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Cystinyl aminopeptidase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Angiotensin IVKi7.0 [1], 56.23 [2], 60.0 [3], 62.4 [4], 831.76 [5]
Ethyl 2-(acetylamino)-7-hydroxy-4-quinolin-3-yl-4H-chromene-3-carboxylateKi20.0 [1], 30.0 [2]
2-[2-[[[(5R,8S,11S)-11-Amino-8-[(4-hydroxyphenyl)methyl]-7,10-dioxo-1,2-dithia-6,9-diazacyclotridecane-5-carbonyl]amino]methyl]phenyl]acetic acidKi282.0 [1], 1191.0 [2], 10200.0 [3]
(5S,8S,11S)-11-Amino-N-benzyl-8-[(4-hydroxyphenyl)methyl]-7,10-dioxo-1,2-dithia-6,9-diazacyclotridecane-5-carboxamideKi54.8 [1], 95.7 [2], 13800.0 [3]
2-[2-[[[(4R,8S,11S)-11-Amino-8-[(4-hydroxyphenyl)methyl]-6,10-dioxo-1,2-dithia-5,9-diazacyclotridecane-4-carbonyl]amino]methyl]phenyl]acetic acidKi3.3 [1], 35.1 [2], 1265.0 [3]
2-[2-[[[(4S,8S,11S)-11-Amino-8-[(4-hydroxyphenyl)methyl]-6,10-dioxo-1,2-dithia-5,9-diazacyclotridecane-4-carbonyl]amino]methyl]phenyl]acetic acidKi242.0 [1], 23100.0 [2], 26100.0 [3]
(4R,8S,11S)-11-Amino-N-benzyl-8-[(4-hydroxyphenyl)methyl]-6,10-dioxo-1,2-dithia-5,9-diazacyclotridecane-4-carboxamideKi18.5 [1], 22.5 [2], 3458.0 [3]
(4R,8S,11S)-11-Amino-8-[(4-hydroxyphenyl)methyl]-6,10-dioxo-N-(pyridin-3-ylmethyl)-1,2-dithia-5,9-diazacyclotridecane-4-carboxamideKi93.7 [1], 633.0 [2], 5416.0 [3]
2-[2-[[[(5S,9S,12S)-12-Amino-9-[(4-hydroxyphenyl)methyl]-7,11-dioxo-1,2-dithia-6,10-diazacyclotetradecane-5-carbonyl]amino]methyl]phenyl]acetic acidKi5.2 [1], 10.0 [2], 357.0 [3]
2-[2-[[[(5R,9S,12S)-12-Amino-9-[(4-hydroxyphenyl)methyl]-7,11-dioxo-1,2-dithia-6,10-diazacyclotetradecane-5-carbonyl]amino]methyl]phenyl]acetic acidKi34.9 [1], 230.0 [2], 13879.0 [3]
(2S)-2-[[(2S)-1-[(2S)-2-[[(4R,7S,10R)-10-Amino-7-[(4-hydroxyphenyl)methyl]-6,9-dioxo-1,2-dithia-5,8-diazacycloundecane-4-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acidKi5506.0 [1], 6599.0 [2], 16900.0 [3]
(2S)-2-[[(2S)-1-[(2S)-2-[[(5R,8S,11R)-11-Amino-8-[(4-hydroxyphenyl)methyl]-7,10-dioxo-1,2-dithia-6,9-diazacyclotridecane-5-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acidKi196.0 [1], 303.0 [2], 1488.0 [3]
2-[2-[[[(5R,8S,11R)-11-Amino-8-[(4-hydroxyphenyl)methyl]-7,10-dioxo-1,2-dithia-6,9-diazacyclotridecane-5-carbonyl]amino]methyl]phenyl]acetic acidKi22.5 [1], 25.3 [2], 1501.0 [3]
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acidKi9.3 [1], 62.4 [2], 1139.0 [3]
[(2S)-2-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamoyl]-4-methylpentyl]-[(1R)-1-amino-3-phenylpropyl]phosphinic acidIC5030.0 [1], 57.0 [2]
[(2S)-2-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]-4,4-diphenylbutyl]-[(1R)-1-amino-3-phenylpropyl]phosphinic acidIC5032.0 [1]
[(2S)-2-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]-4,4-diphenylbutyl]-[(1R)-1-amino-3-phenylpropyl]phosphinic acidKi18.0 [1]
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acidKi1200.0 [1], 6800.0 [2]
2-[[[(2S)-1-[3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acidKi12000.0 [1], 13000.0 [2]
2-[2-[[[(2S)-1-[3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]pyrrolidine-2-carbonyl]amino]methyl]phenyl]acetic acidKi7400.0 [1], 14000.0 [2]
2-[[[(2S)-1-[3-[[(2S)-2-Aminohexanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acidKi2500.0 [1], 6300.0 [2]
2-[2-[[[(2S)-1-[3-[[(2S)-2-Aminohexanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]pyrrolidine-2-carbonyl]amino]methyl]phenyl]acetic acidKi1400.0 [1], 3300.0 [2]
2-[[[(2S)-2-[[3-[[(2S)-2-Aminohexanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-4-methylpentanoyl]amino]methyl]benzoic acidKi3700.0 [1], 3900.0 [2]
2-[2-[[[(2S)-2-[[3-[[(2S)-2-Aminohexanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-4-methylpentanoyl]amino]methyl]phenyl]acetic acidKi3100.0 [1], 3900.0 [2]
2-[[[(2S,3R)-2-[[3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-3-methylpentanoyl]amino]methyl]benzoic acidKi1300.0 [1], 12000.0 [2]
