0 [1]
1-[4-[(E)-2-(3-Chloro-5-pyridin-4-ylphenyl)ethenyl]phenyl]-4-propan-2-ylsulfonylpiperazineIC50565.0 [1]
1-[4-[(E)-2-(3-Chloro-5-pyridin-4-ylphenyl)ethenyl]phenyl]-4-methylsulfonylpiperazineIC50840.0 [1]
1-[4-[(E)-2-(3-Chloro-5-pyridin-4-ylphenyl)ethenyl]phenyl]-4-cyclopropylsulfonylpiperazineIC50416.0 [1]
4-[4-[(E)-2-(3-Chloro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazine-1-carboximidamideIC5010000.0 [1]
Chembl4125902IC5010000.0 [1]
2-[4-[4-[(E)-2-[3-Chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]-4,5-dihydro-1,3-oxazoleIC503500.0 [1]
1-[4-[(E)-2-[3-Fluoro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-propan-2-ylsulfonylpiperazineIC50700.0 [1]
2-[4-[4-[(E)-2-[3-Fluoro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]-4,5-dihydro-1,3-oxazoleIC5010000.0 [1]
4-[4-[(E)-2-[3-Fluoro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazine-1-carboximidamideIC5010000.0 [1]
2-[4-[4-[(E)-2-[3-Fluoro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]-5,6-dihydro-4H-1,3-oxazineIC501000.0 [1]
2-[4-[4-[(E)-2-(3-Chloro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazin-1-yl]-4,5-dihydro-1,3-oxazoleIC501200.0 [1]
1-[4-[(E)-2-[3-Chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-methylsulfonylpiperazineIC502200.0 [1]
4-[4-[(E)-2-[3-Chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazine-1-carboximidamideIC5010000.0 [1]
1-[4-[(E)-2-[3-Fluoro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]-4-methylsulfonylpiperazineIC5010000.0 [1]
Chembl4128449IC50540.0 [1]
Chembl4129721IC50430.0 [1]
Chembl4127385IC50340.0 [1]
Chembl4126284IC50520.0 [1]
Chembl4128621IC501380.0 [1]
4-[4-[(E)-2-(3-Fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazine-1-carboximidamideIC5010000.0 [1]
2-[4-[4-[(E)-2-(3-Fluoro-5-pyridin-4-ylphenyl)ethenyl]phenyl]piperazin-1-yl]-4,5-dihydro-1,3-oxazoleIC501200.0 [1]
(1S,2R,5S,7R,9R,11R,12S,16S)-2,16-Dimethyl-15-pyridin-3-ylpentacyclo[9.7.0.02,7.07,9.012,16]octadec-14-en-5-olIC5042.1 [1]
trans-KetoconazoleIC506570.0 [1]
(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-phenyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-olIC50700.0 [1]
(2S)-2-[5-(3-Cyclopropyl-6-fluoroimidazo[1,2-a]pyridin-2-yl)pyridin-3-yl]-1,1,1-trifluoropropan-2-olIC5010000.0 [1]
(3S,5S,6S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-pyridin-3-yl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diolIC50234.0 [1]
(3S,5S,6Z,8R,9S,10R,13S,14S)-6-Hydroxyimino-10,13-dimethyl-17-pyridin-3-yl-1,2,3,4,5,7,8,9,11,12,14,15-dodecahydrocyclopenta[a]phenanthren-3-olIC501390.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-methylsulfonylpiperazineIC501600.0 [1]
2-[5-(1-Cyclopropyl-5,6-difluoro-1H-benzimidazol-2-yl)pyridin-3-yl]propan-2-olIC5010000.0 [1]
1-Cyclopropyl-5,6-difluoro-2-(5-fluoropyridin-3-yl)benzimidazoleIC5010000.0 [1]
1-Cyclopropyl-5,6-difluoro-2-(5-fluoro-4-methylpyridin-3-yl)benzimidazoleIC5010000.0 [1]
4-(3-Cyclopropyl-6-fluoroimidazo[1,2-a]pyridin-2-yl)isoquinolineIC5010000.0 [1]
3-Cyclopropyl-6-fluoro-2-(5-fluoropyridin-3-yl)imidazo[1,2-a]pyridineIC5010000.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(trifluoromethylsulfonyl)piperazineIC5049.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-thiophen-2-ylsulfonylpiperazineIC50148.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylimidazol-2-yl)sulfonylpiperazineIC508.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(methylsulfonylmethylsulfonyl)piperazineIC5020.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(difluoromethylsulfonyl)piperazineIC5026.0 [1]
2-[4-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]sulfonylacetonitrileIC5078.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(2-methoxyethylsulfonyl)piperazineIC50166.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(oxan-4-ylsulfonyl)piperazineIC50123.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-ethylsulfonylpiperazineIC50271.0 [1]
