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Cyclin T1 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
4-[[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.27 [1], 0.28 [2]
4-[[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.01 [1], 0.02 [2]
4-[[5-Chloro-4-[6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.03 [1], 0.15 [2]
4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amineIC5020.0 [1]
Cdk9-IN-2IC500.03 [1]
4-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[[(3R)-oxan-3-yl]methylamino]pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-[[(2S)-oxolan-2-yl]methyl]cyclohexane-1,4-diamineIC500.01 [1]
1-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-4-N-(2-methoxyethyl)-4-N-methylcyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-[[(2R)-oxolan-2-yl]methyl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-[[(2S)-oxolan-2-yl]methyl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[3-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[3-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.0 [1]
4-N-[4-[3-Bromo-6-(oxan-4-ylmethylamino)pyridin-2-yl]-5-chloropyridin-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[4-[3-Bromo-6-(oxan-4-ylmethylamino)pyridin-2-yl]-5-chloropyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-[2-(trifluoromethoxy)ethyl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[6-[[(4R)-2,2-dimethyloxan-4-yl]methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[[(4S)-2,2-dimethyloxan-4-yl]methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[3,5-dichloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[5-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[(4-methyloxan-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[5-fluoro-6-[(4-methyloxan-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[6-[(4-fluorooxan-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
1-N-[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]-4-N,4-N-dimethylcyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[(3,5-difluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.01 [1]
1-N-[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]-4-N-(2-methoxyethyl)-4-N-methylcyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[[(2S,6R)-2,6-dimethyloxan-4-yl]methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[5-fluoro-6-[(4-methyloxan-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]-1-N-(1,1-dioxothiolan-3-yl)cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[5-chloro-6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-[[5-Chloro-4-[5-chloro-6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.01 [1]
4-[[5-Chloro-4-[6-[[(3R)-oxan-3-yl]methylamino]pyrazin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.01 [1]
4-[[5-Chloro-4-[6-[[(3S)-oxan-3-yl]methylamino]pyrazin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.01 [1]
4-N-[5-Chloro-4-[6-[[(3S)-oxan-3-yl]methylamino]pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[methyl(oxan-4-ylmethyl)amino]pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[4-[3-Chloro-6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[3,5-difluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Fluoro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-[[5-Chloro-4-[6-(oxan-3-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.01 [1]
4-[[5-Chloro-4-[6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.01 [1]
4-N-[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.42 [1]
(2S)-3-[[4-[[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]amino]-1,1,1-trifluoropropan-2-olIC500.0 [1]
4-[[5-Chloro-4-[3-chloro-6-[(2,2-dimethyloxan-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.0 [1]
4-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-[[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[5-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-(2-methylsulfonylethyl)cyclohexane-1,4-diamineIC500.0 [1]
1-N-[5-Chloro-4-[3-chloro-6-[[(3R)-oxan-3-yl]methylamino]pyridin-2-yl]pyridin-2-yl]-4-N-[(2R)-1-methoxypropan-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[5-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-(oxetan-2-ylmethyl)cyclohexane-1,4-diamineIC500.0 [1]
2-[[4-[[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]amino]ethanolIC500.01 [1]
2-[[4-[[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]amino]ethanolIC500.02 [1]
1-N-[5-Chloro-4-[3-chloro-6-[[(3S)-oxan-3-yl]methylamino]pyridin-2-yl]pyridin-2-yl]-4-N-[(2R)-1-methoxypropan-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[4-[3-Chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]-5-fluoropyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]-N-[(1R,3S)-3-(methylaminomethyl)cyclopentyl]pyridin-2-amineIC500.01 [1]
1-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-4-N-[(2R)-1-methoxypropan-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
1-N-[5-Chloro-4-[3-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-4-N-[(2R)-1-methoxypropan-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
1-N-[5-Chloro-4-[5-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-4-N-[(2R)-1-methoxypropan-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
