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Cyclooxygenase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
PhenidoneIC5012000.0 [1], 94000.0 [2]
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineIC505800.0 [1], 12000.0 [2], 97000.0 [3]
6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazoleIC50100000.0 [1], 300000.0 [2]
PrifeloneIC505.7 [1], 500.0 [2]
2,3-Di-t-butyl-4-(2-(3-pyridyl)ethenyl)phenolIC50260.0 [1], 670.0 [2]
2,6-Di-tert-butyl-4-(2-thiophen-2-yl-vinyl)-phenolIC5034.0 [1], 63.0 [2]
2-Ethylamino-5,7-dimethyl-4-pyridin-3-ylmethyl-benzothiazol-6-ol; dihydrochlorideIC50100000.0 [1], 300000.0 [2]
AspirinIC5015000.0 [1]
IndomethacinIC5010.0 [1]
CelecoxibIC5089.0 [1]
IsoliquiritigeninIC50130000.0 [1]
LicofeloneIC50160.0 [1]
TomelukastIC5044000.0 [1]
ButeinIC50120000.0 [1]
alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolIC505300.0 [1]
4'-HydroxydiclofenacIC507079457.84 [1]
N-(3-Phenoxycinnamyl)acetohydroxamic acidIC503200.0 [1]
PirmagrelIC5010000.0 [1]
5-HydroxydiclofenacIC50446683.59 [1]
RomazaritIC506500000.0 [1]
ClobuzaritIC50950000.0 [1]
alpha-(3,5-Di-tert-Butyl-4-hydroxybenzylidene)gamma-butyrolactoneIC50110.0 [1]
6-Maleimidocaproic acidIC50800000.0 [1]
2-Anilinophenylacetic acidIC503467368.5 [1]
2',3,4-TrihydroxychalconeIC5044000.0 [1]
N-(4-Benzyloxybenzyl)acetohydroxamic acidIC5022000.0 [1]
N-Benzyl-2-(pyridin-3-yl)quinazolin-4-amineIC5050000.0 [1]
3'-Hydroxy-4'-methoxydiclofenacIC503388441.56 [1]
2-(2-(2-Chlorophenylamino)phenyl)acetic acidIC504897788.19 [1]
EnofelastIC501300.0 [1]
3-((N-(Aminocarbonyl)-N-hydroxyamino)methyl)-6-phenoxychromeneIC5036000.0 [1]
3'-HydroxydiclofenacIC50100000000.0 [1]
Chembl4169347IC5023.0 [1]
2-(2-(2,5-Dichlorophenylamino)phenyl)acetic acidIC5010000000.0 [1]
4',5-DihydroxydiclofenacIC50912010.84 [1]
Octyl MaleimideIC509000.0 [1]
(E)-3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-oneIC5063000.0 [1]
2,6-Dimethyl-4-[(E)-2-phenylethenyl]phenolIC504200.0 [1]
2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)phenolIC50780.0 [1]
N-(Carboxyheptyl)maleimideIC50100.0 [1]
Benzeneacetic acid, 2-[(3,5-dichlorophenyl)amino]-IC5012589254.12 [1]
3-[1-[(4-Chlorophenyl)methyl]-3-(3,3-dimethylbutanoyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidIC502.0 [1]
5-(3,5-Ditert-butyl-4-hydroxyphenyl)-3H-1,3,4-thiadiazole-2-thione;2-hydroxyethyl(trimethyl)azaniumIC50800.0 [1]
1,1-Diethyl-3-[(2R)-2-hydroxy-2-[3-(quinolin-2-ylmethoxy)phenyl]ethyl]-3-methylureaIC50100000.0 [1]
4-[(E)-2-(4-Methoxyphenyl)ethenyl]-2,6-di-tert-butylphenolIC5010000.0 [1]
2,6-Di-tert-butyl-4-(2-p-tolyl-vinyl)-phenolIC5010000.0 [1]
4-[(E)-2-(4-Fluorophenyl)ethenyl]-2,6-di-tert-butylphenolIC50610.0 [1]
2,6-Diisopropyl-4-(2-pyridin-3-yl-vinyl)-phenolIC5010000.0 [1]
2,6-Di(propan-2-yl)-4-[(E)-2-thiophen-2-ylethenyl]phenolIC501000.0 [1]
2-[2-(2,6-Dimethylanilino)phenyl]acetic acidIC50165958690.74 [1]
(E)-3-(4-Hydroxy-3,5-dimethylstyryl)benzoic acidIC5010000.0 [1]
N-NonylmaleimideIC5012000.0 [1]
(5E)-2-Amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-oneIC50390.0 [1]
N-[4-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]but-3-yn-2-yl]-N-hydroxyacetamideIC5030.0 [1]
7-Ethyl-5-methoxy-2-(methylamino)-4-(3-pyridinylmethyl)-1,3-benzothiazol-6-olIC50100000.0 [1]
2-[(3-Pyridinylmethyl)amino]-4,5,7-trimethylbenzothiazol-6-olIC50100000.0 [1]
5-Methyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indol-2-olIC50400.0 [1]
