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Cysteinyl leukotriene receptor 1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
MontelukastIC500.5 [1], 0.78 [2], 2.3 [3]
MontelukastKi1.14 [1]
ZafirlukastIC501.8 [1], 1.9 [2], 14.0 [3]
ZafirlukastKi0.86 [1]
Leukotriene D4IC500.7 [1], 7.0 [2]
Leukotriene D4Ki0.6 [1]
PranlukastIC500.8 [1], 4.3 [2], 4.4 [3]
3-[(3-Carboxycyclohexyl)carbamoyl]-4-[3-[4-(4-cyclohexyloxybutoxy)phenyl]propoxy]benzoic AcidIC5010000.0 [1]
4-(3-Carboxypropyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC508.5 [1], 11.0 [2]
Montelukast sodiumIC502.3 [1], 310.0 [2]
BayCysLT2IC502500.0 [1]
4-[3-(Carboxymethyl)-4-[(E)-2-[4-(4-phenoxybutoxy)phenyl]ethenyl]indol-1-yl]butanoic acidIC5012.0 [1], 13.0 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(6,7-Dihydro-5H-cyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.44 [1], 0.5 [2]
CI-959 free acidIC50200.0 [1], 2200.0 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(8-methyl-5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.47 [1], 0.51 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(5,7-Dihydrothieno[3,4-b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.21 [1], 0.61 [2]
2-[1-[[(1R)-1-[3-[(E)-2-(6,6-Dimethyl-5,7-dihydrocyclopenta[b]pyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.34 [1], 0.56 [2]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5,6,7,8-tetrahydroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.19 [1], 0.25 [2]
DiethylstilbestrolKi8872.0 [1]
ClotrimazoleKi16586.0 [1]
VerlukastumIC508.0 [1]
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propylchromene-2-carboxylic acidIC504000.0 [1]
Pranlukast hemihydrateIC5023.0 [1]
Sulindac sulfideKi14684.0 [1]
PobilukastKi10.0 [1]
(S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acidKi5455.0 [1]
Benzoic acid, 2-[[3-(2-quinolinylmethoxy)phenyl]amino]-IC5023.0 [1]
4-[(4S,5R,6E,8E,10Z,13Z)-1-Carboxy-4-hydroxynonadeca-6,8,10,13-tetraen-5-yl]sulfanylbenzoic acidIC50440.0 [1]
AblukastIC504000.0 [1]
GemilukastIC501.7 [1]
4-Oxo-2-(3-(quinolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC5017.0 [1]
7-(Quinolin-2-ylmethoxy)-N-[2-[4-(2H-tetrazol-5-yl)phenyl]ethyl]naphthalene-2-carboxamideIC503.4 [1]
4-Oxo-2-(4-(2-(quinolin-2-yl)vinyl)phenyl)-4H-chromene-8-carboxylic acidIC50270.0 [1]
6-Bromo-4-oxo-2-(3-(quinolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC5031.0 [1]
4-Butoxy-3-(3-(3-(quinolin-2-ylmethoxy)phenyl)acryloyl)benzoic acidIC50300.0 [1]
4-Hydroxy-3-(3-(3-(2-(quinolin-2-yl)vinyl)phenyl)acryloyl)benzonitrileIC50346.0 [1]
2-(3-(3-(Quinolin-2-ylmethoxy)phenyl)acryloyl)benzoic acidIC5031.0 [1]
4-Oxo-2-(3-(2-(quinolin-2-yl)vinyl)phenyl)-4H-chromene-6-carboxylic acidIC50408.0 [1]
(E)-1-[2-Hydroxy-5-(2H-tetrazol-5-ylmethoxy)phenyl]-3-[3-[(E)-2-quinolin-2-ylethenyl]phenyl]prop-2-en-1-oneIC5045.0 [1]
2-Hydroxy-5-methyl-3-(3-(3-(2-(quinolin-2-yl)vinyl)phenyl)acryloyl)benzoic acidIC50105.0 [1]
5-Chloro-2-hydroxy-3-(3-(3-(2-(quinolin-2-yl)vinyl)phenyl)acryloyl)benzoic acidIC506.6 [1]
5-Bromo-2-hydroxy-3-(3-(3-(2-(quinolin-2-yl)vinyl)phenyl)acryloyl)benzoic acidIC50207.0 [1]
