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Cyclooxygenase-2 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
CelecoxibIC5080.0 [1]
IndomethacinIC50900.0 [1]
IndomethacinKi1500.0 [1]
RofecoxibIC50300.0 [1]
IbuprofenIC501400.0 [1]
5-Bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiopheneIC5030.0 [1]
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamideIC50610.0 [1]
AspirinIC5019800.0 [1]
AspirinKi52000.0 [1]
DiclofenacIC5050.0 [1]
NimesulideIC50700.0 [1]
1-((4-Methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazoleIC50100.0 [1]
EtoricoxibIC50810.0 [1]
ValdecoxibIC5040.0 [1]
ResveratrolIC501300.0 [1]
1-Fluoro-4-[2-(4-methylsulfonylphenyl)cyclopenten-1-yl]benzeneIC5026.0 [1]
NaproxenIC5012400.0 [1]
LumiracoxibIC50130.0 [1]
LumiracoxibKi320.0 [1]
CarprofenIC50100.0 [1], 102.0 [2], 3900.0 [3], 38000.0 [4]
3-(3,4-Difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanoneIC5030.0 [1], 230.0 [2], 480.0 [3], 900.0 [4]
1-Methoxy-4-[2-(4-methylsulfonylphenyl)-1-cyclopentenyl]benzeneIC500.5 [1], 5.0 [2], 5.01 [3], 7.0 [4]
KetoprofenIC5026.0 [1], 61.0 [2], 690.0 [3], 3800.0 [4]
FlurbiprofenIC5010.0 [1], 1060.0 [2], 1995.26 [3]
Flufenamic acidIC5016.0 [1], 20.0 [2], 9300.0 [3]
4-(5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamideIC500.45 [1], 10.0 [2]
ThioflosulideIC5020.0 [1], 23.0 [2], 29.0 [3], 140.0 [4]
4-[5-Phenyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamideIC5032.0 [1], 32.36 [2], 160.0 [3]
3-(5-Chlorofuran-2-yl)-4-phenyl-5-methylisoxazoleIC50100000.0 [1]
3-[[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl]-1-(4-methylsulfonylphenyl)-5-phenylpyrazoleIC5045.0 [1], 50.0 [2], 9700.0 [3]
N-(3-Phenoxy-4-pyridinyl)trifluoromethanesulfonamideIC50400.0 [1], 620.0 [2]
1-Fluoro-4-[2-[4-(methylsulfonyl)phenyl]-4,4-dimethyl-1-cyclopentenyl]benzeneIC5015.0 [1], 15.14 [2], 15000.0 [3]
4-[6-(4-Fluorophenyl)spiro[2.4]hept-5-en-5-yl]benzenesulfonamideIC503.0 [1], 3.02 [2]
1-(5-Chloro-1,3-benzoxazol-2-yl)-N-[(1S,2S)-2-phenylmethoxycyclopentyl]piperidine-4-carboxamideIC5034.7 [1], 934.0 [2], 7560.0 [3], 100000.0 [4]
5-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)spiro[2.4]hept-5-eneIC501.1 [1], 7.59 [2], 8.0 [3]
Oleanolic acidIC5087000.0 [1], 295000.0 [2]
MeloxicamIC50160.0 [1], 490.0 [2], 700.0 [3]
WogoninIC5046000.0 [1]
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazoleIC506300.0 [1], 10000.0 [2], 74900.0 [3]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC5011060.0 [1], 79200.0 [2], 100000.0 [3]
LicofeloneIC50370.0 [1], 30000.0 [2]
Indolo[2,1-b]quinazoline-6,12-dioneIC5064.0 [1]
CimicoxibIC505.0 [1], 66.0 [2], 100.0 [3]
TebufeloneIC50100.0 [1]
MavacoxibIC5040.74 [1], 41.0 [2]
4-[5-(4-Amino-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC50338.84 [1], 340.0 [2]
2-(4,6-Diphenethoxypyrimidin-2-ylthio)hexanoic acidIC5010.0 [1], 40000.0 [2]
4-[5-(4-Methoxy-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC507.94 [1], 8.0 [2]
COX-2 Inhibitor IIC50650.0 [1], 4300.0 [2]
4-Desmethyl-2-methyl CelecoxibIC5069.0 [1], 69.18 [2]
1,1-Diphenyl-2-(4-mesylphenyl)-1-hexeneIC5014.0 [1], 2700.0 [2]
N-[4-(3,4-Dichlorophenyl)phenyl]-4-hydroxy-1,1-dioxo-2H-1lambda6,2-benzothiazine-3-carboxamideIC50100000.0 [1], 263000.0 [2]
4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC50120.0 [1], 120.23 [2]
4-[5-(4-Methylamino-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5015.85 [1], 16.0 [2]
1-(4-Methanesulfonyl-phenyl)-2-p-tolyl-4-trifluoromethyl-1H-imidazoleIC50158.49 [1], 160.0 [2], 180.0 [3]
4-Desmethyl-3-methyl CelecoxibIC50109.65 [1], 110.0 [2]
4-[5-(4-Nitrophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamideIC502630.0 [1], 2630.27 [2]
4-[5-(3,4-Dimethoxy-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC50600.0 [1], 602.56 [2]
4-[5-(2-Chloro-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5056.0 [1], 56.23 [2]
4-[5-(3,4-Dichloro-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5015.0 [1], 15.14 [2]
4-[5-(2-Fluoro-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5057.54 [1], 58.0 [2]