2-[2-[[[(2S,3R)-2-[[3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-3-methylpentanoyl]amino]methyl]phenyl]acetic acidKi1300.0 [1], 8900.0 [2]
2-[[[(2S,3R)-2-[[3-[[(2S)-2-Aminohexanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-3-methylpentanoyl]amino]methyl]benzoic acidKi1800.0 [1], 2300.0 [2]
2-[2-[[[(2S,3R)-2-[[3-[[(2S)-2-Aminohexanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-3-methylpentanoyl]amino]methyl]phenyl]acetic acidKi1000.0 [1], 1400.0 [2]
2-[2-[[[(2S,3R)-2-[[3-Amino-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-3-methylpentanoyl]amino]methyl]phenyl]acetic acidKi97000.0 [1], 100000.0 [2]
2-[2-[[[3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]methyl]phenyl]acetic acidKi16000.0 [1], 86000.0 [2]
2-(2-((3-(4-Hydroxybenzyl)-5-aminobenzamido)methyl)phenyl)acetic acidKi35000.0 [1], 100000.0 [2]
(2S,3R)-2-[[3-[[(2S)-2-Amino-3-methylbutanoyl]amino]-5-[(4-hydroxyphenyl)methyl]benzoyl]amino]-3-methylpentanoic acidKi76000.0 [1], 100000.0 [2]
2-Amino-7-hydroxy-4-(4-methoxyphenyl)-4H-chromene-3-carbonitrileKi100000.0 [1]
2-Amino-7-hydroxy-4-pyridin-3-yl-4H-chromene-3-carbonitrileKi100000.0 [1]
2-Amino-7-hydroxy-4-(3,4,5-trimethoxyphenyl)-4H-chromene-3-carbonitrileKi100000.0 [1]
2-Amino-4-(3,4-dimethoxyphenyl)-7-hydroxy-4H-chromene-3-carbonitrileKi50000.0 [1]
Ethyl 2-amino-7-hydroxy-4-phenyl-4H-chromene-3-carboxylateKi100000.0 [1]
Ethyl 2-amino-7-hydroxy-4-(4-nitrophenyl)-4H-chromene-3-carboxylateKi7700.0 [1]
Ethyl 2-amino-7-hydroxy-4-(4-methylphenyl)-4H-chromene-3-carboxylateKi100000.0 [1]
3-Amino-1-pyridin-3-yl-1H-benzo[f]chromene-2-carboxylic acid ethyl esterKi100000.0 [1]
Ethyl 2-amino-4-(4-bromophenyl)-7-hydroxy-4H-chromene-3-carboxylateKi100000.0 [1]
Inhibitor 19 [PMID: 21476495]Ki1.8 [1]
Ethyl 2-amino-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylateKi1800.0 [1]
Methyl N-[4-Amino-3-(L-Arginylamino)benzene-1-Carbonyl]-L-TyrosinateIC50966.0 [1]
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-(Aminomethyl)-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acidKi100.0 [1]
(3S)-3-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-(Aminomethyl)-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-4-phenylbutanoic acidKi27.54 [1]
Ethyl 2-amino-4-(3-chlorophenyl)-7-hydroxy-4H-chromene-3-carboxylateKi35000.0 [1]
2-Amino-7-hydroxy-4-(3-methoxyphenyl)-4H-chromene-3-carbonitrileKi100000.0 [1]
Methyl (2S)-6-amino-2-[[4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]hexanoateIC5010300.0 [1]
CID 71817810IC506000.0 [1]
2-Amino-4-(3,5-dimethoxyphenyl)-7-hydroxy-4H-chromene-3-carbonitrileKi100000.0 [1]
2-Amino-4-(4-dimethylaminophenyl)-7-hydroxy-4H-1-benzopyran-3-carbonitrileKi100000.0 [1]
Methyl 4-amino-3-[[(2S)-2-amino-3-(4-phenylmethoxyphenyl)propanoyl]amino]benzoateIC5010000.0 [1]
4-Amino-3-[[(2S)-2-amino-3-(4-phenylmethoxyphenyl)propanoyl]amino]benzoic acidIC5010700.0 [1]
Methyl 4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoateIC5057000.0 [1]
4-Amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acidIC5010900.0 [1]
Methyl 4-amino-3-[[(2S)-2-amino-4-(4-phenylmethoxyphenyl)butanoyl]amino]benzoateIC502100.0 [1]
Methyl 4-amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoateIC5012000.0 [1]
Methyl 4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoateIC507200.0 [1]
Methyl 4-amino-3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]benzoateIC5014600.0 [1]
4-Amino-3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]benzoic acidIC5034000.0 [1]
(2S)-5-Amino-2-[[4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]pentanoic acidIC50100000.0 [1]
(2S)-6-Amino-2-[[4-amino-3-[[(2S)-2-amino-3-phenylpropanoyl]amino]benzoyl]amino]hexanoic acidIC503800.0 [1]
(2S)-6-Amino-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]hexanoic acidIC504800.0 [1]
