| 12,14-Dimethyl-9-(5-methylfuran-2-yl)-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 250.0 [1] |
| CFTR(inh)-172 | IC50 | 300.0 [1], 380.0 [2] |
| BPO-27 (racemate) | IC50 | 8.0 [1], 40.0 [2] |
| 9-(5-Bromofuran-2-yl)-12,14-dimethyl-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 90.0 [1], 200.0 [2] |
| 9-(5-Bromofuran-2-yl)-12,14-dimethyl-4-nitro-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-13,15-dione | IC50 | 25.0 [1], 120.0 [2] |
| 12,14-Dimethyl-9-(5-methylfuran-2-yl)-4-nitro-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-13,15-dione | IC50 | 25.0 [1], 100.0 [2] |
| Ethyl 9-(5-bromofuran-2-yl)-12,14-dimethyl-13,15-dioxo-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-4-carboxylate | IC50 | 25.0 [1], 50.0 [2] |
| 9-(5-Bromofuran-2-yl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 50.0 [1], 90.0 [2] |
| 9-(5-Iodofuran-2-yl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 100.0 [1], 170.0 [2] |
| Glyburide | IC50 | 15000.0 [1] |
| Apigenin | Ki | 81000.0 [1] |
| N-[(E)-(3,5-Dibromo-2,4-dihydroxyphenyl)methylideneamino]-2-(naphthalen-2-ylamino)acetamide | IC50 | 5000.0 [1] |
| N-(2-(5-Chloro-2-methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)benzamide | IC50 | 6000.0 [1] |
| 2-(1-Hydroxypentyl)-6-methyl-3-(2-phenylethyl)-1H-Indole-5-carboxylic acid | IC50 | 160000.0 [1] |
| 12,14-Dimethyl-9-(3-nitrophenyl)-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 1200.0 [1] |
| 4,5,12,14-Tetramethyl-9-(5-methylfuran-2-yl)-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-13,15-dione | IC50 | 800.0 [1] |
| N-[12-(5-Chloro-2-methoxyanilino)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]-2,2-dimethylpropanamide | IC50 | 2300.0 [1] |
| 2-((2-Carboxyethyl)carbamoyl)-6-methyl-3-phenethyl-1H-indole-5-carboxylic acid | IC50 | 490000.0 [1] |
| 4-((4-Oxo-2-thioxo-3-(4-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 15000.0 [1] |
| 3-(Hydroxymethyl)-5-methyl-2-pentyl-1-phenethyl-1H-indole-6-carboxylic acid | IC50 | 380000.0 [1] |
| N-[12-(5-Chloro-2-methoxyanilino)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]cyclopropanecarboxamide | IC50 | 8900.0 [1] |
| N-[12-(5-Chloro-2-methoxyanilino)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]-2-methylpropanamide | IC50 | 5800.0 [1] |
| N-[12-(5-Chloro-2-methoxyanilino)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]-2-methylbutanamide | IC50 | 6600.0 [1] |
| Methyl 4-[[12-(5-chloro-2-methoxyanilino)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]amino]-4-oxobutanoate | IC50 | 8800.0 [1] |
| N-[12-(5-Chloro-2-methoxyanilino)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]-1,2-oxazole-5-carboxamide | IC50 | 4800.0 [1] |
| N-[12-[5-Chloro-2-(dimethylamino)anilino]-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]-2,2-dimethylpropanamide | IC50 | 6900.0 [1] |
| 2,2-Dimethyl-N-[12-[(3-methylpyridin-2-yl)amino]-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]propanamide | IC50 | 7200.0 [1] |
| N-[12-[3-(Dimethylamino)anilino]-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]-2,2-dimethylpropanamide | IC50 | 2200.0 [1] |
| N-[12-(2-Methoxy-5-nitroanilino)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraen-4-yl]-2,2-dimethylpropanamide | IC50 | 3600.0 [1] |
| 2-(3-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)phenoxy)acetic acid | IC50 | 30000.0 [1] |
| 3-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 1500.0 [1] |
| (Z)-5-(4-(1H-Tetrazol-5-yl)benzylidene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one | IC50 | 760.0 [1] |
| 5-(4-(2H-Tetrazol-5-yl)benzylidene)-3-(3-(trifluoromethyl)phenyl)thiazolidine-2,4-dione | IC50 | 17000.0 [1] |
