Cysteinyl leukotriene receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylic acid	IC50	35.0 [1], 50.12 [2], 510.0 [3], 4000.0 [4]
	7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylic acid	Ki	1000.0 [1]
	Zafirlukast	IC50	5.0 [1]
	Zafirlukast	Ki	0.3 [1], 2.0 [2]
	Montelukast	IC50	0.43 [1], 0.64 [2]
	Pranlukast	IC50	0.04 [1]
	Pranlukast	Ki	0.8 [1]
	Sodium;7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylate	IC50	100.0 [1]
	Sodium;7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylate	Ki	2007.0 [1]
	Tomelukast	Ki	600.0 [1], 800.0 [2]
	alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol	IC50	510.0 [1]
	alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol	Ki	700.0 [1]
	Cyclopentyl N-[1-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]indazol-6-yl]carbamate	IC50	1.0 [1]
	Cyclopentyl N-[1-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]indazol-6-yl]carbamate	Ki	0.2 [1]
	Ritolukast	IC50	6000.0 [1]
	Ritolukast	Ki	35.0 [1]
	2-((3-(3-(1H-Tetrazol-5-yl)propoxy)phenoxy)methyl)quinoline	IC50	79.0 [1]
	2-((3-(3-(1H-Tetrazol-5-yl)propoxy)phenoxy)methyl)quinoline	Ki	42.0 [1]
	4-Hexyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	208.93 [1], 210.0 [2]
	4-Heptyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	70.0 [1], 70.79 [2]
	4-Octyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	100.0 [1]
	4-Nonyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	158.49 [1], 160.0 [2]
	4-Decyl-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	500.0 [1], 501.19 [2]
	4-Pentoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	100.0 [1]
	4-Hexoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	12.88 [1], 13.0 [2]
	4-Heptoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	8.91 [1], 9.0 [2]
	4-Octoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	14.0 [1], 14.13 [2]
	4-Nonoxy-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide	IC50	19.95 [1], 20.0 [2]
	4-Hexyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	15.0 [1], 15.14 [2]
	4-Heptyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	4.17 [1], 4.2 [2]
	4-Octyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	5.5 [1]
	4-Nonyl-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	7.0 [1], 7.08 [2]
	4-Hexoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	0.85 [1], 0.86 [2]
	4-Heptoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	0.5 [1]
	4-Octoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	5.5 [1]
	4-Nonoxy-N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]benzamide	IC50	7.4 [1], 7.41 [2]
	4-[4-(2-Quinolylmethoxy)phenoxy]butyric acid	IC50	800.0 [1]
	4-[4-(2-Quinolylmethoxy)phenoxy]butyric acid	Ki	1200.0 [1]
	2-[4-[4-(1H-Tetrazol-5-yl)butyl]phenoxymethyl]quinoline	IC50	36.0 [1]
	2-[4-[4-(1H-Tetrazol-5-yl)butyl]phenoxymethyl]quinoline	Ki	18.0 [1]
	2-[1-[[(1R)-1-[3-[(E)-2-(5-Ethyl-6-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	2.7 [1], 50.4 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(6,7-Dihydro-5H-cyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.5 [1], 4.5 [2]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(8-methyl-5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.51 [1], 0.63 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(6-Butyl-5-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.5 [1], 0.9 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(5,7-Dihydrothieno[3,4-b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.21 [1], 2.1 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(6,6-Dimethyl-5,7-dihydrocyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.34 [1], 0.43 [2]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5-methyl-6-propan-2-ylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	4.7 [1], 4.9 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-[6-Ethyl-5-(trifluoromethyl)pyridin-2-yl]ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	25.2 [1], 36.9 [2]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.19 [1], 1.8 [2]
	2-[4-[3-(1H-Tetrazol-5-yl)propoxy]phenoxymethyl]quinoline	IC50	250.0 [1]
	2-[4-[3-(1H-Tetrazol-5-yl)propoxy]phenoxymethyl]quinoline	Ki	69.0 [1]
	4-[3-(2-Quinolylmethoxy)phenoxy]butyric acid	IC50	240.0 [1]
	4-[3-(2-Quinolylmethoxy)phenoxy]butyric acid	Ki	130.0 [1]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.58 [1], 1.8 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(7,7-Dimethyl-5,6-dihydrocyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.35 [1], 0.87 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dihydrothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.74 [1], 4.8 [2]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5-methyl-6-propylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.5 [1], 0.7 [2]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-[5-methyl-6-(2-methylpropyl)pyridin-2-yl]ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	1.2 [1], 1.4 [2]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(7-methyl-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.73 [1], 1.35 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(8,8-Dimethyl-6,7-dihydro-5H-quinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.75 [1], 2.6 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(7,7-Dimethyl-6,8-dihydro-5H-quinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.17 [1], 0.19 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(6-Ethyl-5-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.8 [1], 3.4 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(5-Chloro-6-ethylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	1.2 [1], 1.7 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(5,6-Dimethylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.9 [1], 24.8 [2]
	2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-thieno[3,2-b]pyridin-5-ylethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	1.31 [1], 20.4 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2-Chlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.57 [1], 0.72 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Difluorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.26 [1], 0.42 [2]
	2-[1-[[(1R)-1-[3-[2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)cyclopropyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	9.12 [1], 10.9 [2]
	2-[1-[[(1R)-1-[3-[(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)methoxy]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.42 [1], 2.2 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(hydroxymethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.48 [1]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	1.21 [1], 4.12 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[4-(1-hydroxycyclobutyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.29 [1], 0.58 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[3-(1-hydroxycyclobutyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.24 [1], 0.44 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[4-(trifluoromethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	1.43 [1], 3.84 [2]
	2-[1-[[(1R)-1-[3-[(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)oxymethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	150.0 [1]
	2-[1-[[(1R)-1-[3-[2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.42 [1], 3.21 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(trifluoromethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.87 [1], 1.95 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-(4-fluorophenyl)propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.65 [1], 1.09 [2]
	2-[1-[[(1R)-3-(4-Bromophenyl)-1-[3-[(E)-2-(2,3-dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	1.03 [1], 1.95 [2]
	2-[1-[[(1R)-3-(2-Bromophenyl)-1-[3-[(E)-2-(2,3-dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	1.93 [1], 2.6 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-phenylpropyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.34 [1], 0.37 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(1-hydroxycyclobutyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.34 [1], 0.74 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[4-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.2 [1], 0.56 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(2,3-Dichlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.34 [1], 0.89 [2]
	2-[1-[[(1R)-1-[3-[(E)-2-(3-Chlorothieno[3,2-b]pyridin-5-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid	IC50	0.54 [1], 1.58 [2]
	MK-571 sodium	Ki	0.2 [1]
	Pobilukast	Ki	5.0 [1]
	N-(p-Amylcinnamoyl)anthranilic acid	IC50	14000.0 [1]
	4-((3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl)-gamma-oxobenzenebutanoic acid	Ki	6200.0 [1]
	5-(2-(8-Phenyloctyl)phenyl)-4,6-dithianonanedioic acid	Ki	245.0 [1]
	2-((4-((2-(1H-Tetrazol-5-ylmethyl)phenyl)methoxy)phenoxy)methyl)quinoline	Ki	3.0 [1]
	Iralukast sodium	Ki	26.0 [1]
	1-(2-Hydroxy-3-propyl-4-((4-(1H-tetrazol-5-ylmethyl)phenoxy)methyl)phenyl)ethanone	IC50	10.0 [1]
	(E)-2-(2-(Quinolin-2-yl)vinyl)phenol	IC50	50000.0 [1]
	Benzenepropanoic acid, beta-((2-carboxyethyl)thio)-2-(8-phenyloctyl)-, (betaS)-	Ki	60.0 [1]
	5-(2-Dodecylphenyl)-4,6-dithianonanedioic acid	Ki	445.0 [1]
	N-[5-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]-4-chloro-2-methylphenyl]-2H-tetrazole-5-carboxamide	IC50	1000.0 [1]
	4-[(E)-2-(Quinolin-2-yl)ethenyl]phenol	IC50	50000.0 [1]
	Cyclopentyl N-[3-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]-1-methylindol-5-yl]carbamate	Ki	0.8 [1]
	Butanoic acid, 2,2-diethyl-4-((3-((7-fluoro-2-quinolinyl)methoxy)phenyl)amino)-4-oxo-	IC50	0.2 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Cysteinyl leukotriene receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/cysteinyl-leukotriene-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Cysteinyl leukotriene receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cysteinyl-leukotriene-receptor-inhibitors-ic50-ki.
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