6-Bromo-4-oxo-2-(4-(quinolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC50500.0 [1]
N-{6-Bromo-4-oxo-2-[4-(quinolin-2-ylmethoxy)-phenyl]-4H-chromene-8-carbonyl}-benzenesulfonamideIC50382.0 [1]
4-Hydroxy-3-(3-(3-(quinolin-2-ylmethoxy)phenyl)acryloyl)benzoic acidIC50609.0 [1]
2-(3-(4-(Quinolin-2-ylmethoxy)phenyl)acryloyl)benzoic acidIC50143.0 [1]
4-Oxo-2-(4-(quinazolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC501100.0 [1]
2-[3-[2-(2-Quinolyl)ethenyl]phenyl]-4-oxo-6-methyl-4H-1-benzopyran-8-carboxylic acidIC5013.0 [1]
5-Chloro-2-hydroxy-3-(3-(3-(quinolin-2-ylmethoxy)phenyl)acryloyl)benzoic acidIC50104.0 [1]
6-Bromo-4-oxo-2-(3-(2-(quinolin-2-yl)vinyl)phenyl)-4H-chromene-8-carboxylic acidIC5017.0 [1]
4-Oxo-2-(3-(2-(quinolin-2-yl)vinyl)phenyl)-4H-chromene-6-carbonitrileIC501700.0 [1]
3-Chloro-4-hydroxy-5-(3-(4-(quinolin-2-ylmethoxy)phenyl)acryloyl)benzoic acidIC501700.0 [1]
6-Bromo-2-(3-((7-chloroquinolin-2-yl)methoxy)phenyl)-4-oxo-4H-chromene-8-carboxylic acidIC5012.0 [1]
3-[4-(2-Quinolylmethoxy)cinnamoyl]-4-hydroxybenzoic acidIC50450.0 [1]
2-Hydroxy-3-(3-(3-(quinolin-2-ylmethoxy)phenyl)acryloyl)benzoic acidIC50415.0 [1]
6-Bromo-4-oxo-2-(3-(quinazolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC50101.0 [1]
8-Carboxy-4'-(2-quinolinylmethoxy)flavoneIC50530.0 [1]
4-(2-Quinolylmethoxy)-2'-hydroxy-5'-(1H-tetrazol-5-yl)chalconeIC5014.0 [1]
2-[1-[[(1R)-1-[3-[(E)-2-(5-Ethyl-6-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC502.7 [1]
2-[1-[[(1R)-1-[3-[(E)-2-(6-Butylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC502.4 [1]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-pyridin-2-ylethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC50190.0 [1]
2-[1-[[7-(2-Quinolinylmethoxy)-2-naphthyl]sulfonylamino]ethyl]phenylacetic acidIC508.4 [1]
4-(4-(4-(Quinolin-2-ylmethoxy)benzylcarbamoyl)phenyl)butanoic acidIC5044.0 [1]
4-[[7-(2-Quinolinylmethoxy)-2-naphthylmethoxy]methyl]benzoic acidIC507.3 [1]
2-[6-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-N-[4-(1H-tetrazol-5-yl)-benzyl]-propionamideIC509.2 [1]
4-((7-(Quinolin-2-ylmethoxy)naphthalen-2-ylcarbamoyloxy)methyl)benzoic acidIC509.0 [1]
4-(2-(N-Methyl-7-(quinolin-2-ylmethoxy)naphthalene-2-sulfonamido)ethyl)benzoic acidIC5013.0 [1]
4-(4-(7-(Quinolin-2-ylmethoxy)naphthalen-2-yloxy)butyl)benzoic acidIC5021.0 [1]
3-[2-[7-(2-Quinolinylmethoxy)-2-naphthylmethoxy]ethyl]benzoic acidIC504.6 [1]
4-(4-{[6-(Quinolin-2-ylmethoxy)-naphthalene-2-carbonyl]-amino}-phenyl)-butyric acidIC507.3 [1]
4-Oxo-2-(1H-tetrazol-5-yl)-4H-chromene-8-carboxylic acid 4-(quinolin-2-ylmethoxy)-benzylamideIC5086.0 [1]
4-[4-[[7-(2-Quinolinylmethoxy)-2-naphthyl]carbonylamino]phenyl]butyric acidIC501.5 [1]
2-(4-(2-(6-(Quinolin-2-ylmethoxy)naphthalen-2-yl)propanamido)phenyl)acetic acidIC5030.0 [1]
4-(2-Methyl-1-(7-(quinolin-2-ylmethoxy)naphthalene-2-sulfonamido)propan-2-yl)benzoic acidIC503.8 [1]
2-[4-(Quinolin-2-ylmethoxy)-phenyl]-N-[4-(1H-tetrazol-5-yl)-benzyl]-acetamideIC5038.0 [1]
2-[1-[[(1R)-1-[3-[(E)-2-(6-Butyl-5-methylpyridin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC500.9 [1]