1-N-[5-Chloro-4-[6-[(2,2-dimethyloxan-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]-4-N-[(2R)-1-methoxypropan-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
1-N-[5-Chloro-4-[6-[[(4S)-2,2-dimethyloxan-4-yl]methylamino]pyridin-2-yl]pyridin-2-yl]-4-N-[(2R)-1-methoxypropan-2-yl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[5-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-[(1,1-dioxothian-4-yl)methyl]cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[5-fluoro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[6-[(3,5-difluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.02 [1]
4-N-[5-Chloro-4-[6-[(5-fluoropyridin-3-yl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.06 [1]
4-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
3-Chloro-6-[5-chloro-2-[(4-pyrrolidin-1-ylcyclohexyl)amino]pyridin-4-yl]-N-(oxan-4-ylmethyl)pyrazin-2-amineIC500.01 [1]
5-[2-[(4-Aminocyclohexyl)amino]-5-chloropyridin-4-yl]-3-N-(oxan-4-ylmethyl)pyrazine-2,3-diamineIC500.01 [1]
4-N-[5-Chloro-4-[3-methyl-6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[6-[[(2R)-6-oxaspiro[2.5]octan-2-yl]amino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.05 [1]
(1R,3R)-3-N-[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclopentane-1,3-diamineIC500.01 [1]
(1S,3R)-3-[[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]-N,N-dimethylcyclopentane-1-carboxamideIC500.02 [1]
5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-amineIC500.54 [1]
4-N-[5-Chloro-4-[6-[[(2S,6R)-2,6-dimethyloxan-4-yl]methylamino]pyridin-2-yl]pyridin-2-yl]-1-N-(2-methoxyethyl)cyclohexane-1,4-diamineIC500.0 [1]
4-N-[5-Chloro-4-[6-[(1,1-dioxothian-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
N-[4-(Aminomethyl)cyclohexyl]-5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-amineIC500.01 [1]
5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]-N-piperidin-4-ylpyridin-2-amineIC500.03 [1]
4-N-[4-[3-Chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.03 [1]
4-N-[5-Chloro-4-[6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-[[[6-[5-Chloro-2-[(4-hydroxycyclohexyl)amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrileIC500.0 [1]
4-[[[6-[5-Chloro-2-[[4-(oxan-4-ylamino)cyclohexyl]amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrileIC500.0 [1]
5-Chloro-N-(1-ethylsulfonylpiperidin-4-yl)-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-amineIC500.24 [1]
N-[4-[[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]-2-(dimethylamino)acetamideIC500.01 [1]
4-N-[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]-1-N-(2-methylsulfonylethyl)cyclohexane-1,4-diamineIC500.02 [1]
4-N-[4-[6-[(3-Fluorophenyl)methylamino]pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
N-[4-[[5-Chloro-4-[6-(oxan-4-ylmethylamino)pyrazin-2-yl]pyridin-2-yl]amino]cyclohexyl]acetamideIC500.08 [1]
4-N-[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]-1-N-methylcyclohexane-1,4-diamineIC500.01 [1]
(2S)-3-[[4-[[5-Chloro-4-[3-chloro-6-[(2,2-dimethyloxan-4-yl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]amino]-1,1,1-trifluoropropan-2-olIC500.0 [1]
5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]-N-[2-[(3R)-piperidin-3-yl]ethyl]pyridin-2-amineIC500.01 [1]
(1S,3R)-3-[[5-Chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclopentane-1-carboxylic acidIC500.02 [1]
1-N-Benzyl-4-N-[4-[6-[(3-fluorophenyl)methylamino]pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.02 [1]
1-[(3R)-3-[[[6-[2-[(4-Aminocyclohexyl)amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]piperidin-1-yl]ethanoneIC500.14 [1]
Ethyl 2-[[4-[[5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]amino]-1,3-oxazole-4-carboxylateIC500.02 [1]
4-[[[6-[5-Chloro-2-[[4-(ethylamino)cyclohexyl]amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrileIC500.0 [1]
4-[[5-Chloro-4-[6-[(3,5-difluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.01 [1]
4-N-[5-Chloro-4-[3-chloro-6-(oxan-4-ylmethylamino)pyridin-2-yl]pyridin-2-yl]-1-N-(2-methylsulfonylethyl)cyclohexane-1,4-diamineIC500.01 [1]
4-N-[5-Chloro-4-[5-fluoro-6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.01 [1]
4-N-[4-[6-[(3-Fluorophenyl)methylamino]pyridin-2-yl]-5-methylpyridin-2-yl]cyclohexane-1,4-diamineIC500.02 [1]
4-N-[5-Chloro-4-[6-(oxan-4-ylmethylamino)-3-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl]cyclohexane-1,4-diamineIC500.04 [1]
4-[[[6-[5-Chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]pyridin-4-yl]-3-fluoropyridin-2-yl]amino]methyl]oxane-4-carbonitrileIC500.0 [1]
Tert-butyl 4-[[5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]piperidine-1-carboxylateIC500.05 [1]
4-[[5-Chloro-4-[6-(piperidin-4-ylamino)pyridin-2-yl]pyridin-2-yl]amino]cyclohexan-1-olIC500.04 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Cyclin T1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/cyclin-t1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Cyclin T1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/cyclin-t1-inhibitors-ic50-ki.
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