1-[4-[[(2S,4R)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-ylsulfonylpiperazineIC5051.0 [1]
3-Cyclopropyl-6-fluoro-2-(5-fluoro-4-methylpyridin-3-yl)imidazo[1,2-a]pyridineIC5010000.0 [1]
3-Cyclopropyl-2-(4-ethyl-5-fluoropyridin-3-yl)-6-fluoroimidazo[1,2-a]pyridineIC5010000.0 [1]
2-[5-[4-(Trifluoromethyl)indazol-1-yl]pyridin-3-yl]propan-2-olIC5010000.0 [1]
(2S)-1,1,1-Trifluoro-2-[5-(3-methylindazol-1-yl)pyridin-3-yl]propan-2-olIC5010000.0 [1]
(2S)-1,1,1-Trifluoro-2-[5-[3-(trifluoromethyl)indazol-1-yl]pyridin-3-yl]propan-2-olIC5010000.0 [1]
(2R)-1,1,1-Trifluoro-2-[5-(3-methylindazol-1-yl)pyridin-3-yl]propan-2-olIC5010000.0 [1]
1-Cyclopropylsulfonyl-4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazineIC5028.0 [1]
Chembl4128368IC50316.0 [1]
4-[4-[[2-(2-Chlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]-N,N-dimethylpiperazine-1-carboxamideIC50800.0 [1]
1-Cyclopropylsulfonyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]piperazineIC50262.0 [1]
1-(3-Chloropropylsulfonyl)-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]piperazineIC501100.0 [1]
4-[4-[[2-(2-Chlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]pyridineIC50391.0 [1]
1-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]-4-propan-2-ylsulfonylpiperazineIC50110.0 [1]
1-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]-4-pyridin-3-ylsulfonylpiperazineIC50273.0 [1]
1-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]-4-[3-(trifluoromethoxy)phenyl]sulfonylpiperazineIC50170.0 [1]
4-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]pyridineIC5068.0 [1]
1-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]-4-ethylsulfonylpiperazineIC50130.0 [1]
1-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]-4-(1H-imidazol-5-ylsulfonyl)piperazineIC50426.0 [1]
3-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxan-5-yl]oxymethyl]phenyl]piperazin-1-yl]sulfonylbenzonitrileIC50415.0 [1]
(3S,5S,6E,8R,9S,10R,13S,14S)-6-Hydroxyimino-10,13-dimethyl-17-pyridin-3-yl-1,2,3,4,5,7,8,9,11,12,14,15-dodecahydrocyclopenta[a]phenanthren-3-olIC5010300.0 [1]
4-[3-[(E)-2-(4-Bromophenyl)ethenyl]-5-fluorophenyl]pyridineIC502600.0 [1]
1-Cyclopropylsulfonyl-4-[4-[2-(3-fluoro-5-pyridin-4-ylphenyl)ethyl]phenyl]piperazineIC501200.0 [1]
1-[4-[2-(3-Fluoro-5-pyridin-4-ylphenyl)ethyl]phenyl]-4-(trifluoromethylsulfonyl)piperazineIC502800.0 [1]
[4-[4-[(E)-2-[3-Chloro-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]-cyclopropylmethanoneIC501400.0 [1]
1-[4-[4-[2-(3-Fluoro-5-pyridin-4-ylphenyl)ethyl]phenyl]piperazin-1-yl]ethanoneIC5010000.0 [1]
1-Ethylsulfonyl-4-[4-[2-(3-fluoro-5-pyridin-4-ylphenyl)ethyl]phenyl]piperazineIC501600.0 [1]
4-[3-Fluoro-5-[(E)-2-(4-pyridin-4-ylphenyl)ethenyl]phenyl]pyridineIC50850.0 [1]
1-[4-[4-[(E)-2-(3-Chloro-5-pyridin-3-ylphenyl)ethenyl]phenyl]piperazin-1-yl]ethanoneIC5010000.0 [1]
1-[4-[4-[(E)-2-[3-Hydroxy-5-(imidazol-1-ylmethyl)phenyl]ethenyl]phenyl]piperazin-1-yl]ethanoneIC502400.0 [1]
1-[4-[4-[(E)-2-(3-Fluoro-5-pyridin-3-ylphenyl)ethenyl]phenyl]piperazin-1-yl]ethanoneIC5010000.0 [1]
1-[4-[4-[(E)-2-[3-Chloro-5-(2-methyl-1-pyridin-3-ylprop-1-enyl)phenyl]ethenyl]phenyl]piperazin-1-yl]ethanoneIC502400.0 [1]
4-[3-Fluoro-5-[2-(4-pyridin-4-ylphenyl)ethyl]phenyl]pyridineIC50490.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cytochrome P450 21 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/cytochrome-p450-21-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 20). Quest Database™ Cytochrome P450 21 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cytochrome-p450-21-inhibitors-ic50-ki.
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