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Cyclooxygenase-1 Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
CelecoxibIC5014000.0 [1]
IndomethacinIC50110.0 [1]
RofecoxibIC5019000.0 [1]
5-Bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiopheneIC50600.0 [1]
NimesulideIC5010900.0 [1]
1-((4-Methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazoleIC50100000.0 [1]
IbuprofenIC506300.0 [1]
DiclofenacIC5015.0 [1]
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamideIC50100000.0 [1]
AspirinIC50560100.0 [1]
AspirinKi62000.0 [1]
1-Fluoro-4-[2-(4-methylsulfonylphenyl)cyclopenten-1-yl]benzeneIC5050000.0 [1]
EtoricoxibIC50100000.0 [1]
ValdecoxibIC50100000.0 [1]
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazoleIC509.0 [1]
3-(5-Chlorofuran-2-yl)-4-phenyl-5-methylisoxazoleIC50500.0 [1]
ResveratrolIC50830.0 [1], 1100.0 [2], 2840.0 [3], 4120.0 [4], 195500.0 [5]
NaproxenIC50350.0 [1], 3200.0 [2], 11000.0 [3]
3-(3,4-Difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanoneIC5013000.0 [1], 15300.0 [2], 50000.0 [3], 100000.0 [4]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-oneIC508100.0 [1], 8800.0 [2], 35090.0 [3], 52000.0 [4]
ThioflosulideIC501600.0 [1], 10000.0 [2], 50000.0 [3], 100000.0 [4]
1-Methoxy-4-[2-(4-methylsulfonylphenyl)-1-cyclopentenyl]benzeneIC505000.0 [1], 9900.0 [2], 9920.0 [3]
3-[[3-Fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl]-1-(4-methylsulfonylphenyl)-5-phenylpyrazoleIC5010.0 [1], 10000.0 [2], 26080.0 [3]
N-(3-Phenoxy-4-pyridinyl)trifluoromethanesulfonamideIC50140.0 [1], 2200.0 [2]
MeloxicamIC501400.0 [1], 2200.0 [2], 36600.0 [3]
Flufenamic acidIC502230.0 [1], 3000.0 [2]
TebufeloneIC50250.0 [1]
4-[2-(3-Fluoro-4-methoxyphenyl)phenyl]benzenesulfonamideIC5013182.57 [1], 13200.0 [2], 71600.0 [3]
N-(3-Phenoxy-4-pyridinyl)methanesulfonamideIC50410.0 [1], 4900.0 [2]
6,8-Dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic AcidIC50740.0 [1], 32000.0 [2]
N-(3-Phenylamino-4-pyridinyl)trifluoromethanesulfonamideIC50180.0 [1]
1-Fluoro-4-[2-[4-(methylsulfonyl)phenyl]-4,4-dimethyl-1-cyclopentenyl]benzeneIC5018300.0 [1]
4-[6-(4-Fluorophenyl)spiro[2.4]hept-5-en-5-yl]benzenesulfonamideIC50330.0 [1], 5400.0 [2]
5-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)spiro[2.4]hept-5-eneIC50140.0 [1], 5400.0 [2]
N-[1-Oxo-6-(thiazol-2-ylsulfanyl)-indan-5-yl]-methanesulfonamideIC5010000.0 [1], 13000.0 [2], 100000.0 [3]
3-(3-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-5H-furan-2-oneIC5050000.0 [1], 65000.0 [2], 86000.0 [3]
N-Butan-2-yl-4-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-2-amineIC5062000.0 [1], 66200.0 [2], 100000.0 [3]
5-Acetoxymethyl-3-(5-chlorofuran-2-yl)-4-phenylisoxazoleIC505000.0 [1], 20000.0 [2], 23000.0 [3]
CianidanolIC5036700.0 [1], 80000.0 [2]
Oleanolic acidIC50380000.0 [1]
KetoprofenIC502.0 [1], 330.0 [2]
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazoleIC502000.0 [1], 5000.0 [2]
PiroxicamIC501300.0 [1], 85113.8 [2]
FlurbiprofenIC5010.0 [1], 1995.26 [2]
CyanidinIC5090000000.0 [1]
CarprofenIC5013200.0 [1], 59000.0 [2]
LumiracoxibIC507.0 [1], 10000.0 [2]
LoxoprofenIC506500.0 [1], 100000.0 [2]
RutaecarpineIC508700.0 [1]
4-(5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamideIC5017800.0 [1], 31400.0 [2]
LicofeloneIC50160.0 [1], 800.0 [2]
DexibuprofenIC5098.65 [1], 2600.0 [2]
Loxoprofen sodiumIC5023500.0 [1], 24000.0 [2]
FirocoxibIC5025000.0 [1], 100000.0 [2]
MofezolacIC501.4 [1], 7.9 [2]
3-(3-Fluorophenyl)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-oneIC5014000.0 [1], 70000.0 [2]
(-)-EpiafzelechinIC506400.0 [1], 15000.0 [2]
CimicoxibIC501900.0 [1], 3300.0 [2]
[4,5-Bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazinyl)methanoneIC5028.0 [1], 90.0 [2]
1-(4-Methanesulfonyl-phenyl)-2-p-tolyl-4-trifluoromethyl-1H-imidazoleIC5025900.0 [1], 26000.0 [2]