2-[1-[[(1R)-3-[2-(2-Hydroxypropan-2-yl)phenyl]-1-[3-[(E)-2-(5-methyl-6-propan-2-ylpyridin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC504.9 [1]
6-[(E)-2-[3-[(1R)-1-[[1-(Carboxymethyl)cyclopropyl]methylsulfanyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]phenyl]ethenyl]pyridine-3-carboxylic acidIC50421.0 [1]
2-[1-[[(1R)-1-[3-[(E)-2-[6-Ethyl-5-(trifluoromethyl)pyridin-2-yl]ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acidIC5025.2 [1]
4-(2-((7-(Quinolin-2-ylmethoxy)naphthalen-2-yl)methoxy)ethyl)benzoic acidIC502.7 [1]
6-Chloro-4-oxo-2-(3-(2-(quinolin-2-yl)vinyl)phenyl)-4H-chromene-8-carboxylic acidIC5011.0 [1]
6-Bromo-4-oxo-3-propoxy-2-(3-(quinolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC5044.0 [1]
6-Bromo-3-hydroxy-4-oxo-2-(3-(quinolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC5038.0 [1]
3-(2-(Dimethylamino)ethoxy)-4-oxo-2-(4-(quinolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acidIC504000.0 [1]
6-Bromo-4-oxo-3-(quinolin-2-ylmethoxy)-2-[3-(quinolin-2-ylmethoxy)phenyl]chromene-8-carboxylic acidIC5063.0 [1]
4-[2-(Methylsulfonylcarbamoyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acidIC5022.0 [1]
4-(3-Carboxypropyl)-8-[[4-(4-phenylbutoxy)phenyl]methoxy]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC5058.0 [1]
4-[8-[(E)-2-[4-(4-Phenylbutoxy)phenyl]ethenyl]-2-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acidIC500.59 [1]
4-(3-Carboxypropyl)-8-[[4-(4-phenoxybutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC5032.0 [1]
4-(3-Carboxypropyl)-8-[[4-(5-phenylpentoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC50120.0 [1]
4-[8-[2-[4-(4-Phenylbutoxy)phenyl]ethyl]-2-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acidIC5035.0 [1]
(2R)-4-(3-Carboxypropyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC5051.0 [1]
(2S)-4-(3-Carboxypropyl)-8-[[4-(4-phenylbutoxy)benzoyl]amino]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC5017.0 [1]
4-[8-[[4-(4-Phenylbutoxy)benzoyl]amino]-2-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzoxazin-4-yl]butanoic acidIC500.79 [1]
4-(3-Carboxypropyl)-8-[(E)-2-[4-(4-phenoxybutoxy)phenyl]ethenyl]-2,3-dihydro-1,4-benzoxazine-2-carboxylic acidIC5024.0 [1]
1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanoneIC5024.1 [1]
1-[2-Hydroxy-4-[[3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]-3-(trifluoromethyl)phenyl]ethanoneIC50112.0 [1]
1-[2-Hydroxy-3-methyl-4-[[4-[3-(2H-tetrazol-5-yl)phenoxy]phenyl]methoxy]phenyl]ethanoneIC501430.0 [1]
4-(1-Carboxymethyl-7-(4-(4-phenoxybutyloxy)styryl)-1H-indole-3-yl)butyric acidIC501.5 [1]
7-[[4-(4-Phenylbutoxy)benzoyl]amino]-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acidIC504600.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cysteinyl leukotriene receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/cysteinyl-leukotriene-receptor-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Cysteinyl leukotriene receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cysteinyl-leukotriene-receptor-1-inhibitors-ic50-ki.
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