4-[5-(2-Methoxy-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC50288.4 [1], 290.0 [2]
4-[4-Chloro-5-(4-chloro-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC505.25 [1], 5.3 [2]
4-(4-Methoxy-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonamideIC5079.43 [1], 80.0 [2]
4-[3-Carbamoyl-4-chloro-5-(4-chlorophenyl)-1H-pyrazole-1-yl]benzenesulfonamideIC501090.0 [1], 1096.48 [2]
4-[5-(4-Methoxy-3-methyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC509.3 [1], 9.33 [2]
4-(4-Cyano-5-p-tolyl-pyrazol-1-yl)-benzenesulfonamideIC5075.86 [1], 76.0 [2]
4-[5-(4-Chloro-phenyl)-4-methyl-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5021.88 [1], 22.0 [2]
4-[5-(4-Chloro-phenyl)-4-ethyl-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5028.0 [1], 28.18 [2]
4-[5-(3-Chloro-4-methylamino-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5026.92 [1], 27.0 [2]
2-Benzo[1,3]dioxol-5-yl-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-1H-imidazoleIC50170.0 [1], 280.0 [2], 281.84 [3]
4-[2-(3-Fluoro-4-methoxyphenyl)phenyl]benzenesulfonamideIC5033.0 [1], 33.11 [2]
3-((4-(Trifluoromethyl)Phenyl)Amino)Benzoic AcidIC50100000.0 [1]
1-(4-(Methylsulfonyl)phenyl]-2-phenyl-4-trifluoromethyl-1H-imidazoleIC50120.0 [1], 120.23 [2], 130.0 [3]
4-[3-Cyano-5-(4-fluoro-phenyl)-pyrazol-1-yl]-benzenesulfonamideIC50338.84 [1], 340.0 [2]
1-(4-Methanesulfonyl-phenyl)-2-m-tolyl-4-trifluoromethyl-1H-imidazoleIC5060.0 [1], 60.26 [2], 80.0 [3]
3-(4-Bromo-2-fluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC50149.97 [1], 150.0 [2]
4-[5-(2,4-Dichloro-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5056.0 [1], 56.23 [2]
N-(3-Phenoxy-4-pyridinyl)methanesulfonamideIC5037500.0 [1], 100000.0 [2]
6,8-Dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic AcidIC5018.0 [1], 300.0 [2]
4-Chloro-5-(3-fluoro-4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-1H-imidazoleIC504.0 [1], 90.0 [2], 156.0 [3]
4-(4-Chloro-3-methyl-5-phenyl-pyrazol-1-yl)-benzenesulfonamideIC5028.0 [1], 28.18 [2]
4-[2-(3-Chloro-4-methoxyphenyl)phenyl]benzenesulfonamideIC5019.0 [1], 19.05 [2]
4-[2-(4-Methoxyphenyl)-1-cyclopentenyl]benzenesulfonamideIC502.0 [1]
4-[5-(3-Chloro-4-methoxy-5-methyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC5066.0 [1], 66.07 [2]
1-(4-Chlorophenyl)-2-[4-(methylsulfonyl)phenyl]benzeneIC50140.0 [1], 141.25 [2]
4-[4-Chloro-5-(4-chloro-phenyl)-3-hydroxymethyl-pyrazol-1-yl]-benzenesulfonamideIC50338.84 [1], 340.0 [2]
4-[4-Bromo-5-(4-chloro-phenyl)-pyrazol-1-yl]-benzenesulfonamideIC5030.9 [1], 31.0 [2]
4-[2-(4-Fluorophenyl)phenyl]benzenesulfonamideIC5061.0 [1], 61.66 [2]
4-[2-(3-Chloro-4-fluorophenyl)phenyl]benzenesulfonamideIC5016.98 [1], 17.0 [2]
1-(4-Fluorophenyl)-4-formyl-5-methyl-2-(4-methylsulfonylphenyl)pyrroleIC503230.0 [1], 3235.94 [2]
2-Chloro-1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]phenyl]benzeneIC50360.0 [1], 363.08 [2]
4-[5-(3-Ethyl-4-methoxy-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamideIC50426.58 [1], 430.0 [2]
3-(4-Chloro-2-fluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC50199.99 [1], 200.0 [2]
N-(3-Phenylamino-4-pyridinyl)trifluoromethanesulfonamideIC5090.0 [1]
1-(4-Fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carbonitrileIC50750.0 [1], 758.58 [2]
2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[(2R)-1-hydroxypropan-2-yl]acetamideIC50170.0 [1]
2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[(2S)-1-hydroxypropan-2-yl]acetamideIC50270.0 [1]
2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamideIC50440.0 [1]
2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[(1S)-2-hydroxy-1-phenylethyl]acetamideIC5085.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclooxygenase-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/cyclooxygenase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Cyclooxygenase-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclooxygenase-2-inhibitors-ic50-ki.
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