2-Benzo[1,3]dioxol-5-yl-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-1H-imidazoleIC501100.0 [1]
3-((4-(Trifluoromethyl)Phenyl)Amino)Benzoic AcidIC50100000.0 [1]
1-(7-Tert-butyl-3,3-dimethyl-2,3-dihydrobenzofuran-5-yl)-4-cyclopropylbutan-1-oneIC507000.0 [1]
1-(4-(Methylsulfonyl)phenyl]-2-phenyl-4-trifluoromethyl-1H-imidazoleIC50723000.0 [1], 755000.0 [2]
1-(4-Methanesulfonyl-phenyl)-2-m-tolyl-4-trifluoromethyl-1H-imidazoleIC5078000.0 [1], 90000.0 [2]
3-(4-Bromo-2-fluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC5022800.0 [1], 22803.42 [2]
6,7-Dimethyl-2-[4-(methylsulfonyl)phenyl]-3-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidineIC5010000.0 [1]
4-Chloro-5-(3-fluoro-4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-1H-imidazoleIC505800.0 [1], 10000.0 [2]
1-(4-Methanesulfonyl-phenyl)-2-o-tolyl-4-trifluoromethyl-1H-imidazoleIC50577000.0 [1], 789000.0 [2]
1-(7-Tert-butyl-3,3-dimethyl-2,3-dihydrobenzofuran-5-yl)butan-1-oneIC5095.0 [1]
4-[2-(3-Chloro-4-methoxyphenyl)phenyl]benzenesulfonamideIC508128.31 [1], 8200.0 [2]
4-[2-(4-Chlorophenyl)phenyl]benzenesulfonamideIC503900.0 [1], 3981.07 [2]
4-[2-(4-Methoxyphenyl)-1-cyclopentenyl]benzenesulfonamideIC50200.0 [1]
4-[2-(4-Fluorophenyl)phenyl]benzenesulfonamideIC5019000.0 [1], 19054.61 [2]
4-[2-(3-Chloro-4-fluorophenyl)phenyl]benzenesulfonamideIC509200.0 [1], 9332.54 [2]
3-(4-Chloro-2-fluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC5018800.0 [1], 18801.82 [2]
2-Desmethylsulindac SulfideIC50116.0 [1], 1800.0 [2]
N-[3-(3-Bromophenylamino)-4-pyridinyl]trifluoromethanesulfonamideIC50910.0 [1]
3-[(4-Nitrophenyl)amino]benzoic AcidIC5030760.0 [1]
5,5-Dimethyl-3-(1-methylethoxy)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanoneIC50100000.0 [1]
3-(2,4-Difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC5022299.75 [1], 22300.0 [2]
1-[2-(4-Methylsulfonylphenyl)-1-cyclopentenyl]-4-trifluoromethylbenzeneIC50100000.0 [1]
2-(5-Methoxy-1H-benzimidazole-2-ylthiomethyl)-3-pentadecylphenolIC50384000.0 [1]
5,6-Dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic AcidIC50690.0 [1], 1510.0 [2]
(2S,3S)-trans-delta-ViniferinIC504300.0 [1], 26000.0 [2]
3-(4-Fluoro-2-methyl-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC5021198.25 [1], 21200.0 [2]
2-(4-Methanesulfonyl-phenyl)-6-methyl-3-o-tolyloxy-pyran-4-oneIC5022800.0 [1], 22803.42 [2]
6-(4-Fluorophenyl)-7-[4-(methylsulfonyl)phenyl]spiro[3.4]oct-6-eneIC50100000.0 [1]
3-(4-Bromo-2-chloro-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC5035196.54 [1], 35200.0 [2]
3-(4-Chloro-2-methyl-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC5036559.48 [1], 36600.0 [2]
3-(2-Chloro-4-methyl-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC5016595.87 [1], 16600.0 [2]
3-(2-Fluoro-4-methyl-phenoxy)-2-(4-methanesulfonyl-phenyl)-6-methyl-pyran-4-oneIC506900.0 [1], 6902.4 [2]
AtractylochromeneIC503300.0 [1]
3-(2-Methylphenyl)-4-(4-sulfamoylphenyl)-4-oxazoline-2-oneIC5028973.44 [1], 29000.0 [2]
3-(4-Hydroxy-phenyl)-4-(4-methanesulfonyl-phenyl)-5H-furan-2-oneIC506500.0 [1], 250000.0 [2]
3,4-Diphenyl-5-ethylisoxazoleIC5050.0 [1]
1-Methyl-4-[2-(4-methylsulfonylphenyl)-1-cyclopentenyl]benzeneIC50100000.0 [1]
1-(7-Tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-pentan-1-oneIC502000.0 [1]
3-(3-Fluoro-4-methoxyphenyl)-4-(4-sulfamoylphenyl)-4-oxazoline-2-oneIC505100.0 [1], 5105.05 [2]
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-spiro[4.4]non-2-eneIC50100000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclooxygenase-1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/cyclooxygenase-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Cyclooxygenase-1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclooxygenase-1-inhibitors-ic50-ki.
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