2-[(3-Pyridinylmethyl)amino]-4-phenylbenzothiazol-6-olIC509600.0 [1]
Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amineIC5051000.0 [1]
2-[(3-Pyridinylmethyl)amino]-4-methylnaphtho[1,2-d]thiazol-5-olIC505500.0 [1]
4,7-Dimethyl-2-[(3-pyridinylmethyl)amino]-1,3-benzothiazol-6-olIC50100000.0 [1]
2-(Ethylamino)-4,5-dimethyl-7-(3-pyridinylmethyl)-1,3-benzothiazol-6-olIC50100000.0 [1]
2-(Ethylamino)-4,7-dimethyl-5-(3-pyridinylmethyl)-1,3-benzothiazol-6-olIC50100000.0 [1]
2-Carboxy-5-Maleimidophenyl AcetateIC50300000.0 [1]
7-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)heptanoic acidIC50570000.0 [1]
4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-YL)methyl]benzoic acidIC5027000.0 [1]
9-(2,5-Dioxo-3-pyrrolin-1-yl)nonanoic acidIC5026000.0 [1]
2-[2-(2,5-Dioxopyrrol-1-yl)ethoxy]benzoic acidIC50250000.0 [1]
10-(2,5-Dioxopyrrol-1-yl)decanoic acidIC5037000.0 [1]
2-Acetyloxy-5-(2,5-dioxopyrrol-1-yl)benzoic acidIC5029000.0 [1]
2-[(3-Pyridinylmethyl)amino]-5,7-dimethoxybenzothiazol-6-olIC50100000.0 [1]
3-(4-Hydroxy-3,5-dimethyl-benzylidene)-dihydro-furan-2-oneIC5010000.0 [1]
2-[(2,4-Dichlorophenyl)amino]phenylacetic acidIC5014125375.45 [1]
4-[(E)-2-(2-Pyridinyl)ethenyl]-2,6-dimethylphenolIC502500.0 [1]
2,6-Dimethyl-4-(2-pyridin-4-yl-vinyl)-phenolIC5010000.0 [1]
(5R)-3-Methyl-5-[3-(quinolin-2-ylmethoxy)phenyl]-1,3-oxazolidin-2-oneIC50100000.0 [1]
N-Hydroxy-N-methyl-3-(3-phenoxy-phenyl)-acrylamideIC505000.0 [1]
2,6-Ditert-butyl-4-[(E)-2-(5-chlorothiophen-2-yl)ethenyl]phenolIC50670.0 [1]
9-(4-Chlorophenyl)sulfonyl-6-methylsulfonyl-2,3-dihydro-1H-carbazol-4-oneIC5034.0 [1]
9-[(4-Chlorophenyl)methyl]-6-methylsulfonyl-1,2,3,4-tetrahydrocarbazoleIC5027.0 [1]
9-[(4-Chlorophenyl)methyl]-6-methoxy-2,2-dimethyl-1,3-dihydrocarbazol-4-oneIC5044.0 [1]
(4-Chlorophenyl)-(6-methylsulfonyl-1,2,3,4-tetrahydrocarbazol-9-yl)methanoneIC5038.0 [1]
9-(4-Chlorobenzoyl)-6-methoxy-2,2-dimethyl-1,3-dihydrocarbazol-4-oneIC5050.0 [1]
9-[(4-Chlorophenyl)methyl]-6-methylsulfonyl-2,3-dihydro-1H-carbazol-4-oneIC5033.0 [1]
9-(4-Chlorophenyl)sulfonyl-6-methoxy-2,2-dimethyl-1,3-dihydrocarbazol-4-oneIC5041.0 [1]
9-(4-Chlorophenyl)sulfonyl-6-methylsulfonyl-1,2,3,4-tetrahydrocarbazoleIC5028.0 [1]
2-[(2,6-Dichloro-3-methoxy-4-hydroxyphenyl)amino]phenylacetic acidIC5013803842.65 [1]
[2-(2,3-Dimethylanilino)phenyl]acetic acidIC50501187233.63 [1]
2-[2-(2-Chloro-6-iodoanilino)phenyl]acetic acidIC50501187233.63 [1]
2-[2-(2,3,5,6-Tetramethylanilino)phenyl]acetic acidIC50165958690.74 [1]
2-[(2,3-Dichlorophenyl)amino]phenylacetic acidIC50100000000.0 [1]
2-[2-(3-Chloro-2-methylanilino)phenyl]acetic acidIC5091201083.94 [1]
[2-(2,6-Dichloro-3-methoxyanilino)phenyl]acetic acidIC5091201083.94 [1]
2-[(2-Chloro-3-methylphenyl)amino]phenylacetic acidIC5050118723.36 [1]
2-[(2,6-Diethylphenyl)amino]phenylacetic acidIC5014791083.88 [1]
2-[(3,4-Dichlorophenyl)amino]phenylacetic acidIC507079457.84 [1]
4-[(E)-2-(2-Thienyl)ethenyl]-2,6-diethylphenolIC5010000.0 [1]
2-Methoxy-6-methyl-4-(2-thiophen-2-yl-vinyl)-phenolIC503100.0 [1]
2-Ethyl-6-methoxy-4-(2-thiophen-2-yl-vinyl)-phenolIC501400.0 [1]
2-Methoxy-6-propyl-4-(2-thiophen-2-yl-vinyl)-phenolIC501300.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclooxygenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/cyclooxygenase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Cyclooxygenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclooxygenase-inhibitors-ic50-ki.
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