| (2S,3S,4R)-3,4-Dihydroxy-2,4-dimethyl-3H-pyrimido[2,1-a]isoquinoline-2-carboxylic acid | IC50 | 15.0 [1] |
| (2R,4S,5R,6S)-2-Nonyl-6-phenyl-7-oxa-1-azabicyclo[3.2.1]octan-4-ol | IC50 | 58620.0 [1] |
| (Z)-4-((3-(2,3-Dimethylphenyl)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 7000.0 [1] |
| 5-(4-Pyridinylmethylene)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one | IC50 | 28000.0 [1] |
| 4-[[4-Chloro-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]pyrrol-3-yl]amino]benzoic acid | IC50 | 36000.0 [1] |
| 2-(4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)phenoxy)acetic acid | IC50 | 2600.0 [1] |
| (5Z)-5-(4-Hydroxybenzylidene)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one | IC50 | 24000.0 [1] |
| 9-(3-Chlorophenyl)-17-(2-fluorophenyl)-12,14-dimethyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2500.0 [1] |
| 17-(2-Fluorophenyl)-4,5,12,14-tetramethyl-9-(5-methylfuran-2-yl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-13,15-dione | IC50 | 1500.0 [1] |
| 5-(3,5-Dibromo-4-hydroxybenzylidene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one | IC50 | 7000.0 [1] |
| 2-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 15000.0 [1] |
| 9-(4-Hydroxyphenyl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 4500.0 [1] |
| 9-(2-Fluorophenyl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2000.0 [1] |
| 9-(3-Methoxyphenyl)-12,14-dimethyl-17-(3-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 1700.0 [1] |
| 9-(3-Fluorophenyl)-12,14-dimethyl-17-(3-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 8000.0 [1] |
| 9-(2-Fluorophenyl)-12,14-dimethyl-17-(3-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2500.0 [1] |
| 12,14-Dimethyl-17-(2-methylphenyl)-9-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 5000.0 [1] |
| 12,14-Dimethyl-17-(2-methylphenyl)-9-(3-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 3000.0 [1] |
| 9-(3-Methoxyphenyl)-12,14-dimethyl-17-(2-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 3000.0 [1] |
| 9-(4-Hydroxyphenyl)-4,5,12,14-tetramethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-13,15-dione | IC50 | 1500.0 [1] |
| 4-((4-Oxo-2-thioxo-3-(2-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 12000.0 [1] |
| 2-Hydroxy-5-((4-oxo-2-thioxo-3-(2-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 14000.0 [1] |
| 2-(4-Carboxybutyl)-3-(hydroxymethyl)-5-methyl-1-(2-phenylethyl)indole-6-carboxylic acid | IC50 | 170000.0 [1] |
| 12-N-(5-Chloro-2-methoxyphenyl)-3,11-dithia-5,13-diazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,12-tetraene-4,12-diamine | IC50 | 11000.0 [1] |
| N-[13-(5-Chloro-2-methoxyanilino)-3,12-dithia-5,14-diazatricyclo[9.3.0.02,6]tetradeca-1(11),2(6),4,13-tetraen-4-yl]-2,2-dimethylpropanamide | IC50 | 4100.0 [1] |
| 9-(3-Methoxyphenyl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 1700.0 [1] |
| 4-[2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]sulfanylbenzoic acid | IC50 | 7000.0 [1] |
| 2-Hydroxy-5-[(Z)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid | IC50 | 1400.0 [1] |
| (5Z)-2-Sulfanylidene-3-[3-(trifluoromethyl)phenyl]-5-[(3,4,5-trihydroxyphenyl)methylidene]-1,3-thiazolidin-4-one | IC50 | 11000.0 [1] |
| 4-((3-(4-Fluoro-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 1500.0 [1] |
| 4-((3-(4-Chloro-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 15000.0 [1] |
| 4-((3-(3,5-Bis(trifluoromethyl)phenyl)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 14000.0 [1] |
| 3-((3-(4-Fluoro-3-(trifluoromethyl)phenyl)-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 5000.0 [1] |
| 4-[[4-Oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidine-5-carbothioyl]amino]benzoic acid | IC50 | 9000.0 [1] |