Methyl (2S)-6-amino-2-[[4-amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoyl]amino]hexanoateIC5010700.0 [1]
Methyl (2S)-6-amino-2-[[4-amino-3-[[(2S)-2-amino-4-(4-phenylmethoxyphenyl)butanoyl]amino]benzoyl]amino]hexanoateIC505700.0 [1]
(2S)-6-Amino-2-[[4-amino-3-[[(2S)-2-amino-4-methylpentanoyl]amino]benzoyl]amino]hexanoic acidIC504100.0 [1]
Methyl (2S)-6-amino-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]hexanoateIC50100000.0 [1]
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-methylbutanoateIC5012000.0 [1]
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-methylbutanoic acidIC50100000.0 [1]
Methyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-(4-hydroxyphenyl)propanoateIC5022000.0 [1]
Methyl (2S,3R)-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-hydroxybutanoateIC50100000.0 [1]
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoateIC507100.0 [1]
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC50100000.0 [1]
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-4-(4-phenylmethoxyphenyl)butanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoateIC50933.0 [1]
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC504400.0 [1]
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-methylbutanoateIC501300.0 [1]
(2S)-2-[[4-Amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-methylbutanoic acidIC50100000.0 [1]
Methyl (2S)-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-(4-hydroxyphenyl)propanoateIC501200.0 [1]
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoateIC50105.0 [1]
(2S)-2-[[4-Amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC50296.0 [1]
Methyl (2S)-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-5-(diaminomethylideneamino)pentanoateIC5031000.0 [1]
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]benzoyl]amino]-3-methylbutanoic acidIC503300.0 [1]
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC50655.0 [1]
Methyl 3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoateIC5031000.0 [1]
Methyl 3-amino-4-[[(2S)-2-amino-3-(4-phenylmethoxyphenyl)propanoyl]amino]benzoateIC501700.0 [1]
Methyl 3-amino-4-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoateIC508300.0 [1]
Methyl 3-amino-4-[[(2S)-2-aminohexanoyl]amino]benzoateIC503300.0 [1]
Methyl 3-amino-4-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]benzoateIC5039600.0 [1]
Methyl (2S)-6-amino-2-[(3,4-diaminobenzoyl)amino]hexanoateIC50100000.0 [1]
Methyl (2S)-2-[(3,4-diaminobenzoyl)amino]-3-(4-hydroxyphenyl)propanoateIC509900.0 [1]
Benzyl (2S)-2-[(3,4-diaminobenzoyl)amino]-3-(1H-indol-3-yl)propanoateIC5022500.0 [1]
(2S)-2-[(3,4-Diaminobenzoyl)amino]-3-(1H-indol-3-yl)propanoic acidIC50100000.0 [1]
Methyl (2S)-2-[(3,4-diaminobenzoyl)amino]-5-(diaminomethylideneamino)pentanoateIC502500.0 [1]
Methyl (2S)-6-amino-2-[[3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]hexanoateIC5020600.0 [1]
Benzyl (2S)-2-[[3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-methylbutanoateIC5014400.0 [1]
(2S)-2-[[3-Amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-methylbutanoic acidIC5020200.0 [1]
Methyl (2S)-2-[[3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-(4-hydroxyphenyl)propanoateIC501300.0 [1]
Benzyl (2S)-2-[[3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoateIC502400.0 [1]
Methyl (2S)-2-[[3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-5-(diaminomethylideneamino)pentanoateIC504700.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cystinyl aminopeptidase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Dec. 2024, https://www.aatbio.com/data-sets/cystinyl-aminopeptidase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 20). Quest Database™ Cystinyl aminopeptidase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cystinyl-aminopeptidase-inhibitors-ic50-ki.
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