| 5-(3,5-Dibromo-2,4-dihydroxybenzylidene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one | IC50 | 8000.0 [1] |
| (5Z)-5-[(1-Oxidopyridin-1-ium-4-yl)methylidene]-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one | IC50 | 8700.0 [1] |
| 4-[[4-Oxo-2-thioxo-3-[2-methyl-3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl] benzoic acid | IC50 | 8200.0 [1] |
| 2-(4-Carboxy-1-hydroxybutyl)-6-methyl-3-(2-phenylethyl)-1H-indole-5-carboxylic acid | IC50 | 330000.0 [1] |
| 2-Hydroxy-4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidine-5-carbothioyl]amino]benzoic acid | IC50 | 25000.0 [1] |
| 4-[[4-Oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-yl]methyl]benzoic acid | IC50 | 27000.0 [1] |
| 4-(4-(3-(Trifluoromethyl)phenyl)thiazol-2-ylamino)benzoic acid | IC50 | 28000.0 [1] |
| 2-Hydroxy-5-(4-(3-(trifluoromethyl)phenyl)thiazol-2-ylamino)benzoic acid | IC50 | 32000.0 [1] |
| 4-((4-Oxo-2-thioxo-3-m-tolylthiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 5000.0 [1] |
| 3-((4-Oxo-2-thioxo-3-(4-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 13000.0 [1] |
| 2-((4-Oxo-2-thioxo-3-(2-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 18000.0 [1] |
| 3-((4-Oxo-2-thioxo-3-(2-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 19000.0 [1] |
| 2-((4-Oxo-2-thioxo-3-(4-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 20000.0 [1] |
| 4-[(Z)-[3-[2-Chloro-5-(trifluoromethyl)phenyl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]benzoic acid | IC50 | 20000.0 [1] |
| 2-Hydroxy-5-((4-oxo-2-thioxo-3-(4-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid | IC50 | 25000.0 [1] |
| (5Z)-2-Sulfanylidene-3-[3-(trifluoromethyl)phenyl]-5-[(2,3,4-trihydroxyphenyl)methylidene]-1,3-thiazolidin-4-one | IC50 | 28000.0 [1] |
| 12,14-Dimethyl-9-(5-methylfuran-2-yl)-17-(3-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 700.0 [1] |
| 12,14-Dimethyl-9,17-diphenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2500.0 [1] |
| 9-(4-Hydroxy-2-methoxyphenyl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 100000.0 [1] |
| 9-(2,3-Difluorophenyl)-12,14-dimethyl-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 1200.0 [1] |
| 9-(4-Hydroxyphenyl)-12,14-dimethyl-17-(3-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 1700.0 [1] |
| 12,14-Dimethyl-17-(2-methylphenyl)-9-(3-nitrophenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2000.0 [1] |
| 12,14-Dimethyl-9-(5-methylfuran-2-yl)-17-(2-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 800.0 [1] |
| 17-(2-Fluorophenyl)-9-(3-methoxyphenyl)-12,14-dimethyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2000.0 [1] |
| 9-(2-Fluoro-3-nitrophenyl)-12,14-dimethyl-17-(3-methylphenyl)-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2000.0 [1] |
| 9-(5-Iodofuran-2-yl)-12,14-dimethyl-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 500.0 [1] |
| 12,14-Dimethyl-9-(5-methylfuran-2-yl)-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 150.0 [1] |
| 9-(5-Chlorofuran-2-yl)-12,14-dimethyl-17-(3-methylphenyl)-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 370.0 [1] |
| 12,14-Dimethyl-9-(5-methylfuran-2-yl)-17-(3-methylphenyl)-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 600.0 [1] |
| 9-(5-Bromofuran-2-yl)-12,14-dimethyl-4-nitro-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-13,15-dione | IC50 | 170.0 [1] |
| 4-Chloro-12,14-dimethyl-9-(5-methylfuran-2-yl)-5-nitro-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 170.0 [1] |
| Ethyl 12,14-dimethyl-9-(5-methylfuran-2-yl)-13,15-dioxo-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-4-carboxylate | IC50 | 80.0 [1] |
| 12,14-Dimethyl-9-(5-methylfuran-2-yl)-8-nitroso-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | IC50 | 2000.0 [1] |